Randomized Trials
RCT: Among patients with acute MI and anemia, a restrictive transfusion strategy resulted in a noninferior rate of major cardiovascular events compared to a liberal transfusion strategy
10 Feb, 2021 | 01:39h | UTCEffect of a Restrictive vs Liberal Blood Transfusion Strategy on Major Cardiovascular Events Among Patients With Acute Myocardial Infarction and Anemia: The REALITY Randomized Clinical Trial – JAMA (free for a limited period)
Commentary: Restrictive vs. Liberal Blood Transfusion Strategy for MI and Anemia – American College of Cardiology
Commentary on Twitter
Effect of Restrictive vs Liberal Blood Transfusion Strategy on Adults With Myocardial Infarction and Anemia https://t.co/PUtmUj0haw
— JAMA Cardiology (@JAMACardio) February 9, 2021
RCT: In patients with generalized myasthenia gravis prescribed azithromycin, rapid tapering of prednisone is beneficial and safe compared to slow tapering
10 Feb, 2021 | 01:32h | UTC
Commentary on Twitter
Rapid tapering of high-dose #prednisone therapy in patients with moderate to severe generalized #myastheniagravis on azathioprine appears to be well tolerated and associated with good outcome https://t.co/1nHZuy8kPN
— JAMA Neurology (@JAMANeuro) February 8, 2021
RCT: Among children with Myelomeningocele, long term results confirm the benefits of prenatal repair compared to standard postnatal repair
10 Feb, 2021 | 01:28h | UTCPrenatal Repair and Physical Functioning Among Children With Myelomeningocele: A Secondary Analysis of a Randomized Clinical Trial – JAMA Pediatrics (free for a limited period)
Editorial: Long-term Outcomes of Children After Fetal Surgery for Spina Bifida—Toward Sustainability – JAMA Pediatrics (free for a limited period)
Commentaries: Spina Bifida Repair: The Sooner the Better – Physician’s Weekly AND Prenatal Myelomeningocele Repair Tied to Better Function – HealthDay
Commentary on Twitter
Previous work reported that prenatal versus postnatal repair of myelomeningocele resulted in improved physical functioning. A secondary analysis at #jamapeds reports that these improvements persist into school age. https://t.co/2aehk5L6pi pic.twitter.com/hASLEUcvqm
— JAMA Pediatrics (@JAMAPediatrics) February 9, 2021
RCT: Dobutamine-sparing vs. dobutamine-to-all strategy in cardiac surgery
9 Feb, 2021 | 00:57h | UTC
RCT: Total Body Irradiation vs. Chemotherapy Conditioning in Childhood ALL
9 Feb, 2021 | 00:39h | UTCCommentary: TBI Beats Chemoconditioning for ALL Transplants in Children – Medscape (free registration required)
Commentary on Twitter
Total body irradiation or chemotherapy conditioning in childhood acute lymphoblastic leukemia (ALL) — outcomes suggest there's still a role for TBI https://t.co/ICTC0iEGN8 #leusm #pedonc #pedcsm #JCO pic.twitter.com/xARMBlSeni
— ASCO Publications (@ASCO_pubs) December 26, 2020
Small RCT: Peginterferon lambda increases viral clearance in outpatients with COVID-19
9 Feb, 2021 | 01:36h | UTC
RCT: In patients with cirrhosis treated with TIPS, prophylactic rifaximin reduced the risk for Hepatic Encephalopathy
7 Feb, 2021 | 21:10h | UTCThe Use of Rifaximin in the Prevention of Overt Hepatic Encephalopathy After Transjugular Intrahepatic Portosystemic Shunt: A Randomized Controlled Trial – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentary: Rifaximin prevents overt hepatic encephalopathy after TIPS – HealthDay
Commentary on Twitter
New findings published in @AnnalsofIM:
In patients with #cirrhosis treated with TIPS, rifaximin was well tolerated and reduced the risk for overt HE. #Rifaximin should therefore be considered for prophylaxis of post-TIPS HE https://t.co/d2p9dfcx3s. pic.twitter.com/M7zwmUxQA3
— Annals of Int Med (@AnnalsofIM) February 2, 2021
RCT: Day-of-surgery video calls and phone calls increase patient satisfaction with outpatient surgery experience
9 Feb, 2021 | 00:44h | UTCCommentary: Day-of-Surgery Post-op Talks with Patients Worth the Effort – OrthoBuzz
RCT: Posaconazole noninferior to voriconazole for primary treatment of invasive aspergillosis
7 Feb, 2021 | 21:00h | UTCPosaconazole versus voriconazole for primary treatment of invasive aspergillosis: a phase 3, randomised, controlled, non-inferiority trial – The Lancet (link to abstract – $ for full-text)
RCT: Enteral lipid supplement reduces the risk of severe retinopathy of prematurity
7 Feb, 2021 | 21:04h | UTCCommentary: Halved risk for severe retinal disease in extremely premature infants – University of Gothenburg
Commentary on Twitter
A new study at #jamapeds reports that enteral fatty acid supplementation with AA and DHA lowers the risk of retinopathy of prematurity among extremely preterm infants. https://t.co/skN41O2YX4 pic.twitter.com/c9bv3V6wbn
— JAMA Pediatrics (@JAMAPediatrics) February 4, 2021
[Press release – not published yet] Sinovac Announces Phase III Results of Its COVID-19 Vaccine
7 Feb, 2021 | 21:29h | UTCSinovac Announces Phase III Results of Its COVID-19 Vaccine
Commentaries: Expert reaction to announcement of results of phase III of Sinovac vaccine in China – Science Media Centre AND Sinovac says COVID-19 vaccine effective in preventing hospitalization, death – Reuters
Commentary on Twitter (thread – click for more)
Sinovac's CoronaVac's phase 3 trial results: some data from Turkey in press release. Brazilian trial, much as Brazil announced: 50.65% vaccine efficacy for all symptomatic disease, 83.7% for people requiring medical care – & no severe or fatal disease..1/n https://t.co/dsCvQZAGKe
— Hilda Bastian, PhD (@hildabast) February 6, 2021