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Phase 2 RCT | Lenacapavir every 26 weeks or daily in combination with oral daily antiretroviral therapy for initial treatment of HIV

27 Jan, 2023 | 12:00h | UTC

Lenacapavir administered every 26 weeks or daily in combination with oral daily antiretroviral therapy for initial treatment of HIV: a randomised, open-label, active-controlled, phase 2 trial – The Lancet HIV (link to abstract – $ for full-text)

 

Post-trial follow-up | Nivolumab and Doxorubicin, Vinblastine, and Dacarbazine in early-stage unfavorable Hodgkin Lymphoma

27 Jan, 2023 | 11:58h | UTC

Nivolumab and Doxorubicin, Vinblastine, and Dacarbazine in Early-Stage Unfavorable Hodgkin Lymphoma: Final Analysis of the Randomized German Hodgkin Study Group Phase II NIVAHL Trial – Journal of Clinical Oncology

Commentaries:

NIVAHL Trial: Nivolumab and AVD Show Favorable Long-Term Safety and Efficacy in Early-Stage Unfavorable Classical Hodgkin Lymphoma – ASCO Daily News

Concomitant and Sequential Nivolumab, Doxorubicin, Vinblastine, and Dacarbazine in Early-Stage Unfavorable Hodgkin Lymphoma: Final Analysis of German Hodgkin Study Group NIVAHL Trial – The ASCO Post

Original Study: Efficacy of Nivolumab and AVD in Early-Stage Unfavorable Classic Hodgkin Lymphoma: The Randomized Phase 2 German Hodgkin Study Group NIVAHL Trial – JAMA Oncology

 

RCT | Shoulder stretching vs. shoulder muscle strength training for the prevention of baseball-related arm injuries

27 Jan, 2023 | 11:57h | UTC

Shoulder stretching versus shoulder muscle strength training for the prevention of baseball-related arm injuries: a randomized, active-controlled, open-label, non-inferiority study – Scientific Reports

 

Commentary on Twitter

 

Review | The blood–brain barrier and optimization of antibiotics for the treatment of CNS infections in adults

27 Jan, 2023 | 11:55h | UTC

The Blood–Brain Barrier and Pharmacokinetic/Pharmacodynamic Optimization of Antibiotics for the Treatment of Central Nervous System Infections in Adults – Antibiotics

 

M-A | Proximal gastrectomy with double-tract-reconstruction vs. total gastrectomy in gastric and gastroesophageal junction cancer patients

27 Jan, 2023 | 11:54h | UTC

Systematic review and meta-analysis comparing proximal gastrectomy with double-tract-reconstruction and total gastrectomy in gastric and gastroesophageal junction cancer patients: Still no sufficient evidence for clinical decision-making – Surgery

 

WHO Report | Cholera global situation

26 Jan, 2023 | 12:56h | UTC

Cholera – Global situation – World Health Organization

Commentary: WHO Report: Cholera Resurgent in 2022 After Years of Decline – JAMA

 

Essential medicines for mental disorders: comparison of 121 national lists with WHO recommendations

26 Jan, 2023 | 12:55h | UTC

Essential medicines for mental disorders: comparison of 121 national lists with WHO recommendations – Archives of Public Health

 

Cohort Study | Dietary exposure to nitrites and nitrates linked to increased risk of type 2 diabetes

26 Jan, 2023 | 12:54h | UTC

Dietary exposure to nitrites and nitrates in association with type 2 diabetes risk: Results from the NutriNet-Santé population-based cohort study – PLOS Medicine

Commentaries:

Expert reaction to study on association of nitrite additives with increased risk of type 2 diabetes – Science Media Centre

What is the association between nitrite and nitrate exposure and type 2 diabetes? – News Medical

Total Nitrite Consumption Tied to Higher Type 2 Diabetes Risk – HealthDay

 

M-A | Dose–response effects of exercise and caloric restriction on visceral adiposity in overweight and obese adults

26 Jan, 2023 | 12:52h | UTC

Dose–response effects of exercise and caloric restriction on visceral adiposity in overweight and obese adults: a systematic review and meta-analysis of randomised controlled trials – British Journal of Sports Medicine

 

Commentary on Twitter

 

RCT | Continued enteral nutrition until extubation was noninferior to a 6-h fasting strategy before extubation in patients in the ICU

26 Jan, 2023 | 12:49h | UTC

Continued enteral nutrition until extubation compared with fasting before extubation in patients in the intensive care unit: an open-label, cluster-randomised, parallel-group, non-inferiority trial – The Lancet Respiratory Medicine (free registration required)

Invited Commentary: Continuation of enteral nutrition until extubation in critically ill patients – The Lancet Respiratory Medicine

 

Commentary on Twitter

 

SR | Protective effectiveness of previous SARS-CoV-2 infection and hybrid immunity against the omicron variant and severe disease

26 Jan, 2023 | 12:47h | UTC

Protective effectiveness of previous SARS-CoV-2 infection and hybrid immunity against the omicron variant and severe disease: a systematic review and meta-regression – The Lancet Infectious Diseases

Editorial: The benefit of vaccination after previous SARS-CoV-2 infection in the omicron era – The Lancet Infectious Diseases

News Release: University of Calgary and WHO researchers find hybrid immunity is the best protection against COVID-19

Commentaries:

Review finds hybrid immunity provides best protection against Omicron – CIDRAP

Hybrid Immunity Protects Better Against Hospitalisation and Severe COVID Infection – Health Policy Watch

 

Review | Spotlight on vaccine-induced thrombosis and thrombocytopenia (VITT)

26 Jan, 2023 | 12:46h | UTC

Spotlight on vaccine-induced thrombosis and thrombocytopenia (VITT) – Blood

 

FDA warns of risks of body sculpting

26 Jan, 2023 | 12:44h | UTC

FDA Warns of Risks of Body Sculpting – JAMA

Statement: Non-Invasive Body Contouring Technologies – U.S. Food & Drug Administration

 

The digitization and decentralization of clinical trials

26 Jan, 2023 | 12:43h | UTC

The Digitization and Decentralization of Clinical Trials – Mayo Clinic Proceedings

 

Analysis | Finding bias before the first patient is enrolled

26 Jan, 2023 | 12:42h | UTC

Finding Bias Before the First Patient is Enrolled – Sensible Medicine

 

AAP Clinical Report | Maintaining and improving the oral health of young children

26 Jan, 2023 | 12:41h | UTC

Maintaining and Improving the Oral Health of Young Children – Pediatrics

News Release: American Academy of Pediatrics Updates Recommendations on Maintaining, Improving Children’s Oral Health – American Academy of Pediatrics

 

Evidence-Based Guidance | Medical nutrition therapy in ECMO patients

26 Jan, 2023 | 12:28h | UTC

Medical Nutrition Therapy in ECMO Patients: Evidence-Based Guidance for Clinical Practice – Journal of Parenteral and Enteral Nutrition

 

AHA Statement | Perioperative care for children with congenital heart disease presenting for noncardiac procedures

26 Jan, 2023 | 12:26h | UTC

Perioperative Considerations for Pediatric Patients With Congenital Heart Disease Presenting for Noncardiac Procedures: A Scientific Statement From the American Heart Association – Circulation: Cardiovascular Quality and Outcomes

Commentary: AHA Weighs in on Risks of Noncardiac Surgery in Congenital HD Patients – TCTMD

 

SR | Oral nutritional interventions in frail older people who are malnourished or at risk of malnutrition

26 Jan, 2023 | 12:25h | UTC

Oral nutritional interventions in frail older people who are malnourished or at risk of malnutrition: a systematic review – Health Technology Assessment

 

Preliminary study suggests decompression surgery may improve symptoms in neurogenic thoracic outlet syndrome

26 Jan, 2023 | 12:23h | UTC

Surgery Versus Continued Conservative Treatment for Neurogenic Thoracic Outlet Syndrome: the First Randomised Clinical Trial (STOPNTOS Trial) – European Journal of Vascular and Endovascular Surgery

Related: Neurogenic Thoracic Outlet Syndrome: Presentation, diagnosis, and treatment – Deutsches Ärzteblatt international

 

Neurogenic thoracic outlet syndrome: presentation, diagnosis, and treatment

26 Jan, 2023 | 12:22h | UTC

Neurogenic Thoracic Outlet Syndrome: Presentation, diagnosis, and treatment – Deutsches Ärzteblatt international

 

The treatment of coronary artery disease: current status six decades after the first bypass operation

26 Jan, 2023 | 12:20h | UTC

The Treatment of Coronary Artery Disease: Current status six decades after the first bypass operation – Deutsches Ärzteblatt international

 

M-A | Post-operative outcomes of pre-thoracic surgery respiratory muscle training vs. aerobic exercise training

26 Jan, 2023 | 12:19h | UTC

Post-Operative Outcomes of Pre-Thoracic Surgery Respiratory Muscle Training Vs. Aerobic Exercise Training: A Systematic Review and Network Meta-analysis – Archives of Physical Medicine and Rehabilitation (link to abstract – $ for full-text)

 

Cohort study | Endovascular balloon occlusion of the aorta may be an alternative to resuscitative thoracotomy in traumatic hemorrhagic shock

26 Jan, 2023 | 12:18h | UTC

Zone 1 Endovascular Balloon Occlusion of the Aorta vs Resuscitative Thoracotomy for Patient Resuscitation After Severe Hemorrhagic Shock – JAMA Surgery (link to abstract – $ for full-text)

Related: Systematic review to evaluate algorithms for REBOA use in trauma and identify a consensus for patient selection – Trauma Surgery and Acute Care Open

 

Commentary on Twitter

 

Systematic review to evaluate algorithms for REBOA use in trauma and identify a consensus for patient selection

26 Jan, 2023 | 12:13h | UTC

Systematic review to evaluate algorithms for REBOA use in trauma and identify a consensus for patient selection – Trauma Surgery and Acute Care Open

Related: Zone 1 Endovascular Balloon Occlusion of the Aorta vs Resuscitative Thoracotomy for Patient Resuscitation After Severe Hemorrhagic Shock – JAMA Surgery (link to abstract – $ for full-text)

 

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