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Randomized Trials

RCT: Fixed (40 mg twice daily) or variable (0.5 mg/kg twice daily) dosing of prophylactic enoxaparin after surgical procedures

26 Mar, 2021 | 08:23h | UTC

Optimal Dosing of Prophylactic Enoxaparin after Surgical Procedures: Results of the Double-Blind, Randomized, Controlled FIxed or Variable Enoxaparin (FIVE) Trial – Plastic and Reconstructive Surgery (link to abstract – $ for full-text)

 


Covid: The London bus trip that saved maybe a million lives (about the creation of the RECOVERY Trial)

26 Mar, 2021 | 08:53h | UTC

Covid: The London bus trip that saved maybe a million lives – BBC

Related: Covid-19: The Inside Story of the RECOVERY Trial

 

Commentary on Twitter

 


RCT: Effect of Intrawound Vancomycin Powder in Operatively Treated High-risk Tibia Fractures

25 Mar, 2021 | 08:04h | UTC

Effect of Intrawound Vancomycin Powder in Operatively Treated High-risk Tibia Fractures: A Randomized Clinical Trial – JAMA Surgery (free for a limited period)

 


RCT: Effect of continued weekly subcutaneous Semaglutide vs. placebo on weight loss maintenance in adults with overweight or obesity

24 Mar, 2021 | 08:05h | UTC

Effect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss Maintenance in Adults With Overweight or Obesity: The STEP 4 Randomized Clinical Trial – JAMA (free for a limited period)

Commentaries: Continuing Semaglutide Leads to Further Weight Loss – NEJM Journal Watch AND STEP 4: Long-term treatment needed for full semaglutide benefit – MedwireNews

Podcast: Semaglutide for Weight Loss – JAMA

 

Commentary on Twitter

 


RCT: No benefit from marine Omega-3 fatty acid and Vitamin D supplementation on incident atrial fibrillation

17 Mar, 2021 | 02:38h | UTC

Effect of Marine Omega-3 Fatty Acid and Vitamin D Supplementation on Incident Atrial Fibrillation: A Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Omega-3 Fatty Acids and Atrial Fibrillation – JAMA (free for a limited period)

 


Platelet tests pre-CABG may safely shorten washout waits, cut costs

16 Mar, 2021 | 01:44h | UTC

Platelet Tests Pre-CABG May Safely Shorten Washout Waits, Cut Costs – TCTMD

Original study: Platelet Reactivity in Patients With Acute Coronary Syndromes Awaiting Surgical Revascularization – Journal of the American College of Cardiology

 


RCT: No benefit from probiotic therapy in critical illness

16 Mar, 2021 | 01:30h | UTC

Early and sustained Lactobacillus plantarum probiotic therapy in critical illness: the randomised, placebo-controlled, restoration of gut microflora in critical illness trial (ROCIT) – Intensive Care Medicine

 

Commentary on Twitter

 


RCT: Little benefit from osteopathic manipulative treatment on activity limitations in patients with nonspecific subacute and chronic low back pain

16 Mar, 2021 | 01:39h | UTC

Effect of Osteopathic Manipulative Treatment vs Sham Treatment on Activity Limitations in Patients With Nonspecific Subacute and Chronic Low Back Pain: A Randomized Clinical Trial – JAMA Internal Medicine (free for a limited period)

Visual abstract: Effect of Osteopathic Manipulative Treatment vs Sham Treatment on Activity Limitations in Patients With Nonspecific Subacute and Chronic Low Back Pain

 


Phase 2 RCT: Donanemab in early Alzheimer’s Disease

14 Mar, 2021 | 20:21h | UTC

Donanemab in Early Alzheimer’s Disease – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Experimental Alzheimer’s drug could slow cognitive decline in patients, early results suggest – CNN AND Alzheimer’s study shows mixed results for Lilly’s donanemab on secondary outcomes – First World Pharma

 

Commentary on Twitter

 


Clinical trial shows alcohol use disorder recovery can start without sobriety

14 Mar, 2021 | 20:17h | UTC

Clinical trial shows alcohol use disorder recovery can start without sobriety – Washington State University

Original study: Combining behavioral harm-reduction treatment and extended-release naltrexone for people experiencing homelessness and alcohol use disorder in the USA: a randomised clinical trial – The Lancet Psychiatry

 

Commentary on Twitter (thread – click for more)

 


RCT: Efficacy of a combination of conservative therapies vs. an education comparator on clinical outcomes in thumb base osteoarthritis

14 Mar, 2021 | 20:13h | UTC

Efficacy of a Combination of Conservative Therapies vs an Education Comparator on Clinical Outcomes in Thumb Base Osteoarthritis: A Randomized Clinical Trial – JAMA Internal Medicine (free for a limited period)

Commentary: Mix of treatments could be way to restore hand function in thumb-base osteoarthritis – University of Sydney

 

Commentary on Twitter

 


70-gene signature as an aid for treatment decisions in early breast cancer: updated results of the phase 3 randomised MINDACT trial with an exploratory analysis by age

14 Mar, 2021 | 20:07h | UTC

70-gene signature as an aid for treatment decisions in early breast cancer: updated results of the phase 3 randomised MINDACT trial with an exploratory analysis by age – The Lancet Oncology (link to abstract – $ for full-text)

 


RCT: Effect of ventral vs. dorsal spinal surgery on patient-reported physical functioning in patients with cervical spondylotic myelopathy

10 Mar, 2021 | 08:26h | UTC

Effect of Ventral vs Dorsal Spinal Surgery on Patient-Reported Physical Functioning in Patients With Cervical Spondylotic Myelopathy: A Randomized Clinical Trial – JAMA (free for a limited period)

Commentary: First-of-its kind study compares two surgeries head-to-head for common neck condition – Beth Israel Lahey Health

 


RCT: 5 days of high-dose amoxicillin therapy noninferior to 10 days for the treatment of pediatric community-acquired pneumonia

9 Mar, 2021 | 02:29h | UTC

Short-Course Antimicrobial Therapy for Pediatric Community-Acquired Pneumonia: The SAFER Randomized Clinical Trial – JAMA Pediatrics (free for a limited period)

Editorial: Rightsizing Treatment for Pneumonia in Children

Commentary: Five days of antibiotics fine for children with pneumonia – McMaster University

 

Commentary on Twitter (thread – click for more)

 


3-Year Outcomes of Transcatheter Mitral Valve Repair in Patients With Heart Failure

9 Mar, 2021 | 02:22h | UTC

3-Year Outcomes of Transcatheter Mitral Valve Repair in Patients With Heart Failure – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: 3-Year Outcomes of Transcatheter Mitral Valve Repair in Heart Failure – American College of Cardiology

 


Propofol vs. Volatile Anesthetics: RCT finds no difference in postoperative pulmonary complications after lung resection surgery

9 Mar, 2021 | 02:17h | UTC

Comparative Effect of Propofol and Volatile Anesthetics on Postoperative Pulmonary Complications After Lung Resection Surgery: A Randomized Clinical Trial – Anesthesia & Analgesia (link to abstract – $ for full-text)

Related study: No difference in postoperative cognition with intravenous (propofol-based) vs. volatile (sevoflurane-based) anesthetics in elderly patients undergoing laparoscopic abdominal surgery

 


RCT: Primary tumor resection plus chemotherapy vs. chemotherapy alone for colorectal cancer patients with asymptomatic, synchronous unresectable metastases

7 Mar, 2021 | 19:23h | UTC

Primary Tumor Resection Plus Chemotherapy Versus Chemotherapy Alone for Colorectal Cancer Patients With Asymptomatic, Synchronous Unresectable Metastases (JCOG1007; iPACS): A Randomized Clinical Trial – Journal of Clinical Oncology

Original study: No Survival Benefit to Primary Resection Before Chemo in Metastatic Colorectal Cancer – Medscape / Reuters

 

 


RCT: Half-dose vs. full-dose Edoxaban in 14,014 patients with Atrial Fibrillation

7 Mar, 2021 | 19:13h | UTC

Randomized, Double-Blind Comparison of Half-Dose Versus Full-Dose Edoxaban in 14,014 Patients With Atrial Fibrillation – Journal of the American College of Cardiology

Commentary: Lower Dose of Edoxaban Supported in ENGAGE-AF-TIMI 48 Analysis – TCTMD

 


Study: Cancer patients benefit from using automated device to manage their symptoms

7 Mar, 2021 | 19:21h | UTC

Cancer patients benefit from using automated device to manage their symptoms – News Medical / University of Leeds

Original study: Phase III Randomized Controlled Trial of eRAPID: eHealth Intervention During Chemotherapy – Journal of Clinical Oncology

Editorial: Benefits of Digital Symptom Monitoring With Patient-Reported Outcomes During Adjuvant Cancer Treatment – Journal of Clinical Oncology

 


Conversion of Propranolol to Carvedilol in patients with cirrhosis and ascites: Small randomized, open label study suggests improvement in outcomes

7 Mar, 2021 | 19:08h | UTC

Conversion of Propranolol to Carvedilol Improves Renal Perfusion and Outcome in Patients With Cirrhosis and Ascites – Clinical Gastroenterology (link to abstract – $ for full-text)

 


RCT: Biologic mesh implantation is associated with serious abdominal wall complications in patients undergoing emergency abdominal surgery

7 Mar, 2021 | 19:07h | UTC

Biologic mesh implantation is associated with serious abdominal wall complications in patients undergoing emergency abdominal surgery: A randomized-controlled clinical trial – Trauma & Acute Care Surgery (link to abstract – $ for full-text)

 


RCT: Rituximab vs. tocilizumab in anti-TNF inadequate responder patients with rheumatoid arthritis

7 Mar, 2021 | 19:06h | UTC

Rituximab versus tocilizumab in anti-TNF inadequate responder patients with rheumatoid arthritis (R4RA): 16-week outcomes of a stratified, biopsy-driven, multicentre, open-label, phase 4 randomised controlled trial – The Lancet

Commentary: Precision medicine in rheumatology: are we getting closer? – The Lancet

 

Commentary on Twitter

 


Randomized, crossover trial: A comparison of two hybrid closed-loop systems in adolescents and young adults with type 1 diabetes

7 Mar, 2021 | 19:03h | UTC

A comparison of two hybrid closed-loop systems in adolescents and young adults with type 1 diabetes (FLAIR): a multicentre, randomised, crossover trial – The Lancet (link to abstract – $ for full-text)

 

Commentary on Twitter

 


RCT: Evaluation of oral dextrose gel for prevention of neonatal hypoglycemia

7 Mar, 2021 | 19:01h | UTC

Evaluation of oral dextrose gel for prevention of neonatal hypoglycemia (hPOD): A multicenter, double-blind randomized controlled trial – PLOS Medicine

 


RCT: Safety of combined division vs. separate division of the splenic vein in patients undergoing distal pancreatectomy

5 Mar, 2021 | 08:25h | UTC

Safety of Combined Division vs Separate Division of the Splenic Vein in Patients Undergoing Distal Pancreatectomy: A Noninferiority Randomized Clinical Trial – JAMA Surgery

Commentaries: An Evidence-Based Beneficial Shortcut for Distal Pancreatic Resection – JAMA Surgery AND Surgical Shortcut Noninferior to Standard Technique for Pancreatic Resection – Physician’s Weekly

 

Commentary on Twitter

 


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