Dermatology
Review: Histiocytosis
4 May, 2021 | 08:29h | UTC
New studies in patients with moderate-to-severe psoriasis show greater skin clearance with Bimekizumab, a monoclonal IgG1 antibody that selectively inhibits both interleukin-17A and interleukin-17F
25 Apr, 2021 | 21:08h | UTCStudy 1: Bimekizumab versus Secukinumab in Plaque Psoriasis – New England Journal of Medicine
Study 2: Bimekizumab versus Adalimumab in Plaque Psoriasis – New England Journal of Medicine
Related studies: Bimekizumab efficacy and safety in moderate to severe plaque psoriasis (BE READY): a multicentre, double-blind, placebo-controlled, randomised withdrawal phase trial – The Lancet AND Bimekizumab versus ustekinumab for the treatment of moderate to severe plaque psoriasis (BE VIVID): efficacy and safety from a 52-week, multicentre, double-blind, active comparator and placebo controlled phase 3 trial – The Lancet
RCT: Atenolol has similar efficacy as propranolol with fewer adverse events in the treatment of problematic infantile hemangiomas
20 Apr, 2021 | 05:32h | UTCEfficacy and Safety of Propranolol vs Atenolol in Infants With Problematic Infantile Hemangiomas: A Randomized Clinical Trial – JAMA Otolaryngology-Head & Neck Surgery (link to abstract – $ for full-text)
Diagnosis and management of leukocytoclastic vasculitis
14 Apr, 2021 | 01:26h | UTCDiagnosis and management of leukocytoclastic vasculitis – Internal and Emergency Medicine
Cohort study: Higher cumulative exposure to Thiazide diuretics linked to an increased risk of skin cancer in people older than 65 years
13 Apr, 2021 | 05:08h | UTCCommentaries: Thiazides May Up Risk for Skin Cancer in Older Adults – HealthDay AND Some blood pressure medication linked to higher risk of skin cancer, study finds – CTV News
Related study: Case-Control Study: Possible Association of Hydrochlorothiazide Use and Risk of Melanoma
Guidelines of care for the management of actinic keratosis
9 Apr, 2021 | 03:20h | UTC
RCT: Upadacitinib vs. Adalimumab for Psoriatic Arthritis
5 Apr, 2021 | 00:57h | UTCTrial of Upadacitinib and Adalimumab for Psoriatic Arthritis – New England Journal of Medicine (link to abstract – $ for full-text)
RCT: Abrocitinib vs. Placebo or Dupilumab for Atopic Dermatitis
26 Mar, 2021 | 08:27h | UTCAbrocitinib versus Placebo or Dupilumab for Atopic Dermatitis – New England Journal of Medicine
Systematic review: Interventions for cutaneous disease in systemic lupus erythematosus
17 Mar, 2021 | 02:30h | UTCInterventions for cutaneous disease in systemic lupus erythematosus – Cochrane Library
Clinical Update: Diagnosis and Treatment of Nonscarring Hair Loss in Primary Care in 2021
10 Mar, 2021 | 08:14h | UTCDiagnosis and Treatment of Nonscarring Hair Loss in Primary Care in 2021 – JAMA (free for a limited period)
Some experience delayed rash after Moderna shot, study says
5 Mar, 2021 | 08:44h | UTCSome Experience Delayed Rash After Moderna Shot, Study Says – Bloomberg
Original study: Delayed Large Local Reactions to mRNA-1273 Vaccine against SARS-CoV-2 – New England Journal of Medicine
Expert consensus on practical aspects in the treatment of chronic urticaria
3 Mar, 2021 | 08:28h | UTC
Phase 3 Trials of Tirbanibulin Ointment for Actinic Keratosis
2 Mar, 2021 | 01:24h | UTCPhase 3 Trials of Tirbanibulin Ointment for Actinic Keratosis – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
The tubulin polymerization and Src kinase inhibitor tirbanibulin was superior to placebo ointment in clearing actinic keratoses on the face and scalp at 2 months. As is typical of the disorder, lesions recurred in 47% of patients at 1 year.
— NEJM (@NEJM) February 17, 2021
Indian Guidelines for pediatric skin care in neonates, infants, and children
28 Feb, 2021 | 20:37h | UTCIndian Academy of Pediatrics Guidelines for Pediatric Skin Care
Cutaneous findings in SARS-CoV-2-associated Multisystem Inflammatory Disease in Children (MIS-C)
23 Feb, 2021 | 01:57h | UTC
Cohort study: Association of potent and very potent topical corticosteroids and the risk of osteoporosis and major osteoporotic fractures
26 Jan, 2021 | 00:38h | UTCEditorial: Topical Corticosteroids and Glucocorticoid-Induced Osteoporosis—Cumulative Dose and Duration Matter
Commentaries: Prolonged Use of Topical Steroids Associated with Increased Risk of Osteoporosis – Physician’s Weekly AND Potent Topical Corticosteroids Tied to Increased Fracture Risk – NEJM Journal Watch
Author Interview: Association of Topical Corticosteroids and Risk of Osteoporosis and Major Osteoporotic Fractures – JAMA
Commentary on Twitter
In a cohort study of 723 251 users of potent or very potent topical #corticosteroids, use of these drugs was associated with increased risk of #osteoporosis and major osteoporotic fracture with a dose-response association for cumulative use https://t.co/m5Rp4n0NvK
— JAMA Dermatology (@JAMADerm) January 20, 2021
EuroGuiDerm Guideline on the systemic treatment of Psoriasis vulgaris – Part 1: treatment and monitoring recommendations
21 Jan, 2021 | 00:48h | UTC
An epidemic of overdiagnosis: Melanoma diagnoses sky rocket
20 Jan, 2021 | 01:30h | UTCAn epidemic of overdiagnosis: Melanoma diagnoses sky rocket – Brigham and Women’s Hospital AND Does Screening for Skin Cancer Result in Melanoma Overdiagnosis? – Univadis
Original study: The Rapid Rise in Cutaneous Melanoma Diagnoses ($)
Related: Overdiagnosis: what it is and what it isn’t – BMJ Evidence Based Medicine (free) AND Overdiagnosis across medical disciplines: a scoping review – The BMJ Open (free) AND Too much medical care: bad for you, bad for health care systems – STAT News (free) AND Screening: How overdiagnosis and other harms can undermine the benefits – Health News Review (free) AND Overdiagnosis: causes and consequences in primary health care – Canadian Family Physician (free) AND Five warning signs of overdiagnosis – The Conversation (free) AND What is overdiagnosed cancer? And why does it matter? – Croakey (free) AND Blame rising cancer overdiagnosis on ‘irrational exuberance’ for early detection – STAT (free) AND Preventing overdiagnosis and the harms of too much sport and exercise medicine – British Journal of Sports Medicine (free)
Meta-analysis: Comparison of the loop technique with incision and drainage for skin and soft tissue abscesses
20 Jan, 2021 | 01:22h | UTC
Commentary on Twitter
Loop drainage technique (LDT) vs conventional I&D (CID) for cutaneous abscess
8 studies (n=910)
CID failed in 69/487 pts (14%)
LDT failed in 35/423 pts (8%)
OR 2.02 (95% CI 1.29 to 3.18) https://t.co/JVRZWFfyUe@MGottliebMD @GillianMD1 @AcademicEmerMed @SAEMonline #AEM pic.twitter.com/HJfnou4NYc— Gary D Peksa 💊 (@garyDpeksa) October 15, 2020
CDC Guidelines for Gonococcal Infection, 2020. CDC recommends a single 500 mg intramuscular dose of ceftriaxone for uncomplicated gonorrhea, with oral doxycycline for 7 days when chlamydial coinfection has not been excluded
18 Dec, 2020 | 09:40h | UTCCommentary: CDC Guidelines Recommend Ceftriaxone Monotherapy for Uncomplicated Gonorrhea – NEJM Journal Watch
Commentary on Twitter
New recommendations by the CDC for gonococcal infections pic.twitter.com/ZYbMt5cpyP
— Garrett Hile, PharmD, BCCCP (@GarrettHile) December 18, 2020
Podcast: Management of Cellulitis
15 Dec, 2020 | 01:20h | UTC
Systematic review: Among patients with advanced chronic kidney disease and uremic pruritus, gabapentinoids are the most studied treatments and show the greatest reduction in itch scores
13 Dec, 2020 | 23:16h | UTCInterventions for itch in people with advanced chronic kidney disease – Cochrane Library
Commentary: What is the best treatment for itch in people with chronic kidney disease? – Cochrane Library
Teledermatology used for triage reduces dermatology referrals and improves access to specialists in the most severe or surgical cases
6 Dec, 2020 | 23:37h | UTCTeledermatology reduces dermatology referrals and improves access to specialists – EClinicalMedicine
NICE Guideline: Human and animal bites. Assessment, indications for antibiotic prophylaxis in uninfected bites, and choice of antibiotic are reviewed
5 Nov, 2020 | 09:02h | UTC
Systemic treatments for eczema: A network meta‐analysis
4 Oct, 2020 | 22:45h | UTCSystemic treatments for eczema: a network meta‐analysis – Cochrane Library