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Pediatrics – Critical Care & Emergencies

Risk factors for SARS-CoV-2 related severe Multisystem Inflammatory Syndrome in Children investigated in a Swedish population-based study.

23 Jun, 2022 | 10:36h | UTC

News Release: Risk factors for severe COVID-19 complication in children investigated in Swedish population-based study – Karolinska Institutet

Original Study: Risk factors for multisystem inflammatory syndrome in children – A population-based cohort study of over 2 million children – The Lancet Regional Health Europe

 


M-A: Incidence and etiology of infant Gram-negative bacteremia and meningitis in children.

23 Jun, 2022 | 10:27h | UTC

Incidence and aetiology of infant Gram-negative bacteraemia and meningitis: systematic review and meta-analysis – Archives of Disease in Childhood

 


Retrospective cohort study: Association of patient characteristics with postoperative mortality in children undergoing tonsillectomy.

22 Jun, 2022 | 11:14h | UTC

Association of Patient Characteristics With Postoperative Mortality in Children Undergoing Tonsillectomy in 5 US States – JAMA (free for a limited period)

Editorials: Mortality After Pediatric Tonsillectomy—Does the “D” Word Have a Place in Tonsillectomy Discussions? – JAMA Otolaryngology-Head & Neck Surgery

 


M-A: Contemporary trends in global mortality of sepsis among young infants less than 90 days.

22 Jun, 2022 | 11:03h | UTC

Contemporary Trends in Global Mortality of Sepsis Among Young Infants Less Than 90 Days: A Systematic Review and Meta-Analysis – Frontiers in Pediatrics

 


#CCR22 – RCT: High-flow nasal cannula therapy met criteria for noninferiority compared to CPAP for the liberation from respiratory support in acutely ill children in the ICU.

16 Jun, 2022 | 11:10h | UTC

Effect of High-Flow Nasal Cannula Therapy vs Continuous Positive Airway Pressure Therapy on Liberation From Respiratory Support in Acutely Ill Children Admitted to Pediatric Critical Care Units: A Randomized Clinical Trial – JAMA (free for a limited period)

 

Commentary on Twitter

 


Cohort Study: Prevalence, characteristics, and determinants of suboptimal care in the initial management of community-onset severe bacterial infections in children.

14 Jun, 2022 | 10:52h | UTC

Prevalence, Characteristics, and Determinants of Suboptimal Care in the Initial Management of Community-Onset Severe Bacterial Infections in Children – JAMA Network Open

 


Case Series | Outbreak of hepatitis in children: clinical course of children with acute liver failure admitted to the intensive care unit.

13 Jun, 2022 | 10:46h | UTC

Outbreak of hepatitis in children: clinical course of children with acute liver failure admitted to the intensive care unit – Intensive Care Medicine (if the link is paywalled, try this one)

Related: Investigating acute hepatitis of unknown origin in children (several resources on the subject)

 

Commentary on Twitter

 


Another study suggests the Omicron variant is associated with a reduced risk of Multisystem Inflammatory Syndrome in Children compared to previous SARS-CoV-2 variants.

10 Jun, 2022 | 12:38h | UTC

Risk and Phenotype of Multisystem Inflammatory Syndrome in Vaccinated and Unvaccinated Danish Children Before and During the Omicron Wave – JAMA Pediatrics

Related study: Severity and Incidence of Multisystem Inflammatory Syndrome in Children During 3 SARS-CoV-2 Pandemic Waves in Israel – JAMA AND Commentary: Kids’ COVID syndrome—MIS-C—less severe in Omicron – CIDRAP

 

Commentary on Twitter

 


RCT: Effect of point-of-care testing for respiratory pathogens on antibiotic use in children.

10 Jun, 2022 | 11:16h | UTC

Effect of Point-of-Care Testing for Respiratory Pathogens on Antibiotic Use in Children: A Randomized Clinical Trial – JAMA Network Open

 

Commentary on Twitter

 


CDC Report: Pediatric melatonin ingestions in the US.

9 Jun, 2022 | 11:32h | UTC

Pediatric Melatonin Ingestions — United States, 2012–2021 – Morbidity and Mortality Weekly Report

Commentaries:

Thousands of kids are getting sick from downing melatonin pills – NPR

Melatonin poisoning reports are up in kids, study says – Associated Press

Melatonin Overdoses Among Kids Are Up 530%, New Research Finds – TIME

Reports of melatonin poisoning in kids have increased 530% since 2012 – Yahoo News

 

Commentary on Twitter

 


M-A: Intelligence outcome of pediatric intensive care unit survivors.

8 Jun, 2022 | 10:36h | UTC

Intelligence outcome of pediatric intensive care unit survivors: a systematic meta-analysis and meta-regression – BMC Medicine

 


Systematic Review: Positioning for acute respiratory distress in hospitalized infants and children.

7 Jun, 2022 | 11:17h | UTC

Positioning for acute respiratory distress in hospitalised infants and children – Cochrane Library

Summary: Positioning for hospitalised infants and children with acute respiratory distress

 


State of the Art Review | Dengue: A growing problem with new interventions.

2 Jun, 2022 | 10:54h | UTC

Dengue: A Growing Problem With New Interventions – Pediatrics

 


Systematic Review: Corticosteroids for the treatment of Kawasaki disease in children.

1 Jun, 2022 | 11:05h | UTC

Corticosteroids for the treatment of Kawasaki disease in children – Cochrane Library

Summary: Using corticosteroids to treat Kawasaki disease – Cochrane Library

 


M-A: Prevalence of respiratory viruses in community-acquired pneumonia in children.

1 Jun, 2022 | 10:57h | UTC

Prevalence of respiratory viruses in community-acquired pneumonia in children: a systematic review and meta-analysis – The Lancet Child & Adolescent Health (link to abstract – $ for full-text)

 

Commentary on Twitter

 


Recommendation document on rapid intravenous rehydration in acute gastroenteritis.

31 May, 2022 | 11:27h | UTC

Recommendation document on rapid intravenous rehydration in acute gastroenteritis – Anales de Pediatría (English Edition)

 


Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in children younger than 5 years in 2019.

27 May, 2022 | 12:15h | UTC

Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in children younger than 5 years in 2019: a systematic analysis – The Lancet

Commentaries:

Need for improved global measurement of early childhood respiratory syncytial virus disease – The Lancet (free registration required)

RSV kills 100,000 kids under age 5 a year worldwide – CHEST Physician

 


Systematic Review: Airway complications resulting from pediatric esophageal button battery impaction.

27 May, 2022 | 11:49h | UTC

Airway Complications Resulting From Pediatric Esophageal Button Battery Impaction: A Systematic Review – JAMA Otolaryngology-Head & Neck Surgery (free for a limited period)

Invited Commentary: Pediatric Button Battery Injuries—Current State and What’s Next? – JAMA Otolaryngology-Head & Neck Surgery

 


Modified ABCDEF-bundles for critically ill pediatric patients – what could they look like?

24 May, 2022 | 07:43h | UTC

Modified ABCDEF-Bundles for Critically Ill Pediatric Patients – What Could They Look Like? – Frontiers in Pediatrics

Related:

ABCDEF Bundle – Society of Critical Care Medicine

The ABCDEF Bundle: Science and Philosophy of How ICU Liberation Serves Patients and Families – Critical Care Medicine

 


What’s sending kids to hospitals with hepatitis—coronavirus, adenovirus, or both?

23 May, 2022 | 01:48h | UTC

What’s sending kids to hospitals with hepatitis—coronavirus, adenovirus, or both? – Science

Related:

Investigation into acute hepatitis of unknown aetiology in children in England Technical briefing 3 – UK Health Security Agency

Case numbers of acute hepatitis of unknown aetiology among children in 24 countries up to 18 April 2022 compared to the previous 5 years – Eurosurveillance

Severe acute hepatitis and acute liver failure of unknown origin in children: a questionnaire-based study within 34 paediatric liver centres in 22 European countries and Israel, April 2022 – Eurosurveillance

Severe acute hepatitis in children: investigate SARS-CoV-2 superantigens – The Lancet Gastroenterology & Hepatology

Puzzling pediatric hepatitis cases echo an earlier mysterious illness – STAT

Why COVID is a key suspect in severe hepatitis cases in kids worldwide – CBC

Hepatitis outbreak in children: What do we know so far? – Imperial College London

Explaining the unexplained hepatitis in children – The Lancet Infectious Diseases

Epidemiological update: Hepatitis of unknown aetiology in children – European Centre for Disease Prevention and Control

Unexplained hepatitis cases in kids rise to 348 in 20 nations – CIDRAP

Investigation into acute hepatitis of unknown aetiology in children in England Technical briefing 2 – UK Health Security Agency

With usual suspects ruled out, disease detectives try to crack mystery of viral hepatitis cases in kids – STAT

Acute Hepatitis and Adenovirus Infection Among Children — Alabama, October 2021–February 2022 – Morbidity and Mortality Weekly Report

The CDC and WHO Have Reported an Unusual Cluster of Severe Pediatric Hepatitis Cases – Science-Based Medicine

Investigation into acute hepatitis of unknown aetiology in children in England Technical briefing – UK Health Security Agency

Multi-Country – Acute, severe hepatitis of unknown origin in children – World Health Organization

WHO says 12 countries have reported unusual cases of hepatitis in kids – STAT

CDC Alerts Providers to Hepatitis Cases of Unknown Origin – Centers for Disease Control and Prevention

Recommendations for Adenovirus Testing and Reporting of Children with Acute Hepatitis of Unknown Etiology – Centers for Disease Control and Prevention

Could Mysterious Hepatitis Cases be Triggered by COVID-19? – Health Policy Watch

Increase in hepatitis (liver inflammation) cases in children under investigation – UK Health Security Agency

U.S., U.K. investigating unusual cases of hepatitis in young children – STAT

Acute hepatitis of unknown aetiology – the United Kingdom of Great Britain and Northern Ireland – World Health Organization

Increase in acute hepatitis of unknown origin among children – United Kingdom – European Centre for Disease Prevention and Control

Mysterious liver illness seen in kids in US, Europe – Associated Press

 


Study Commentary | Antibiotics for pediatric pneumonia: might less be enough?

17 May, 2022 | 10:39h | UTC

Antibiotics for Pediatric Pneumonia: Might Less Be Enough? – Annals of Emergency Medicine

Original Study: Effect of Amoxicillin Dose and Treatment Duration on the Need for Antibiotic Re-treatment in Children With Community-Acquired Pneumonia: The CAP-IT Randomized Clinical Trial – JAMA

Related:

Extended Versus Standard Antibiotic Course Duration in Children <5 Years of Age Hospitalized With Community-acquired Pneumonia in High-risk Settings: Four-week Outcomes of a Multicenter, Double-blind, Parallel, Superiority Randomized Controlled Trial – The Pediatric Infectious Disease Journal

Short- vs Standard-Course Outpatient Antibiotic Therapy for Community-Acquired Pneumonia in Children: The SCOUT-CAP Randomized Clinical Trial – JAMA Pediatrics

Appropriate Use of Short-Course Antibiotics in Common Infections: Best Practice Advice From the American College of Physicians – Annals of Internal Medicine

Short-Course Antimicrobial Therapy for Pediatric Community-Acquired Pneumonia: The SAFER Randomized Clinical Trial – JAMA Pediatrics

Treatment of UTIs in Infants <2 Months: A Living Systematic Review – Hospital Pediatrics

Effect of 7 vs 14 Days of Antibiotic Therapy on Resolution of Symptoms Among Afebrile Men With Urinary Tract Infection: A Randomized Clinical Trial – JAMA

Seven versus fourteen Days of Antibiotic Therapy for uncomplicated Gram-negative Bacteremia: a Non-inferiority Randomized Controlled Trial – Clinical Infectious Diseases

Efficacy of short-course antibiotic treatments for community-acquired pneumonia in adults: A systematic review and meta-analysis – Antimicrobial Agents and Chemotherapy

 


Hypotheses | Severe acute hepatitis in children: investigate SARS-CoV-2 superantigens.

16 May, 2022 | 02:22h | UTC

Severe acute hepatitis in children: investigate SARS-CoV-2 superantigens – The Lancet Gastroenterology & Hepatology

Related:

Why COVID is a key suspect in severe hepatitis cases in kids worldwide – CBC

Hepatitis outbreak in children: What do we know so far? – Imperial College London

Explaining the unexplained hepatitis in children – The Lancet Infectious Diseases

Epidemiological update: Hepatitis of unknown aetiology in children – European Centre for Disease Prevention and Control

Unexplained hepatitis cases in kids rise to 348 in 20 nations – CIDRAP

Investigation into acute hepatitis of unknown aetiology in children in England Technical briefing 2 – UK Health Security Agency

With usual suspects ruled out, disease detectives try to crack mystery of viral hepatitis cases in kids – STAT

Acute Hepatitis and Adenovirus Infection Among Children — Alabama, October 2021–February 2022 – Morbidity and Mortality Weekly Report

The CDC and WHO Have Reported an Unusual Cluster of Severe Pediatric Hepatitis Cases – Science-Based Medicine

Investigation into acute hepatitis of unknown aetiology in children in England Technical briefing – UK Health Security Agency

Multi-Country – Acute, severe hepatitis of unknown origin in children – World Health Organization

WHO says 12 countries have reported unusual cases of hepatitis in kids – STAT

CDC Alerts Providers to Hepatitis Cases of Unknown Origin – Centers for Disease Control and Prevention

Recommendations for Adenovirus Testing and Reporting of Children with Acute Hepatitis of Unknown Etiology – Centers for Disease Control and Prevention

Could Mysterious Hepatitis Cases be Triggered by COVID-19? – Health Policy Watch

Increase in hepatitis (liver inflammation) cases in children under investigation – UK Health Security Agency

U.S., U.K. investigating unusual cases of hepatitis in young children – STAT

Acute hepatitis of unknown aetiology – the United Kingdom of Great Britain and Northern Ireland – World Health Organization

Increase in acute hepatitis of unknown origin among children – United Kingdom – European Centre for Disease Prevention and Control

Mysterious liver illness seen in kids in US, Europe – Associated Press

 

Commentary on Twitter

 


Systematic Review: Ultrasound for pediatric peripheral intravenous catheter insertion.

16 May, 2022 | 01:28h | UTC

Ultrasound for Pediatric Peripheral Intravenous Catheter Insertion: A Systematic Review – Pediatrics

 


Epidemiological update: Hepatitis of unknown etiology in children.

12 May, 2022 | 10:12h | UTC

Epidemiological update: Hepatitis of unknown aetiology in children – European Centre for Disease Prevention and Control

Related:

Unexplained hepatitis cases in kids rise to 348 in 20 nations – CIDRAP

Investigation into acute hepatitis of unknown aetiology in children in England Technical briefing 2 – UK Health Security Agency

With usual suspects ruled out, disease detectives try to crack mystery of viral hepatitis cases in kids – STAT

Acute Hepatitis and Adenovirus Infection Among Children — Alabama, October 2021–February 2022 – Morbidity and Mortality Weekly Report

The CDC and WHO Have Reported an Unusual Cluster of Severe Pediatric Hepatitis Cases – Science-Based Medicine

Investigation into acute hepatitis of unknown aetiology in children in England Technical briefing – UK Health Security Agency

Multi-Country – Acute, severe hepatitis of unknown origin in children – World Health Organization

WHO says 12 countries have reported unusual cases of hepatitis in kids – STAT

CDC Alerts Providers to Hepatitis Cases of Unknown Origin – Centers for Disease Control and Prevention

Recommendations for Adenovirus Testing and Reporting of Children with Acute Hepatitis of Unknown Etiology – Centers for Disease Control and Prevention

Could Mysterious Hepatitis Cases be Triggered by COVID-19? – Health Policy Watch

Increase in hepatitis (liver inflammation) cases in children under investigation – UK Health Security Agency

U.S., U.K. investigating unusual cases of hepatitis in young children – STAT

Acute hepatitis of unknown aetiology – the United Kingdom of Great Britain and Northern Ireland – World Health Organization

Increase in acute hepatitis of unknown origin among children – United Kingdom – European Centre for Disease Prevention and Control

Mysterious liver illness seen in kids in US, Europe – Associated Press

 

Commentary on Twitter (thread – click for more)

 


Group B streptococcus infection during pregnancy and infancy: estimates of regional and global burden.

12 May, 2022 | 10:03h | UTC

Group B streptococcus infection during pregnancy and infancy: estimates of regional and global burden – The Lancet Global Health

Invited Commentary: Variation of invasive neonatal GBS disease across the regions – The Lancet Global Health

 

Commentary on Twitter

 


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