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General Gynecology

RCT | Mammography screening with AI reduces workload by 44.3% without loss in detection efficacy

4 Aug, 2023 | 12:13h | UTC

Artificial intelligence-supported screen reading versus standard double reading in the Mammography Screening with Artificial Intelligence trial (MASAI): a clinical safety analysis of a randomised, controlled, non-inferiority, single-blinded, screening accuracy study – The Lancet Oncology (link to abstract – $ for full-text)

News Release: First randomized trial finds AI-supported mammography screening is safe and almost halves radiologist workload – Lancet


Large Mammography Study Shows Significant Benefits with AI-Aided Screening – Diagnostic Imaging

Expert reaction to interim safety analysis of randomised trial on AI-supported mammography screening – Science Media Centre


Systematic Review | Moderate evidence supports interactive mobile phone interventions for contraception use enhancement

25 Jul, 2023 | 13:25h | UTC

Mobile phone‐based interventions for improving contraception use – Cochrane Library


FDA approves first nonprescription daily oral contraceptive

19 Jul, 2023 | 14:25h | UTC

FDA Approves First Nonprescription Daily Oral Contraceptive – U.S. Food & Drug Administration

Commentary: FDA approves first daily over-the-counter birth control pill, Opill – a pharmacist and public health expert explain this new era in contraception – The Conversation


Cohort Study | Long-term use of menopausal hormone therapy linked to heightened dementia risk

11 Jul, 2023 | 14:04h | UTC

Menopausal hormone therapy and dementia: nationwide, nested case-control study – The BMJ

Editorial: Menopausal hormone therapy and dementia – The BMJ

News Release: Menopausal hormone therapy linked to increased rate of dementia – BMJ Newsroom

Commentaries: Expert reaction to observational study on HRT and dementia – Science Media Centre


RCT | Effect of mifepristone vs. placebo for treatment of adenomyosis with pain symptoms

5 Jul, 2023 | 01:06h | UTC

Effect of Mifepristone vs Placebo for Treatment of Adenomyosis With Pain Symptoms: A Randomized Clinical Trial – JAMA Network Open

See also: Visual Abstract


SR | Gonadotropin‐releasing hormone analogues for endometriosis

3 Jul, 2023 | 14:14h | UTC

Gonadotropin‐releasing hormone analogues for endometriosis – Cochrane Library

Summary: Gonadotrophin-releasing hormone analogues for pain associated with endometriosis – Cochrane Library


SR | Oral contraceptives containing drospirenone for premenstrual syndrome

3 Jul, 2023 | 14:13h | UTC

Oral contraceptives containing drospirenone for premenstrual syndrome – Cochrane Library

Summary: Birth control pills with drospirenone for treating premenstrual syndrome – Cochrane Library


RCT | Noninferior results with quick resumption of activity after pelvic organ prolapse surgery

30 Jun, 2023 | 14:38h | UTC

Standard Restrictions vs Expedited Activity After Pelvic Organ Prolapse Surgery: A Randomized Clinical Trial – JAMA Surgery (link to abstract – $ for full-text)

See also: Visual Abstract

Commentary: No Need to Avoid Exercise After Prolapse Surgery, Study Finds – HealthDay


M-A | The effectiveness and safety of laparoscopic uterosacral ligament suspension

30 Jun, 2023 | 14:37h | UTC

The effectiveness and safety of laparoscopic uterosacral ligament suspension: a systematic review and meta-analysis – BJOG


FIGO staging of endometrial cancer: 2023

29 Jun, 2023 | 13:53h | UTC

FIGO staging of endometrial cancer: 2023 – Gynecology & Obstetrics


Cohort Study | Increased depression risk observed in first two years of oral contraceptive use

23 Jun, 2023 | 13:19h | UTC

Population-based cohort study of oral contraceptive use and risk of depression – Epidemiology and Psychiatric Sciences

News Release: New study links contraceptive pills and depression – Uppsala University

Commentary: Depression Risk May Rise During First Two Years of Oral Contraceptive Use – Psychiatric News Alert


Commentary on Twitter


SR | Effectiveness of anticholinergic drugs for treating people with overactive bladder syndrome

12 Jun, 2023 | 13:41h | UTC

Oral anticholinergic drugs versus placebo or no treatment for managing overactive bladder syndrome in adults – Cochrane Library

Summary: Effectiveness of anticholinergic drugs for treating people with overactive bladder syndrome – Cochrane Library


Podcast | Ascend your understanding of pelvic inflammatory disease

6 Jun, 2023 | 14:23h | UTC

#83: Ascend Your Understanding of Pelvic Inflammatory Disease (PID) – The Cribsiders


#ASCO23 – RCT | Simple hysterectomy shown non-inferior to radical hysterectomy in low-risk early-stage cervical cancer

5 Jun, 2023 | 13:43h | UTC

An international randomized phase III trial comparing radical hysterectomy and pelvic node dissection (RH) vs simple hysterectomy and pelvic node dissection (SH) in patients with low-risk early-stage cervical cancer (LRESCC):  A Gynecologic Cancer Intergroup study led by the Canadian Cancer Trials Group (CCTG CX.5-SHAPE). – American Society of Clinical Oncology (link to abstract – not published yet)


SHAPE Trial: Radical Hysterectomy May Not Be Needed for Early-Stage, Low-Risk Cervical Cancer – ASCO Daily News

Simple Hysterectomy May Be a Safe Option for Patients With Early-Stage, Low-Risk Cervical Cancer – The ASCO Post


Cohort Study | Associations of menstrual cycle regularity and length with cardiovascular diseases

1 Jun, 2023 | 12:07h | UTC

Associations of Menstrual Cycle Regularity and Length With Cardiovascular Diseases: A Prospective Study From UK Biobank – Journal of the American Heart Association

News Release: Long or short menstrual cycles linked to higher risk of CVD including atrial fibrillation – American Heart Association


Review | Managing menopausal symptoms, fertility, and bone health in breast cancer women on endocrine therapy

30 May, 2023 | 11:40h | UTC

Advances in the Management of Menopausal Symptoms, Fertility Preservation, and Bone Health for Women With Breast Cancer on Endocrine Therapy – ASCO Educational Book


A pragmatic approach to the management of menopause

25 May, 2023 | 11:30h | UTC

A pragmatic approach to the management of menopause – Canadian Medical Association Journal

News Release: Managing menopause: Hormone therapy is back – Canadian Medical Association Journal


RCT | Spironolactone enhances acne outcomes and offers a viable alternative to oral antibiotics

24 May, 2023 | 13:27h | UTC

Summary: The SAFA (Spironolactone for Adult Female Acne) trial was a multicenter, phase 3, double-blind, randomized controlled trial in England and Wales and evaluated the efficacy of spironolactone for treating adult women with acne vulgaris. A total of 410 women, aged ≥18 years and suffering from facial acne for a minimum of six months, were randomly assigned to receive either 50 mg/day of spironolactone or a placebo, increasing to 100 mg/day until week 24.

The primary outcome was measured by the Acne-Specific Quality of Life (Acne-QoL) symptom subscale score at week 12 and 24. The trial demonstrated that spironolactone improved Acne-QoL scores more effectively than the placebo, particularly at week 24. Additionally, more participants in the spironolactone group reported acne improvement, and treatment success was significantly higher in this group at week 12. Mild side effects, notably headaches, were more common in the spironolactone group.

The findings from the SAFA trial highlight spironolactone’s effectiveness, safety, and tolerability in treating adult women with acne vulgaris, suggesting it is a viable alternative to long-term antibiotic treatments. Future research is proposed on higher initial dosages of spironolactone, and its effects on different subgroups like patients with different ages, body mass index, and ethnicity.

Article: Effectiveness of spironolactone for women with acne vulgaris (SAFA) in England and Wales: pragmatic, multicentre, phase 3, double blind, randomised controlled trial – The BMJ

Editorial: What do we know about prescribing spironolactone for acne? – The BMJ

News Release: Non-antibiotic treatment for women with persistent acne shown to be effective – University of Southhampton


USPSTF Draft Statement recommends biennial screening mammography for women ages 40 to 74 years

22 May, 2023 | 13:56h | UTC

Breast Cancer: Screening – U.S. Preventive Services Task Force

Critical perspectives on the statement:

Earlier screening for breast cancer: Benefits and harms – Lown Institute

Video: Mammography – Does it save lives? | The USPSTF is incorrect | I review ALL the data – By Dr. Vinay Prasad

Why more mammograms aren’t the solution to breast cancer – Vox


RCT | Neck–shoulder region training for chronic headache in women

15 May, 2023 | 12:59h | UTC

Neck–Shoulder Region Training for Chronic Headache in Women: A Randomized Controlled Trial – Clinical Rehabilitation


Commentary on Twitter


RCT | Transvenous occlusion of incompetent pelvic veins to treat chronic pelvic pain in women

15 May, 2023 | 12:54h | UTC

Transvenous occlusion of incompetent pelvic veins to treat chronic pelvic pain in women: A randomised controlled trial – BJOG


Single-arm study | Halting endocrine therapy for pregnancy not linked to increased breast cancer events vs. a control cohort

10 May, 2023 | 16:01h | UTC

Interrupting Endocrine Therapy to Attempt Pregnancy after Breast Cancer – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Temporary Interruption of Adjuvant Endocrine Treatment to Attempt Pregnancy Does Not Increase Short-Term Risk for Worsening Breast Cancer Outcomes – ESMO


Commentary on Twitter


Cohort Study | Limited evidence linking COVID-19 vaccines to menstrual disturbance or postmenopausal bleeding

9 May, 2023 | 14:52h | UTC

Association between SARS-CoV-2 vaccination and healthcare contacts for menstrual disturbance and bleeding in women before and after menopause: nationwide, register based cohort study – The BMJ

News Release: New study finds no increased risk of menstrual changes after covid-19 vaccination – BMJ Newsroom

Commentary: Large study shows no changes to menstrual cycles after COVID vaccination – CIDRAP


A prospective study of the association between SARS-CoV-2 infection and COVID-19 vaccination with changes in usual menstrual cycle characteristics.

Editorial: Menstruation and Covid-19 vaccination.


Commentary on Twitter


Enhanced recovery after surgery (ERAS) society guidelines for gynecologic oncology: addressing implementation challenges

5 May, 2023 | 14:53h | UTC

Enhanced recovery after surgery (ERAS®) society guidelines for gynecologic oncology: Addressing implementation challenges – 2023 update – Gynecologic Oncology


RCT | Levonorgestrel IUS vs. hysteroscopic niche resection for postmenstrual spotting in cesarean scar

3 May, 2023 | 15:15h | UTC

Comparing levonorgestrel intrauterine system with hysteroscopic niche resection in women with postmenstrual spotting related to a niche in the uterine cesarean scar: a randomized, open-label, controlled trial – American Journal of Obstetrics & Gynecology


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