Maternal-fetal Medicine
USPSTF Recommendations | Screen for anxiety disorders in adults, including pregnant and postpartum women
30 Jun, 2023 | 15:03h | UTCEditorial: Are There Reasons to Fear Anxiety Screening? – JAMA
Evidence Report: Anxiety Screening: Evidence Report and Systematic Review for the US Preventive Services Task Force – JAMA
Patient Page: Screening for Anxiety Disorders in Adults – JAMA
Author Interview: USPSTF Recommendations: Screening for Depression and Suicide Risk in Adults, and Screening for Anxiety Disorders in Adults – JAMA
RCT | Acupuncture, doxylamine–pyridoxine, and their combination in nausea treatment during pregnancy
29 Jun, 2023 | 13:56h | UTCAcupuncture and Doxylamine–Pyridoxine for Nausea and Vomiting in Pregnancy: A Randomized, Controlled, 2 × 2 Factorial Trial – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentary: Combo treatment eases nausea and vomiting of pregnancy – MDedge
RCT | LMWH does not increase live birth rates in women with thrombophilia and recurrent miscarriage
21 Jun, 2023 | 13:39h | UTCHeparin for women with recurrent miscarriage and inherited thrombophilia (ALIFE2): an international open-label, randomised controlled trial – The Lancet (link to abstract – $ for full-text)
Commentary on Twitter (thread – click for more)
New study: Many women with recurrent miscarriage are tested for inherited thrombophilia. If confirmed positive, daily subcutaneous low-molecular-weight heparin (LMWH) is given.
This is despite an absence of evidence that such treatment is beneficial ? https://t.co/0IuFhvjlZr
— The Lancet (@TheLancet) June 2, 2023
Guideline | Screening and diagnosis of significant hemoglobinopathies
20 Jun, 2023 | 12:32h | UTC
SR | Automated mandatory bolus vs. basal infusion for maintenance of epidural analgesia in labor
20 Jun, 2023 | 12:24h | UTC
Triple trouble | Uncovering the risks and benefits of early fetal reduction in trichorionic triplets in a large national Danish cohort study
19 Jun, 2023 | 13:39h | UTC
M-A | Postpartum care up to 1 year after pregnancy
14 Jun, 2023 | 14:39h | UTC
SR | Management of postpartum hypertensive disorders of pregnancy
14 Jun, 2023 | 14:37h | UTC
M-A | Elevated HbA1c in gestational diabetes mellitus tied to 1.7-fold rise in large for gestational age incidence
13 Jun, 2023 | 13:39h | UTC
Guideline | Prevention and therapy of preterm birth
12 Jun, 2023 | 13:45h | UTCPrevention and Therapy of Preterm Birth. Guideline of the DGGG, OEGGG and SGGG
Review | Pregnancy as an early cardiovascular moment: peripartum cardiovascular health
12 Jun, 2023 | 13:36h | UTCPregnancy as an Early Cardiovascular Moment: Peripartum Cardiovascular Health – Circulation Research
Commentary on Twitter
@CircRes Alert! Compendium on Early #CVD#Pregnancy as an Early #Cardiovascular Moment: #Peripartum Cardiovascular Health https://t.co/tqOWn9AU0O
Authored by Drs. @heartdocsadiya, NA Cameron, and KJ Lindley pic.twitter.com/KlOXura8Y2
— Circulation Research (@CircRes) June 10, 2023
Brief Review | What BP target is appropriate for pregnant patients with mild chronic hypertension?
6 Jun, 2023 | 14:20h | UTC
Review | Patient-centered care in the management of cancer during pregnancy
6 Jun, 2023 | 14:10h | UTCPatient-Centered Care in the Management of Cancer During Pregnancy – ASCO Educational Book
See other articles in the series: 2023 ASCO Educational Book
M-A | Maternal alcohol consumption and the risk of miscarriage in the first and second trimesters
1 Jun, 2023 | 12:10h | UTC
M-A | Labor induction at 39 weeks: improved outcomes but increased shoulder dystocia for nulliparous women
31 May, 2023 | 14:10h | UTC
WHO Report | Global progress in tackling maternal and newborn deaths stalls since 2015
25 May, 2023 | 11:36h | UTCNews Release: Global progress in tackling maternal and newborn deaths stalls since 2015: UN – World Health Organization
WHO Report | 152 million babies born preterm in the last decade
23 May, 2023 | 13:15h | UTCNews Release: 152 million babies born preterm in the last decade – World Health Organization
Report: Born too soon: decade of action on preterm birth – World Health Organization
Consensus Statement | Management of arrhythmias during pregnancy
23 May, 2023 | 13:00h | UTC2023 HRS Expert Consensus Statement on the Management of Arrhythmias During Pregnancy – Heart Rhythm
News Release: Management of Arrhythmias During Pregnancy Consensus Statement Emphasizes Shared Decision-Making – European Heart Rhythm
Special Supplement | Labor and delivery at term – partograms, labor disorders, analgesia/anesthesia, and fever
22 May, 2023 | 13:51h | UTC
Cluster RCT | Early detection and treatment bundle reduces postpartum hemorrhage complications
16 May, 2023 | 15:02h | UTCSummary: An international, cluster-randomized trial assessed the effectiveness of a multicomponent clinical intervention for postpartum hemorrhage in patients having vaginal delivery. The study involved 80 secondary-level hospitals across Kenya, Nigeria, South Africa, and Tanzania, with 210,132 patients. The intervention group utilized a calibrated blood-collection drape for early detection of postpartum hemorrhage and a first-response treatment bundle, while the control group received usual care.
The primary outcome measured was a composite of severe postpartum hemorrhage (blood loss ≥1000 ml), laparotomy for bleeding, or maternal death from bleeding. The results showed a significant reduction in primary-outcome events in the intervention group (1.6%) compared to the usual-care group (4.3%) with a risk ratio of 0.40 (95% CI, 0.32 to 0.50; P<0.001). Postpartum hemorrhage detection rates were 93.1% and 51.1% in the intervention and usual-care groups, respectively, and treatment bundle adherence was 91.2% and 19.4%, respectively.
These findings demonstrate that early detection of postpartum hemorrhage and the use of a bundled treatment approach can significantly reduce the risk of severe postpartum hemorrhage, laparotomy for bleeding, or death from bleeding among patients having vaginal delivery. The results have important implications for improving clinical practice and reducing postpartum hemorrhage complications globally.
Article: Randomized Trial of Early Detection and Treatment of Postpartum Hemorrhage – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Lifesaving solution dramatically reduces severe bleeding after childbirth – World Health Organization
Commentary on Twitter
In a large, cluster-randomized trial involving patients with PPH after vaginal delivery, a multicomponent intervention lowered the risk of severe PPH, laparotomy for bleeding, or maternal death from bleeding. Full results of the E-MOTIVE trial: https://t.co/NjcE4Q1rxM#IMNHC2023
— NEJM (@NEJM) May 9, 2023
RCT | Optimizing the timing of whooping cough immunization in mums through investigating pertussis vaccination in pregnancy
16 May, 2023 | 14:49h | UTC
Care plan for individuals at risk for preeclampsia: shared approach to education, strategies for prevention, surveillance and follow up
10 May, 2023 | 16:04h | UTCCommentary: Care Plan Developed for Individuals at Risk for Preeclampsia – HealthDay
Single-arm study | Halting endocrine therapy for pregnancy not linked to increased breast cancer events vs. a control cohort
10 May, 2023 | 16:01h | UTCInterrupting Endocrine Therapy to Attempt Pregnancy after Breast Cancer – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
In women with previous breast cancer who temporarily discontinued adjuvant endocrine therapy to attempt pregnancy, the frequency of breast cancer events was below the prespecified safety threshold and similar to that in controls (POSITIVE trial). https://t.co/zM3f4SbgjE
— NEJM (@NEJM) May 3, 2023
RCT | Early treatment of gestational diabetes slightly lowers risk of adverse neonatal outcomes
9 May, 2023 | 14:55h | UTCTreatment of Gestational Diabetes Mellitus Diagnosed Early in Pregnancy – New England Journal of Medicine (link to abstract – $ for full-text)
News Release: Early treatment of gestational diabetes for those at higher risk beneficial, study finds – Western Sidney University
RCT | Single-dose intravenous iron not superior to oral iron for pregnancy anemia
8 May, 2023 | 12:52h | UTCNews Release: Landmark Malawi trial boosts iron levels in pregnant women – Walter and Eliza Hall Institute of Medical Research
Commentary from the author on Twitter
Very excited to announce the publication of our clinical trial – REVAMP – in @TheLancet: https://t.co/Zpd9500u6b. We evaluated intravenous iron vs oral iron's efficacy and safety in recovering anaemia in Malawian pregnant women. Check out this thread to learn what we found? pic.twitter.com/que9hefUhM
— Ricardo Ataide (@ricardoataide) April 24, 2023