Open access
Open access
Powered by Google Translator Translator

Pediatrics – Endocrinology

Multinational Study | No correlation between Covid-19 and onset of type 1 diabetes in children

8 Aug, 2023 | 13:32h | UTC

SARS-CoV-2 — No Increased Islet Autoimmunity or Type 1 Diabetes in Teens – New England Journal of Medicine

 


Do-it-yourself automated insulin delivery: a health-care practitioner user’s guide

7 Aug, 2023 | 14:44h | UTC

Do-It-Yourself Automated Insulin Delivery: A Health-care Practitioner User’s Guide – Canadian Journal of Diabetes

 


Scientific Statement | Addressing childhood obesity to reduce adult CV risk through lifestyle

27 Jul, 2023 | 13:03h | UTC

Lifestyle interventions to change trajectories of obesity-related cardiovascular risk from childhood onset to manifestation in adulthood: a joint scientific statement of the task force for childhood health of the European Association of Preventive Cardiology and the European Childhood Obesity Group – European Journal of Preventive Cardiology

News Release: How to stop obese children having heart disease in adulthood – European Society of Cardiology

 


USPSTF Statement | Evidence lacking for lipid disorders screening in asymptomatic children and adolescents

20 Jul, 2023 | 11:13h | UTC

Screening for Lipid Disorders in Children and Adolescents: US Preventive Services Task Force Recommendation Statement – JAMA

Evidence Report: Screening for Lipid Disorders in Children and Adolescents: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force – JAMA

Editorial: Still “on the Fence” About Universal Childhood Lipid Screening: The USPSTF Reaffirms an I Statement – JAMA

Patient Page: Screening for Lipid Disorders in Children and Adolescents – JAMA

Commentary: USPSTF: Screening Kids for Lipid Disorders Still Needs More Data – TCTMD

 


Single Arm Trial | Low-carbohydrate diet improves glycemic control in type 1 diabetes

13 Jul, 2023 | 13:04h | UTC

Effects of a low-carbohydrate diet in adults with type 1 diabetes management: A single arm non-randomised clinical trial – PLOS One

Related:

Management of Type 1 Diabetes With a Very Low–Carbohydrate Diet – Pediatrics (link to abstract – $ for full-text)

Meta-analysis of randomized trials: patients adhering to a low carbohydrate diet for six months may experience remission of diabetes without adverse consequences

RCT | A calorie-unrestricted low-carbohydrate, high-fat diet resulted in short-term weight loss and better glycemic control.

Comparison of the Effectiveness of Low Carbohydrate Versus Low Fat Diets, in Type 2 Diabetes: Systematic Review and Meta-Analysis of Randomized Controlled Trials – Nutrients

Consensus Statement: Effect of carbohydrate-restricted diets and intermittent fasting on obesity, type 2 diabetes mellitus, and hypertension management.

Effects of a 6-month, low-carbohydrate diet on glycaemic control, body composition, and cardiovascular risk factors in patients with type 2 diabetes: An open-label randomized controlled trial – Diabetes, Obesity and Metabolism

Lower carbohydrate diets for adults with type 2 diabetes – British Journal of Nutrition

Low carbohydrate diet: Insights from a general practice service in patients with type 2 diabetes

Diabetes Canada Position Statement on Low-Carbohydrate Diets for Adults With Diabetes: A Rapid Review – Canadian Journal of Diabetes

Low Carbohydrate Diets for Diabetes: A Review of the Clinical Effectiveness and Guidelines – Canadian Agency for Drugs and Technologies in Health

Adapting diabetes medication for low carbohydrate management of type 2 diabetes: a practical guide – British Journal of General Practice

 


Review | Child and adolescent obesity

30 May, 2023 | 11:45h | UTC

Child and adolescent obesity – Nature Reviews Disease Primers (if the link is paywalled, try this one)

 

Commentary on Twitter

 


Current recommendations for the management of pediatric diabetic ketoacidosis

25 May, 2023 | 11:31h | UTC

Current recommendations for management of paediatric diabetic ketoacidosis – Paediatrics & Child Health

 


Graves’ disease in children: an update

25 May, 2023 | 11:18h | UTC

Graves’ Disease in Children: An Update – Clinical Medicine Insights: Endocrinology and Diabetes

 


FDA warns of use of selective androgen receptor modulators (SARMs) among teens, young adults

10 May, 2023 | 16:00h | UTC

FDA Warns of Use of Selective Androgen Receptor Modulators (SARMs) Among Teens, Young Adults – U.S. Food & Drug Administration

Commentaries:

FDA issues warning for bodybuilding products marketed to teens, young adults – AAP News

Young Men Are Using Banned ‘SARM’ Supplements to Bulk Up, With Harmful Results – HealthDay


Podcast | Congenital hypothyroidism

6 Apr, 2023 | 13:11h | UTC

#78: Congenital Hypothyroidism – The Cribsiders

 


Analysis | Global coverage and design of sugar-sweetened beverage taxes

5 Apr, 2023 | 12:43h | UTC

Global Coverage and Design of Sugar-Sweetened Beverage Taxes – JAMA Network Open

Related:

The introduction of sugary drinks tax in the UK was followed by a drop in obesity cases among children

WHO manual on sugar-sweetened beverage taxation policies to promote healthy diets.

M-A: Outcomes following taxation of sugar-sweetened beverages.

Public Policies to Reduce Sugary Drink Consumption in Children and Adolescents – Pediatrics

Cutting back on sugar-sweetened beverages: What works? – Cochrane Library

Association of a Beverage Tax on Sugar-Sweetened and Artificially Sweetened Beverages With Changes in Beverage Prices and Sales at Chain Retailers in a Large Urban Setting – JAMA

Association between tax on sugar sweetened beverages and soft drink consumption in adults in Mexico: open cohort longitudinal analysis of Health Workers Cohort Study – The BMJ

Potential impact on prevalence of obesity in the UK of a 20% price increase in high sugar snacks: modelling study – The BMJ

Changes in food purchases after the Chilean policies on food labelling, marketing, and sales in schools: a before and after study – The Lancet Planetary Health

Association of a Sweetened Beverage Tax With Soda Consumption in High School Students – JAMA Pediatrics

Sugar-sweetened beverage taxes: Lessons to date and the future of taxation – PLOS Medicine

Banning the promotion of soft drinks could be more effective than a sugar tax – The Conversation

Sugar tax: why health experts want it but politicians and industry are resisting – The Guardian

 

Commentary on Twitter

 


Assessment of childhood short stature: a GP guide

3 Apr, 2023 | 13:28h | UTC

Assessment of childhood short stature: a GP guide – British Journal of General Practice (free for a limited period)

 


Review | Graves’disease in children

22 Mar, 2023 | 13:08h | UTC

Graves’ disease: moving forwards – Archives of Disease in Childhood

 


RCT | Closed-loop insulin delivery system enhances blood sugar control in young children with type 1 diabetes

20 Mar, 2023 | 13:54h | UTC

Summary: The study enrolled 102 young children between ages 2 and 5, randomized in a 2:1 ratio to either a closed-loop control system of insulin delivery (“artificial pancreas”) or a standard care comparison group. During the 13 weeks of study follow-up, participants in the artificial pancreas group spent 12% more time within their target blood glucose range compared to the standard care group.

The closed-loop group experienced two cases of severe hypoglycemia, while the standard-care group had one case. In the closed-loop group, one case of diabetic ketoacidosis occurred due to a problem with the insulin pump.

Article: Trial of Hybrid Closed-Loop Control in Young Children with Type 1 Diabetes – New England Journal of Medicine (link to abstract – $ for full-text)

News Releases:

Artificial Pancreas Developed at UVA Improves Blood Sugar Control for Kids Ages 2-6, Study Finds – University of Virginia

NIH-supported trial shows artificial pancreas improves blood glucose control in young children – National Institutes of Health

 

Commentary on Twitter

 


M-A | Global prevalence of diabetic retinopathy in pediatric type 2 diabetes

20 Mar, 2023 | 13:12h | UTC

Global Prevalence of Diabetic Retinopathy in Pediatric Type 2 Diabetes: A Systematic Review and Meta-analysis – JAMA Network Open

 


Current recommendations for management of pediatric diabetic ketoacidosis

10 Mar, 2023 | 14:38h | UTC

Current recommendations for management of paediatric diabetic ketoacidosis – Canadian Pediatric Society

 


Report | Economic impact of overweight and obesity to surpass $4 trillion by 2035

6 Mar, 2023 | 14:32h | UTC

Summary:

A recent report from the World Obesity Federation has issued a warning that the number of people worldwide suffering from overweight or obesity could increase significantly by 2035, surpassing the 50% mark. The report, called the World Obesity Atlas 2023, also highlights the significant economic impact of this trend, estimating that the cost of overweight and obesity could reach $4.32tn annually by 2035, equivalent to almost 3% of the global GDP.

The report also identifies two groups that are particularly at risk: children and individuals from lower-income countries. Childhood obesity is a growing concern, as the report predicts it could double by 2035. Additionally, lower-income countries face a rapid increase in obesity prevalence, with nine out of 10 countries with the greatest expected increases in obesity coming from low or lower-middle income countries.

 

Report: World Obesity Atlas 2023

News release: Economic impact of overweight and obesity to surpass $4 trillion by 2035

Commentary: Report: Obesity could cost the world over $4 trillion a year by 2035 – STAT

Related:

Report: Tenfold increase in childhood and adolescent obesity in four decades

Global cost of obesity-related illness to hit $1.2tn a year from 2025

Trends and predictions of malnutrition and obesity in 204 countries and territories: an analysis of the Global Burden of Disease Study 2019 – eClinicalMedicine

Global inequalities in the double burden of malnutrition and associations with globalization: a multilevel analysis of Demographic and Healthy Surveys from 55 low-income and middle-income countries, 1992–2018.

The Lancet Series: The Double Burden of Malnutrition

 


M-A | Sugar-sweetened beverage consumption and weight gain in children and adults

6 Mar, 2023 | 14:04h | UTC

Article: Sugar-sweetened beverage consumption and weight gain in children and adults: a systematic review and meta-analysis of prospective cohort studies and randomized controlled trials – The American Journal of Clinical Nutrition

News Release: More evidence that sugary drinks cause weight gain – University of Toronto

 


Youth-onset type 2 diabetes: the epidemiology of an awakening epidemic

2 Mar, 2023 | 13:01h | UTC

Youth-Onset Type 2 Diabetes: The Epidemiology of an Awakening Epidemic – Diabetes Care

 


RCT | Tight glycemic control did not preserve pancreatic beta cell function in newly diagnosed pediatric type 1 diabetes

27 Feb, 2023 | 13:16h | UTC

Summary: The study aimed to determine if intensive diabetes management with an automated insulin delivery system could help preserve pancreatic beta cell function in youth with newly diagnosed type 1 diabetes. The randomized clinical trial included 113 youths aged 7 to 17 years and found that although the mean time in the target range of 70 to 180 mg/dL was 78% in the intensive management group vs. 64% in the standard care group, intensive diabetes management did not affect the decline in pancreatic C-peptide secretion at 52 weeks. The study concluded that near normalization of glucose levels instituted immediately after diagnosis of type 1 diabetes did not preserve pancreatic beta cell function in youth.

Article: Effect of Tight Glycemic Control on Pancreatic Beta Cell Function in Newly Diagnosed Pediatric Type 1 Diabetes: A Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Preserving Pancreatic Beta Cell Function in Recent-Onset Type 1 Diabetes – JAMA (free for a limited period)

 

Commentary on Twitter

 


RCT | Verapamil partially preserved pancreatic beta cell function in newly diagnosed pediatric type 1 diabetes

27 Feb, 2023 | 13:14h | UTC

Summary: The study aimed to determine whether verapamil could preserve pancreatic beta cell function in children and adolescents with newly diagnosed type 1 diabetes. The randomized clinical trial involved 88 participants who were given either verapamil or placebo once daily for 52 weeks. The study found that C-peptide levels were 30% higher in the verapamil group compared to the placebo group at 52 weeks, and the percentage of participants with a 52-week peak C-peptide level of 0.2 pmol/mL or greater was 95% in the verapamil group compared to 71% in the placebo group. The study also found that verapamil was well tolerated with few adverse events. The results suggest that verapamil may partially preserve stimulated C-peptide secretion in children and adolescents with newly diagnosed type 1 diabetes. However, further studies with patient-relevant outcomes are needed to determine the long-term effectiveness and the optimal length of therapy.

Article: Effect of Verapamil on Pancreatic Beta Cell Function in Newly Diagnosed Pediatric Type 1 Diabetes: A Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Preserving Pancreatic Beta Cell Function in Recent-Onset Type 1 Diabetes – JAMA (free for a limited period)

News Release: Verapamil shows beneficial effect on the pancreas in children with newly-diagnosed type 1 diabetes – University of Minnesota

 

Commentary on Twitter

 


M-A | Low-dose insulin infusion is safe and effective in treating diabetic ketoacidosis in children

23 Feb, 2023 | 13:40h | UTC

Summary: The article discusses a systematic review and meta-analysis of randomized controlled trials comparing low-dose insulin at 0.05 units/kg/hr to standard dose at 0.1 units/kg/hr for children with diabetic ketoacidosis (DKA). The study found that low-dose insulin infusion is probably as efficacious and safer than standard-dose insulin in treating DKA in children, as it has no effect on the time to resolution of hyperglycemia or acidosis and probably reduces the risk of developing hypokalemia and hypoglycemia. However, the results are limited by imprecision and generalizability to other settings since all studies were performed in a single country. Therefore, further studies are required to identify the optimal insulin dose for children with DKA in terms of safety and effectiveness.

Article: Insulin Infusion Dosing in Pediatric Diabetic Ketoacidosis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials – Critical Care Explorations

 


RCT | Outcomes in children of women with type 2 diabetes exposed to metformin vs. placebo during pregnancy

8 Feb, 2023 | 12:32h | UTC

Outcomes in children of women with type 2 diabetes exposed to metformin versus placebo during pregnancy (MiTy Kids): a 24-month follow-up of the MiTy randomised controlled trial – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)

 


The introduction of sugary drinks tax in the UK was followed by a drop in obesity cases among children

1 Feb, 2023 | 13:32h | UTC

Associations between trajectories of obesity prevalence in English primary school children and the UK soft drinks industry levy: An interrupted time series analysis of surveillance data – PLOS Medicine

News Releases:

UK soft drink taxes associated with decreased obesity in girls – PLOS

Sugary drinks tax may have prevented over 5,000 cases of obesity a year in year six girls alone – University of Cambridge

Commentaries:

Expert reaction to study looking at the UK sugary drinks tax and obesity in children – Science Media Centre

UK sugar tax ‘prevents 5,000 cases of obesity in year 6 girls annually’ – The Guardian

Related:

WHO manual on sugar-sweetened beverage taxation policies to promote healthy diets.

M-A: Outcomes following taxation of sugar-sweetened beverages.

Public Policies to Reduce Sugary Drink Consumption in Children and Adolescents – Pediatrics

Cutting back on sugar-sweetened beverages: What works? – Cochrane Library

Association of a Beverage Tax on Sugar-Sweetened and Artificially Sweetened Beverages With Changes in Beverage Prices and Sales at Chain Retailers in a Large Urban Setting – JAMA

Impact of sugar‐sweetened beverage taxes on purchases and dietary intake: Systematic review and meta‐analysis – Obesity Reviews

Association between tax on sugar sweetened beverages and soft drink consumption in adults in Mexico: open cohort longitudinal analysis of Health Workers Cohort Study – The BMJ

Potential impact on prevalence of obesity in the UK of a 20% price increase in high sugar snacks: modelling study – The BMJ

Changes in food purchases after the Chilean policies on food labelling, marketing, and sales in schools: a before and after study – The Lancet Planetary Health

Association of a Sweetened Beverage Tax With Soda Consumption in High School Students – JAMA Pediatrics

Sugar-sweetened beverage taxes: Lessons to date and the future of taxation – PLOS Medicine

Banning the promotion of soft drinks could be more effective than a sugar tax – The Conversation

Sugar tax: why health experts want it but politicians and industry are resisting – The Guardian

 

Commentary from the author on Twitter (thread – click for more)

 


M-A | Association between autism spectrum disorders and cardiometabolic diseases

1 Feb, 2023 | 13:11h | UTC

Association Between Autism Spectrum Disorders and Cardiometabolic Diseases: A Systematic Review and Meta-analysis – JAMA Pediatrics (free for a limited period)

Editorial: Autism, Physical Health Conditions, and a Need for Reform – JAMA Pediatrics (free for a limited period)

 

Commentary on Twitter

 


Stay Updated in Your Specialty

Telegram Channels
Free

WhatsApp alerts 10-day free trial

No spam, just news.