Valvular Heart Disease
M-A: Reduced risk of infective endocarditis following dental procedures with antibiotic prophylaxis in high-risk individuals
26 Apr, 2024 | 12:07h | UTCStudy Design and Population:
This systematic review and meta-analysis evaluated the impact of antibiotic prophylaxis on the incidence of infective endocarditis following invasive dental procedures. Researchers analyzed data from 1,152,345 cases sourced from PubMed, Cochrane-CENTRAL, Scopus, and other databases up to May 2023. The study included various research designs, such as case-control, cohort, and time-trend studies, assessing the effectiveness of antibiotic prophylaxis across different risk groups.
Main Findings:
The meta-analysis revealed that antibiotic prophylaxis significantly lowers the risk of infective endocarditis among individuals at high risk (pooled relative risk, 0.41; 95% CI, 0.29-0.57), with consistent findings across studies of good quality. However, the effectiveness of prophylaxis in individuals at moderate or low/unknown risk remains unsupported by sufficient evidence. Time-trend studies provided mixed results, with some indicating no change or an increase in infective endocarditis incidence post-guideline changes in 2007.
Implications for Practice:
The findings support the continued use of antibiotic prophylaxis for high-risk individuals undergoing invasive dental procedures, aligning with current guidelines from the American Heart Association and European Society of Cardiology. The lack of clear benefits in moderate and low-risk groups suggests a need for further research to optimize prophylaxis guidelines and ensure effective risk stratification in clinical practice.
Reference (link to abstract – $ for full-text):
Registry Analysis | Incidence and impact of pacemaker implantation after TAVR with self-expanding valves
8 Aug, 2023 | 13:29h | UTCIncidence, Predictors, and Prognostic Impact of New Permanent Pacemaker Implantation After TAVR With Self-Expanding Valves – JACC: Cardiovascular Interventions (link to abstract – $ for full-text)
Commentaries:
Pacemaker Implantation Still Risky, Not Rare With Self-Expanding TAVI Devices – TCTMD
BSH guideline for anticoagulant management of pregnant individuals with mechanical heart valves
2 Aug, 2023 | 14:01h | UTC
Debate | Do all patients with asymptomatic severe aortic stenosis need valve replacement?
2 Aug, 2023 | 13:58h | UTC
Commentary on Twitter
Great debate just published in #EHJ: all patients with asymptomatic severe aortic stenosis need valve replacement.https://t.co/2BclgoYvKj#aorticstenosis @escardio @ESC_Journals pic.twitter.com/Qslzw6EiCa
— EHJ Editor-in-Chief (@ehj_ed) August 1, 2023
Consensus Paper | Diagnosis and management of infective endocarditis in adults
1 Aug, 2023 | 14:34h | UTC
Registry Analysis | Similar 1-year mortality rates post-TAVR in cardiogenic shock patients surviving 30-day mark
31 Jul, 2023 | 13:47h | UTC
Commentary on Twitter
Outcomes of transcatheter aortic valve replacement in patients with cardiogenic shock https://t.co/Ci1MIWVYuE @escardio #EHJ #ESCYoung @ehj_ed @rladeiraslopes pic.twitter.com/zwvFUT8lKt
— European Society of Cardiology Journals (@ESC_Journals) June 29, 2023
Cohort Study | Examining patient demographics, microbiology, and mortality in infectious endocarditis after TAVI
25 Jul, 2023 | 13:48h | UTC
Case Series | Cutibacterium acnes endocarditis often misdiagnosed due to absence of typical symptoms and delayed culture results
17 Jul, 2023 | 13:31h | UTC
M-A | Family screening for bicuspid aortic valve and aortic dilatation
5 Jul, 2023 | 01:01h | UTC
Commentary on Twitter
Family screening for bicuspid aortic valve and aortic dilatation: a meta-analysis https://t.co/8rc4Uysf5o @escardio #EHJ #ESCYoung pic.twitter.com/p4XRzb3mzb
— European Society of Cardiology Journals (@ESC_Journals) June 15, 2023
Cohort Study | Risk and outcome of infective endocarditis in streptococcal bloodstream infections according to streptococcal species
22 Jun, 2023 | 15:09h | UTC
RCT | No superior recovery with minithoracotomy over sternotomy in mitral valve repair
20 Jun, 2023 | 12:51h | UTCMinithoracotomy vs Conventional Sternotomy for Mitral Valve Repair: A Randomized Clinical Trial – JAMA (free for a limited period)
See also: Visual Abstract
Review | Treatment of Enterococcus faecalis infective endocarditis
30 May, 2023 | 11:54h | UTCTreatment of Enterococcus faecalis Infective Endocarditis: A Continuing Challenge – Antibiotics
Scientific Statement | Acute heart failure and valvular heart disease
30 May, 2023 | 11:53h | UTC
RCT | Apixaban fails to match warfarin in preventing valve thrombosis in On-X mechanical heart valve patients
22 May, 2023 | 13:44h | UTCApixaban or Warfarin in Patients with an On-X Mechanical Aortic Valve – NEJM Evidence
Commentary: Apixaban or Warfarin in Patients With On-X Mechanical Aortic Valve – American College of Cardiology
Commentary on Twitter
“…in patients with an On-X mechanical aortic valve, apixaban was not noninferior to warfarin and failed to meet our safety threshold… for the prevention of valve thrombosis or valve-related thromboembolism.” https://t.co/XEcOJiGIYU#CardioTwitter #Afib
— NEJM Evidence (@NEJMEvidence) May 11, 2023
Formal consensus study on surgery to replace the aortic valve in adults aged 18–60 years
10 May, 2023 | 15:38h | UTCFormal consensus study on surgery to replace the aortic valve in adults aged 18–60 years – Heart
Commentary on Twitter
Formal consensus study on surgery to replace the aortic valve in adults aged 18–60 years https://t.co/69qlooAuhp pic.twitter.com/6hVWMElYqq
— Heart_BMJ (@Heart_BMJ) April 23, 2023
Review | Challenges in cardiology: diagnosis of native and prosthetic valve endocarditis
9 May, 2023 | 14:19h | UTCSee all articles in the series here
Review | DOACs and rheumatic valvulopathy: always a red light?
9 May, 2023 | 14:15h | UTCDOACs and rheumatic valvulopathy: always a red light? – European Heart Journal Supplements
See all articles in the series here
Expert Panel | Appropriate use criteria for the management of aortic stenosis
5 May, 2023 | 15:22h | UTC
Perspective | Proposal of a model of care for outpatient antimicrobial therapy for infective endocarditis
12 Apr, 2023 | 13:08h | UTCOutpatient Parenteral Antimicrobial Therapy for Infective Endocarditis—Model of Care – Antibiotics
Commentary on Twitter
?️⚡️ @antibioticsmdpi
Outpatient Parenteral Antimicrobial Therapy for Infective Endocarditis—Model of Care#IDTwitter #IEWikiguidelines https://t.co/uI88p1l7nR pic.twitter.com/2JiFTKR5fr— Antibiotic Steward Bassam Ghanem?? (@ABsteward) February 10, 2023
Rheumatic heart disease: JACC focus seminar
6 Apr, 2023 | 13:17h | UTCRheumatic Heart Disease: JACC Focus Seminar – Journal of the American College of Cardiology
Review | Multi-modality cardiac imaging evaluation of infective endocarditis
30 Mar, 2023 | 14:05h | UTCContemporary Review of Multi-Modality Cardiac Imaging Evaluation of Infective Endocarditis – Life
SR | Diagnostic accuracy of heart auscultation for detecting valve disease
29 Mar, 2023 | 13:23h | UTC
Consensus Paper | Recommendations for the provision of infective endocarditis services
15 Mar, 2023 | 15:13h | UTC
RCT | Three-year outcomes after transcatheter or surgical aortic valve replacement in low-risk patients with aortic stenosis
14 Mar, 2023 | 13:47h | UTCThree-Year Outcomes After Transcatheter or Surgical Aortic Valve Replacement in Low-Risk Patients with Aortic Stenosis – Journal of the American College of Cardiology (link to abstract – $ for full-text)
News Release: Benefits of TAVR Remain Consistent in Patients at Low Surgical Risk at Three Years – American College of Cardiology
Commentary on Twitter
#ACC23/#WCCardio #JACC LBCT SimPub: Data from the Evolut Low Risk trial demonstrated that #TAVR at 3 years showed durable benefits compared with surgery with respect to all-cause mortality or disabling stroke. https://t.co/PtEEFI1P1t#vhdAS #SAVR #CardioTwitter @kashishgoelmd pic.twitter.com/x0milxBGxO
— JACC Journals (@JACCJournals) March 5, 2023
Cohort Study | Effect of prosthesis-patient mismatch on long-term clinical outcomes after bioprosthetic aortic valve replacement
10 Mar, 2023 | 14:32h | UTCSummary: The study examined the impact of prosthesis-patient mismatch (PPM) on long-term clinical outcomes following bioprosthetic surgical aortic valve replacement (SAVR). The observational cohort study analyzed data from 16,423 patients who underwent bioprosthetic SAVR in Sweden from 2003 to 2018.
Results showed that increasing grades of PPM were associated with higher long-term mortality and heart failure hospitalization. Severe PPM was linked to an increased risk of heart failure, but moderate PPM did not have significant clinical significance. The study also found that PPM was not associated with aortic valve reintervention. The incidence of moderate and severe PPM has decreased in Sweden since 2013 but remained common.