Randomized Trials
RCT: Irrigating acetic acid solution during colonoscopy for the detection of sessile serrated neoplasia
4 Mar, 2021 | 08:16h | UTC
RCT: Laparoscopic anterior resection with or without transanal tube for rectal cancer patients
4 Mar, 2021 | 08:02h | UTCLaparoscopic anterior resection with or without transanal tube for rectal cancer patients – A multicenter randomized controlled trial – The American Journal of Surgery (link to abstract – $ for full-text)
Using Bayesian Methods to Augment the Interpretation of Critical Care Trials. An Overview of Theory and Example Reanalysis of the Alveolar Recruitment for Acute Respiratory Distress Syndrome Trial
3 Mar, 2021 | 08:36h | UTC
Commentary on Twitter
I love this paper on Bayes.
Aren’t trials just like medical tests: they update our prior knowledge or beliefs?
If you can discuss a trial using its p-wave or confidence intervals, why not its posterior probabilities given *justified* priors.
(Yes, I am enthralled!) https://t.co/w1ym9jgQD5
— John Mandrola, MD (@drjohnm) March 1, 2021
RCT: High flow oxygen does not change the risk of mortality in patients with a suspected acute coronary syndrome
3 Mar, 2021 | 08:37h | UTC
Commentary on Twitter
Supplementary high flow oxygen given for ischaemic symptoms to patients with suspected acute coronary syndrome was not associated with a change in 30 day mortality, finds new #BMJResearchhttps://t.co/CDhfFyVL88
— The BMJ (@bmj_latest) March 2, 2021
RCT: Effect of Blinatumomab vs. Chemotherapy in children with high-risk first-relapse B-Cell Acute Lymphoblastic Leukemia
3 Mar, 2021 | 08:19h | UTCEffect of Blinatumomab vs Chemotherapy on Event-Free Survival Among Children With High-risk First-Relapse B-Cell Acute Lymphoblastic Leukemia: A Randomized Clinical Trial – JAMA (free for a limited period)
Related study: Effect of Postreinduction Therapy Consolidation With Blinatumomab vs Chemotherapy on Disease-Free Survival in Children, Adolescents, and Young Adults With First Relapse of B-Cell Acute Lymphoblastic Leukemia: A Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Blinatumomab for Treatment of Children With High-risk Relapsed B-Cell Acute Lymphoblastic Leukemia – JAMA (free for a limited period)
RCT: Omega-3 supplements do not reduce cardiovascular events in elderly patients after myocardial infarction
3 Mar, 2021 | 08:13h | UTCEffects of n-3 Fatty Acid Supplements in Elderly Patients After Myocardial Infarction: A Randomized, Controlled Trial – Circulation (link to abstract – $ for full-text)
Commentary: Omega-3 fatty acids did not reduce risk of cardiac events in elderly heart attack survivors – News Medical
Commentary on Twitter
OMEMI: In RCT of elderly patients with a recent acute myocardial infarction, n-3 fatty acid supplementation did not reduce clinical events. Read more: https://t.co/nGs5DGGtmT #AHAJournals @Oslounivsykehus @UniOslo @pmyhre @AAKalstad pic.twitter.com/I3Gr89ztyj
— Circulation (@CircAHA) February 11, 2021
Five-year outcomes from randomized, phase III trials: Nivolumab vs. Docetaxel in previously treated non–small-cell lung cancer
3 Mar, 2021 | 08:10h | UTC
Commentary on Twitter
At 5 years of follow up in CheckMate 017 and 057 trials, nivolumab continues to demonstrate a survival benefit vs docetaxel in patients with previously-treated advanced NSCLC https://t.co/oswZhdAPTW #JCO #lcsm #immunoonc pic.twitter.com/4FZJlfig99
— ASCO Publications (@ASCO_pubs) February 9, 2021
RCT: Extended vs. limited pelvic lymph node dissection during radical prostatectomy for intermediate- and high-risk prostate cancer
3 Mar, 2021 | 08:05h | UTCExtended Versus Limited Pelvic Lymph Node Dissection During Radical Prostatectomy for Intermediate- and High-risk Prostate Cancer: Early Oncological Outcomes from a Randomized Phase 3 Trial – European Urology (link to abstract – $ for full-text)
Commentary: Extended pelvic lymph node dissection during RP does not appear beneficial – Urology Times
Commentary on Twitter
Extended Versus Limited Pelvic Lymph Node Dissection During Radical Prostatectomy for Intermediate- and High-risk Prostate Cancer: Early Oncological Outcomes from a Randomized Phase 3 Trial#VisualAbstract https://t.co/7fAFlKmfTf@jeanlestingi @qdtrinh @RafaelFCoelho2 pic.twitter.com/es53WpXBFR
— European Urology (@EUplatinum) December 10, 2020
RCT: Similar outcomes with intermittent vs. continuous pulse oximetry in hospitalized infants with stabilized bronchiolitis
2 Mar, 2021 | 01:42h | UTCIntermittent vs Continuous Pulse Oximetry in Hospitalized Infants With Stabilized Bronchiolitis: A Randomized Clinical Trial – JAMA Pediatrics (link to abstract – $ for full-text)
Editorial: Should We Prioritize Deimplementation of Continuous Pulse Oximetry in Bronchiolitis Care?
Laparoscopic Roux-en-Y gastric bypass vs. laparoscopic sleeve gastrectomy: 5-year outcomes of merged data from two randomized clinical trials
2 Mar, 2021 | 01:27h | UTCVisual abstract: Merged SLEEVEPASS and SM-BOSS trials
Phase 3 Trials of Tirbanibulin Ointment for Actinic Keratosis
2 Mar, 2021 | 01:24h | UTCPhase 3 Trials of Tirbanibulin Ointment for Actinic Keratosis – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
The tubulin polymerization and Src kinase inhibitor tirbanibulin was superior to placebo ointment in clearing actinic keratoses on the face and scalp at 2 months. As is typical of the disorder, lesions recurred in 47% of patients at 1 year.
— NEJM (@NEJM) February 17, 2021
RCT: 3-Year outcomes of transcatheter mitral valve repair in patients with heart failure
2 Mar, 2021 | 01:20h | UTC3-Year Outcomes of Transcatheter Mitral Valve Repair in Patients With Heart Failure – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Commentary: 3-Year Outcomes of Transcatheter Mitral Valve Repair in Heart Failure – American College of Cardiology
Targeted spraying to prevent malaria in low-transmission setting halves cost of current practice
28 Feb, 2021 | 21:25h | UTCNews release: Targeted spraying to prevent malaria in low-transmission setting halves cost of current practice – Wits University
Commentary on Twitter
New paper from @davidjbath @CatKPitt and colleagues @LSHTM_CHIL @LSHTM_malaria
Targeting spraying for malaria control is safe, less costly, and cost-effective compared with standard spraying
With low incidence, these funds could be spent elsewhere?https://t.co/OCb9qhqBCX https://t.co/a0sD4uhymo
— Centre for Health Economics In London (CHIL) (@LSHTM_CHIL) February 26, 2021
Turning houses into ‘lethal mosquito lures’ nearly halves incidence of malaria in children
28 Feb, 2021 | 21:26h | UTC
Commentary on Twitter (thread – click for more)
Incredibly pleased to finally be able to share this with the world @PSUScience @LSHTM @LSTMnews
Impact and cost-effectiveness of a lethal house lure against malaria transmission in central Côte d'Ivoire: a two-arm, cluster-randomised controlled trialhttps://t.co/aPkvtHMDSS
— Eleanore Sternberg (@EDSternberg) February 25, 2021
RCT: Baclofen reduces agitation in patients with unhealthy alcohol use receiving mechanical ventilation, but results in a longer time receiving mechanical ventilation and more extended ICU stay
28 Feb, 2021 | 21:09h | UTCEditorial: Baclofen to Prevent Agitation Caused by Alcohol Withdrawal in the ICU
Video presentation: Effect of Baclofen on Agitation-Related Events Among Mechanically Ventilated Patients With Alcohol Use Disorder
Commentary on Twitter
In this phase 3 RCT, high-dose baclofen reduced agitation-related events vs placebo in patients with unhealthy alcohol use receiving mechanical ventilation; considering the modest effect & secondary endpoints & adverse events, further research is needed https://t.co/gHWEqZKfFv
— JAMA (@JAMA_current) February 23, 2021
RCT: Balanced opioid-free anesthesia with Dexmedetomidine resulted in a greater incidence of serious adverse events, especially hypoxemia and bradycardia
28 Feb, 2021 | 21:03h | UTC
RCT: similar outcomes in patients with heart failure with preserved ejection fraction randomized to high-intensity interval training vs. moderate continuous training vs. guideline-based physical activity advice
28 Feb, 2021 | 21:06h | UTCEffect of High-Intensity Interval Training, Moderate Continuous Training, or Guideline-Based Physical Activity Advice on Peak Oxygen Consumption in Patients With Heart Failure With Preserved Ejection Fraction: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
Commentary: Hold Off on HIIT for Patients with Heart Failure with Preserved EF – Physician’s Weekly
Commentary on Twitter
In this RCT, high-intensity interval training was no better at improving peak V̇O₂ at 3 months vs moderate continuous or guideline control training, in patients with #HFpEF https://t.co/CZzAcQESLg @TUMSportMedizin @jamacardiology @jamainternalmed #VisualAbstract
— JAMA Cardiology (@JAMACardio) February 22, 2021
RCT: An intensive blood pressure lowering strategy after successful endovascular therapy in acute ischemic stroke did not reduce radiographic intraparenchymal hemorrhage rates
28 Feb, 2021 | 20:59h | UTCSafety and efficacy of intensive blood pressure lowering after successful endovascular therapy in acute ischaemic stroke (BP-TARGET): a multicentre, open-label, randomised controlled trial – The Lancet Neurology (link to abstract – $ for full-text)
RCT: Endoscopic surgery improves survival compared with intensity-modulated radiotherapy in resectable locally recurrent nasopharyngeal carcinoma
28 Feb, 2021 | 20:45h | UTC
Conflicting results from 2 randomized trials testing Tocilizumab for Covid-19
26 Feb, 2021 | 08:48h | UTC
Commentary on Twitter
Why do 2 randomized trials of tocilizumab, an interleukin-6 blocker, for severe covid-19, have opposite results?
Today @NEJMhttps://t.co/g8LCrhhpLyhttps://t.co/BcN3wOwsl0 pic.twitter.com/sLrQUYI1pf— Eric Topol (@EricTopol) February 25, 2021
Phase 2 trial: Muscarinic cholinergic receptor agonist and peripheral antagonist for schizophrenia
26 Feb, 2021 | 08:30h | UTCMuscarinic Cholinergic Receptor Agonist and Peripheral Antagonist for Schizophrenia – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Phase II Results Promising for New Schizophrenia Drug Combo – MedPage Today
RCT: Topical intranasal tranexamic acid does not reduce the need for nasal packing in epistaxis
21 Feb, 2021 | 22:02h | UTCThe Use of Tranexamic Acid to Reduce the Need for Nasal Packing in Epistaxis (NoPAC): Randomized Controlled Trial – Annals of Emergency Medicine (link to abstract – $ for full-text)
Commentary on Twitter
TXA wasn't better than placebo in epistaxis in this well done RCT https://t.co/qA3yEXyvaM
Excellent work @adamreuben + team
Many of us (myself included) believed TXA a game changer in epistaxis
This trial must make us reexamine our practice pic.twitter.com/5QQsihlGC6
— Anand Swaminathan (@EMSwami) February 20, 2021
RCT: Five oral analgesics (including opioids) are equally effective for the treatment of acute musculoskeletal extremity pain in the emergency department
21 Feb, 2021 | 21:39h | UTCA Randomized Trial Comparing the Efficacy of Five Oral Analgesics for Treatment of Acute Musculoskeletal Extremity Pain in the Emergency Department – Annals of Emergency Medicine (link to abstract – $ for full-text)
Commentary on Twitter
Hot off the Press: A Randomized Trial Comparing the Efficacy of
Five Oral Analgesics for Treatment of Acute
Musculoskeletal Extremity Pain in the Emergency
Department https://t.co/qfUNn2TgZM @benjaminbwf pic.twitter.com/BzVM3W5F0L— AnnalsofEM (@AnnalsofEM) December 30, 2020
RCT: Vitamin D3 does not improve outcomes in hospitalized patients with moderate to severe COVID-19
18 Feb, 2021 | 03:20h | UTCEditorial: Vitamin D3 to Treat COVID-19: Different Disease, Same Answer
In this RCT a single high dose of #vitaminD3 (100K IU) raised mean serum 25OH D levels but had no effect on hospital LOS (primary outcome), in-hospital mortality, ICU admission, or need for mechanical ventilation (secondary outcomes) https://t.co/eozVaYnb25
— JAMA (@JAMA_current) February 17, 2021
RCT: Levonorgestrel-releasing intrauterine system vs. endometrial ablation for heavy menstrual bleeding
18 Feb, 2021 | 02:38h | UTC