Fertility/Reproductive Medicine | Page 2 of 3 | Links Medicus Content Curation & Alerts in Medicine

RCT | Intravenous immunoglobulin treatment in women with four or more recurrent pregnancy losses.

12 Jul, 2022 | 11:53h | UTC

Intravenous immunoglobulin treatment in women with four or more recurrent pregnancy losses: A double-blind, randomised, placebo-controlled trial – eClinicalMedicine

Infertility, recurrent pregnancy loss, and risk of stroke: pooled analysis of individual patient data of 618 851 women.

27 Jun, 2022 | 11:59h | UTC

Infertility, recurrent pregnancy loss, and risk of stroke: pooled analysis of individual patient data of 618 851 women – The BMJ

News Release: Infertility and pregnancy loss may increase women’s risk of stroke – BMJ Newsroom

Commentary on Twitter

Infertility and pregnancy loss are associated with an increased risk of non-fatal and fatal stroke in later life, finds study.

Early monitoring of women who have experienced miscarriage or stillbirth could lower the risk, the researchers suggest https://t.co/fYrNfpz6fC

— The BMJ (@bmj_latest) June 24, 2022

RCT: Transfer of thawed frozen embryo versus fresh embryo to improve the healthy baby rate in women undergoing IVF.

21 Jun, 2022 | 10:32h | UTC

Transfer of thawed frozen embryo versus fresh embryo to improve the healthy baby rate in women undergoing IVF: the E-Freeze RCT – Health Technology Assessment

[News release – not published yet] Women not being routinely informed that a common anesthetic may lessen contraception effectiveness, doctors warn.

9 Jun, 2022 | 11:31h | UTC

Women not being routinely informed that a common anesthetic may lessen contraception effectiveness, doctors warn – The European Society of Anaesthesiology and Intensive Care (ESAIC)

Commentary: Women in UK ‘seldom’ told drug used in surgery can impede contraception – The Guardian

RCT: Efficacy of bariatric surgery in treating women with obesity and polycystic ovary syndrome.

3 Jun, 2022 | 11:05h | UTC

Efficacy of Bariatric Surgery in the Treatment of Women With Obesity and Polycystic Ovary Syndrome – The Journal of Clinical Endocrinology & Metabolism

Systematic Review: Cleavage‐stage versus blastocyst‐stage embryo transfer in assisted reproductive technology.

1 Jun, 2022 | 11:02h | UTC

Cleavage‐stage versus blastocyst‐stage embryo transfer in assisted reproductive technology – Cochrane Library

Summary: When trying to have a baby through assisted conception, is it better to transfer the embryo to the womb on day 3 or day 5? – Cochrane Library

Commentary on Twitter

Transferring fresh embryos at the blastocyst stage (day 5 to 6) may increase live births compared to transfer at cleavage stage (day 2 to 3). We are uncertain if blastocyst‐stage transfer increases multiple pregnancy or miscarriage @CochraneLibrary https://t.co/O5CrUPTpet pic.twitter.com/YNdrwCIkmt

— Cochrane Gynaecology & Fertility (@CochraneCGF) May 25, 2022

Cohort Study: Analysis of antiemetic use after initiation of hormone therapy.

27 May, 2022 | 11:21h | UTC

Analysis of Antiemetic Use After Initiation of Hormone Therapy – JAMA Network Open

M-A: Effectiveness and harms of contraceptive counseling and provision interventions for women.

26 May, 2022 | 10:23h | UTC

Effectiveness and Harms of Contraceptive Counseling and Provision Interventions for Women: A Systematic Review and Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)

Annals Video Summary: Effectiveness and Harms of Contraceptive Counseling and Provision Interventions for Women: A Systematic Review and Meta-analysis

Commentary: Contraceptive counseling, provision increases use, reduces unintended pregnancy – ACP Internist

Endometrial scratch to increase live birth rates in women undergoing first-time in vitro fertilization: RCT and systematic review.

12 May, 2022 | 07:53h | UTC

Endometrial scratch to increase live birth rates in women undergoing first-time in vitro fertilisation: RCT and systematic review – Health Technology Assessment

Survey: Despite insufficient evidence of benefit, many fertility specialists still perform endometrial scratching before in vitro fertilization.

Endometrial scratching: what’s the latest evidence? – “we are uncertain whether endometrial injury has an effect on the probability of getting pregnant and having a baby”.

A Randomized Trial of Endometrial Scratching before In Vitro Fertilization – New England Journal of Medicine

Obesity and risk of female reproductive conditions: A Mendelian randomization study.

27 Apr, 2022 | 01:31h | UTC

Obesity and risk of female reproductive conditions: A Mendelian randomisation study – PLOS Medicine

News Release: Obesity may increase risk of some female reproductive disorders – PLOS

Cohort Study: Infertility in women linked to increased risk of heart failure with preserved ejection fraction.

20 Apr, 2022 | 09:44h | UTC

Infertility and Risk of Heart Failure in the Women’s Health Initiative – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Podcast: Infertility and Risk of Heart Failure in the Women’s Health Initiative

Commentaries:

Infertility in Women Linked to Subsequent Risk of HFpEF – TCTMD

MGH study finds infertility associated with increased risk of heart failure – MedicalResearch

M-A: Risk of recurrence in women with venous thromboembolism related to estrogen-containing contraceptives.

6 Apr, 2022 | 10:55h | UTC

Risk of recurrence in women with venous thromboembolism related to estrogen-containing contraceptives: Systematic review and meta-analysis – Journal of Thrombosis and Haemostasis

IVF add-ons: why you should be cautious of these expensive procedures if you’re trying to conceive.

1 Apr, 2022 | 08:44h | UTC

IVF add-ons: why you should be cautious of these expensive procedures if you’re trying to conceive – The Conversation

Survey: Despite insufficient evidence of benefit, many fertility specialists still perform endometrial scratching before in vitro fertilization.

Endometrial scratching: what’s the latest evidence? – “we are uncertain whether endometrial injury has an effect on the probability of getting pregnant and having a baby”.

A Randomized Trial of Endometrial Scratching before In Vitro Fertilization – New England Journal of Medicine

Study shows whole-genome risk prediction of common diseases in human preimplantation embryos is feasible, leading to ethical concerns.

Randomized Trial: Conventional in vitro fertilization resulted in a cumulative live-birth rate that was noninferior to live-birth rates with the addition of preimplantation genetic testing for aneuploidy.

RCT: Intracytoplasmic sperm injection vs. conventional in-vitro fertilization in couples with infertility in whom the male partner has normal total sperm count and motility – no difference in livebirth rates between the strategies

Randomized Trial: Acupuncture Not Effective for Improving the Likelihood of In Vitro Fertilization

Research: Transfer of Fresh versus Frozen Embryos in Ovulatory Women

Randomized trial: Freeze-all vs. fresh blastocyst transfer strategy during in vitro fertilization in women with regular menstrual cycles

Guidance on the need for contraception related to use of pharmaceuticals: providing information on the proper use of pharmaceuticals in patients with reproductive potential.

31 Mar, 2022 | 07:49h | UTC

Guidance on the need for contraception related to use of pharmaceuticals: the Japan Agency for Medical Research and Development Study Group for providing information on the proper use of pharmaceuticals in patients with reproductive potential

Cohort Study: Preconception paternal use of metformin linked to increased risk of congenital problems in offspring.

29 Mar, 2022 | 10:04h | UTC

Preconception Antidiabetic Drugs in Men and Birth Defects in Offspring: A Nationwide Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries:

Paternal metformin use associated with major birth defects if used during period of sperm development – American College of Physicians

Expert reaction to study of birth defects and diabetic men using metformin during sperm development – Science Media Centre

Study shows whole-genome risk prediction of common diseases in human preimplantation embryos is feasible, leading to ethical concerns.

22 Mar, 2022 | 09:42h | UTC

Whole-genome risk prediction of common diseases in human preimplantation embryos – Nature Medicine

Invited Commentaries:

Polygenic embryo testing: understated ethics, unclear utility – Nature Medicine

The uncertain science of preimplantation and prenatal genetic testing – Nature Medicine

Commentary: As genetic testing of human embryos expand, researchers call for frank assessment of profound ethical implications – The Hastings Center

Commentary on Twitter (thread – click for more)

Preimplantation genetic testing of human embryos is a rapidly advancing field, but scientists and ethicists are calling for caution.
We present 3 articles highlighting new research and expert commentary on this controversial topic.
THREAD ?

— Nature Medicine (@NatureMedicine) March 21, 2022

RCT: A preconception lifestyle intervention for weight loss did not improve fertility rates among women with obesity and infertility.

15 Mar, 2022 | 08:34h | UTC

Effects of preconception lifestyle intervention in infertile women with obesity: The FIT-PLESE randomized controlled trial – PLOS Medicine

Commentary: Weight loss doesn’t help pregnancy chances, study finds – University of Virginia Health System

Choosing Wisely Canada: Canadian fertility and andrology society’s list of top items physicians and patients should question in fertility medicine.

14 Mar, 2022 | 01:23h | UTC

Choosing Wisely Canada: Canadian fertility and andrology society’s list of top items physicians and patients should question in fertility medicine – Archives of Gynecology and Obstetrics (if the link is paywalled, try this one)

See complete lists of low-value practices: Choosing Wisely U.S. / Choosing Wisely UK / Choosing Wisely Australia AND Choosing Wisely Canada

Bioethics | The rupture of anonymity for sperm donors—a tangled web of conflicting rights.

14 Mar, 2022 | 00:49h | UTC

The rupture of anonymity for sperm donors—a tangled web of conflicting rights – The BMJ

Commentary on Twitter

Direct-to-consumer DNA testing has torn the veil separating social family and genetic heritage. This Opinion article examines how it has brought the rights of donor conceived people to information into conflict with donors’ right to privacyhttps://t.co/avX64dbnhb

— The BMJ (@bmj_latest) March 11, 2022

Survey: Despite insufficient evidence of benefit, many fertility specialists still perform endometrial scratching before in vitro fertilization.

9 Feb, 2022 | 08:19h | UTC

Endometrial scratching in Australia, New Zealand and the United Kingdom (UK): a follow-up survey – Human Fertility

Commentary: Too Many Fertility Specialists Still Use a Painful, Useless Procedure: Study – HealthDay

Endometrial scratching: what’s the latest evidence? – “we are uncertain whether endometrial injury has an effect on the probability of getting pregnant and having a baby”.

A Randomized Trial of Endometrial Scratching before In Vitro Fertilization – New England Journal of Medicine

Opinion | “The use of polygenic risk scores in pre-implantation genetic testing: an unproven, unethical practice”.

26 Jan, 2022 | 01:52h | UTC

The use of polygenic risk scores in pre-implantation genetic testing: an unproven, unethical practice – European Journal of Human Genetics

Commentary: ‘Unproven and unethical’: experts warn against genetic embryo tests – The Guardian

Randomized Trial: Conventional in vitro fertilization resulted in a cumulative live-birth rate that was noninferior to live-birth rates with the addition of preimplantation genetic testing for aneuploidy.

28 Nov, 2021 | 21:14h | UTC

Live Birth with or without Preimplantation Genetic Testing for Aneuploidy – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: New research casts fresh doubt on a common procedure that promises to increase the odds of IVF – STAT

Systematic Review: Agents for ovarian stimulation for intrauterine insemination (IUI) in ovulatory women with infertility.

11 Nov, 2021 | 08:23h | UTC

Summary: Which medicines are most effective for women trying to get pregnant by ‘intrauterine insemination’ (where sperm is placed directly in the womb)? – Cochrane Library

Original Study: Agents for ovarian stimulation for intrauterine insemination (IUI) in ovulatory women with infertility – Cochrane Library

COVID vaccines show no signs of harming fertility or sexual function.

26 Aug, 2021 | 09:12h | UTC

COVID Vaccines Show No Signs of Harming Fertility or Sexual Function – Scientific American

Endometrial scratching: what’s the latest evidence? – “we are uncertain whether endometrial injury has an effect on the probability of getting pregnant and having a baby”.

8 Aug, 2021 | 23:33h | UTC

Endometrial scratching: what’s the latest evidence? – Cochrane Library

Original Review: Endometrial injury for pregnancy following sexual intercourse or intrauterine insemination – Cochrane Library

Commentary on Twitter

Endometrial scratching is a procedure that is sometimes done with the aim of increasing the chance of pregnancy, but its use is debated. @SarahLensen of @CochraenCGF explains the latest Cochrane evidence in this new @CochraneUK blog: https://t.co/IFyYlXvS6v pic.twitter.com/PDEWRx4JPA

— Cochrane (@cochranecollab) August 6, 2021

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