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Inflammatory Bowell

Review | Pediatric-onset inflammatory bowel disease: recent developments

27 Jul, 2023 | 12:57h | UTC

Inflammatory bowel disease: recent developments – Archives of Disease in Childhood

 


Systematic Review | Vedolizumab for induction and maintenance of remission in Crohn’s disease

20 Jul, 2023 | 10:51h | UTC

Vedolizumab for induction and maintenance of remission in Crohn’s disease – Cochrane Library

 


RCT | Mirikizumab outperforms placebo in inducing and maintaining remission in ulcerative colitis

10 Jul, 2023 | 13:25h | UTC

Mirikizumab as Induction and Maintenance Therapy for Ulcerative Colitis – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Mirikizumab Bests Placebo in Treating Patients With Ulcerative Colitis – HCP Live

 

Commentary on Twitter

 


Consensus Paper | Gut microbiota and fecal microbiota transplantation in inflammatory bowel disease

26 Jun, 2023 | 00:26h | UTC

The first international Rome consensus conference on gut microbiota and faecal microbiota transplantation in inflammatory bowel disease – Gut

 


RCT | JAK inhibitor Upadacitinib shows superiority over placebo for moderate-to-severe Crohn’s disease

1 Jun, 2023 | 12:08h | UTC

Upadacitinib Induction and Maintenance Therapy for Crohn’s Disease – New England Journal of Medicine (link to abstract – $ for full-text)

 


Review | Identifying, understanding and managing fecal urgency in inflammatory bowel diseases

4 May, 2023 | 13:38h | UTC

Identifying, understanding and managing fecal urgency in inflammatory bowel diseases – Clinical Gastroenterology and Hepatology

 


SR | Fecal transplantation for treatment of inflammatory bowel disease

2 May, 2023 | 13:39h | UTC

Fecal transplantation for treatment of inflammatory bowel disease – Cochrane Library

Commentary: Expert reaction to two Cochrane reviews looking at stool transplants for recurrent Clostridium difficile infection, and for inflammatory bowel disease – Science Media Centre

 


RCT | Anti-TNF in combination with low dose methotrexate vs anti-TNF monotherapy in pediatric Crohn’s disease

26 Apr, 2023 | 13:55h | UTC

Comparative Effectiveness of Anti-TNF in Combination with Low Dose Methotrexate vs Anti-TNF Monotherapy in Pediatric Crohn’s Disease: a Pragmatic Randomized Trial – Gastroenterology (link to abstract – $ for full-text)

News Release: Researchers Announce Findings from Landmark Clinical Trial for Pediatric Crohn’s Disease – University of North Carolina Health Care System

 


Brief Review | Chronic cough and inflammatory bowel disease: an under-recognized association?

18 Apr, 2023 | 13:07h | UTC

Chronic cough and inflammatory bowel disease: an under-recognised association? – Breathe

 

Commentary on Twitter

 


RCT | Etrasimod outperforms placebo in ulcerative colitis induction & maintenance

6 Apr, 2023 | 12:56h | UTC

Etrasimod as induction and maintenance therapy for ulcerative colitis (ELEVATE): two randomised, double-blind, placebo-controlled, phase 3 studies – The Lancet

 

Commentary on Twitter

 


Global, regional and national burden of inflammatory bowel disease in 204 countries and territories from 1990 to 2019

5 Apr, 2023 | 13:27h | UTC

Global, regional and national burden of inflammatory bowel disease in 204 countries and territories from 1990 to 2019: a systematic analysis based on the Global Burden of Disease Study 2019 – BMJ Open

 


RCT | Vedolizumab for the treatment of chronic pouchitis

3 Apr, 2023 | 13:49h | UTC

Vedolizumab for the Treatment of Chronic Pouchitis – New England Journal of Medicine (link to abstract – $ for full-text)

News Release: New hope for patients after vedolizumab found effective to treat Chronic Pouchitis – University of Oxford

 

Commentary on Twitter

 


M-A | Has the therapeutical ceiling been reached in Crohn’s disease randomized controlled trials?

17 Mar, 2023 | 12:55h | UTC

Has the therapeutical ceiling been reached in Crohn’s disease randomized controlled trials? A systematic review and meta-analysis – UEG Journal

 


RCT | Induction therapy with olamkicept vs. placebo in patients with active ulcerative colitis

13 Mar, 2023 | 14:48h | UTC

Effect of Induction Therapy With Olamkicept vs Placebo on Clinical Response in Patients With Active Ulcerative Colitis: A Randomized Clinical Trial – JAMA (free for a limited period)

 

Commentary on Twitter

 


Cohort Study | Endoscopic biopsy with normal mucosa associated with elevated risk of inflammatory bowel disease for at least 30 years

8 Mar, 2023 | 14:10h | UTC

Summary:

This study explored the long-term risk of inflammatory bowel disease (IBD) after an endoscopic biopsy with normal mucosa. The researchers identified individuals in Sweden with a lower or upper gastrointestinal (GI) biopsy of normal mucosa, their matched population references, and unexposed full siblings.

They found that individuals with a previous lower or upper GI biopsy showing normal mucosa were at persistently higher risk of overall IBD, ulcerative colitis, and Crohn’s disease compared to their matched population references and unexposed full siblings, and the increased risk persisted at least 30 years after the biopsy with normal findings.

The findings suggest a substantial symptomatic period before IBD diagnosis, and clinicians should be aware of the long-term increased risk of IBD in those with symptoms requiring GI investigation but with a finding of histologically normal mucosa.

Article: Long-term risk of inflammatory bowel disease after endoscopic biopsy with normal mucosa: A population-based, sibling-controlled cohort study in Sweden – PLOS Medicine

Commentary: Risk for IBD Remains High After Endoscopic Biopsy With Normal Mucosa – HealthDay

 


AGA Guideline | Role of biomarkers for the management of ulcerative colitis

22 Feb, 2023 | 12:38h | UTC

AGA Clinical Practice Guideline on the Role of Biomarkers for the Management of Ulcerative Colitis – Gastroenterology

News Release: New AGA guideline recommends blood and stool tests for monitoring ulcerative colitis – American Gastroenterological Association

 


Review | Perioperative optimization of Crohn’s disease

17 Feb, 2023 | 12:39h | UTC

Perioperative optimization of Crohn’s disease – Annals of Gastroenterological Surgery

 


Cohort Study | Antibiotics, hormonal therapies, oral contraceptives, and NSAIDS linked to increased risk of inflammatory bowel disease

16 Feb, 2023 | 14:59h | UTC

Associations of Antibiotics, Hormonal Therapies, Oral Contraceptives, and Long-Term NSAIDS With Inflammatory Bowel Disease: Results From the Prospective Urban Rural Epidemiology (PURE) Study – Clinical Gastroenterology and Hepatology (link to abstract – $ for full-text)

Commentary: Antibiotics, hormonal medications, oral contraceptives, and long-term NSAID tied with IBD – Medical Dialogues

 


Brief Review | Surgical management of ulcerative colitis

13 Feb, 2023 | 12:30h | UTC

Surgical management of ulcerative colitis – British Journal of Surgery

 


ESPEN guideline on clinical nutrition in inflammatory bowel disease

7 Feb, 2023 | 14:02h | UTC

ESPEN guideline on Clinical Nutrition in inflammatory bowel disease – Clinical Nutrition

 


RCT | Withdrawal of infliximab or concomitant immunosuppressant therapy in patients with Crohn’s disease on combination therapy

17 Jan, 2023 | 13:10h | UTC

Withdrawal of infliximab or concomitant immunosuppressant therapy in patients with Crohn’s disease on combination therapy (SPARE): a multicentre, open-label, randomised controlled trial – The Lancet Gastroenterology & Hepatology

Invited commentary: Treatment withdrawal in Crohn’s disease: slowly becoming clearer – The Lancet Gastroenterology & Hepatology (free registration required)

 

Commentary on Twitter

 


Cohort Study | Antibiotic exposure linked to increased risk of inflammatory bowel disease

13 Jan, 2023 | 13:25h | UTC

Antibiotic use as a risk factor for inflammatory bowel disease across the ages: a population-based cohort study – Gut

News Release: Frequent use of antibiotics may heighten inflammatory bowel disease risk in over 40s – BMJ Newsroom

Commentaries: 

Antibiotics may increase risk of inflammatory bowel disease, study finds – CIDRAP

Antibiotic Exposure Positively Linked to IBD Development – HealthDay

 

Commentary on Twitter

 


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