Pediatrics – Critical Care & Emergencies
Systematic Review: Cortisol levels during acute illnesses in children and adolescents.
24 Jun, 2022 | 10:54h | UTC
Risk factors for SARS-CoV-2 related severe Multisystem Inflammatory Syndrome in Children investigated in a Swedish population-based study.
23 Jun, 2022 | 10:36h | UTC
M-A: Incidence and etiology of infant Gram-negative bacteremia and meningitis in children.
23 Jun, 2022 | 10:27h | UTC
Retrospective cohort study: Association of patient characteristics with postoperative mortality in children undergoing tonsillectomy.
22 Jun, 2022 | 11:14h | UTCAssociation of Patient Characteristics With Postoperative Mortality in Children Undergoing Tonsillectomy in 5 US States – JAMA (free for a limited period)
M-A: Contemporary trends in global mortality of sepsis among young infants less than 90 days.
22 Jun, 2022 | 11:03h | UTC
#CCR22 – RCT: High-flow nasal cannula therapy met criteria for noninferiority compared to CPAP for the liberation from respiratory support in acutely ill children in the ICU.
16 Jun, 2022 | 11:10h | UTCEffect of High-Flow Nasal Cannula Therapy vs Continuous Positive Airway Pressure Therapy on Liberation From Respiratory Support in Acutely Ill Children Admitted to Pediatric Critical Care Units: A Randomized Clinical Trial – JAMA (free for a limited period)
Commentary on Twitter
Among acutely ill children clinically assessed to require noninvasive respiratory support in a pediatric critical care unit, HFNC met the criterion for noninferiority compared with CPAP for time to liberation from respiratory support. https://t.co/WvU2fKLDOJ #CCR22
— JAMA (@JAMA_current) June 16, 2022
Cohort Study: Prevalence, characteristics, and determinants of suboptimal care in the initial management of community-onset severe bacterial infections in children.
14 Jun, 2022 | 10:52h | UTC
Case Series | Outbreak of hepatitis in children: clinical course of children with acute liver failure admitted to the intensive care unit.
13 Jun, 2022 | 10:46h | UTCOutbreak of hepatitis in children: clinical course of children with acute liver failure admitted to the intensive care unit – Intensive Care Medicine (if the link is paywalled, try this one)
Related: Investigating acute hepatitis of unknown origin in children (several resources on the subject)
Commentary on Twitter
Outbreak of non-A-E hepatitis in children, 🇬🇧 data. Good outcomes if ALF by dedicated liver #ICU with early referral to Tx centres, recognizing neuro-deterioration, high-volume #ECLS, close neuromonitoring/protection & support by hepatology/Tx physicians
📎https://t.co/GYAMaZbVGD pic.twitter.com/GA58vJWQIz— Intensive Care Medicine (@yourICM) June 10, 2022
Another study suggests the Omicron variant is associated with a reduced risk of Multisystem Inflammatory Syndrome in Children compared to previous SARS-CoV-2 variants.
10 Jun, 2022 | 12:38h | UTCRelated study: Severity and Incidence of Multisystem Inflammatory Syndrome in Children During 3 SARS-CoV-2 Pandemic Waves in Israel – JAMA AND Commentary: Kids’ COVID syndrome—MIS-C—less severe in Omicron – CIDRAP
Commentary on Twitter
Study found that the risk of multisystem inflammatory syndrome in children (MIS-C) following SARS-CoV-2 infection during the #Omicron wave substantially lower compared to previous #SARSCoV2 variants. https://t.co/GYrz9XA72Z
— JAMA Pediatrics (@JAMAPediatrics) June 8, 2022
RCT: Effect of point-of-care testing for respiratory pathogens on antibiotic use in children.
10 Jun, 2022 | 11:16h | UTC
Commentary on Twitter
In a randomized controlled trial of 1243 children, point-of-care testing for respiratory pathogens did not reduce antibiotic consumption in acutely ill children. https://t.co/KnD4zRx2bf
— JAMA Network Open (@JAMANetworkOpen) June 9, 2022
CDC Report: Pediatric melatonin ingestions in the US.
9 Jun, 2022 | 11:32h | UTCPediatric Melatonin Ingestions — United States, 2012–2021 – Morbidity and Mortality Weekly Report
Commentaries:
Thousands of kids are getting sick from downing melatonin pills – NPR
Melatonin poisoning reports are up in kids, study says – Associated Press
Melatonin Overdoses Among Kids Are Up 530%, New Research Finds – TIME
Reports of melatonin poisoning in kids have increased 530% since 2012 – Yahoo News
Commentary on Twitter
New MMWR describes a 530% increase in pediatric melatonin ingestions reported to US poison control over the last decade; the largest increase occurred during the pandemic. https://t.co/SwJqTRG4s9 pic.twitter.com/AUxBrGX0Hj
— MMWR (@CDCMMWR) June 3, 2022
M-A: Intelligence outcome of pediatric intensive care unit survivors.
8 Jun, 2022 | 10:36h | UTC
Systematic Review: Positioning for acute respiratory distress in hospitalized infants and children.
7 Jun, 2022 | 11:17h | UTCPositioning for acute respiratory distress in hospitalised infants and children – Cochrane Library
Summary: Positioning for hospitalised infants and children with acute respiratory distress
State of the Art Review | Dengue: A growing problem with new interventions.
2 Jun, 2022 | 10:54h | UTCDengue: A Growing Problem With New Interventions – Pediatrics
Systematic Review: Corticosteroids for the treatment of Kawasaki disease in children.
1 Jun, 2022 | 11:05h | UTCCorticosteroids for the treatment of Kawasaki disease in children – Cochrane Library
Summary: Using corticosteroids to treat Kawasaki disease – Cochrane Library
M-A: Prevalence of respiratory viruses in community-acquired pneumonia in children.
1 Jun, 2022 | 10:57h | UTCPrevalence of respiratory viruses in community-acquired pneumonia in children: a systematic review and meta-analysis – The Lancet Child & Adolescent Health (link to abstract – $ for full-text)
Commentary on Twitter
#Respiratory viruses are frequently detected in community-acquired #pneumonia among #children of all ages and geographical regions. Most common viruses were #RSV (23%) and #rhinovirus (22%) in the pre-COVID years
New Research by @MejbahBhuiyan & team: https://t.co/4ph2Isotcu
— The Lancet Child & Adolescent Health (@LancetChildAdol) May 31, 2022
Recommendation document on rapid intravenous rehydration in acute gastroenteritis.
31 May, 2022 | 11:27h | UTC
Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in children younger than 5 years in 2019.
27 May, 2022 | 12:15h | UTCCommentaries:
Need for improved global measurement of early childhood respiratory syncytial virus disease – The Lancet (free registration required)
RSV kills 100,000 kids under age 5 a year worldwide – CHEST Physician
Systematic Review: Airway complications resulting from pediatric esophageal button battery impaction.
27 May, 2022 | 11:49h | UTCAirway Complications Resulting From Pediatric Esophageal Button Battery Impaction: A Systematic Review – JAMA Otolaryngology-Head & Neck Surgery (free for a limited period)
Invited Commentary: Pediatric Button Battery Injuries—Current State and What’s Next? – JAMA Otolaryngology-Head & Neck Surgery
Modified ABCDEF-bundles for critically ill pediatric patients – what could they look like?
24 May, 2022 | 07:43h | UTCRelated:
ABCDEF Bundle – Society of Critical Care Medicine
What’s sending kids to hospitals with hepatitis—coronavirus, adenovirus, or both?
23 May, 2022 | 01:48h | UTCWhat’s sending kids to hospitals with hepatitis—coronavirus, adenovirus, or both? – Science
Related:
Puzzling pediatric hepatitis cases echo an earlier mysterious illness – STAT
Why COVID is a key suspect in severe hepatitis cases in kids worldwide – CBC
Hepatitis outbreak in children: What do we know so far? – Imperial College London
Explaining the unexplained hepatitis in children – The Lancet Infectious Diseases
Unexplained hepatitis cases in kids rise to 348 in 20 nations – CIDRAP
Multi-Country – Acute, severe hepatitis of unknown origin in children – World Health Organization
WHO says 12 countries have reported unusual cases of hepatitis in kids – STAT
Could Mysterious Hepatitis Cases be Triggered by COVID-19? – Health Policy Watch
U.S., U.K. investigating unusual cases of hepatitis in young children – STAT
Mysterious liver illness seen in kids in US, Europe – Associated Press
Study Commentary | Antibiotics for pediatric pneumonia: might less be enough?
17 May, 2022 | 10:39h | UTCAntibiotics for Pediatric Pneumonia: Might Less Be Enough? – Annals of Emergency Medicine
Related:
Treatment of UTIs in Infants <2 Months: A Living Systematic Review – Hospital Pediatrics
Hypotheses | Severe acute hepatitis in children: investigate SARS-CoV-2 superantigens.
16 May, 2022 | 02:22h | UTCRelated:
Why COVID is a key suspect in severe hepatitis cases in kids worldwide – CBC
Hepatitis outbreak in children: What do we know so far? – Imperial College London
Explaining the unexplained hepatitis in children – The Lancet Infectious Diseases
Unexplained hepatitis cases in kids rise to 348 in 20 nations – CIDRAP
Multi-Country – Acute, severe hepatitis of unknown origin in children – World Health Organization
WHO says 12 countries have reported unusual cases of hepatitis in kids – STAT
Could Mysterious Hepatitis Cases be Triggered by COVID-19? – Health Policy Watch
U.S., U.K. investigating unusual cases of hepatitis in young children – STAT
Mysterious liver illness seen in kids in US, Europe – Associated Press
Commentary on Twitter
A solid hypothesis for the basis of the mysterious, severe acute hepatitis in children: superantigen formation from prior Covid viral reservoir in the GI tract with superimposed adenovirus infection https://t.co/1eehyQmlhi @LancetGastroHep pic.twitter.com/UqCAh3igMH
— Eric Topol (@EricTopol) May 14, 2022
Systematic Review: Ultrasound for pediatric peripheral intravenous catheter insertion.
16 May, 2022 | 01:28h | UTCUltrasound for Pediatric Peripheral Intravenous Catheter Insertion: A Systematic Review – Pediatrics
Epidemiological update: Hepatitis of unknown etiology in children.
12 May, 2022 | 10:12h | UTCRelated:
Unexplained hepatitis cases in kids rise to 348 in 20 nations – CIDRAP
Multi-Country – Acute, severe hepatitis of unknown origin in children – World Health Organization
WHO says 12 countries have reported unusual cases of hepatitis in kids – STAT
Could Mysterious Hepatitis Cases be Triggered by COVID-19? – Health Policy Watch
U.S., U.K. investigating unusual cases of hepatitis in young children – STAT
Mysterious liver illness seen in kids in US, Europe – Associated Press
Commentary on Twitter (thread – click for more)
Update: #Hepatitis of unknown aetiology in children – 11 May 2022
Approximately 106 cases have been identified in 14 EU/EEA countries and 450 cases are reported worldwide.
The cause of the disease is still under investigation.
Read more: https://t.co/B0lLm7I0dV— ECDC Outbreaks (@ECDC_Outbreaks) May 11, 2022