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Cardiology

Guidelines for anesthesiologists on patient blood management in cardiac surgery.

17 Oct, 2021 | 21:22h | UTC

2021 Clinical Practice Guidelines for Anesthesiologists on Patient Blood Management in Cardiac Surgery – Journal of Cardiothoracic and Vascular Anesthesia

 

Commentary on Twitter

 

Statins linked to reduced risk of death from COVID-19 in major population study – “Randomized studies will be needed to ascertain whether there is a causal relationship, note the researchers”.

15 Oct, 2021 | 02:47h | UTC

News release: Statins linked to reduced risk of death from COVID-19 in major population study – Karolinska Institutet

Original study: HMG-CoA reductase inhibitors and COVID-19 mortality in Stockholm, Sweden: A registry-based cohort study – PLOS Medicine

Commentaries:

Expert reaction to study looking at statins and risk of death from COVID-19 – Science Media Centre

People taking statins less likely to die from Covid, study suggests – The Guardian

 

FDA issues food industry guidance for reduction of sodium in processed and packaged foods.

15 Oct, 2021 | 02:29h | UTC

News Release: To Improve Nutrition and Reduce the Burden of Disease, FDA Issues Food Industry Guidance for Voluntarily Reducing Sodium in Processed and Packaged Foods – U.S. Food & Drug Administration

Guidance for Industry: Voluntary Sodium Reduction Goals – U.S. Food & Drug Administration

Commentaries:

FDA Issues New Guidance on Sodium Targets for Food Industry – TCTMD

Reducing Sodium Intake in the US: Healthier Lives, Healthier Future – JAMA

FDA Reduces Recommended Salt Levels in Americans’ Food – HealthDay

FDA guidance to food industry aims to reduce sodium consumption – American Heart Association

New FDA guidance aims to drastically cut salt in food supply – NBC News

 

Former CDC director: Low sodium salt could save millions of lives.

15 Oct, 2021 | 02:27h | UTC

Former CDC director: Low sodium salt could save millions of lives – CNN

Related:

Is salt good for you after all? The evidence says no.

#ESCCongress – Cluster RCT: Among patients at increased risk for stroke, salt substitution (75% sodium chloride and 25% potassium chloride by mass) reduced the rates of stroke, major cardiovascular events, and death from any cause.

Systematic Review: Altered dietary salt intake for people with chronic kidney disease.

New WHO benchmarks help countries reduce salt intake and save lives.

RCT: Reduced-sodium added-potassium salt substitute reduces blood pressure in hypertensive patients

Potassium Enriched Salt Substitution Could Prevent a Large Number of Cardiovascular Deaths

Meta-Analysis: Effect of Reduction in Dietary Sodium on Blood Pressure Levels

Cluster Randomized Trial: Effect of Salt Substitution on Community-wide Blood Pressure and Hypertension Incidence

 

Meta-analysis of cohort studies: High intake of fatty acid in nuts, seeds and plant oils linked to lower risk of death.

15 Oct, 2021 | 02:22h | UTC

News release: High intake of fatty acid in nuts, seeds and plant oils linked to lower risk of death – The BMJ

Original study: Dietary intake and biomarkers of alpha linolenic acid and risk of all cause, cardiovascular, and cancer mortality: systematic review and dose-response meta-analysis of cohort studies – The BMJ

Commentaries:

Current evidence on dietary intakes of fatty acids and mortality – The BMJ

Expert reaction to systematic review and meta-analysis on consumption of dietary fatty acids (alpha linolenic acid) and risk of death – Science Media Centre

Related: Total dietary fat intake, fat quality, and health outcomes: A scoping review of systematic reviews of prospective studies.

 

Commentary on Twitter

 

Systematic Review: There is not enough evidence from randomized trials to inform about the effects of additional antihypertensive drugs in patients with hypertension‐induced left ventricular hypertrophy.

15 Oct, 2021 | 02:20h | UTC

Pharmacotherapy for hypertension‐induced left ventricular hypertrophy – Cochrane Library

Summary: What are the main benefits and risks of drugs for reducing blood pressure in the treatment of people with thickening of the heart muscle caused by high blood pressure? – Cochrane Library

 

Commentary on Twitter

 

M-A: Predictors of permanent pacemaker implantation in patients undergoing transcatheter aortic valve replacement.

15 Oct, 2021 | 02:19h | UTC

Predictors of Permanent Pacemaker Implantation in Patients Undergoing Transcatheter Aortic Valve Replacement ‐ A Systematic Review and Meta‐Analysis – Journal of the American Heart Association

 

Commentary on Twitter

 

Cohort study: Among women with congenital Long QT, progestin oral contraceptives were linked to a 2.8-fold increased risk of cardiovascular events in those not receiving B-blocker therapy.

15 Oct, 2021 | 02:17h | UTC

Use of oral contraceptives in women with congenital long QT syndrome – Heart Rhythm (link to abstract – $ for full-text)

Commentary: Progestin OCs Triple CV Events in Women With Congenital Long QT – TCTMD

 

Trends in use and outcomes of same-day discharge following elective percutaneous coronary intervention.

15 Oct, 2021 | 02:15h | UTC

Trends in Use and Outcomes of Same-Day Discharge Following Elective Percutaneous Coronary Intervention – JACC: Cardiovascular Interventions (link to abstract – $ for full-text)

Commentaries:

Trends in Same-Day Discharge for Elective PCI – American College of Cardiology

Same-Day Discharge After Elective PCI: No Increases in 30-Day Mortality, Rehospitalization – Physician’s Weekly

 

M-A: Outcomes after transcatheter aortic valve replacement in bicuspid versus tricuspid anatomy – device success and 1-year survival rates are similar, but patients with bicuspid valves have a higher risk for periprocedural complications.

14 Oct, 2021 | 09:51h | UTC

Outcomes After Transcatheter Aortic Valve Replacement in Bicuspid Versus Tricuspid Anatomy: A Systematic Review and Meta-Analysis – JACC: Cardiovascular Interventions

 

Podcast with Dr Walter Willett: CardioNutrition – Why are findings from prospective, epidemiologic cohort studies important in informing dietary recommendations?

14 Oct, 2021 | 09:49h | UTC

ACC CardiaCast: CardioNutrition – Why Are Findings From Prospective, Epidemiologic Cohort Studies Important In Informing Dietary Recommendations? – American College of Cardiology

 

Commentary on Twitter

 

USPSTF draft statement revises previous guidance and now recommends against initiating low-dose aspirin use for the primary prevention of CVD in adults aged 60 years or older.

13 Oct, 2021 | 01:36h | UTC

USPSTF Draft Recommendation Statement: Aspirin Use to Prevent Cardiovascular Disease – U.S. Preventive Services Task Force

Commentaries:

Advice shifting on aspirin use for preventing heart attacks – Associated Press

Taking aspirin to prevent heart attack may cause more harm than good, task force says – NPR

Related Randomized Trials:

Randomized Trial: Aspirin for Primary Prevention of Cardiovascular Disease

Randomized Trial: Effects of Aspirin for Primary Prevention in Persons with Diabetes

Randomized Trial: Effect of Aspirin on All-Cause Mortality in the Healthy Elderly

Related Meta-Analysis:

Meta-Analysis: Association of Aspirin Use for Primary Prevention with Cardiovascular Events and Bleeding Events

Meta-Analysis: Efficacy and Safety of Aspirin for Primary Prevention of Cardiovascular Events

Aspirin for primary prevention of cardiovascular disease: a meta-analysis with a particular focus on subgroups – BMC Medicine

Related Opinions:

Aspirin for Primary Prevention: Is This the End of the Road?

Evidence evolving on aspirin as prevention – ACP Internist

 

Commentary on Twitter

 

M-A: Omega-3 fatty acids supplementation is associated with increased risk of atrial fibrillation.

13 Oct, 2021 | 01:27h | UTC

Effect of Long-Term Marine Omega-3 Fatty Acids Supplementation on the Risk of Atrial Fibrillation in Randomized Controlled Trials of Cardiovascular Outcomes: A Systematic Review and Meta-Analysis – Circulation (link to abstract – $ for full-text)

Related:

M-A: Omega-3 fatty acids supplementation increases the risk of atrial fibrillation in patients with lipid disorders.

More data suggests no cardiovascular benefit from Omega-3 supplementation – secondary analysis of STRENGHT trial did not show an association between achieved Omega-3 fatty acid levels and major adverse cardiovascular outcomes in patients with high cardiovascular risk.

RCT: Omega-3 supplements do not reduce cardiovascular events in elderly patients after myocardial infarction

#AHA20 – Randomized trial: High-dose Omega-3 fatty acids did not reduce the risk of cardiac events in patients at high cardiovascular risk

Meta-Analysis of Randomized Trials: Little Benefit from Omega-3 Intake to Reduce Cardiovascular Disease Risk

 

Commentary on Twitter

 

Review: Optimal diet for cardiovascular and planetary health.

13 Oct, 2021 | 01:22h | UTC

Optimal diet for cardiovascular and planetary health – Heart

 

AHA Scientific Statement: Medication Adherence and Blood Pressure Control.

12 Oct, 2021 | 00:09h | UTC

Medication Adherence and Blood Pressure Control: A Scientific Statement From the American Heart Association – Hypertension

News release: Health system crucial to improve medication adherence for people managing hypertension – American Heart Association

Top Things to Know: Medication Adherence and Blood Pressure Control – American Heart Association

Commentary: Medication Adherence – Is It Really the Patient’s Fault? – American Heart Association

 

RCT: In stable patients who have undergone PCI for acute myocardial infarction, de-escalation from aspirin + ticagrelor to aspirin + clopidogrel after 1 month reduced bleeding events without increasing cardiovascular risk.

12 Oct, 2021 | 00:06h | UTC

Unguided de-escalation from ticagrelor to clopidogrel in stabilised patients with acute myocardial infarction undergoing percutaneous coronary intervention (TALOS-AMI): an investigator-initiated, open-label, multicentre, non-inferiority, randomised trial – The Lancet (link to abstract – $ for full-text)

Commentary: Adopting a clopidogrel-based DAPT strategy after PCI boosts outcomes for heart attack patients – Cardiovascular Business

 

Heart-inflammation risk from Pfizer COVID vaccine is very low.

10 Oct, 2021 | 21:42h | UTC

Heart-inflammation risk from Pfizer COVID vaccine is very low – Nature

Original studies:

Large cohort study with over 2.5 million individuals showed the incidence of myocarditis after the Pfizer vaccine was 2.13 cases per 100,000 persons.

Study with over 5.1 million vaccinated individuals showed the incidence of myocarditis after the receipt of the Pfizer vaccine was low and more common after the second dose in young male recipients.

 

Study suggests a 30-second interval between automated office blood pressure measurements is as accurate and reliable as a 60-second interval.

8 Oct, 2021 | 10:09h | UTC

Impact of 30- Versus 60-Second Time Intervals Between Automated Office Blood Pressure Measurements on Measured Blood Pressure – Hypertension (link to abstract – $ for full-text)

 

Commentary on Twitter

 

Large cohort study with over 2.5 million individuals showed the incidence of myocarditis after the Pfizer vaccine was 2.13 cases per 100,000 persons.

7 Oct, 2021 | 10:51h | UTC

Myocarditis after Covid-19 Vaccination in a Large Health Care Organization – New England Journal of Medicine

Commentary: Studies Highlight Rarity of Myocarditis With mRNA COVID-19 Vaccines – TCTMD

Related Study: Myocarditis after BNT162b2 mRNA Vaccine against Covid-19 in Israel – New England Journal of Medicine

 

Commentaries on Twitter

 

Study with over 5.1 million vaccinated individuals showed the incidence of myocarditis after the receipt of the Pfizer vaccine was low and more common after the second dose in young male recipients.

7 Oct, 2021 | 10:49h | UTC

Myocarditis after BNT162b2 mRNA Vaccine against Covid-19 in Israel – New England Journal of Medicine

Commentary: Studies Highlight Rarity of Myocarditis With mRNA COVID-19 Vaccines – TCTMD

Related study: Myocarditis after Covid-19 Vaccination in a Large Health Care Organization – New England Journal of Medicine

 

Commentaries on Twitter

 

Sweden, Denmark pause Moderna COVID-19 vaccine for younger age groups.

7 Oct, 2021 | 10:45h | UTC

Sweden, Denmark pause Moderna COVID-19 vaccine for younger age groups – Reuters

 

Varied extent of mitral annular disjunction among cases with different phenotypes of mitral valve prolapse.

7 Oct, 2021 | 10:12h | UTC

Varied Extent of Mitral Annular Disjunction Among Cases With Different Phenotypes of Mitral Valve Prolapse – JACC: Case Reports

 

Commentary on Twitter

 

Cohort study: Adding a new antihypertensive to existing regimens is associated with greater blood pressure reductions than maximizing dose.

6 Oct, 2021 | 09:57h | UTC

Adding a New Medication Versus Maximizing Dose to Intensify Hypertension Treatment in Older Adults: A Prospective Observational Study – Annals of Internal Medicine

News release: When blood pressure needs more control, what’s better: An additional drug or more of the same? – Michigan Medicine

Commentary: Adding an antihypertensive to existing regimens associated with greater BP reduction than maximizing dose, with some caveats in adherence – ACP Internist

Related: #ESCCongress – RCT: Initial hypertension treatment with a single pill with 4 drugs at quarter doses (irbesartan 37.5 mg, amlodipine 1.25 mg, indapamide 0.625 mg, and bisoprolol 2.5 mg) achieved better BP lowering vs. standard monotherapy (irbesartan 150 mg).

 

Commentary on Twitter (thread – click for more)

 

Is salt good for you after all? The evidence says no.

6 Oct, 2021 | 08:52h | UTC

Is salt good for you after all? The evidence says no – The Conversation

Related:

#ESCCongress – Cluster RCT: Among patients at increased risk for stroke, salt substitution (75% sodium chloride and 25% potassium chloride by mass) reduced the rates of stroke, major cardiovascular events, and death from any cause.

Systematic Review: Altered dietary salt intake for people with chronic kidney disease.

New WHO benchmarks help countries reduce salt intake and save lives.

RCT: Reduced-sodium added-potassium salt substitute reduces blood pressure in hypertensive patients

Potassium Enriched Salt Substitution Could Prevent a Large Number of Cardiovascular Deaths

Meta-Analysis: Effect of Reduction in Dietary Sodium on Blood Pressure Levels

Cluster Randomized Trial: Effect of Salt Substitution on Community-wide Blood Pressure and Hypertension Incidence

 

Review: Inhibition of platelet aggregation after coronary stenting in patients receiving oral anticoagulation.

6 Oct, 2021 | 08:46h | UTC

Inhibition of Platelet Aggregation After Coronary Stenting in Patients Receiving Oral Anticoagulation – Deutsches Ärzteblatt International

 

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