Antibiotics alone for uncomplicated appendicitis: Oral Moxifloxacin almost as good as intravenous Ertapenem + oral Levofloxacin

Effect of Oral Moxifloxacin vs Intravenous Ertapenem Plus Oral Levofloxacin for Treatment of Uncomplicated Acute Appendicitis: The APPAC II Randomized Clinical Trial – JAMA

Editorial: Evolving Issues in the Use of Antibiotics for the Treatment of Uncomplicated Appendicitis

Commentary: More Support for Single-Drug Antibiotics for Uncomplicated Appendicitis – Physician’s Weekly

Commentary on Twitter

In this RCT comparing 7d oral moxifloxacin vs 2d IV ertapenam 5d oral levofloxacin metronidazole for adults w uncomplicated #appendicitis, Tx success was >65% for both, but oral #antibiotics did not meet noninferiority criteria vs IV PO https://t.co/SwcopsGZTm #VisualAbstract

— JAMA (@JAMA_current) January 12, 2021