Transplantation – Liver
Extracorporeal CPR dissemination and integration with organ preservation in the USA: ethical and logistical considerations
28 Apr, 2023 | 12:47h | UTC
Perspective | Liver transplantation for patients with severe acute on chronic liver failure: it is time to change paradigms
25 Apr, 2023 | 14:37h | UTC
Commentary on Twitter
Liver #Tx in severe acute on chronic failure
➡️ #ICU care crucial in ACLF-3
➡️ improve referrals to LT centers & pre-LT workup
➡️ to decide to put pt on waitlist consider donor shortage/collective utility of LT
➡️ identifying transplantability window
🖇️ https://t.co/VZxDyZ1k74 pic.twitter.com/6YOcd5rzMu— Intensive Care Medicine (@yourICM) April 19, 2023
Guidelines for the management of adult acute and acute-on-chronic liver failure in the ICU
17 Apr, 2023 | 13:19h | UTCGuidelines for the Management of Adult Acute and Acute-on-Chronic Liver Failure in the ICU: Neurology, Peri-Transplant Medicine, Infectious Disease, and Gastroenterology Considerations – Critical Care Medicine (free for a limited period)
Executive Summary: Guidelines for the Management of Adult Acute and Acute-on-Chronic Liver Failure in the ICU: Neurology, Peri-Transplant Medicine, Infectious Disease, and Gastroenterology Considerations – Critical Care Medicine (free for a limited period)
Overcoming size disparity in liver transplant access: prioritizing smaller donors for smaller candidates
3 Apr, 2023 | 13:41h | UTCAssociation of Body Surface Area With Access to Deceased Donor Liver Transplant and Novel Allocation Policies – JAMA Surgery (free for a limited period)
Invited Commentary: Addressing Size-Based Disparities in Liver Transplant – JAMA Surgery (free for a limited period)
Commentary on Twitter
In this study, liver waitlist candidates with the smallest body surface areas had a disadvantage due to size. Prioritizing allocation of smaller liver donors to smaller candidates may help overcome this disparity. https://t.co/p5F76Hgzm0
— JAMA Surgery (@JAMASurgery) March 30, 2023
Expanding Organ Usage: UK study finds organs from patients with a primary brain tumor are a viable option
27 Mar, 2023 | 13:27h | UTCSummary: A national cohort study in the UK investigated the risk of cancer transmission from deceased donors with primary brain tumors to organ recipients. The study found no cases of brain tumor transmission among 778 transplants from 282 donors with primary brain tumors, including 262 from donors with high-grade tumors. Organ transplant survival was equivalent to that in matched controls, and some organs from donors with high-grade tumors were less likely to be transplanted.
The results suggest that the risk of cancer transmission in transplants from deceased donors with primary brain tumors is lower than previously thought. Furthermore, the study indicated that donors with brain tumors provided good-quality organs with favorable risk markers and excellent transplant outcomes. Some organs from donors with high-grade tumors were underutilized, indicating a possible aversion by transplant clinicians or patients to use these organs.
These findings imply that it may be possible to safely expand organ usage from donors with primary brain tumors without negatively impacting outcomes, potentially benefiting many patients waiting for a transplant. Although this might lead to a slight rise in transplant numbers in the UK, the findings may hold particular significance for nations with stricter guidelines, such as the United States. The study’s findings can help transplant clinicians discuss the risks and benefits of accepting organ offers from such donors.
Current status of liver transplantation for non-B non-C liver cirrhosis and hepatocellular carcinoma
17 Feb, 2023 | 12:36h | UTC
Post-transplant biliary complications: advances in pathophysiology, diagnosis, and treatment
3 Feb, 2023 | 14:01h | UTC
Guidance on developing and/or expanding pediatric solid organ transplantation programs in low- and middle-income countries.
6 Dec, 2022 | 13:47h | UTC
Expert consensus on liver transplantation perioperative evaluation and rehabilitation for acute-on-chronic liver failure.
21 Nov, 2022 | 14:21h | UTC
Review | Determining prognosis of alcoholic liver disease and alcoholic hepatitis.
4 Nov, 2022 | 13:17h | UTC
ERAS Guidelines for perioperative care for liver surgery.
1 Nov, 2022 | 12:16h | UTCRelated:
Complete List of Enhanced Recovery After Surgery (ERAS) Society Guidelines
AHA Scientific Statement | Emerging evidence on coronary heart disease screening in kidney and liver transplantation candidates.
24 Oct, 2022 | 14:11h | UTCTop Things to Know: Emerging Evidence on Coronary Heart Disease (CHD) Screening in Kidney and Liver Transplantation Candidates – American Heart Association
Meta-analysis of observational studies | In patients with hepatocellular carcinoma, intraoperative blood salvage during liver transplantation appears safe.
30 Aug, 2022 | 12:03h | UTC
Supplement | The role of liver transplantation in acute-on-chronic liver failure.
25 Aug, 2022 | 11:57h | UTCHomepage: The Role of Liver Transplantation in Acute-on-Chronic Liver Failure – Clinical Liver Disease
Introduction: The Role of Liver Transplantation in Acute-on-Chronic Liver Failure
Identifying the patient with acute-on-chronic liver failure: navigating through multiple definitions
Pretransplant management of the patient with severe acute-on-chronic liver failure
Transplantation in Acute-on-Chronic Liver Failure: Feasibility and Futility
Palliative Care in the Patient With Acute-on-Chronic Liver Failure
Con: Patients With Acute-on-Chronic Liver Failure Should Not Receive Priority on the Waiting List
Review | Acute liver failure management and liver transplantation.
15 Aug, 2022 | 11:41h | UTCCAQ Corner: Acute liver failure management and liver transplantation – Liver Transplantation
Case-Control Study | Survival benefit of living-donor liver transplant.
4 Aug, 2022 | 13:59h | UTCSurvival Benefit of Living-Donor Liver Transplant – JAMA Surgery
Commentaries:
Just How Low a Model for End-stage Liver Disease Score Benefits From Living-Donor Liver Transplant? – JAMA Surgery (free for a limited period)
Low MELD Score No Barrier to Long Survival After Living-Donor Transplant — End-stage liver disease patients with scores as low as 11 achieved survival of 13 years or beyond – MedPage Today (free registration required)
Review | Liver transplantation in alcohol-related liver disease and alcohol-related hepatitis.
6 Jul, 2022 | 11:22h | UTCThe role of T-tubes and abdominal drains on short-term outcomes in liver transplantation – A systematic review of the literature and expert panel recommendations.
26 May, 2022 | 10:04h | UTC
Bring it on: Top five antimicrobial stewardship challenges in transplant infectious diseases and practical strategies to address them.
29 Apr, 2022 | 10:51h | UTC
Commentary on Twitter
🆕💥Review Article @ASHE_Journal
Bring it on: Top five antimicrobial stewardship challenges in transplant infectious diseases and practical strategies to address them #IDTwitter #medtwitter #TwitteRx #MedEd https://t.co/ToPLQXtC4r pic.twitter.com/pZQWWb3ZSx— Antibiotic Steward Bassam Ghanem🆔🔥 (@ABsteward) April 28, 2022
Under a http://creativecommons.org/licenses/by/4.0/ license
Cohort Study: Recipient and donor outcomes after living-donor liver transplant for unresectable colorectal liver metastases.
6 Apr, 2022 | 10:23h | UTCCommentaries:
Living-Donor Liver Transplant Promising for CRC With Liver Mets – HealthDay
Commentary on Twitter
Study suggests living-donor liver transplant is a promising option for meticulously selected patients with unresectable colorectal cancer liver metastases. https://t.co/p6Jbzb73DL
— JAMA Surgery (@JAMASurgery) March 30, 2022
Review: Cardiac considerations in liver transplantation.
18 Feb, 2022 | 08:26h | UTCCardiac considerations in liver transplantation – Cleveland Clinic Journal of Medicine
Review: Advance care planning and goals of care discussions in advanced liver disease.
2 Feb, 2022 | 08:17h | UTC
RCT: Impact of portable normothermic blood-based machine perfusion on outcomes of liver transplant.
1 Feb, 2022 | 08:58h | UTCCommentaries:
Normothermic Machine Perfusion Improves Outcomes in Liver Transplant Recipients – Physician’s Weekly
Machine Perfusion Cuts Early Graft Dysfunction in Liver Transplantation – MedPage Today (free registration required)
Related:
RCT: Hypothermic machine perfusion in liver transplantation
Transplantation of Discarded Livers Following Viability Testing with Normothermic Machine Perfusion
Commentaries on Twitter
Study found portable normothermic oxygenated machine perfusion of donor liver grafts resulted in improved outcomes of liver transplantation and in more livers being transplanted. https://t.co/PZzvFriJvB pic.twitter.com/2icSfxoLDF
— JAMA Surgery (@JAMASurgery) January 5, 2022
Study found portable normothermic oxygenated machine perfusion of donor liver grafts resulted in improved outcomes of liver transplantation and in more livers being transplanted. https://t.co/TKEsTf8Htu pic.twitter.com/tg2xDGDyOS
— JAMA Surgery (@JAMASurgery) January 5, 2022
Consensus statement on hemostatic management, anticoagulation, and antiplatelet therapy in liver transplantation.
20 Jan, 2022 | 08:47h | UTC
Clinical Guideline: Acute-on-chronic liver failure.
11 Jan, 2022 | 02:43h | UTCAcute-on-Chronic Liver Failure Clinical Guidelines – American Journal of Gastroenterology
Related: Guidelines for the Management of Adult Acute and Acute-on-Chronic Liver Failure in the ICU
Commentary on Twitter
📣NEW ACG Guidelines Acute-on-Chronic #Liver Failure by @JasmohanBajaj et al.
📕https://t.co/T3CqvOAMrj#Cirrhosis #GItwitter #LiverTwitter #MostReadinRed pic.twitter.com/LHwIkUtGZt
— AJG – The American Journal of Gastroenterology (@AmJGastro) January 10, 2022