Pathology
Single-arm phase 2 study | Neoadjuvant pembrolizumab in localized microsatellite instability high/deficient mismatch repair solid tumors
24 Jan, 2023 | 14:19h | UTCNeoadjuvant Pembrolizumab in Localized Microsatellite Instability High/Deficient Mismatch Repair Solid Tumors – Journal of Clinical Oncology (link to abstract – $ for full-text)
Commentary: Neoadjuvant Pembrolizumab in Localized MSI-H/dMMR Solid Tumors – The ASCO Post
Glomerulonephritis: immunopathogenesis and immunotherapy
17 Jan, 2023 | 13:12h | UTCGlomerulonephritis: immunopathogenesis and immunotherapy – Nature Reviews Immunology (if the link is paywalled, try this one)
Commentary on Twitter
A Review in @NatRevImmunol proposes a new grouping of glomerulonephritis disorders based on their underlying immunopathogenesis, with a view to improving diagnosis, mechanistic understanding and treatment of these immune-mediated kidney diseases. https://t.co/5EsGFBpU3K pic.twitter.com/KULbWS0xMz
— Nature Portfolio (@NaturePortfolio) January 15, 2023
ASCO Guideline | Immunotherapy and biomarker testing in recurrent and metastatic head and neck cancers
9 Jan, 2023 | 14:41h | UTCNews Release: ASCO Publishes New Guideline on Immunotherapy, Biomarker Testing in Advanced Head and Neck Cancer – ASCO Daily News
Review | Role of AI and digital pathology for colorectal immuno-oncology.
16 Dec, 2022 | 13:11h | UTCRole of AI and digital pathology for colorectal immuno-oncology – British Journal of Cancer
Review | Acute and chronic alcoholic pancreatitis, including paraduodenal pancreatitis.
2 Dec, 2022 | 14:08h | UTC
Sudden cardiac death in the young: a consensus statement on recommended practices for cardiac examination by the pathologist.
17 Nov, 2022 | 12:27h | UTC
RCT | Transbronchial needle aspiration combined with cryobiopsy in the diagnosis of mediastinal diseases.
10 Nov, 2022 | 13:54h | UTCTransbronchial needle aspiration combined with cryobiopsy in the diagnosis of mediastinal diseases: a multicentre, open-label, randomised trial – The Lancet Respiratory Medicine (link to abstract – $ for full-text)
Commentary on Twitter
NEW—Mediastinal cryobiopsy + standard EBUS-TBNA = significant improvement in diagnostic yield for mediastinal lesions. This combined approach is a valid first-line diagnostic tool for mediastinal diseases.
Study from Prof Felix Herth, & colleagues https://t.co/DGJCrKVDbI pic.twitter.com/cvG89hNIHS
— The Lancet Respiratory Medicine (@LancetRespirMed) October 24, 2022
Brief Review | Close collaboration between pathologists and intensivists to understand (not just) coronavirus disease.
4 Nov, 2022 | 13:37h | UTC
Commentary on Twitter
Pathologists & intensivists collaborating to understand (not just) #COVID19
➡️ facing an unknown entity: challenge in #ICU
➡️ lightening pathophysiological shadow: demand for autopsies
➡️ formalizing interdisciplinary exchange to optimize outcome#FOAMcc
🗞️https://t.co/0a48Vontzn pic.twitter.com/K9zTl5b8vp— Intensive Care Medicine (@yourICM) November 2, 2022
Guideline | Reporting of surgically removed lymph nodes for breast tumors.
25 Oct, 2022 | 13:20h | UTC
Cohort Study | Genetic sequencing of pancreatic cyst fluid reveals diverse genomic alterations that may guide clinical management.
20 Oct, 2022 | 12:24h | UTCNews Release: Genetic test for pancreatic cancer outperforms current guidelines – University of Pittsburgh
Commentary from the author on Twitter (thread – click for more)
A tweetorial on our study (https://t.co/OCqCRJEMdx). But, first a case: Young female w/ a 1.9 cm incidental pancreatic cyst. No concerning features, but KRAS, TP53 and SMAD4 mutations on molecular testing. Surgical resection: #IPMN w/ a small #PancreaticCancer. #Pathology #GIPath pic.twitter.com/hMJQ4OAUld
— Aatur Singhi, MD PhD (@PancPathologist) October 10, 2022
Study | Plaque histology and myocardial disease in sudden coronary death.
30 Sep, 2022 | 12:41h | UTC
Consensus Recommendations | Standardizing pathologic evaluation of breast carcinoma after neoadjuvant chemotherapy.
23 Aug, 2022 | 12:52h | UTC
Spindle cell lesions of the breast: a diagnostic algorithm.
23 Aug, 2022 | 12:51h | UTC
Review | Drug regimens of novel antibiotics in critically ill patients with varying renal functions.
23 Aug, 2022 | 12:49h | UTC
Review | Barrett Esophagus.
17 Aug, 2022 | 14:26h | UTCBarrett Esophagus: A Review – JAMA (free for a limited period)
Audio clinical review: Barrett Esophagus – JAMA
Review | Liver biopsy in patients with alcohol-associated liver disease with acute-on-chronic liver failure.
22 Jul, 2022 | 11:28h | UTC
Guidelines on germline testing for urologic tumor syndromes.
15 Jul, 2022 | 12:49h | UTCGuidelines on Germline Testing for Urologic Tumor Syndromes – European Urology Focus
Review | The promise of precision medicine in rheumatology.
12 Jul, 2022 | 12:38h | UTCThe promise of precision medicine in rheumatology – Nature Reviews Rheumatology
Commentary on Twitter
A Review in @NatureMedicine discusses recent efforts to dissect cellular and molecular heterogeneity across multiple systemic autoimmune rheumatic diseases and future directions for implementing stratification approaches for SARD treatment. https://t.co/5EGTkQjasR pic.twitter.com/NAgbnyU96O
— Nature Portfolio (@NaturePortfolio) July 8, 2022
M-A | Does it really pay-off? Comparison of lymphadenectomy versus observational approach in skin melanoma with positive sentinel node biopsy.
12 Jul, 2022 | 12:37h | UTC
Evaluation of the molecular landscape of pediatric thyroid nodules and use of a multigene genomic classifier in children.
8 Jul, 2022 | 11:20h | UTC
Commentaries on Twitter
A multigene classifier reveals that malignant pediatric thyroid nodules have a unique molecular landscape vs those in adults. The classifier had a sensitivity of 96% & specificity of 78% for cancer detection & might reduce the need for diagnostic surgery: https://t.co/hdsPjGe9IR
— NatureRevClinOncol (@NatRevClinOncol) June 16, 2022
Pediatric thyroid cancer is on the rise. Its genomic landscape is unique; but, this retrospective case series shows that it may still be amenable to molecular classification—potentially decreasing diagnostic surgery & opening avenues for targeted therapy. https://t.co/KiYMsB1qGM
— JAMA Oncology (@JAMAOnc) June 10, 2022
Opinion | Renaming Gleason Score 6 prostate to noncancer: a flawed idea scientifically and for patient care.
30 Jun, 2022 | 10:44h | UTCOriginal Opinion Paper: Low-Grade Prostate Cancer: Time to Stop Calling It Cancer – Journal of Clinical Oncology
ASCO Guideline Update: Biomarkers for systemic therapy in metastatic breast cancer.
29 Jun, 2022 | 11:40h | UTC
Commentary on Twitter
‼️ 🆕 @ASCO guideline update published in #JCO by @lynnhenrymd et al: Biomarkers for #SystemicTherapy in Metastatic #BreastCancer ➡️ https://t.co/qAzT9WNKTF #bcsm #biomarkers @AngieDemichele pic.twitter.com/3WtAt8TK5w
— Journal of Clinical Oncology (@JCO_ASCO) June 27, 2022
Consensus report on anatomy, pathophysiology and clinical significance of the gastro-esophageal junction.
23 Jun, 2022 | 10:26h | UTC
Causes of liver cancer are changing around the world: some up, some down.
13 Jun, 2022 | 07:54h | UTCNews Release: Causes of Liver Cancer are Changing Around the World: Some Up, Some Down – UC San Diego Health
Original Study: Changing global epidemiology of liver cancer from 2010 to 2019: NASH is the fastest growing cause of liver cancer – Cell Metabolism (link to abstract – $ for full-text)
Circulating tumor DNA as a biomarker in patients with stage III and IV Wilms tumor.
8 Jun, 2022 | 10:43h | UTCCommentary: Analysis of Circulating Tumor DNA as a Biomarker in Stage III and IV Wilms Tumor – The ASCO Post