RCT | Higher dose corticosteroids increase mortality in hypoxic COVID-19 patients on simple oxygen

Higher dose corticosteroids in patients admitted to hospital with COVID-19 who are hypoxic but not requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial – The Lancet

Editorial: Higher-dose dexamethasone for patients with COVID-19 and hypoxaemia? – The Lancet

Commentary: Higher-dose corticosteroids tied to 60% more deaths in low-oxygen COVID patients – CIDRAP

Commentary on Twitter (thread – click for more)

Low-dose corticosteroids have been shown to reduce mortality for patients with COVID-19 requiring oxygen or ventilatory support.

A new study evaluated the use of a higher dose of corticosteroids in this patient group. https://t.co/uJGSYSBQAO

— The Lancet (@TheLancet) April 13, 2023