Randomized Trials
RCT: Fixed (40 mg twice daily) or variable (0.5 mg/kg twice daily) dosing of prophylactic enoxaparin after surgical procedures
26 Mar, 2021 | 08:23h | UTCOptimal Dosing of Prophylactic Enoxaparin after Surgical Procedures: Results of the Double-Blind, Randomized, Controlled FIxed or Variable Enoxaparin (FIVE) Trial – Plastic and Reconstructive Surgery (link to abstract – $ for full-text)
Covid: The London bus trip that saved maybe a million lives (about the creation of the RECOVERY Trial)
26 Mar, 2021 | 08:53h | UTCCovid: The London bus trip that saved maybe a million lives – BBC
Related: Covid-19: The Inside Story of the RECOVERY Trial
Commentary on Twitter
Very cool story by @JamesTGallagher about a convo on a London bus that led to the creation of the RECOVERY trial, which has been a shining (& too rare) example of how to do critical research in a pandemic. Bravo @PeterHorby & @MartinLandray h/t @hildabast https://t.co/BRSJLSFXdc
— Helen Branswell (@HelenBranswell) March 25, 2021
RCT: Effect of Intrawound Vancomycin Powder in Operatively Treated High-risk Tibia Fractures
25 Mar, 2021 | 08:04h | UTCEffect of Intrawound Vancomycin Powder in Operatively Treated High-risk Tibia Fractures: A Randomized Clinical Trial – JAMA Surgery (free for a limited period)
RCT: Effect of continued weekly subcutaneous Semaglutide vs. placebo on weight loss maintenance in adults with overweight or obesity
24 Mar, 2021 | 08:05h | UTCEffect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss Maintenance in Adults With Overweight or Obesity: The STEP 4 Randomized Clinical Trial – JAMA (free for a limited period)
Commentaries: Continuing Semaglutide Leads to Further Weight Loss – NEJM Journal Watch AND STEP 4: Long-term treatment needed for full semaglutide benefit – MedwireNews
Podcast: Semaglutide for Weight Loss – JAMA
Commentary on Twitter
In this RCT, weekly subcutaneous subcutaneous semaglutide resulted in increased weight loss over 48 weeks vs placebo in adults with #overweight or #obesity https://t.co/Ze6zHCG1Fd
— JAMA (@JAMA_current) March 23, 2021
RCT: No benefit from marine Omega-3 fatty acid and Vitamin D supplementation on incident atrial fibrillation
17 Mar, 2021 | 02:38h | UTCEffect of Marine Omega-3 Fatty Acid and Vitamin D Supplementation on Incident Atrial Fibrillation: A Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Omega-3 Fatty Acids and Atrial Fibrillation – JAMA (free for a limited period)
Platelet tests pre-CABG may safely shorten washout waits, cut costs
16 Mar, 2021 | 01:44h | UTCPlatelet Tests Pre-CABG May Safely Shorten Washout Waits, Cut Costs – TCTMD
RCT: No benefit from probiotic therapy in critical illness
16 Mar, 2021 | 01:30h | UTC
Commentary on Twitter
Early & sustained untargeted administration of probiotics to adults admitted to #ICU safe, but not associated with improved outcomes. ROCIT, restoration of gut microflora in critical illness, trial visual abstract full text open access #FOAMcc on @yourICM https://t.co/mP4bkHpqSs pic.twitter.com/bu3EGUyDCm
— Intens Care Med (@yourICM) March 15, 2021
RCT: Little benefit from osteopathic manipulative treatment on activity limitations in patients with nonspecific subacute and chronic low back pain
16 Mar, 2021 | 01:39h | UTCEffect of Osteopathic Manipulative Treatment vs Sham Treatment on Activity Limitations in Patients With Nonspecific Subacute and Chronic Low Back Pain: A Randomized Clinical Trial – JAMA Internal Medicine (free for a limited period)
Visual abstract: Effect of Osteopathic Manipulative Treatment vs Sham Treatment on Activity Limitations in Patients With Nonspecific Subacute and Chronic Low Back Pain
Phase 2 RCT: Donanemab in early Alzheimer’s Disease
14 Mar, 2021 | 20:21h | UTCDonanemab in Early Alzheimer’s Disease – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Experimental Alzheimer’s drug could slow cognitive decline in patients, early results suggest – CNN AND Alzheimer’s study shows mixed results for Lilly’s donanemab on secondary outcomes – First World Pharma
Commentary on Twitter
In a phase 2 trial, patients with early Alzheimer’s disease who received donanemab, an antibody that targets amyloid deposits, showed a better composite score for cognition & ability to perform activities of daily living at 76 weeks than those who received placebo. #ADPD2021
— NEJM (@NEJM) March 13, 2021
Clinical trial shows alcohol use disorder recovery can start without sobriety
14 Mar, 2021 | 20:17h | UTC
Commentary on Twitter (thread – click for more)
1/A new trial found a harm reduction treatment effective in reducing drinking in persons experiencing homelessness – from @TheLancetPsych — I was happy to write the editorial—. Press summary here: https://t.co/WoLVWqinm6
— Stefan Kertesz, MD (@StefanKertesz) March 12, 2021
RCT: Efficacy of a combination of conservative therapies vs. an education comparator on clinical outcomes in thumb base osteoarthritis
14 Mar, 2021 | 20:13h | UTCEfficacy of a Combination of Conservative Therapies vs an Education Comparator on Clinical Outcomes in Thumb Base Osteoarthritis: A Randomized Clinical Trial – JAMA Internal Medicine (free for a limited period)
Commentary: Mix of treatments could be way to restore hand function in thumb-base osteoarthritis – University of Sydney
Commentary on Twitter
In people with thumb base #osteoarthritis, a combination of conservative treatments provided small beneficial effects on hand function at 6 weeks, but not pain, compared to an education control. Effects on hand function and pain were greater at 12 weeks https://t.co/lxaIubgTKT
— JAMA Internal Medicine (@JAMAInternalMed) March 9, 2021
70-gene signature as an aid for treatment decisions in early breast cancer: updated results of the phase 3 randomised MINDACT trial with an exploratory analysis by age
14 Mar, 2021 | 20:07h | UTC70-gene signature as an aid for treatment decisions in early breast cancer: updated results of the phase 3 randomised MINDACT trial with an exploratory analysis by age – The Lancet Oncology (link to abstract – $ for full-text)
RCT: Effect of ventral vs. dorsal spinal surgery on patient-reported physical functioning in patients with cervical spondylotic myelopathy
10 Mar, 2021 | 08:26h | UTCEffect of Ventral vs Dorsal Spinal Surgery on Patient-Reported Physical Functioning in Patients With Cervical Spondylotic Myelopathy: A Randomized Clinical Trial – JAMA (free for a limited period)
RCT: 5 days of high-dose amoxicillin therapy noninferior to 10 days for the treatment of pediatric community-acquired pneumonia
9 Mar, 2021 | 02:29h | UTCShort-Course Antimicrobial Therapy for Pediatric Community-Acquired Pneumonia: The SAFER Randomized Clinical Trial – JAMA Pediatrics (free for a limited period)
Editorial: Rightsizing Treatment for Pneumonia in Children
Commentary: Five days of antibiotics fine for children with pneumonia – McMaster University
Commentary on Twitter (thread – click for more)
This is fantastic! In outpatient community acquired pneumonia (CAP) a 5 day course of amoxicillin is just as effective as a 10 day course. A small thread follow1/6https://t.co/ewceFEe4gw
— Ricardo Quinonez, MD (@QuinonezRicardo) March 8, 2021
3-Year Outcomes of Transcatheter Mitral Valve Repair in Patients With Heart Failure
9 Mar, 2021 | 02:22h | UTC3-Year Outcomes of Transcatheter Mitral Valve Repair in Patients With Heart Failure – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Commentaries: 3-Year Outcomes of Transcatheter Mitral Valve Repair in Heart Failure – American College of Cardiology
Propofol vs. Volatile Anesthetics: RCT finds no difference in postoperative pulmonary complications after lung resection surgery
9 Mar, 2021 | 02:17h | UTCComparative Effect of Propofol and Volatile Anesthetics on Postoperative Pulmonary Complications After Lung Resection Surgery: A Randomized Clinical Trial – Anesthesia & Analgesia (link to abstract – $ for full-text)
RCT: Primary tumor resection plus chemotherapy vs. chemotherapy alone for colorectal cancer patients with asymptomatic, synchronous unresectable metastases
7 Mar, 2021 | 19:23h | UTCOriginal study: No Survival Benefit to Primary Resection Before Chemo in Metastatic Colorectal Cancer – Medscape / Reuters
Primary tumor resection followed by chemotherapy in patients with metastatic colorectal cancer doesn't improve survival over chemotherapy alone https://t.co/iOYqjaABzi @JCOG_official #crcsm #JCO pic.twitter.com/RCj2OHEehH
— ASCO Publications (@ASCO_pubs) March 5, 2021
RCT: Half-dose vs. full-dose Edoxaban in 14,014 patients with Atrial Fibrillation
7 Mar, 2021 | 19:13h | UTCCommentary: Lower Dose of Edoxaban Supported in ENGAGE-AF-TIMI 48 Analysis – TCTMD
Study: Cancer patients benefit from using automated device to manage their symptoms
7 Mar, 2021 | 19:21h | UTCOriginal study: Phase III Randomized Controlled Trial of eRAPID: eHealth Intervention During Chemotherapy – Journal of Clinical Oncology
Conversion of Propranolol to Carvedilol in patients with cirrhosis and ascites: Small randomized, open label study suggests improvement in outcomes
7 Mar, 2021 | 19:08h | UTCConversion of Propranolol to Carvedilol Improves Renal Perfusion and Outcome in Patients With Cirrhosis and Ascites – Clinical Gastroenterology (link to abstract – $ for full-text)
RCT: Biologic mesh implantation is associated with serious abdominal wall complications in patients undergoing emergency abdominal surgery
7 Mar, 2021 | 19:07h | UTCBiologic mesh implantation is associated with serious abdominal wall complications in patients undergoing emergency abdominal surgery: A randomized-controlled clinical trial – Trauma & Acute Care Surgery (link to abstract – $ for full-text)
RCT: Rituximab vs. tocilizumab in anti-TNF inadequate responder patients with rheumatoid arthritis
7 Mar, 2021 | 19:06h | UTCCommentary: Precision medicine in rheumatology: are we getting closer? – The Lancet
Commentary on Twitter
For patients with rheumatoid #arthritis and low or absent B-cell lineage expression signature in synovial tissue, tocilizumab is more effective than rituximab, suggests the first biopsy-driven trial. Read the results in full: https://t.co/XjzOqeBwdc pic.twitter.com/hODUwDy8BP
— The Lancet (@TheLancet) January 26, 2021
Randomized, crossover trial: A comparison of two hybrid closed-loop systems in adolescents and young adults with type 1 diabetes
7 Mar, 2021 | 19:03h | UTCA comparison of two hybrid closed-loop systems in adolescents and young adults with type 1 diabetes (FLAIR): a multicentre, randomised, crossover trial – The Lancet (link to abstract – $ for full-text)
Commentary on Twitter
In a crossover trial of adolescents and young adults with type 1 #diabetes, daytime hyperglycaemia was reduced without increasing hypoglycaemia using the advanced hybrid closed-loop system compared with the 670G system. Read the study: https://t.co/WtU9O3uGkb pic.twitter.com/bf8HV6scKQ
— The Lancet (@TheLancet) January 18, 2021
RCT: Evaluation of oral dextrose gel for prevention of neonatal hypoglycemia
7 Mar, 2021 | 19:01h | UTC
RCT: Safety of combined division vs. separate division of the splenic vein in patients undergoing distal pancreatectomy
5 Mar, 2021 | 08:25h | UTCCommentaries: An Evidence-Based Beneficial Shortcut for Distal Pancreatic Resection – JAMA Surgery AND Surgical Shortcut Noninferior to Standard Technique for Pancreatic Resection – Physician’s Weekly
Commentary on Twitter
Isolating the splenic vein from the pancreatic parenchyma is deemed unnecessary https://t.co/y4pE5632m4 pic.twitter.com/wumc5gopQs
— JAMA Surgery (@JAMASurgery) March 3, 2021