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Critical Care

M-A: Hypothermic vs. normothermic temperature control after cardiac arrest.

24 Jun, 2022 | 11:51h | UTC

Hypothermic versus Normothermic Temperature Control after Cardiac Arrest – NEJM Evidence

Related:

ERC-ESICM guidelines on temperature control after cardiac arrest in adults – Intensive Care Medicine (if the link is paywalled, try this one)

Target temperature management following cardiac arrest: a systematic review and Bayesian meta-analysis – Critical Care

Targeted temperature management following out-of-hospital cardiac arrest: a systematic review and network meta-analysis of temperature targets – Intensive Care Medicine

Targeted Temperature Management for Cardiac Arrest Due to Non-shockable Rhythm: A Systematic Review and Meta-Analysis of Randomized Controlled Trials – Frontiers in Medicine

Effect of Moderate vs Mild Therapeutic Hypothermia on Mortality and Neurologic Outcomes in Comatose Survivors of Out-of-Hospital Cardiac Arrest: The CAPITAL CHILL Randomized Clinical Trial – JAMA

Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest – New England Journal of Medicine

 


Systematic Review: Parenteral Vitamin C in patients with severe infection.

24 Jun, 2022 | 11:49h | UTC

Parenteral Vitamin C in Patients with Severe Infection: A Systematic Review – NEJM Evidence

Related:

Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit – New England Journal of Medicine

Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis – Intensive Care Medicine

Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial – JAMA

Effect of Vitamin C, Hydrocortisone, and Thiamine vs Hydrocortisone Alone on Time Alive and Free of Vasopressor Support Among Patients With Septic Shock: The VITAMINS Randomized Clinical Trial – JAMA

 


Is shorter always better? The pros and cons of treating Gram-negative bloodstream infections with 7 days of antibiotics.

24 Jun, 2022 | 11:38h | UTC

Is shorter always better? The pros and cons of treating Gram-negative bloodstream infections with 7 days of antibiotics – JAC-Antimicrobial Resistance

 


Hemorrhagic fever with renal syndrome: literature review, epidemiology, clinical picture and pathogenesis.

24 Jun, 2022 | 11:02h | UTC

Hemorrhagic Fever with Renal Syndrome: Literature Review, Epidemiology, Clinical Picture and Pathogenesis – Infections & Chemotherapy

 


Study Commentary | How FAST can you spot a pneumothorax? breaking down a surprising result comparing ultrasound and chest radiograph in traumatic pneumothorax.

24 Jun, 2022 | 10:39h | UTC

How FAST Can You Spot a Pneumothorax? Breaking Down a Surprising Result Comparing Ultrasound and Chest Radiograph in Traumatic Pneumothorax – Annals of Emergency Medicine

Original Study: Not so FAST—Chest ultrasound underdiagnoses traumatic pneumothorax – Journal of Trauma and Acute Care Surgery (link to abstract – $ for full-text)

 


Ivermectin for COVID-19 Cochrane review update: 11 trials and no evidence of benefit shown.

23 Jun, 2022 | 10:38h | UTC

News Release: Ivermectin for COVID-19 review update: 11 trials and no evidence of benefit shown – Liverpool School of Tropical Medicine

Original Article: Ivermectin for preventing and treating COVID‐19 – Cochrane Library

Summary: Ivermectin for preventing and treating COVID-19 – Cochrane Library

 


M-A: Early versus delayed complete revascularization in patients presenting with ST-segment elevation myocardial infarction and multivessel disease.

23 Jun, 2022 | 10:11h | UTC

Early versus delayed complete revascularisation in patients presenting with ST-segment elevation myocardial infarction and multivessel disease: a systematic review and meta-analysis of randomised controlled trials – openheart

 


Consensus Recommendations: Early management of patients with aneurysmal subarachnoid hemorrhage in a hospital with neurosurgical/neuroendovascular facilities.

22 Jun, 2022 | 11:25h | UTC

Part 1: Early management of patients with aneurysmal subarachnoid hemorrhage in a hospital with neurosurgical/neuroendovascular facilities: a consensus and clinical recommendations of the Italian Society of Anesthesia and Intensive Care (SIAARTI)–Part 1 – Journal of Anesthesia, Analgesia and Critical Care

Part 2: Early management of patients with aneurysmal subarachnoid hemorrhage in a hospital with neurosurgical/neuroendovascular facilities: a consensus and clinical recommendations of the Italian Society of Anesthesia and Intensive Care (SIAARTI)—part 2 – Journal of Anesthesia, Analgesia and Critical Care

 


Position Paper: Diagnosis and management of infections caused by multidrug-resistant bacteria.

22 Jun, 2022 | 11:23h | UTC

A position paper for the diagnosis and management of infections caused by multidrug-resistant bacteria: Endorsed by the Italian Society of Infection and Tropical Diseases (SIMIT), the Italian Society of Anti-Infective Therapy (SITA), the Italian Group for Antimicrobial Stewardship (GISA), the Italian Association of Clinical Microbiologists (AMCLI), and the Italian Society of Microbiology (SIM) – International Journal of Antimicrobial Agents

Related Guideline:

IDSA Guidance on the Treatment of Antimicrobial-Resistant Gram-Negative Infections: Version 2.0 – Infectious Diseases Society of America

IDSA Guidance on the Treatment of Antimicrobial-Resistant Gram-Negative Infections: Version 1.0 – Infectious Diseases Society of America

 


Review: Advanced interventions in the pre-hospital resuscitation of patients with non-compressible hemorrhage after penetrating injuries.

22 Jun, 2022 | 11:21h | UTC

Advanced interventions in the pre-hospital resuscitation of patients with non-compressible haemorrhage after penetrating injuries – Critical Care

 


RCT: High-flow nasal cannula vs. conventional oxygen therapy in acute COPD exacerbation with mild hypercapnia.

22 Jun, 2022 | 11:09h | UTC

High-flow nasal cannula versus conventional oxygen therapy in acute COPD exacerbation with mild hypercapnia: a multicenter randomized controlled trial – Critical Care

 


Randomized cross-over study: closed-loop oxygen control improves oxygen therapy in acute hypoxemic respiratory failure patients under high flow nasal oxygen.

22 Jun, 2022 | 11:08h | UTC

Closed-loop oxygen control improves oxygen therapy in acute hypoxemic respiratory failure patients under high flow nasal oxygen: a randomized cross-over study (the HILOOP study) – Critical Care

 


RCT: Low-dose methylprednisolone does not improve outcomes in critically ill patients with severe community-acquired pneumonia.

21 Jun, 2022 | 11:04h | UTC

Low-dose methylprednisolone treatment in critically ill patients with severe community-acquired pneumonia – Intensive Care Medicine

 


Guidelines for the management of patients with severe acute pancreatitis.

21 Jun, 2022 | 10:57h | UTC

Guidelines for the management of patients with severe acute pancreatitis, 2021 – Anaesthesia Critical Care & Pain Medicine

Related:

Evidence-Based Disposition of Acute Pancreatitis – emDocs

2019 WSES guidelines for the management of severe acute pancreatitis – World Journal of Emergency Surgery

American Gastroenterological Association Institute Guideline on Initial Management of Acute Pancreatitis

Pancreatitis – National Institute for Health and Care Excellence

 


Summary of the new 2022 AHA/ASA Guideline on intracerebral hemorrhage.

21 Jun, 2022 | 10:54h | UTC

Intracerebral Hemorrhage 2022 Guideline Update – emDocs

Original Guideline: 2022 Guideline for the Management of Patients With Spontaneous Intracerebral Hemorrhage: A Guideline From the American Heart Association/American Stroke Association – Stroke

Top Things to Know: 2022 Guideline for the Management of Patients With Spontaneous Intracerebral Hemorrhage – American Heart Association

News Release: New guideline refines care for brain bleeds: compression socks, some meds not effective – American Heart Association

 


RCT: A restrictive intravenous fluid strategy does not improve outcomes in ICU patients with septic shock.

20 Jun, 2022 | 10:51h | UTC

Restriction of Intravenous Fluid in ICU Patients with Septic Shock – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: No Fewer Deaths Seen With Restricted IV Fluid for Septic Shock – HealthDay

Related:

Restrictive versus Liberal Fluid Therapy for Major Abdominal Surgery – New England Journal of Medicine

Effect of Slower vs Faster Intravenous Fluid Bolus Rates on Mortality in Critically Ill Patients: The BaSICS Randomized Clinical Trial – JAMA

Fluid administration and monitoring in ARDS: which management? – Intensive Care Medicine

Perioperative liberal versus restrictive fluid strategies and postoperative outcomes: a systematic review and metanalysis on randomised-controlled trials in major abdominal elective surgery – Critical Care

 

Commentary on Twitter

 


[Preprint] Open-label RCT: Baricitinib noninferior to Tocilizumab in hospitalized patients with severe COVID-19.

20 Jun, 2022 | 10:28h | UTC

Tocilizumab versus baricitinib in hospitalized patients with severe COVID-19: an open label, randomized controlled trial – medRxiv

Related:

Baricitinib versus dexamethasone for adults hospitalised with COVID-19 (ACTT-4): a randomised, double-blind, double placebo-controlled trial – The Lancet Respiratory Medicine

Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis – medRxiv

WHO recommends two new drugs to treat COVID-19 – World Health Organization

Efficacy and safety of baricitinib for the treatment of hospitalised adults with COVID-19 (COV-BARRIER): a randomised, double-blind, parallel-group, placebo-controlled phase 3 trial – The Lancet Respiratory Medicine

Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19 – New England Journal of Medicine

 

Commentary on Twitter

 


Brief Review: Helmet noninvasive support in hypoxemic respiratory failure.

20 Jun, 2022 | 01:13h | UTC

Helmet noninvasive support in hypoxemic respiratory failure – Intensive Care Medicine (if the link is paywalled, try this one)

 

Commentary on Twitter

 


RCT: Immune enhancement with Thymosin alpha 1 does not improve outcomes in patients with predicted severe acute necrotizing pancreatitis.

20 Jun, 2022 | 01:11h | UTC

Immune enhancement in patients with predicted severe acute necrotising pancreatitis: a multicentre double-blind randomised controlled trial – Intensive Care Medicine (if the link is paywalled, try this one)

 


Registry-based cohort study: Endovascular treatment vs. best medical management in acute basilar artery occlusion strokes.

17 Jun, 2022 | 11:03h | UTC

Endovascular Treatment Versus Best Medical Management in Acute Basilar Artery Occlusion Strokes: Results From the ATTENTION Multicenter Registry – Circulation (free for a limited period)

Commentary: Endovascular Treatment vs. Best Medical Management in Basilar Artery Occlusion – American College of Cardiology

 

Commentary on Twitter

 


#CCR22 – RCT: Intravenous Vitamin C increases the risk of death or persistent organ dysfunction in adults with sepsis in the intensive care unit.

16 Jun, 2022 | 11:13h | UTC

Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit – New England Journal of Medicine

Related:

Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis – Intensive Care Medicine

Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial – JAMA

Effect of Vitamin C, Hydrocortisone, and Thiamine vs Hydrocortisone Alone on Time Alive and Free of Vasopressor Support Among Patients With Septic Shock: The VITAMINS Randomized Clinical Trial – JAMA

 

Commentary on Twitter

 


#CCR22 – RCT: High-flow nasal cannula therapy met criteria for noninferiority compared to CPAP for the liberation from respiratory support in acutely ill children in the ICU.

16 Jun, 2022 | 11:10h | UTC

Effect of High-Flow Nasal Cannula Therapy vs Continuous Positive Airway Pressure Therapy on Liberation From Respiratory Support in Acutely Ill Children Admitted to Pediatric Critical Care Units: A Randomized Clinical Trial – JAMA (free for a limited period)

 

Commentary on Twitter

 


#CCR22 – RCT: Among critically ill patients undergoing tracheal intubation, administering a 500 ml fluid bolus did not decrease the incidence of severely low blood pressure, cardiac arrest, or death.

16 Jun, 2022 | 11:08h | UTC

Effect of Fluid Bolus Administration on Cardiovascular Collapse Among Critically Ill Patients Undergoing Tracheal Intubation: A Randomized Clinical Trial – JAMA (free for a limited period)

 

Commentary on Twitter

 


Review: The physiological underpinnings of life-saving respiratory support.

16 Jun, 2022 | 11:03h | UTC

The physiological underpinnings of life-saving respiratory support – Intensive Care Medicine

 

Commentary on Twitter

 


Interventions in acute intracranial surgery: an evidence-based perspective.

16 Jun, 2022 | 10:59h | UTC

Interventions in Acute Intracranial Surgery: An Evidence-Based Perspective – World Neurosurgery

 


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