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Hypertension

M-A | Effect of more vs. less intensive BP control on cardiovascular, renal and mortality outcomes in people with type 2 diabetes

29 May, 2023 | 10:37h | UTC

Effect of more versus less intensive blood pressure control on cardiovascular, renal and mortality outcomes in people with type 2 diabetes: A systematic review and meta-analysis – Diabetes & Metabolic Syndrome: Clinical Research & Reviews

 


Cohort Study | Ambulatory blood pressure more predictive of mortality than clinic blood pressure

24 May, 2023 | 13:19h | UTC

Summary: This cohort study analyzed the relationship between clinic and ambulatory blood pressure with mortality. The study utilized data from March 2004 to December 2014, sourced from the Spanish Ambulatory Blood Pressure Registry, which included 59,124 patients from 223 primary care centers across all regions of Spain. Patients were monitored until their date of death or until December 31, 2019.

During a median follow-up of 9.7 years, 7174 (12.1%) patients died, including 2361 (4.0%) due to cardiovascular causes. Findings revealed J-shaped associations for several blood pressure measures. Notably, 24-hour systolic blood pressure had a stronger association with all-cause death (HR 1.41 per 1 SD increment [95% CI 1.36–1.47]) than clinic systolic blood pressure. When adjusted for clinic blood pressure, the association between 24-hour blood pressure and all-cause death remained strong (HR 1.43 [95% CI 1.37–1.49]). Night-time systolic blood pressure was found to be the most predictive of all-cause and cardiovascular death.

The findings imply that ambulatory blood pressure, particularly night-time blood pressure, is more informative about the risk of all-cause death and cardiovascular death than clinic blood pressure. Masked hypertension and sustained hypertension were associated with increased mortality risks, but not white-coat hypertension. These results emphasize the importance of ambulatory blood pressure monitoring in hypertension management and risk prediction. Future research should focus on potential causes and strategies to control night-time blood pressure effectively, considering its substantial association with death risk.

Article: Relationship between clinic and ambulatory blood pressure and mortality: an observational cohort study in 59 124 patients – The Lancet

Commentary: Tight Link Between Ambulatory BP and Mortality Affirmed in Revamped Analysis – TCTMD

 


Underdiagnosis of primary aldosteronism: a review of screening and detection

22 May, 2023 | 13:40h | UTC

Underdiagnosis of Primary Aldosteronism: A Review of Screening and Detection – American Journal of Kidney Diseases

 

Commentary on Twitter

 


Blood pressure variability in clinical practice: past, present and the future

11 May, 2023 | 12:13h | UTC

Blood Pressure Variability in Clinical Practice: Past, Present and the Future – Journal of the American Heart Association

 


M-A | Intensive blood pressure control for patients aged over 60

11 May, 2023 | 12:07h | UTC

Intensive blood pressure control for patients aged over 60: A meta-analysis of the SPRINT, STEP, and ACCORD BP randomized controlled trials – Maturitas

 


M-A | Fruit and vegetable consumption and the risk of hypertension

11 May, 2023 | 12:02h | UTC

Fruit and vegetable consumption and the risk of hypertension: a systematic review and meta-analysis of prospective studies – European Journal of Nutrition


International consensus on standardized clinic blood pressure measurement – a call to action

4 May, 2023 | 14:03h | UTC

International Consensus on Standardized Clinic Blood Pressure Measurement – A Call to Action – American Journal of Medicine

News Release: KDIGO Announces Publication of International Consensus Statement on Standardized Blood Pressure Measurement

 

Commentary on Twitter

 


AHA Scientific Statement | Hypertension in patients treated with in-center maintenance hemodialysis

2 May, 2023 | 14:02h | UTC

Hypertension in Patients Treated With In-Center Maintenance Hemodialysis: Current Evidence and Future Opportunities: A Scientific Statement From the American Heart Association – Hypertension

Top Things to Know: HTN in Patients Treated with In-Center Maintenance Hemodialysis: Current Evidence and Future Opportunities – American Heart Association

 

Commentary on Twitter

 


RCT | Hypotension-avoidance and hypertension-avoidance strategies resulted in similar outcomes in noncardiac surgery

2 May, 2023 | 13:54h | UTC

Hypotension-Avoidance Versus Hypertension-Avoidance Strategies in Noncardiac Surgery: An International Randomized Controlled Trial – Annals of Internal Medicine (link to abstract – $ for full-text)

News Release: Hypotensive-avoidance strategies not associated with decrease in postoperative hypotension or adverse outcomes – American College of Physicians

Commentary: Hypotension-Avoidance No Better than Hypertension-Avoidance for Reducing Post-Op Adverse Events – HCP Live

 

Commentary on Twitter

 


M-A | Low-dose triple and quadruple antihypertensives outperform monotherapy in blood pressure reduction

28 Apr, 2023 | 13:23h | UTC

Efficacy and Safety of Low-Dose Triple and Quadruple Combination Pills vs Monotherapy, Usual Care, or Placebo for the Initial Management of Hypertension: A Systematic Review and Meta-analysis – JAMA Cardiology (free for a limited period)

Commentary: Low-Dose Polypills Top Other Approaches for Initial BP Control: Meta-analysis – TCTMD

Related: #ESCCongress – RCT: Initial hypertension treatment with a single pill with 4 drugs at quarter doses (irbesartan 37.5 mg, amlodipine 1.25 mg, indapamide 0.625 mg, and bisoprolol 2.5 mg) achieved better BP lowering vs. standard monotherapy (irbesartan 150 mg).

 


Cohort Study | The association between antihypertensive treatment and serious adverse events by age and frailty

28 Apr, 2023 | 12:45h | UTC

The association between antihypertensive treatment and serious adverse events by age and frailty: A cohort study – PLOS Medicine

 


Evidence Analysis | Blood pressure targets – how low can you get?

24 Apr, 2023 | 13:47h | UTC

Blood pressure targets – how low can you get? – Evidently Cochrane

Original Article: SR | Blood pressure targets for the treatment of people with hypertension and cardiovascular disease.

 

Commentary on Twitter

 


Guideline Update | Diagnosis and management of hypertension in pregnancy

24 Apr, 2023 | 13:43h | UTC

Hypertension in pregnancy: diagnosis and management – National Institute for Health and Care Excellence

 


Joint statement for assessing and managing high blood pressure in children and adolescents

19 Apr, 2023 | 13:26h | UTC

Chapter 1: How to correctly measure blood pressure in children and adolescents – Frontiers in Pediatrics

Chapter 2: How to manage high blood pressure in children and adolescents – Frontiers in Pediatrics

Related:

AHA Scientific Statement | Pediatric primary hypertension: An underrecognized condition

AHA Scientific Statement: Ambulatory blood pressure monitoring in children and adolescents.

Hypertension in Children and Adolescents: A Position Statement From a Panel of Multidisciplinary Experts Coordinated by the French Society of Hypertension – Frontiers in Pediatrics

USPSTF Statement: Insufficient evidence to recommend screening for high blood pressure in children and adolescents

 


Cluster RCT | Salt substitute outperforms salt restriction in lowering blood pressure in older patients

18 Apr, 2023 | 13:30h | UTC

Salt substitution and salt-supply restriction for lowering blood pressure in elderly care facilities: a cluster-randomized trial – Nature Medicine (if the link is paywalled, try this one)

Commentary: Exploring effectiveness of salt substitutes in elderly care facilities – Medical Xpress

Related:

Salt substitutes vs. regular salt: a quick look.

Effects of salt substitutes on clinical outcomes: a systematic review and meta-analysis – Heart (link to abstract – $ for full-text)

Cluster RCT: A household salt substitution intervention is a cost-effective intervention for preventing stroke and improving quality of life.

#ESCCongress – Cluster RCT: Among patients at increased risk for stroke, salt substitution (75% sodium chloride and 25% potassium chloride by mass) reduced the rates of stroke, major cardiovascular events, and death from any cause.

RCT: Reduced-sodium added-potassium salt substitute reduces blood pressure in hypertensive patients

Potassium Enriched Salt Substitution Could Prevent a Large Number of Cardiovascular Deaths

Cluster Randomized Trial: Effect of Salt Substitution on Community-wide Blood Pressure and Hypertension Incidence

 

Commentary on Twitter

 


Podcast | Resistant hypertension

18 Apr, 2023 | 13:16h | UTC

#390 Resistant Hypertension – The Curbsiders

 


RCT | Heterogeneity in blood pressure response to 4 antihypertensive drugs

17 Apr, 2023 | 13:14h | UTC

Heterogeneity in Blood Pressure Response to 4 Antihypertensive Drugs: A Randomized Clinical Trial – JAMA (free for a limited period)

News Release: Personalized blood pressure treatment more effective – Uppsala University

Commentary: Hypertension: Personalized Treatment May Reduce Need for Higher Doses and Multiple Medications – MedicalResearch.com

 


Twenty‐four-hour ambulatory blood pressure profile in patients with reflex syncope vs. matched controls

12 Apr, 2023 | 13:21h | UTC

Twenty‐Four‐Hour Ambulatory Blood Pressure Profile in Patients With Reflex Syncope and Matched Controls – Journal of the American Heart Association

 


Sodium intake linked to both coronary & carotid atherosclerosis in the Swedish population

10 Apr, 2023 | 13:30h | UTC

The association between sodium intake and coronary and carotid atherosclerosis in the general Swedish population – European Heart Journal Open

 

Commentary on Twitter

 


Blood pressure targets in adults with hypertension | A clinical practice guideline from the AAFP

6 Apr, 2023 | 13:30h | UTC

Blood Pressure Targets in Adults With Hypertension: A Clinical Practice Guideline From the AAFP – American Academy of Family Physicians (PDF)

Commentary: AAFP Issues New Clinical Practice Guideline on Hypertension – Annals of Family Medicine

 


ACC/AHA blood pressure categories | Systematic review of adverse pregnancy outcomes in early pregnancy

6 Apr, 2023 | 12:53h | UTC

American College of Cardiology and American Heart Association blood pressure categories—a systematic review of the relationship with adverse pregnancy outcomes in the first half of pregnancy – American Journal of Obstetrics & Gynecology

 

Commentary on Twitter

 


M-A | Impact of antihypertensive therapy on maternal & neonatal outcomes in mild-moderate pregnancy hypertension

6 Apr, 2023 | 12:51h | UTC

The impact of antihypertensive treatment of mild to moderate hypertension during pregnancy on maternal and neonatal outcomes: An updated meta-analysis of randomized controlled trials – Clinical Cardiology

 


Cross-sectional study | Association between sodium intake and coronary and carotid atherosclerosis

4 Apr, 2023 | 13:42h | UTC

The association between sodium intake and coronary and carotid atherosclerosis in the general Swedish population – European Heart Journal Open

Editorial: Dietary salt intake and atherosclerosis: an area not fully explored – European Heart Journal Open

News Release: High salt diet associated with hardened arteries even in people with normal blood pressure – European Society of Cardiology

 


AHA Scientific Statement | Pediatric primary hypertension: An underrecognized condition

3 Apr, 2023 | 14:05h | UTC

Pediatric Primary Hypertension: An Underrecognized Condition: A Scientific Statement From the American Heart Association – Hypertension

Top Things to Know: Pediatric Primary Hypertension: An Underrecognized Condition – American Heart Association

News Release: Children with high blood pressure often become adults with high blood pressure – American Heart Association

Commentaries:

The Birth of Pediatric Primary Hypertension – American Heart Association

AHA Highlights Pediatric Hypertension in Scientific Statement – HCP Live

 


Podcast | Pears in primary aldosteronism, mineralocorticoid receptor antagonists, and renovascular hypertension

29 Mar, 2023 | 13:07h | UTC

#386 Primary Aldosteronism, MRAs, and Renovascular Hypertension: NephMadness Pod Crawl 2023 – The Curbsiders

 


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