Sleep Medicine
Randomized Trials: Tirzepatide Reduces Apnea-Hypopnea Index and Body Weight in Patients with Obstructive Sleep Apnea and Obesity – N Engl J Med
10 Aug, 2024 | 19:38h | UTCStudy Design and Population: This study comprises two phase 3, double-blind, randomized trials involving adults with moderate-to-severe obstructive sleep apnea (OSA) and obesity. Participants were either using or not using positive airway pressure (PAP) therapy at baseline and received tirzepatide or placebo over 52 weeks.
Main Findings: Tirzepatide significantly reduced the apnea-hypopnea index (AHI) by 20-24 events per hour compared to placebo and also lowered body weight, hypoxic burden, and systolic blood pressure.
Implications for Practice: Tirzepatide offers a promising treatment for reducing OSA severity and associated obesity-related complications, but further research is needed to confirm long-term benefits.
M-A | Efficacy of vibrotactile positional therapy devices on patients with positional obstructive sleep apnea
9 Aug, 2023 | 15:30h | UTC
M-A | Risk and benefits of wakefulness-promoting drugs in obstructive sleep apnea patients
23 May, 2023 | 12:43h | UTCComparative Efficacy and Safety of Wakefulness-Promoting Agents for Excessive Daytime Sleepiness in Patients With Obstructive Sleep Apnea: Systematic Review and Network Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)
News Release: Researchers find best treatment for excessive daytime sleepiness – McMaster University
ATS Research Statement | Causes, consequences, and treatments of sleep and circadian disruption in the ICU
3 May, 2023 | 15:18h | UTC
Commentary on Twitter
Causes, Consequences, and Treatments of Sleep and Circadian Disruption in the ICU: An Official American Thoracic Society Research Statement
? Open Access
? https://t.co/AKHd84D6Ry pic.twitter.com/U4bSRaC5uG— ATS Blue Journal (@ATSBlueEditor) April 13, 2023
RCT | Targeted hypoglossal nerve stimulation may benefit patients with obstructive sleep apnea
11 Apr, 2023 | 14:07h | UTC
Commentary on Twitter
In this study, proximal targeted hypoglossal nerve responses proved safe and effective in treating sleep apnea and improving sleep architecture and quality of life, while comparing favorably with those in distal hypoglossal nerve stimulation trials. https://t.co/yorNGW9uoi
— JAMA Otolaryngology – Head & Neck Surgery (@JAMAOto) April 6, 2023
Review | Role of precision medicine in obstructive sleep apnea
14 Mar, 2023 | 13:28h | UTCRole of precision medicine in obstructive sleep apnoea – BMJ Medicine
Commentary on Twitter
#Review: Role of precision medicine in obstructive sleep #apnoea ▶️https://t.co/OnxOHR2F6T#BMJMedicine pic.twitter.com/GUT3dKkfvL
— BMJMedicine (@BMJMedicine) March 9, 2023
SR | There is insufficient evidence to recommend pharmacological treatments for central sleep apnea in adults
9 Mar, 2023 | 14:01h | UTCPharmacological treatment for central sleep apnoea in adults – Cochrane Library
Summary: Medicines for central sleep apnoea in adults – Cochrane Library
Sleep irregularity linked to subclinical markers of cardiovascular disease
21 Feb, 2023 | 11:51h | UTCSummary: The study examined the association between sleep irregularity and subclinical markers of cardiovascular disease in a population of over 2000 participants with a mean age of 68. The participants completed 7-day wrist actigraphy that detected when they were asleep and awake. The results showed that sleep irregularity, particularly sleep duration irregularity, was associated with subclinical atherosclerosis, including high coronary artery calcium burden and abnormal ankle-brachial index. These associations persisted even after adjusting for cardiovascular disease risk factors and other sleep characteristics such as obstructive sleep apnea, sleep duration, and sleep fragmentation. While it is important to note that observational studies like this one cannot establish causation and may be subject to residual confounding, the findings suggest that promoting regular sleep schedules could be an essential aspect of lifestyle recommendations for preventing cardiovascular disease.
News Release: Irregular sleeping habits may increase risk of atherosclerosis in older adults – American Heart Association
Commentaries:
Sleep Irregularity Linked to Measures of Subclinical Atherosclerosis – HealthDay
Irregular sleep may be harmful to your heart, study finds – CNN
SR | Non‐invasive positive pressure ventilation for central sleep apnea in adults.
7 Dec, 2022 | 14:09h | UTCNon‐invasive positive pressure ventilation for central sleep apnoea in adults – Cochrane Library
Summary: Non-invasive ventilation for people with central sleep apnoea – Cochrane Library
USPSTF Statement | There is insufficient evidence to recommend routine screening for obstructive sleep apnea.
16 Nov, 2022 | 13:46h | UTCEvidence Report: Screening for Obstructive Sleep Apnea in Adults: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force – JAMA
JAMA Patient Page: Screening for Obstructive Sleep Apnea
Author Interview: USPSTF Recommendation: Screening for Obstructive Sleep Apnea in Adults
Commentary: USPSTF: Evidence Inadequate for Recommending OSA Screening – HealthDay
Series | Sleep and sleep disorders.
23 Sep, 2022 | 13:13h | UTCHomepage: Sleep and sleep disorders (free registration required for all articles)
Editorial: Waking up to the importance of sleep
Series:
Understanding and approaching excessive daytime sleepiness
Circadian rhythms and disorders of the timing of sleep
Sleep function: an evolutionary perspective
Commentaries:
How and why do human beings sleep?
Social determinants and health disparities affecting sleep
RCT | Intranasal corticosteroids not beneficial for children with obstructive sleep apnea.
19 Jul, 2022 | 13:27h | UTCA trial of intranasal corticosteroids to treat the childhood obstructive sleep apnea syndrome – CHEST (link to abstract – $ for full-text)
Commentaries:
Intranasal corticosteroids not recommended for most children with OSA: study – Medical Dialogues
Commentary on Twitter
In children with obstructive sleep apnea syndrome, treatment with intranasal corticosteroids did not result in significant polysomnographic, neurobehavioral, and symptom changes compared to placebo, according to research in @journal_CHEST. https://t.co/e4bt4NMv5Z pic.twitter.com/FrIBdoMABf
— American Academy of Sleep Medicine (@AASMorg) July 11, 2022
What cardiologists should know about sleep.
13 Jul, 2022 | 11:32h | UTCWhat cardiologists should know about sleep – European Heart Journal (free for a limited period)
Consensus statements on the diagnosis and management of obstructive sleep apnea in patients with cardiovascular disease.
8 Jul, 2022 | 11:51h | UTC
M-A | Predictors of sleep disordered breathing in children with Down syndrome.
5 Jul, 2022 | 11:33h | UTCLife’s Essential 8: Updating and enhancing the AHA construct of cardiovascular health.
30 Jun, 2022 | 11:31h | UTCNews Release: American Heart Association adds sleep to cardiovascular health checklist
Commentary: Sleep duration matters for heart health, according to new recommendations – CNN
Guideline: Sleep-related breathing disorders in adults.
28 Jun, 2022 | 11:21h | UTCPartial update of the German S3 Guideline Sleep-Related Breathing Disorders in Adults – Somnologie