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Nephrology

Is salt good for you after all? The evidence says no.

6 Oct, 2021 | 08:52h | UTC

Is salt good for you after all? The evidence says no – The Conversation

Related:

#ESCCongress – Cluster RCT: Among patients at increased risk for stroke, salt substitution (75% sodium chloride and 25% potassium chloride by mass) reduced the rates of stroke, major cardiovascular events, and death from any cause.

Systematic Review: Altered dietary salt intake for people with chronic kidney disease.

New WHO benchmarks help countries reduce salt intake and save lives.

RCT: Reduced-sodium added-potassium salt substitute reduces blood pressure in hypertensive patients

Potassium Enriched Salt Substitution Could Prevent a Large Number of Cardiovascular Deaths

Meta-Analysis: Effect of Reduction in Dietary Sodium on Blood Pressure Levels

Cluster Randomized Trial: Effect of Salt Substitution on Community-wide Blood Pressure and Hypertension Incidence

 


Podcast: Urinary Stone Disease.

5 Oct, 2021 | 08:50h | UTC

#298 Urinary Stone Disease Will Rock Your World – The Curbsiders

 


Review: Membranous nephropathy.

1 Oct, 2021 | 10:01h | UTC

Membranous nephropathy – Nature Reviews Disease Primers (free for a limited period)

Infographic: Membranous nephropathy (free for a limited period)

 

Commentary on Twitter

 


Review: Monitoring of Treatment for Arterial Hypertension.

29 Sep, 2021 | 09:59h | UTC

Monitoring of Treatment for Arterial Hypertension – Deutsches Ärzteblatt International

 


Expert panel recommends against use of race in assessment of kidney function.

24 Sep, 2021 | 09:01h | UTC

Expert panel recommends against use of race in assessment of kidney function – STAT

Original Guidance: A Unifying Approach for GFR Estimation: Recommendations of the NKF-ASN Task Force on Reassessing the Inclusion of Race in Diagnosing Kidney Disease – American Journal of Kidney Diseases

 

Commentary on Twitter

 


Landmark articles suggest eliminating race in the estimation of kidney function.

24 Sep, 2021 | 09:03h | UTC

Editorial: Time to Eliminate Health Care Disparities in the Estimation of Kidney Function – New England Journal of Medicine

Study 1: New Creatinine- and Cystatin C–Based Equations to Estimate GFR without Race – New England Journal of Medicine

Study 2: Race, Genetic Ancestry, and Estimating Kidney Function in CKD – New England Journal of Medicine

Commentaries:

NIH-supported study suggests alternative to race-based kidney function calculations – NIH News Releases

Remove Race From Equation Used to Assess Kidney Function, Researchers Say – AJMC

Researchers identify potential approach to eliminate race from equations to estimate kidney function – News Medical

 

Commentary on Twitter

 


KDIGO 2021 clinical practice guideline for the management of glomerular diseases.

21 Sep, 2021 | 09:05h | UTC

KDIGO 2021 clinical practice guideline for the management of glomerular diseases – Kidney Disease: Improving Global Outcomes

Executive summary: KDIGO 2021 Guideline for the Management of Glomerular Diseases – Kidney Disease: Improving Global Outcomes

 


Systematic Review: Non‐pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal replacement therapy.

16 Sep, 2021 | 09:53h | UTC

Non‐pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal replacement therapy – Cochrane Library

Summary: Non-pharmacological interventions for preventing clotting of extracorporeal circuits during continuous kidney replacement therapy – Cochrane Library

 


Covid-19: Infection increases the risk of kidney disease even in mild cases, finds study.

10 Sep, 2021 | 05:33h | UTC

Covid-19: Infection increases the risk of kidney disease even in mild cases, finds study – The BMJ

Original study: Kidney Outcomes in Long COVID – Journal of the American Society of Nephrology

 


Long COVID and kidney disease.

10 Sep, 2021 | 05:31h | UTC

Long COVID and kidney disease – Nature Reviews Nephrology

 


NICE Guideline: Assessment and management of chronic kidney disease.

1 Sep, 2021 | 09:47h | UTC

Chronic kidney disease: assessment and management – National Institute for Health and Care Excellence

 


Study shows that current definitions of chronic kidney disease overestimate the CKD burden in older individuals and results in overdiagnosis.

1 Sep, 2021 | 09:43h | UTC

Accounting for Age in the Definition of Chronic Kidney Disease – JAMA Internal Medicine (free for a limited period)

Invited commentary: Overdiagnosis of Chronic Kidney Disease in Older Adults—An Inconvenient Truth – JAMA Internal Medicine (free for a limited period)

 

Commentary on Twitter

 


#ESCCongress – Cluster RCT: Among patients at increased risk for stroke, salt substitution (75% sodium chloride and 25% potassium chloride by mass) reduced the rates of stroke, major cardiovascular events, and death from any cause.

29 Aug, 2021 | 19:21h | UTC

Effect of Salt Substitution on Cardiovascular Events and Death – New England Journal of Medicine (link to abstract – $ for full-text)

News release: Low-sodium salt prevents stroke – European Society of Cardiology

Commentary: Massive SSaSS Study Shows Switch to Salt Substitute Cuts Stroke, CVD – TCTMD

 

Commentary on Twitter

 


#ESCCongress – RCT: Finerenone reduced CV events in patients with kidney disease and type 2 diabetes (12.4% vs. 14.2% during a median follow-up of 3.4 years), but the risk of hyperkalemia was increased (10.8% vs. 5.3%).

29 Aug, 2021 | 18:14h | UTC

Cardiovascular Events with Finerenone in Kidney Disease and Type 2 Diabetes – New England Journal of Medicine

News release: Finerenone benefits patients with diabetes across spectrum of kidney disease – European Society of Cardiology

Commentaries:

Finerenone in Reducing Cardiovascular Mortality and Morbidity in Diabetic Kidney Disease – FIGARO-DKD – American College of Cardiology

FIGARO-DKD and FIDELITY Findings Show Benefits of Finerenone to Improve Outcomes in Patients With Kidney Disease, Diabetes – American College of Cardiology

Related:

[Abstract Only] Randomized trial: Effect of Finerenone on chronic kidney disease outcomes in Type 2 diabetes

 

Commentary on Twitter

 


#ESCCongress – RCT: Initial hypertension treatment with a single pill with 4 drugs at quarter doses (irbesartan 37.5 mg, amlodipine 1.25 mg, indapamide 0.625 mg, and bisoprolol 2.5 mg) achieved better BP lowering vs. standard monotherapy (irbesartan 150 mg).

29 Aug, 2021 | 18:11h | UTC

Initial treatment with a single pill containing quadruple combination of quarter doses of blood pressure medicines versus standard dose monotherapy in patients with hypertension (QUARTET): a phase 3, randomised, double-blind, active-controlled trial – The Lancet (link to abstract – $ for full-text)

Commentary: Quadruple UltrA-low-dose tReaTment for hypErTension – QUARTET – American College of Cardiology

 


New WHO Guideline for the pharmacological treatment of hypertension in adults.

26 Aug, 2021 | 08:57h | UTC

Guideline for the pharmacological treatment of hypertension in adults – World Health Organization

Related: WHO: More than 700 million people with untreated hypertension – Number of people living with hypertension has doubled to 1.28 billion since 1990.

 

Commentary on Twitter (thread – click for more)

 


Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants.

25 Aug, 2021 | 08:56h | UTC

Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants – The Lancet

Commentary: Global and national high blood pressure burden and control – The Lancet (free registration required)

 

Commentary on Twitter

 


Review: Acute and chronic hyponatremia.

25 Aug, 2021 | 08:50h | UTC

Acute and Chronic Hyponatremia – Frontiers in Medicine

Related:

Randomized trial suggests rapid intermittent bolus of hypertonic saline is the best approach for the treatment of symptomatic hyponatremia

Podcast: Hyponatremia deconstructed

Diagnosis and Management of Disorders of Body Tonicity—Hyponatremia and Hypernatremia: Core Curriculum 2020 – American Journal of Kidney Diseases

Guidelines for the Management of Exercise-Associated Hyponatremia

 


RCT: Catheter-based adrenal ablation remits primary aldosteronism.

25 Aug, 2021 | 08:52h | UTC

Catheter-Based Adrenal Ablation Remits Primary Aldosteronism: A Randomized Medication-Controlled Trial – Circulation (free for a limited period)

 

Commentary on Twitter

 


Things we do for no reason: routinely holding metformin in the hospital.

25 Aug, 2021 | 08:43h | UTC

Things We Do For No Reason™: Routinely Holding Metformin in the Hospital – Journal of Hospital Medicine

 


RCT: No effect of Vitamin D supplementation on kidney function in adults with prediabetes.

25 Aug, 2021 | 08:41h | UTC

Effect of Vitamin D Supplementation on Kidney Function in Adults with Prediabetes: A Secondary Analysis of a Randomized Trial – Clinical Journal of the American Society of Nephrology (link to abstract – $ for full-text)

 

Commentary on Twitter

 


RCT: SGLT2 inhibition reduces the risk of hyperkalemia in patients with diabetes and chronic kidney disease.

24 Aug, 2021 | 08:57h | UTC

Effects of canagliflozin on serum potassium in people with diabetes and chronic kidney disease: the CREDENCE trial – European Heart Journal (link to abstract – $ for full-text)

 

Commentary on Twitter

 


Prioritizing Peritoneal Catheter Placement during the COVID-19 Pandemic – A Perspective of the American Society of Nephrology COVID-19 Home Dialysis Subcommittee.

18 Aug, 2021 | 08:52h | UTC

Prioritizing Peritoneal Catheter Placement during the COVID-19 Pandemic – Clinical Journal of the American Society of Nephrology

 

Commentary on Twitter

 


Cohort study: cardiovascular and kidney outcomes across the glycemic spectrum – Prediabetes and T2D were independently associated atherosclerotic cardiovascular disease; substantial gradient of risk was observed across HbA1c levels.

18 Aug, 2021 | 08:36h | UTC

Cardiovascular and Kidney Outcomes Across the Glycemic Spectrum: Insights From the UK Biobank – Journal of the American College of Cardiology

Commentary: Cardiovascular and Kidney Outcomes in Diabetes and Prediabetes – American College of Cardiology

 


Benefits and risks of frequent or longer hemodialysis: weighing the evidence.

17 Aug, 2021 | 08:37h | UTC

Benefits and risks of frequent or longer haemodialysis: weighing the evidence – Nephrology Dialysis Transplantation

 


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