Nephrology
Organ transplant recipients remain vulnerable to Covid-19 even after second vaccine dose.
6 May, 2021 | 09:03h | UTCOriginal Study: Antibody Response to 2-Dose SARS-CoV-2 mRNA Vaccine Series in Solid Organ Transplant Recipients – JAMA
Cohort study shows inadequate antibody response to mRNA SARS-CoV-2 vaccine among kidney transplant recipients.
6 May, 2021 | 09:01h | UTC
Commentary on Twitter
The studies of mRNA vax in people with transplants are getting bigger: still the same message. Some protection, but not enough. This time, 308 people with kidney transplants in Israel, BNT-Pfizer vaccine https://t.co/Otvt8F11my
— Hilda Bastian, PhD (@hildabast) May 6, 2021
M-A: Pharmacological blood pressure lowering for primary and secondary prevention of cardiovascular disease – “a 5 mm Hg reduction of systolic BP reduced the risk of major CV events by about 10%, irrespective of previous diagnoses of CV disease, and even at normal or high–normal BP values”
3 May, 2021 | 05:29h | UTCCommentaries: Many more people could benefit from blood pressure-lowering medication – The Lancet AND Decisions about antihypertensive treatment should focus on reducing cardiovascular risk – The Lancet
AHA Statement: Management of Stage 1 Hypertension in Adults With a Low 10-Year Risk for Cardiovascular Disease – “There is a lack of randomized clinical trials that have evaluated CVD outcomes among individuals with stage 1 hypertension and a low 10-year ASCVD risk”
30 Apr, 2021 | 08:37h | UTCNews Release: If slightly high blood pressure doesn’t respond to lifestyle change, medication can help – American Heart Association
Top Things to Know: Management of Stage 1 Hypertension in Adults With a Low 10-Year Risk for Cardiovascular Disease – American Heart Association
Commentary: The Hypertension Pandemic: Need for a Strategic Evidence-based Response – American Heart Association
RCT: Reduced dose direct oral anticoagulants may be a safer option to vitamin K antagonists in hemodialysis patients with atrial fibrillation
27 Apr, 2021 | 09:27h | UTCSafety and Efficacy of Vitamin K Antagonists versus Rivaroxaban in Hemodialysis Patients with Atrial Fibrillation: A Multicenter Randomized Controlled Trial – Journal of the American Society of Nephrology (link to abstract – $ for full-text)
Commentary on Twitter
This study finds that patients on hemodialysis with atrial fibrillation experienced decreased cardiovascular events and major bleeding complications with direct oral anticoagulants compared with vitamin K antagonists https://t.co/6FOKkEXtfN pic.twitter.com/PD6qHaeZjT
— JASN_News (@JASN_News) March 22, 2021
Do you really need to drink 8 glasses of water a day? An exercise scientist explains why your kidneys say ‘no’
23 Apr, 2021 | 08:11h | UTC
Outcome of acute kidney injury: how to make a difference?
20 Apr, 2021 | 05:26h | UTCOutcome of acute kidney injury: how to make a difference? – Annals of Intensive Care
Hemodialysis Emergencies: Core Curriculum 2021
16 Apr, 2021 | 06:13h | UTCHemodialysis Emergencies: Core Curriculum 2021 – American Journal of Kidney Diseases
Commentary on Twitter
Hemodialysis Emergencies: Core Curriculum 2021https://t.co/BOQrsABOU3 (FREE)@KeikoGNeph @Mike_J_Choi @MedStarGUH #Hemodialysis pic.twitter.com/KYZRCqm5OA
— AJKD (@AJKDonline) March 26, 2021
Cohort study: Higher cumulative exposure to Thiazide diuretics linked to an increased risk of skin cancer in people older than 65 years
13 Apr, 2021 | 05:08h | UTCCommentaries: Thiazides May Up Risk for Skin Cancer in Older Adults – HealthDay AND Some blood pressure medication linked to higher risk of skin cancer, study finds – CTV News
Related study: Case-Control Study: Possible Association of Hydrochlorothiazide Use and Risk of Melanoma
Another study shows intravenous radiocontrast use is not associated with reduced kidney function
12 Apr, 2021 | 00:44h | UTCCommentaries: Radiocontrast Exposure Safe for Kidney Function – HCP Live AND Exposure to contrast on CTPA doesn’t cause long-term kidney injury – AuntMinnie
Related: ACR/NKF Consensus Statement: “The Risk of Acute Kidney Injury Developing in Patients with Reduced Kidney Function Following Exposure to Intravenous Iodinated Contrast Media has Been Overstated” (Guideline and commentaries)
Commentary on Twitter (thread – click for more)
Our new paper in @JAMAInternalMed: is IV contrast nephrotoxic? Lots of studies say no, but have ⬆️risk of confounding: people who get contrast ≠ people who don't get it. We used a natural experiment to try to overcome this bias https://t.co/XWEEohAvK0 1/5
— Robert Goulden (@EMrobg) April 5, 2021
Diagnostic Test Interpretation: Evaluation of Hypokalemia
6 Apr, 2021 | 01:07h | UTCEvaluation of Hypokalemia – JAMA (free for a limited period)
RCT: Lumasiran, an RNAi Therapeutic for Primary Hyperoxaluria Type 1
5 Apr, 2021 | 01:01h | UTCLumasiran, an RNAi Therapeutic for Primary Hyperoxaluria Type 1 – New England Journal of Medicine (link to abstract – $ for full-text)
RCT: Comparison of two delayed strategies for renal replacement therapy initiation for severe acute kidney injury – waiting too long can be deleterious
2 Apr, 2021 | 09:17h | UTCComparison of two delayed strategies for renal replacement therapy initiation for severe acute kidney injury (AKIKI 2): a multicentre, open-label, randomised, controlled trial – The Lancet (link to abstract – $ for full-text)
RCT: Reduced-sodium added-potassium salt substitute reduces blood pressure in hypertensive patients
1 Apr, 2021 | 03:32h | UTC
Commentaries on Twitter
Our new trial in India – switching from regular salt to a reduced-sodium added-potassium salt substitute for home cooking helps those with hypertension reduce their blood pressure. Important implications for BP control in LMIC settings #diet #globalhealth https://t.co/DD2knGuifT pic.twitter.com/zL8eVUAsdn
— Jason Wu (@Dr_WuJ) March 30, 2021
Salt substitution (70% sodium chloride/30% potassium chloride blend) is an effective, low-cost intervention for BP controlhttps://t.co/EemPEY9T2k pic.twitter.com/xVITnGLEip
— K Pavithran (@drkpavithran) March 31, 2021
Review: Use of urine electrolytes and urine osmolality in the clinical diagnosis of fluid, electrolytes, and acid-base disorders
25 Mar, 2021 | 08:06h | UTC
Commentary on Twitter
Do people use Urine K/crt ratio? for K disorders? What about FeK? TTKG is out! @askrenal –this flow chart makes sense to me https://t.co/8o8a7VYTMQ pic.twitter.com/UVZiFPo4vK
— Kenar Jhaveri (@kdjhaveri) February 20, 2021
Perspective | Prioritizing peritoneal catheter placement during the COVID-19 pandemic
16 Mar, 2021 | 02:16h | UTC
Commentary on Twitter
Individuals receiving dialysis are at high risk of COVID-19 infection, but promoting peritoneal dialysis is one potential way to substantially lower the risk. This perspective outlines how COVID-19 has changed the importance of timely PD catheter insertion https://t.co/Sy2pUShfNU pic.twitter.com/GueiogpO5b
— CJASN (@CJASN) March 12, 2021
Editorial: How I prescribe continuous renal replacement therapy
16 Mar, 2021 | 01:27h | UTCHow I prescribe continuous renal replacement therapy – Critical Care
Managing Patients with Failing Kidney Allograft: Many Questions Remain
12 Mar, 2021 | 08:06h | UTC
Study: Balanced crystalloids vs. saline in critically ill adults with hyperkalemia or acute kidney injury
9 Mar, 2021 | 02:05h | UTCCan We Use LR for Hyperkalemia? – Journal Feed
RCT: Albumin provides no benefit to hospitalized patients with decompensated cirrhosis
4 Mar, 2021 | 08:37h | UTCA Randomized Trial of Albumin Infusions in Hospitalized Patients with Cirrhosis – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Albumin provides no benefit to hospitalized patients with advanced liver disease – University College London
RCT: Mixed findings with Terlipressin plus Albumin for the treatment of Type 1 hepatorenal syndrome
4 Mar, 2021 | 08:35h | UTCTerlipressin plus Albumin for the Treatment of Type 1 Hepatorenal Syndrome – New England Journal of Medicine (link to abstract – $ for full-text)
Management of congenital nephrotic syndrome: consensus recommendations of the ERKNet-ESPN Working Group
4 Mar, 2021 | 08:13h | UTC
Systematic review: Aldosterone antagonists for people with chronic kidney disease requiring dialysis
3 Mar, 2021 | 08:27h | UTCAldosterone antagonists for people with chronic kidney disease requiring dialysis – Cochrane Library
Systematic review: Walking for hypertension
2 Mar, 2021 | 01:14h | UTCWalking for hypertension – Cochrane Library
Summary: The effect of walking on blood pressure control – Cochrane Library
M-A: Adjuvant corticosteroids are effective in lowering the risk of kidney scarring in children with acute pyelonephritis
28 Feb, 2021 | 20:38h | UTCAdjuvant corticosteroids for prevention of kidney scarring in children with acute pyelonephritis: a systematic review and meta-analysis – Archives of Disease in Childhood (link to abstract – $ for full-text)