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Internal Medicine

Study shows overtreatment of diabetes common in nursing home residents with type 2 diabetes.

30 Mar, 2022 | 10:27h | UTC

Glycemic treatment deintensification practices in nursing home residents with type 2 diabetes – Journal of the American Geriatrics Society

Commentaries:

Overtreatment of T2DM Common Among VA Nursing Home Residents – HealthDay

Diabetes treatment deintensification uncommon in nursing home residents – medwire News

 

Global, regional, and national burden of diseases and injuries for adults 70 years and older: systematic analysis for the Global Burden of Disease 2019 Study.

30 Mar, 2022 | 10:24h | UTC

Global, regional, and national burden of diseases and injuries for adults 70 years and older: systematic analysis for the Global Burden of Disease 2019 Study – The BMJ

 

Commentary on Twitter

 

Retrospective Cohort Study: Risks for anaphylaxis with intravenous iron formulations.

30 Mar, 2022 | 10:16h | UTC

Risks for Anaphylaxis With Intravenous Iron Formulations: A Retrospective Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)

News Release: Risk of Severe Allergic Reaction Higher with Two Intravenous Iron-Boosting Products – Rutgers University

Commentary: Risks for Anaphylaxis Compared Among IV Iron Products – HealthDay

 

Systematic Review: Interventions for reducing inflammation in familial Mediterranean fever.

30 Mar, 2022 | 10:13h | UTC

Interventions for reducing inflammation in familial Mediterranean fever – Cochrane Library

Summary: Medicines for reducing inflammation in people with familial Mediterranean fever – Cochrane Library

 

Cluster RCT: A household salt substitution intervention is a cost-effective intervention for preventing stroke and improving quality of life.

29 Mar, 2022 | 10:16h | UTC

Cost-effectiveness of a Household Salt Substitution Intervention: Findings From 20,995 Participants of the Salt Substitute and Stroke Study (SSaSS) – Circulation

Commentary: ACC: Use of Salt Substitute to Prevent Stroke Is Cost-Saving – HealthDay

Original Study: #ESCCongress – Cluster RCT: Among patients at increased risk for stroke, salt substitution (75% sodium chloride and 25% potassium chloride by mass) reduced the rates of stroke, major cardiovascular events, and death from any cause.

Related:

Former CDC director: Low sodium salt could save millions of lives – CNN

Is salt good for you after all? The evidence says no.

Systematic Review: Altered dietary salt intake for people with chronic kidney disease.

New WHO benchmarks help countries reduce salt intake and save lives.

RCT: Reduced-sodium added-potassium salt substitute reduces blood pressure in hypertensive patients

Potassium Enriched Salt Substitution Could Prevent a Large Number of Cardiovascular Deaths

Meta-Analysis: Effect of Reduction in Dietary Sodium on Blood Pressure Levels

Cluster Randomized Trial: Effect of Salt Substitution on Community-wide Blood Pressure and Hypertension Incidence

 

Cohort Study: Coronary artery and cardiac disease are common in patients with type 2 myocardial infarction.

29 Mar, 2022 | 10:14h | UTC

Coronary Artery and Cardiac Disease in Patients With Type 2 Myocardial Infarction: A Prospective Cohort Study – Circulation

Commentary: AHA News: Undiagnosed Heart Disease May Be Common in People With Heart Attacks Not Caused by Clots – HealthDay

 

Commentary on Twitter

 

Myocarditis and pericarditis after COVID-19 vaccination: clinical management guidance for healthcare professionals.

29 Mar, 2022 | 10:09h | UTC

Myocarditis and pericarditis after COVID-19 vaccination: clinical management guidance for healthcare professionals – UK Health Security Agency

Related:

Myocarditis following a third Pfizer vaccination dose in military recruits in Israel.

Myocarditis following COVID-19 BNT162b2 vaccination among adolescents in Hong Kong.

[Preprint] Post-marketing active surveillance of myocarditis and pericarditis following vaccination with COVID-19 mRNA vaccines in persons aged 12-39 years in Italy.

Myocarditis after BNT162b2 vaccination in Israeli adolescents.

Myocarditis cases reported after mRNA-Based COVID-19 vaccination in the US from December 2020 to August 2021.

A case-control study showed an increased risk of myocarditis after COVID-19 vaccination with a messenger RNA vaccine compared to an inactivated virus vaccine.

[Preprint] Risk of myocarditis following sequential COVID-19 vaccinations by age and sex.

Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination vs. SARS-CoV-2 infection.

Case series with 139 adolescents and young adults with suspected myocarditis following mRNA vaccination showed most cases had a mild clinical course and rapid resolution of symptoms.

Heart-inflammation risk from Pfizer COVID vaccine is very low.

Large cohort study with over 2.5 million individuals showed the incidence of myocarditis after the Pfizer vaccine was 2.13 cases per 100,000 persons.

Study with over 5.1 million vaccinated individuals showed the incidence of myocarditis after the receipt of the Pfizer vaccine was low and more common after the second dose in young male recipients.

Large Observational study shows Pfizer Covid vaccine is mostly safe but is associated with increased risk of myocarditis, adenopathy, appendicitis, and herpes zoster.

 

Meta-analysis of randomized trials: GLP1 receptor agonists increase the risk of gallbladder and biliary diseases (RR, 1.37; 95% CI, 1.23-1.52).

29 Mar, 2022 | 10:02h | UTC

Association of Glucagon-Like Peptide-1 Receptor Agonist Use With Risk of Gallbladder and Biliary Diseases: A Systematic Review and Meta-analysis of Randomized Clinical Trials – JAMA Internal Medicine (free for a limited period)

Commentary: GLP-1 Receptor Agonists: How Safe Are They for the Gallbladder?— Link with gallbladder, biliary diseases could be due to weight loss associated with class of drug – MedPage Today (free registration required)

 

Cohort Study: Preconception paternal use of metformin linked to increased risk of congenital problems in offspring.

29 Mar, 2022 | 10:04h | UTC

Preconception Antidiabetic Drugs in Men and Birth Defects in Offspring: A Nationwide Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries:

Paternal metformin use associated with major birth defects if used during period of sperm development – American College of Physicians

Expert reaction to study of birth defects and diabetic men using metformin during sperm development – Science Media Centre

 

Brazilian guidelines for the treatment of outpatients with suspected or confirmed COVID-19.

29 Mar, 2022 | 10:05h | UTC

Brazilian guidelines for the treatment of outpatients with suspected or confirmed COVID-19. A joint guideline of the Brazilian Association of Emergency Medicine (ABRAMEDE), Brazilian Medical Association (AMB), Brazilian Society of Angiology and Vascular Surgery (SBACV), Brazilian Society of Geriatrics and Gerontology (SBGG), Brazilian Society of Infectious Diseases (SBI), Brazilian Society of Family and Community Medicine (SBFMC), and Brazilian Thoracic Society (SBPT) – The Brazilian Journal of Infectious Diseases

 

Cumulative burden of psychiatric disorders and self-harm across 26 adult cancers.

29 Mar, 2022 | 09:58h | UTC

Cumulative burden of psychiatric disorders and self-harm across 26 adult cancers – Nature Medicine

See also: Suicide risk and mortality among patients with cancer – Nature Medicine (if the link is paywalled, try this one)

Invited Commentary: Shining a light on the psychological burden of cancer – Nature Medicine

 

Commentary on Twitter

 

Multidisciplinary consensus for the management of pulmonary thromboembolism.

29 Mar, 2022 | 09:54h | UTC

Multidisciplinary consensus for the management of pulmonary thromboembolism – Archivos de Bronconeumología

 

Review: Acute kidney injury in critically ill patients with cancer.

29 Mar, 2022 | 09:47h | UTC

Acute Kidney Injury in Critically Ill Patients with Cancer – Clinical Journal of the American Society of Nephrology

 

Commentary on Twitter

 

Consensus Recommendations: Management of immune thrombocytopenia.

29 Mar, 2022 | 09:50h | UTC

Management of immune thrombocytopenia: 2022 update of Korean experts recommendations – Blood Research

 

Crossover RCT: Effects of experimental sleep restriction on energy intake, energy expenditure, and visceral obesity.

29 Mar, 2022 | 08:31h | UTC

Effects of Experimental Sleep Restriction on Energy Intake, Energy Expenditure, and Visceral Obesity – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentary: Lack of sleep increases unhealthy abdominal fat, study finds – Mayo Clinic

Related: RCT: Advising overweight patients to increase sleep duration may reduce caloric intake.

 

Before-and-after study: Effectiveness of implementing a preventive urinary catheter care bundle in hip fracture patients.

29 Mar, 2022 | 08:33h | UTC

Effectiveness of implementing a preventive urinary catheter care bundle in hip fracture patients – Journal of Infection Prevention

News Release: Catheter infections went down after more preventive efforts – University of Gothenburg

 

Review: Diagnosis and neurointerventional management of large vessel occlusion acute ischemic stroke.

29 Mar, 2022 | 08:39h | UTC

Diagnosis and Neurointerventional Management of Large Vessel Occlusion Acute Ischemic Stroke – emDocs

 

Review: Short and oral antimicrobial therapy for diabetic foot infection.

29 Mar, 2022 | 08:29h | UTC

Short and oral antimicrobial therapy for diabetic foot infection: a narrative review of current knowledge – Journal of Bone and Joint Infection

 

Review: Challenges in the management of older patients with inflammatory rheumatic diseases.

29 Mar, 2022 | 08:22h | UTC

Challenges in the management of older patients with inflammatory rheumatic diseases – Nature Reviews Rheumatology (if the link is paywalled, try this one)

 

Commentary on Twitter

 

AGA clinical practice update on the role of diet in irritable bowel syndrome.

28 Mar, 2022 | 10:04h | UTC

AGA Clinical Practice Update on the Role of Diet in Irritable Bowel Syndrome: Expert Review – Gastroenterology

Related:

RCT: Efficacy and acceptability of dietary therapies in non-constipated irritable bowel syndrome: a randomized trial of traditional dietary advice, the low FODMAP diet and the gluten-free diet.

10 mistakes in dietary management of irritable bowel syndrome and how to avoid them.

Supplement: Irritable bowel syndrome and related conditions.

RCT: FODMAPs, but not gluten, elicit modest symptoms of irritable bowel syndrome.

RCT: Among patients with diarrhea-predominant irritable bowel syndrome, a low FODMAP diet achieved earlier symptomatic improvements in stool frequency and excessive wind.

British Society of Gastroenterology guidelines on the management of irritable bowel syndrome

Guidelines for the treatment of irritable bowel syndrome

ACG Clinical Guideline: Management of irritable bowel syndrome

M-A: Efficacy of a low-FODMAP diet in adult irritable bowel syndrome

 

Study challenges the theory that light alcohol consumption benefits heart health.

28 Mar, 2022 | 10:09h | UTC

News Release: Large study challenges the theory that light alcohol consumption benefits heart health – Massachusetts General Hospital

Original Study: Association of Habitual Alcohol Intake With Risk of Cardiovascular Disease – JAMA Network Open

Related: No amount of alcohol is good for the heart, says World Heart Federation.

 

Commentary on Twitter

 

Cohort Study: SARS-CoV-2 co-infection with influenza viruses, respiratory syncytial virus, or adenoviruses is associated with increased mortality.

28 Mar, 2022 | 10:03h | UTC

SARS-CoV-2 co-infection with influenza viruses, respiratory syncytial virus, or adenoviruses – The Lancet

Commentary: Patients with Covid and flu double the risk of dying, say scientists – The Guardian

 

Commentary from the author on Twitter (thread – click for more)

https://twitter.com/kennethbaillie/status/1507501279181955076

 

Systematic Review: Symptom‐ and chest‐radiography screening for active pulmonary tuberculosis in HIV‐negative adults and adults with unknown HIV status.

28 Mar, 2022 | 08:54h | UTC

Symptom‐ and chest‐radiography screening for active pulmonary tuberculosis in HIV‐negative adults and adults with unknown HIV status – Cochrane Library

Summary: How accurate are asking about symptoms and doing a chest X-ray to screen for tuberculosis of the lungs among adults who are HIV-negative or with unknown HIV status? – Cochrane Library

 

Half of all women experience false positive mammograms after 10 years of annual screening.

28 Mar, 2022 | 08:53h | UTC

News Release: Half of all women experience false positive mammograms after 10 years of annual screening – University of California – Davis Health

Original Study: Cumulative Probability of False-Positive Results After 10 Years of Screening With Digital Breast Tomosynthesis vs Digital Mammography – JAMA Network Open

 

Commentary on Twitter

 

A practical guide to implementing SMART in asthma management.

28 Mar, 2022 | 08:42h | UTC

A Practical Guide to Implementing SMART in Asthma Management – The Journal of Allergy and Clinical Immunology

 

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