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Antibiotic Stewardship

Global incidence in hospital-associated infections resistant to antibiotics: an analysis of point prevalence surveys from 99 countries

30 Jun, 2023 | 14:33h | UTC

Global incidence in hospital-associated infections resistant to antibiotics: An analysis of point prevalence surveys from 99 countries – PLOS Medicine

 

WHO outlines 40 research priorities on antimicrobial resistance

26 Jun, 2023 | 00:50h | UTC

News release: WHO outlines 40 research priorities on antimicrobial resistance – World Health Organization

Report: Global research agenda for antimicrobial resistance in human health – World Health Organization

 

Commentary on Twitter

 

RCT | High-dose dual-antibiotic cement doesn’t lower infection rates in hip hemiarthroplasty

26 Jun, 2023 | 00:47h | UTC

Summary: This randomized superiority trial studied the effect of high-dose dual-antibiotic loaded cement versus standard care single-antibiotic loaded cement on deep surgical site infection (SSI) rates in hip hemiarthroplasty patients. This large-scale study, conducted in 26 UK hospitals, included people aged 60 and older with a hip fracture.

The trial randomly allocated 4936 participants to either treatment group. The primary outcome was deep SSI at 90 days post-randomisation. Notably, no significant difference was found between the groups. About 1.7% of participants in the single-antibiotic group and 1.2% in the dual-antibiotic group experienced a deep SSI (adjusted odds ratio 1.43; 95% CI 0.87–2.35; p=0.16). This result contradicts previous findings suggesting that high-dose dual-antibiotic cement could reduce infection rates.

Article: High-dose dual-antibiotic loaded cement for hip hemiarthroplasty in the UK (WHiTE 8): a randomised controlled trial – The Lancet

News release: Antibiotic bone cement found not to reduce infection after hip replacement – University of Oxford

 

Review | Differentiating infection, colonization, and sterile inflammation in critical illness

26 Jun, 2023 | 00:41h | UTC

Differentiating infection, colonisation, and sterile inflammation in critical illness: the emerging role of host-response profiling – Intensive Care Medicine (free for a limited period)

 

Commentary on Twitter

 

Review | The antibiotic bead pouch – A useful technique for infection prevention and therapy in trauma surgery

26 Jun, 2023 | 00:35h | UTC

The antibiotic bead pouch – a useful technique for temporary soft tissue coverage, infection prevention and therapy in trauma surgery – Journal of Bone and Joint Infection

 

Review | Therapeutic drug monitoring of antimicrobials in critically ill obese patients

26 Jun, 2023 | 00:29h | UTC

Therapeutic Drug Monitoring of Antimicrobials in Critically Ill Obese Patients – Antibiotics

 

Commentary on Twitter

 

Retrospective study | Increasing prevalence and severity of carbapenem-resistant Klebsiella Pneumoniae in ICUs

23 Jun, 2023 | 13:25h | UTC

Clinical characteristics of carbapenem-resistant Klebsiella pneumoniae infection/colonisation in the intensive care unit: a 9-year retrospective study – BMJ Open

 

Consensus Paper | Primary prophylaxis of invasive fungal diseases in patients with hematological malignancies

23 Jun, 2023 | 13:23h | UTC

Primary prophylaxis of invasive fungal diseases in patients with haematological malignancies: 2022 update of the recommendations of the Infectious Diseases Working Party (AGIHO) of the German Society for Haematology and Medical Oncology (DGHO) – Journal of Antimicrobial Chemotherapy

 

Review | Early lead extraction for infected implanted cardiac electronic devices

22 Jun, 2023 | 15:03h | UTC

Early Lead Extraction for Infected Implanted Cardiac Electronic Devices: JACC Review Topic of the Week – Journal of the American College of Cardiology

 

Review | Antifungal dosing in critically ill patients on extracorporeal membrane oxygenation

21 Jun, 2023 | 13:31h | UTC

Antifungal Dosing in Critically Ill Patients on Extracorporeal Membrane Oxygenation – Clinical Pharmacokinetics

 

The foot in diabetes – a reminder of an ever-present risk

21 Jun, 2023 | 13:10h | UTC

The foot in diabetes – a reminder of an ever-present risk – Clinical Medicine Journal

Related: Guideline Series | Prevention and management of diabetes-related foot disease

 

RCT | Continuous vs. intermittent meropenem administration shows similar mortality and drug-resistance in sepsis patients

19 Jun, 2023 | 14:11h | UTC

Continuous vs Intermittent Meropenem Administration in Critically Ill Patients With Sepsis: The MERCY Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Do Prolonged Infusions of β-Lactam Antibiotics Improve Outcomes in Critically Ill Patients With Sepsis? – JAMA (free for a limited period)

See also: Visual Abstract

Commentary: Trial finds no difference between continuous, intermittent meropenem for sepsis patients – CIDRAP

 

Commentary on Twitter

 

Review | Necessity of antigen testing for Legionella in hospitalized patients with community-acquired pneumonia

19 Jun, 2023 | 13:56h | UTC

Should urine antigen testing for Legionella pneumophila be ordered for all hospitalized patients with community-acquired pneumonia? – Cleveland Clinic Journal of Medicine

 

Review | Bloodstream infection and gram-negative resistance: the role for newer antibiotics

16 Jun, 2023 | 13:57h | UTC

Bloodstream Infection and Gram-Negative Resistance: The Role for Newer Antibiotics – Antibiotics

 

Review | Aminoglycosides for the treatment of severe infection due to resistant gram-negative pathogens

16 Jun, 2023 | 13:56h | UTC

Aminoglycosides for the Treatment of Severe Infection Due to Resistant Gram-Negative Pathogens – Antibiotics

 

Review | Antifungal stewardship interventions in patients with hematologic malignancies

16 Jun, 2023 | 13:47h | UTC

Antifungal Stewardship Interventions in Patients with Hematologic Malignancies

 

Review | Contribution of wastewater to antimicrobial resistance

15 Jun, 2023 | 14:49h | UTC

Contribution of wastewater to Antimicrobial Resistance- A Review article – Journal of Global Antimicrobial Resistance

Related studies on surveillance of wastewater:

Use of Wastewater for Mpox Outbreak Surveillance in California – New England Journal of Medicine

Wastewater network infrastructure in public health: Applications and learnings from the COVID-19 pandemic – PLOS Global Public Health

Opinion: Wastewater analysis can be a powerful public health tool—if it’s done sensibly.

CDC unveils its latest weapon in Covid-19 detection: wastewater.

CDC Report: Using Wastewater Surveillance Data to Support the COVID-19 Response — United States, 2020–2021.

Rapid, large-scale wastewater surveillance and automated reporting system enabled early detection of nearly 85% of COVID-19 cases on a University campus.

[Preprint] Wastewater genomic testing can effectively track COVID-19 variants of concern.

Human Waste Could Be The Next Big Weapon in Controlling COVID-19 – TIME

Next steps for wastewater testing to help end this pandemic — and prevent the next one – STAT

Sewage sleuths helped an Arizona town beat back Covid-19. For wastewater epidemiology, that’s just the start – STAT

The myriad ways sewage surveillance is helping fight COVID around the world – Nature

Testing sewage can give school districts, campuses and businesses a heads-up on the spread of COVID-19 – The Conversation

It’s time to begin a national wastewater testing program for Covid-19 – STAT

Coronavirus: Testing sewage an ‘easy win’ – BBC

Development of wastewater pooled surveillance of SARS-CoV-2 from congregate living settings – high sensitivity, but unable to distinguish new infectious cases from persistent convalescent shedding.

 

M-A | Preoperative IV plus oral antibiotics reduce surgical site infections in elective colorectal surgery

14 Jun, 2023 | 14:31h | UTC

Mechanical bowel preparation and antibiotics in elective colorectal surgery: network meta-analysis – BJS Open

Related:

SR | Mechanical plus oral antibiotic bowel preparation may prevent complications in elective colorectal surgery

M-A: Strategies for antibiotic administration for bowel preparation among patients undergoing elective colorectal surgery – “the addition of oral antibiotics to intravenous antibiotics was associated with a reduction in the incidence of incisional surgical site infection by more than 50%”.

Meta-Analysis: Effects of Mechanical Bowel Preparation and Oral Antibiotics Before Elective Colorectal Surgery

 

Commentary on Twitter

 

Review | Challenges and opportunities in antimicrobial stewardship among hematopoietic stem cell transplant and oncology patients

13 Jun, 2023 | 13:55h | UTC

Challenges and Opportunities in Antimicrobial Stewardship among Hematopoietic Stem Cell Transplant and Oncology Patients – Antibiotics

 

IDSA 2023 Guidance on the treatment of antimicrobial resistant gram-negative infections

12 Jun, 2023 | 13:58h | UTC

IDSA 2023 Guidance on the Treatment of Antimicrobial Resistant Gram-Negative Infections – Infectious Diseases Society of America

Related:

Guidelines for the diagnosis, treatment, prevention and control of infections caused by carbapenem-resistant gram-negative bacilli – Journal of Microbiology, Immunology and Infection

A position paper for the diagnosis and management of infections caused by multidrug-resistant bacteria: Endorsed by the Italian Society of Infection and Tropical Diseases (SIMIT), the Italian Society of Anti-Infective Therapy (SITA), the Italian Group for Antimicrobial Stewardship (GISA), the Italian Association of Clinical Microbiologists (AMCLI), and the Italian Society of Microbiology (SIM) – International Journal of Antimicrobial Agents

The threat of multidrug-resistant/extensively drug-resistant Gram-negative respiratory infections: another pandemic – European Respiratory Review

 

Review | Drivers of inappropriate antibiotic use in low- and middle-income countries

12 Jun, 2023 | 13:35h | UTC

Drivers of inappropriate antibiotic use in low- and middle-income countries – JAC-Antimicrobial Resistance

 

AAOS Appropriate Use Criteria | Prevention of surgical site infections after major extremity trauma

7 Jun, 2023 | 13:58h | UTC

American Academy of Orthopaedic Surgeons Appropriate Use Criteria: Prevention of Surgical Site Infections After Major Extremity Trauma – Journal of the American Academy of Orthopaedic Surgeons

Related:

Centers for Disease Control and Prevention Guideline for the Prevention of Surgical Site Infection, 2017 – JAMA Surgery

Global guidelines on the prevention of surgical site infection – World Health Organization

Surgical site infections: prevention and treatment – National Institute for Health and Care Excellence

APSIC guidelines for the prevention of surgical site infections – Antimicrobial Resistance & Infection Control

Perioperative care bundles for the prevention of surgical-site infections: meta-analysis – British Journal of Surgery

AAOS Guideline: Prevention of surgical site infections after major extremity trauma.

 

Podcast | Ascend your understanding of pelvic inflammatory disease

6 Jun, 2023 | 14:23h | UTC

#83: Ascend Your Understanding of Pelvic Inflammatory Disease (PID) – The Cribsiders

 

RCT | Sulbactam-durlobactam non-inferior to colistin for acinetobacter baumannii-calcoaceticus complex infections

5 Jun, 2023 | 13:31h | UTC

Efficacy and safety of sulbactam–durlobactam versus colistin for the treatment of patients with serious infections caused by Acinetobacter baumannii–calcoaceticus complex: a multicentre, randomised, active-controlled, phase 3, non-inferiority clinical trial (ATTACK) – The Lancet Infectious Diseases (link to abstract – $ for full-text)

News Release: Novel Antibiotic Succeeds in Trial Against Hospital-Acquired Pneumonia – Rutgers University

 

Quality-improvement intervention | Impact of stopping preoperative screening for asymptomatic bacteriuria

2 Jun, 2023 | 12:29h | UTC

If you don’t test, they will not treat: Impact of stopping preoperative screening for asymptomatic bacteriuria – Antimicrobial Stewardship & Healthcare Epidemiology

Commentary: Hospital intervention reduces unnecessary screening, antibiotics for bacteriuria – CIDRAP

 

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