Transplantation – Liver
Review: Advance care planning and goals of care discussions in advanced liver disease.
2 Feb, 2022 | 08:17h | UTC
RCT: Impact of portable normothermic blood-based machine perfusion on outcomes of liver transplant.
1 Feb, 2022 | 08:58h | UTCCommentaries:
Normothermic Machine Perfusion Improves Outcomes in Liver Transplant Recipients – Physician’s Weekly
Machine Perfusion Cuts Early Graft Dysfunction in Liver Transplantation – MedPage Today (free registration required)
Related:
RCT: Hypothermic machine perfusion in liver transplantation
Transplantation of Discarded Livers Following Viability Testing with Normothermic Machine Perfusion
Commentaries on Twitter
Study found portable normothermic oxygenated machine perfusion of donor liver grafts resulted in improved outcomes of liver transplantation and in more livers being transplanted. https://t.co/PZzvFriJvB pic.twitter.com/2icSfxoLDF
— JAMA Surgery (@JAMASurgery) January 5, 2022
Study found portable normothermic oxygenated machine perfusion of donor liver grafts resulted in improved outcomes of liver transplantation and in more livers being transplanted. https://t.co/TKEsTf8Htu pic.twitter.com/tg2xDGDyOS
— JAMA Surgery (@JAMASurgery) January 5, 2022
Consensus statement on hemostatic management, anticoagulation, and antiplatelet therapy in liver transplantation.
20 Jan, 2022 | 08:47h | UTC
Clinical Guideline: Acute-on-chronic liver failure.
11 Jan, 2022 | 02:43h | UTCAcute-on-Chronic Liver Failure Clinical Guidelines – American Journal of Gastroenterology
Related: Guidelines for the Management of Adult Acute and Acute-on-Chronic Liver Failure in the ICU
Commentary on Twitter
?NEW ACG Guidelines Acute-on-Chronic #Liver Failure by @JasmohanBajaj et al.
?https://t.co/T3CqvOAMrj#Cirrhosis #GItwitter #LiverTwitter #MostReadinRed pic.twitter.com/LHwIkUtGZt
— AJG – The American Journal of Gastroenterology (@AmJGastro) January 10, 2022
RCT: Maribavir for refractory Cytomegalovirus infections with or without resistance post-transplant.
7 Dec, 2021 | 08:37h | UTC
Review: Management of alcohol use disorder in patients with cirrhosis in the setting of liver transplantation.
3 Nov, 2021 | 09:45h | UTC
Commentary on Twitter
New content online: Management of alcohol use disorder in patients with cirrhosis in the setting of liver transplantation https://t.co/sWd1Vs6N2c pic.twitter.com/XZo8ETzhEl
— Nature Reviews Gastroenterology & Hepatology (@NatRevGastroHep) November 2, 2021
Consensus Guideline: Liver transplantation for non-resectable colorectal liver metastases.
16 Sep, 2021 | 09:50h | UTCLiver transplantation for non-resectable colorectal liver metastases: the International Hepato-Pancreato-Biliary Association consensus guidelines – The Lancet Gastroenterology & Hepatology (free registration required)
Commentary on Twitter
New online – Liver transplantation for non-resectable colorectal liver metastases: the International Hepato-Pancreato-Biliary Association consensus guidelineshttps://t.co/oZL4X4h7VS@IHPBA @gbonneysurg @eahpba @_ilts_#livertwitter #APHPBA_2021 pic.twitter.com/g6rrVclV5h
— The Lancet Gastroenterology & Hepatology (@LancetGastroHep) September 8, 2021
FDA authorizes additional Covid-19 vaccine dose for certain immunocompromised individuals – Other fully vaccinated individuals do not need an additional vaccine dose right now.
16 Aug, 2021 | 01:22h | UTCCommentaries:
CDC, FDA recommend COVID booster for immune-compromised – CIDRAP
FDA authorizes additional dose of Covid-19 vaccine for the immunocompromised – STAT
Covid booster: US approves third jab for the immunocompromised – BBC
CDC Panel Recommends 3rd Vaccine Dose For Immunocompromised People – NPR
6 Things To Know If You’re Immunocompromised And Considering A 3rd Shot – NPR
CDC recommends third Covid-19 vaccine dose for certain immunocompromised people – CNN
Commentary on Twitter
The Infectious Diseases Society of America (IDSA) supports the @FDA and @CDCgov's decision to authorize a supplemental vaccine dose for immunocompromised patients.
Read our statement: https://t.co/odzzSgIxnY pic.twitter.com/4PZfUwpjhM
— IDSA (@IDSAInfo) August 13, 2021
RCT: third dose of Moderna mRNA vaccine increases immunity in transplant recipients.
12 Aug, 2021 | 09:56h | UTCEditorial: Third Time’s a Charm — Covid-19 Vaccine Hope for Solid-Organ Transplant Recipients
Related:
[Preprint] 3rd AstraZeneca shot gives strong immunity.
Commentaries on Twitter
..1st randomized trial results of 3rd doses of Moderna vax for 120 people with organ transplants: month 4, their minimum anti-RBD antibody levels were 55% for 3rd dose vs 18% (still increasing a little in the placebo group). No cases of acute rejection https://t.co/BcfeyUEhx5 #IC
— Hilda Bastian, PhD (@hildabast) August 11, 2021
The authors conclude that a third-dose booster of mRNA-1273 vaccine should be considered for transplant recipients. https://t.co/Q3gakSaNjd pic.twitter.com/CMN8f7cq29
— NEJM (@NEJM) August 11, 2021
Three doses of an mRNA Covid-19 vaccine in solid-organ transplant recipients can improve the immunogenicity of the vaccine.
24 Jun, 2021 | 10:32h | UTC
Case series: Safety and immunogenicity of a third dose of SARS-CoV-2 vaccine in solid organ transplant recipients.
15 Jun, 2021 | 08:59h | UTCCommentaries: For Transplant Recipients, Third Time May Be the Charm for Better COVID Vaccine Protection – Hopkins Medicine AND Extra COVID Vaccine May Help Protect Transplant Patients – Associated Press
Commentary on Twitter
Our report about 3rd vaccine doses in transplant patients is published! "It is encouraging that antibody titers increased after the 3rd dose in 1/3 of patients who had negative antibody titers and in all patients who had low-positive antibody titers"https://t.co/6XElwyIdAa
— Dorry Segev (@Dorry_Segev) June 14, 2021
Cohort study shows inadequate antibody response to mRNA SARS-CoV-2 vaccine among kidney transplant recipients.
6 May, 2021 | 09:01h | UTC
Commentary on Twitter
The studies of mRNA vax in people with transplants are getting bigger: still the same message. Some protection, but not enough. This time, 308 people with kidney transplants in Israel, BNT-Pfizer vaccine https://t.co/Otvt8F11my
— Hilda Bastian, PhD (@hildabast) May 6, 2021
Organ transplant recipients remain vulnerable to Covid-19 even after second vaccine dose.
6 May, 2021 | 09:03h | UTCOriginal Study: Antibody Response to 2-Dose SARS-CoV-2 mRNA Vaccine Series in Solid Organ Transplant Recipients – JAMA
Systematic review: Interventions for increasing solid organ donor registration
28 Apr, 2021 | 08:11h | UTCInterventions for increasing solid organ donor registration – Cochrane Library
Summary: Interventions for increasing solid organ donor registration – Cochrane Library
Review: Care for the organ transplant recipient on the intensive care unit
8 Apr, 2021 | 08:36h | UTCCare for the organ transplant recipient on the intensive care unit – Journal of Critical Care
Review: Post-Transplant Pregnancy and Contraception
23 Mar, 2021 | 02:10h | UTCPost-Transplant Pregnancy and Contraception – Clinical Journal of the American Society of Nephrology
Immunogenicity of a single dose of SARS-CoV-2 mRNA vaccine in solid organ transplant recipients
17 Mar, 2021 | 02:55h | UTC
RCT: Mixed findings with Terlipressin plus Albumin for the treatment of Type 1 hepatorenal syndrome
4 Mar, 2021 | 08:35h | UTCTerlipressin plus Albumin for the Treatment of Type 1 Hepatorenal Syndrome – New England Journal of Medicine (link to abstract – $ for full-text)
RCT: Albumin provides no benefit to hospitalized patients with decompensated cirrhosis
4 Mar, 2021 | 08:37h | UTCA Randomized Trial of Albumin Infusions in Hospitalized Patients with Cirrhosis – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Albumin provides no benefit to hospitalized patients with advanced liver disease – University College London
Teleneurology-enabled determination of death by neurologic criteria after cardiac arrest or severe neurologic injury
2 Mar, 2021 | 01:32h | UTCTeleneurology-Enabled Determination of Death by Neurologic Criteria After Cardiac Arrest or Severe Neurologic Injury – Neurology (link to abstract – $ for full-text)
RCT: Hypothermic machine perfusion in liver transplantation
25 Feb, 2021 | 08:44h | UTCHypothermic Machine Perfusion in Liver Transplantation — A Randomized Trial – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Cold Perfusion Cuts Liver Transplant Complications – MedPage Today
RCT: In patients with cirrhosis treated with TIPS, prophylactic rifaximin reduced the risk for Hepatic Encephalopathy
7 Feb, 2021 | 21:10h | UTCThe Use of Rifaximin in the Prevention of Overt Hepatic Encephalopathy After Transjugular Intrahepatic Portosystemic Shunt: A Randomized Controlled Trial – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentary: Rifaximin prevents overt hepatic encephalopathy after TIPS – HealthDay
Commentary on Twitter
New findings published in @AnnalsofIM:
In patients with #cirrhosis treated with TIPS, rifaximin was well tolerated and reduced the risk for overt HE. #Rifaximin should therefore be considered for prophylaxis of post-TIPS HE https://t.co/d2p9dfcx3s. pic.twitter.com/M7zwmUxQA3
— Annals of Int Med (@AnnalsofIM) February 2, 2021