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Dermatology

Position Paper | Perioperative antibiotic prophylaxis in skin surgery

3 Aug, 2023 | 13:39h | UTC

Perioperative antibiotic prophylaxis in skin surgery – Position paper of the Antibiotic Stewardship working group of the German Society for Dermatologic Surgery (DGDC) – Journal of the German Society of Dermatology

Part 1: Procedure- and patient-related risk factors

Part 2: Special indications and situations

 


RCT | Risankizumab outperforms apremilast in moderate plaque psoriasis treatment

3 Aug, 2023 | 13:21h | UTC

Comparison of risankizumab and apremilast for the treatment of adult patients with moderate plaque psoriasis eligible for systemic therapy: results from a randomised, open-label, assessor-blinded phase IV (IMMpulse) study – British Journal of Dermatology

Commentary: Risankizumab Shown to be Superior to Apremilast in Treating Adults with Moderate Psoriasis – HCP Live

 


European consensus-based interdisciplinary guideline for invasive cutaneous squamous cell carcinoma

1 Aug, 2023 | 14:24h | UTC

Part 1: Diagnostics and prevention – European Journal of Cancer

Part 2: Treatment – European Journal of Cancer

 


M-A | Updated evidence supports incisional negative pressure wound therapy for surgical site infection prevention

1 Aug, 2023 | 14:15h | UTC

Incisional negative pressure wound therapy for the prevention of surgical site infection: an up-to-date meta-analysis and trial sequential analysis – eClinicalMedicine

 


M-A | Oral isotretinoin and triple topical therapies found most effective in acne vulgaris treatment

26 Jul, 2023 | 13:13h | UTC

Comparative Efficacy of Pharmacological Treatments for Acne Vulgaris: A Network Meta-Analysis of 221 Randomized Controlled Trials – Annals of Family Medicine

News Release: Meta-analysis of research on acne reveals that oral isotretinoin, followed by topical antibiotic, benzoyl peroxide and retinoid, are most effective treatments – American Academy of Family Physicians

 


M-A | Comparison of systemic treatments for chronic plaque psoriasis – Anti-IL17 stands out

25 Jul, 2023 | 13:27h | UTC

Systemic pharmacological treatments for chronic plaque psoriasis: a network meta‐analysis – Cochrane Library

 


Consensus Paper | Pre and post hair transplantation care

24 Jul, 2023 | 12:46h | UTC

An international expert consensus statement focusing on pre and post hair transplantation care – Journal of Dermatological Treatment

 


RCT | Direct oral challenge noninferior to skin testing followed by direct oral challenge in low-risk penicillin allergy patients

18 Jul, 2023 | 13:54h | UTC

Efficacy of a Clinical Decision Rule to Enable Direct Oral Challenge in Patients With Low-Risk Penicillin Allergy: The PALACE Randomized Clinical Trial – JAMA Internal Medicine (free for a limited period)

See also: Visual Abstract

News Release: World-first clinical trial to help millions with penicillin allergies – Vanderbilt University Medical Center

Commentary: Trial supports use of direct oral challenge for penicillin allergy – CIDRAP

 


Guidelines | Management of atopic dermatitis in adults with topical therapies

14 Jul, 2023 | 12:48h | UTC

Guidelines of care for the management of atopic dermatitis in adults with topical therapies – Journal of the American Academy of Dermatology

News Release: American Academy of Dermatology issues updated guidelines for the management of atopic dermatitis in adults with topical therapies

 


Phase 2b RCT | Therapeutic ammonia oxidising bacteria B244 shows promising efficacy in atopic dermatitis

11 Jul, 2023 | 13:40h | UTC

Efficacy and safety of topically applied therapeutic ammonia oxidising bacteria in adults with mild-to-moderate atopic dermatitis and moderate-to-severe pruritus: a randomised, double-blind, placebo-controlled, dose-ranging, phase 2b trial – eClinicalMedicine

 


Consensus Paper | Methotrexate for inflammatory skin disease in pediatric patients

7 Jul, 2023 | 16:16h | UTC

Methotrexate for inflammatory skin disease in pediatric patients: Consensus treatment guidelines – Pediatrics Dermatology

 


EULAR points to consider for the definition of clinical and imaging features suspicious for progression from psoriasis to psoriatic arthritis

27 Jun, 2023 | 13:37h | UTC

EULAR points to consider for the definition of clinical and imaging features suspicious for progression from psoriasis to psoriatic arthritis – Annals of the Rheumatic Diseases

 

Commentary on Twitter

 


Review | Deadly drug rashes: early recognition and multidisciplinary care

21 Jun, 2023 | 13:28h | UTC

Deadly drug rashes: Early recognition and multidisciplinary care – Cleveland Clinic Journal of Medicine

 


Podcast | Hypopigmented and depigmented skin lesions in pediatrics

6 Jun, 2023 | 14:24h | UTC

#84: Hypopigmented & Depigmented Skin Lesions: An En-LIGHT-ening Review – The Cribsiders

 


Guideline | Onychomycosis

1 Jun, 2023 | 12:01h | UTC

Guideline onychomycosis – Journal of the German Society of Dermatology

 


Consensus Paper | Safe skin, safe patients: the value of patient hygiene

31 May, 2023 | 14:06h | UTC

Safe Skin, Safe Patients: The Value of Patient Hygiene – Clinical Consensus Statement – American Journal of Nursing (free for a limited period)

 


SR | Efficacy of negative pressure wound therapy in treating pressure ulcers remains uncertain

31 May, 2023 | 13:53h | UTC

Negative pressure wound therapy for treating pressure ulcers – Cochrane Library

Summary: Negative pressure wound therapy for treating pressure ulcers – Cochrane Library

 


RCT | Microdosed incisional clindamycin reduces infection rate in skin cancer surgery

30 May, 2023 | 12:03h | UTC

Effect of Microdoses of Incisional Antibiotics on the Rate of Surgical Site Infections in Skin Cancer Surgery: A Randomized Clinical Trial – JAMA Surgery (link to abstract – $ for full-text)

See also: Visual Abstract

Commentary: Microdosed Incisional Clindamycin Cuts SSI After Skin Cancer Surgery – HealthDay

 


Acute generalized exanthematous pustulosis: clinical features, differential diagnosis, and management

29 May, 2023 | 10:54h | UTC

Acute Generalized Exanthematous Pustulosis: Clinical Features, Differential Diagnosis, and Management – American Journal of Clinical Dermatology

 


MASCC Guidelines for the prevention and management of acute radiation dermatitis | Part 1 – Systematic review

29 May, 2023 | 10:53h | UTC

MASCC clinical practice guidelines for the prevention and management of acute radiation dermatitis: part 1) systematic review – eClinicalMedicine

Related:

RCT | Bacterial decolonization for prevention of radiation dermatitis

RCT | Mepitel film for the prevention of acute radiation dermatitis in breast cancer.

 


Review | Skin assessments and interventions for maintaining skin integrity in nursing practice

25 May, 2023 | 11:25h | UTC

Skin assessments and interventions for maintaining skin integrity in nursing practice: An umbrella review – International Journal of Nursing Studies

 


Guidelines on the diagnosis and treatment of foot infection in persons with diabetes

24 May, 2023 | 13:30h | UTC

Guidelines on the diagnosis and treatment of foot infection in persons with diabetes – International Working Group on the Diabetic Foot

 


RCT | Spironolactone enhances acne outcomes and offers a viable alternative to oral antibiotics

24 May, 2023 | 13:27h | UTC

Summary: The SAFA (Spironolactone for Adult Female Acne) trial was a multicenter, phase 3, double-blind, randomized controlled trial in England and Wales and evaluated the efficacy of spironolactone for treating adult women with acne vulgaris. A total of 410 women, aged ≥18 years and suffering from facial acne for a minimum of six months, were randomly assigned to receive either 50 mg/day of spironolactone or a placebo, increasing to 100 mg/day until week 24.

The primary outcome was measured by the Acne-Specific Quality of Life (Acne-QoL) symptom subscale score at week 12 and 24. The trial demonstrated that spironolactone improved Acne-QoL scores more effectively than the placebo, particularly at week 24. Additionally, more participants in the spironolactone group reported acne improvement, and treatment success was significantly higher in this group at week 12. Mild side effects, notably headaches, were more common in the spironolactone group.

The findings from the SAFA trial highlight spironolactone’s effectiveness, safety, and tolerability in treating adult women with acne vulgaris, suggesting it is a viable alternative to long-term antibiotic treatments. Future research is proposed on higher initial dosages of spironolactone, and its effects on different subgroups like patients with different ages, body mass index, and ethnicity.

Article: Effectiveness of spironolactone for women with acne vulgaris (SAFA) in England and Wales: pragmatic, multicentre, phase 3, double blind, randomised controlled trial – The BMJ

Editorial: What do we know about prescribing spironolactone for acne? – The BMJ

News Release: Non-antibiotic treatment for women with persistent acne shown to be effective – University of Southhampton

 


Cohort Study | 5-mm margins may be adequate for T1a melanoma excision near critical structures

16 May, 2023 | 14:40h | UTC

Association of Excision Margin Size With Local Recurrence and Survival in Patients With T1a Melanoma at Critical Structures – JAMA Dermatology (link to abstract – $ for full-text)

Commentary: Melanoma Excisions with 5 Millimeter Margins Linked to Less Risk of Local Recurrence – HCP Live

 

Commentary on Twitter

 


The impact of hyperhidrosis on quality of life: a review of the literature

16 May, 2023 | 14:33h | UTC

The Impact of Hyperhidrosis on Quality of Life: A Review of the Literature – American Journal of Clinical Dermatology

 


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