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Internal Medicine

Still coughing after COVID? Here’s why it happens and what to do about it.

1 Apr, 2022 | 09:50h | UTC

Still coughing after COVID? Here’s why it happens and what to do about it – The Conversation

 


Viewpoint: Evaluating the effectiveness of diagnostic tests.

1 Apr, 2022 | 09:47h | UTC

Evaluating the Effectiveness of Diagnostic Tests – JAMA (free for a limited period)

 


Body-mass index and risk of obesity-related complex multimorbidity: an observational multicohort study.

1 Apr, 2022 | 08:49h | UTC

Body-mass index and risk of obesity-related complex multimorbidity: an observational multicohort study – The Lancet Diabetes & Endocrinology

Invited Commentary: The actual burden of obesity—accounting for multimorbidity – The Lancet Diabetes & Endocrinology (free registration required)

 

Commentary on Twitter

 


M-A: Impact of enhanced recovery pathways on safety and efficacy of hip and knee arthroplasty.

1 Apr, 2022 | 08:31h | UTC

Impact of enhanced recovery pathways on safety and efficacy of hip and knee arthroplasty: A systematic review and meta-analysis – World Journal of Orthopedics

Related:

Review: Enhanced recovery after surgery for major orthopedic surgery.

Complete List of Enhanced Recovery After Surgery (ERAS) Society Guidelines (some guidelines are free)

 


Practice review: Evidence-based and effective management of anemia in palliative care patients.

1 Apr, 2022 | 08:21h | UTC

Practice review: Evidence-based and effective management of anaemia in palliative care patients – Palliative Medicine

 


Practice review: Evidence-based management approaches for patients with severe chronic obstructive pulmonary disease (COPD).

1 Apr, 2022 | 08:29h | UTC

Evidence-based management approaches for patients with severe chronic obstructive pulmonary disease (COPD): A practice review – Palliative Medicine

 


Practice review: Evidence-based and effective management of fatigue in patients with advanced cancer.

1 Apr, 2022 | 08:26h | UTC

Practice review: Evidence-based and effective management of fatigue in patients with advanced cancer – Palliative Medicine

 


RCT: Early treatment with ivermectin does not improve outcomes in patients with Covid-19.

31 Mar, 2022 | 08:41h | UTC

Effect of Early Treatment with Ivermectin among Patients with Covid-19- New England Journal of Medicine

Commentary: Ivermectin does not prevent COVID-19 hospitalization, a new study says – NPR

 

Commentary on Twitter

 


RCT: Early outpatient treatment with convalescent plasma reduces the risk of hospitalization in patients with Covid-19.

31 Mar, 2022 | 08:39h | UTC

Early Outpatient Treatment for Covid-19 with Convalescent Plasma – New England Journal of Medicine

Commentaries:

Study finds convalescent plasma can be effective early COVID-19 therapy – Johns Hopkins University School of Medicine

Early Use of High-Titer Plasma Reduced COVID Hospitalizations— Randomized trial that influenced indication shows benefits in a mostly unvaccinated population – MedPage Today (free registration required)

 

Commentary on Twitter

https://twitter.com/NEJM/status/1509278140433981444

 


USPSTF Draft Recommendation Statement: the current evidence is insufficient to recommend screening for obstructive sleep apnea in asymptomatic individuals.

31 Mar, 2022 | 08:42h | UTC

Draft Recommendation Statement: Obstructive Sleep Apnea in Adults: Screening – US Preventive Services Task Force

Commentary: USPSTF: Evidence Lacking for OSA Screening in Asymptomatic Adults – HealthDay

 


Meta-analysis of randomized trials: Clopidogrel is better than aspirin for the secondary prevention of cardiovascular events.

31 Mar, 2022 | 08:31h | UTC

P2Y12 Inhibitor versus Aspirin Monotherapy for Secondary Prevention of Cardiovascular Events: Meta-Analysis of Randomized Trials – European Heart Journal Open

Commentary: Clopidogrel Superior to ‘Divine’ Aspirin Monotherapy in Secondary Prevention – TCTMD

 

Commentary on Twitter

 


M-A: Psychological interventions for chronic, non-specific low back pain.

31 Mar, 2022 | 08:20h | UTC

Psychological interventions for chronic, non-specific low back pain: systematic review with network meta-analysis – The BMJ

News Release: Study sheds light on psychological therapies for chronic low back pain – British Medical Journal

 


RCT: Effect of tacrolimus vs. intravenous cyclophosphamide on complete or partial response in patients with lupus nephritis.

31 Mar, 2022 | 08:18h | UTC

Effect of Tacrolimus vs Intravenous Cyclophosphamide on Complete or Partial Response in Patients With Lupus Nephritis: A Randomized Clinical Trial – JAMA Network Open

 

Commentary on Twitter

 


A Narrative Review on the approach to antimicrobial use in ventilated patients with multidrug resistant organisms in respiratory samples—to treat or not to treat?

31 Mar, 2022 | 08:27h | UTC

A Narrative Review on the Approach to Antimicrobial Use in Ventilated Patients with Multidrug Resistant Organisms in Respiratory Samples—To Treat or Not to Treat? That Is the Question – Antibiotics

 

Commentary on Twitter

https://twitter.com/ABsteward/status/1508917245740818438

 


Association of computed tomography screening with lung cancer stage shift and survival in the United States: quasi-experimental study.

31 Mar, 2022 | 08:23h | UTC

Association of computed tomography screening with lung cancer stage shift and survival in the United States: quasi-experimental study – The BMJ

Editorial: Screening high risk populations for lung cancer

News Release: US lung cancer screening linked to earlier diagnosis and better survival – British Medical Journal

Related:

Screening for Lung Cancer: CHEST Guideline and Expert Panel Report.

USPSTF Statement: begin screening for lung cancer at age 50 years instead of 55 years for patients at risk

Meta-analysis: Lung cancer screening using low-dose computed tomography reduces lung cancer–specific mortality, albeit with a tradeoff of likely overdiagnosis

 

Commentary on Twitter

 


Cohort Study: Mortality associated with mental disorders and comorbid general medical conditions.

31 Mar, 2022 | 08:15h | UTC

Mortality Associated With Mental Disorders and Comorbid General Medical Conditions – JAMA Psychiatry

Commentary: People with Mental Disorders, General Comorbid Conditions Have 11-Year Reduced Life Expectancy – HCP Live

 


Review | Advanced heart failure: guideline-directed medical therapy, diuretics, inotropes, and palliative care.

31 Mar, 2022 | 08:09h | UTC

Advanced heart failure: guideline-directed medical therapy, diuretics, inotropes, and palliative care – ESC Heart Failure

 


Systematic Review: Evidence-based efficacy of methotrexate in adult Crohn’s disease in different intestinal and extraintestinal indications.

31 Mar, 2022 | 07:50h | UTC

Evidence-based efficacy of methotrexate in adult Crohn’s disease in different intestinal and extraintestinal indications – Therapeutic Advances in Gastroenterology

 


The incidence of adult-onset Type 1 Diabetes: a systematic review from 32 countries and regions.

31 Mar, 2022 | 07:52h | UTC

The Incidence of Adult-Onset Type 1 Diabetes: A Systematic Review From 32 Countries and Regions – Diabetes Care

 


[Preprint] Retrospective cohort study: second booster vaccine and Covid-19 mortality in adults 60 to 100 years old.

30 Mar, 2022 | 10:44h | UTC

Second Booster Vaccine and Covid-19 Mortality in Adults 60 to 100 Years Old – Research Square

Commentaries:

Huge Study Finds Second COVID-19 Booster is ‘Life-saving’ for Over 60s – Health Policy Watch

Fourth COVID-19 vaccine dose substantially reduces mortality in the elderly – News Medical

 


U.S. approves second Covid-19 booster for people 50 and older and immunocompromised individuals.

30 Mar, 2022 | 10:42h | UTC

U.S. approves second Covid-19 booster for people 50 and older – STAT

FDA OKs second COVID booster shot for older Americans – CIDRAP

See Guidance: Coronavirus (COVID-19) Update: FDA Authorizes Second Booster Dose of Two COVID-19 Vaccines for Older and Immunocompromised Individuals – U.S. Food & Drug Administration

 


Complicated and uncomplicated S. aureus bacteremia: an international Delphi survey among infectious diseases experts on definitions and treatment.

30 Mar, 2022 | 10:34h | UTC

Complicated and uncomplicated S. aureus bacteremia: an international Delphi survey among infectious diseases experts on definitions and treatment – Clinical Microbiology and Infection

 


The RECOVERY Trial – two years on.

30 Mar, 2022 | 10:38h | UTC

The RECOVERY Trial – two years on – University of Oxford

Related:

How the UK found the first effective Covid-19 treatment — and saved a million lives (about the RECOVERY trial and the effects of Dexamethasone)

Covid: The London bus trip that saved maybe a million lives (about the creation of the RECOVERY Trial)

Low-cost dexamethasone reduces death by up to one third in hospitalised patients with severe respiratory complications of COVID-19 – Recovery Trial

[Preprint] RECOVERY trial shows Baricitinib reduces deaths in patients hospitalized with COVID-19.

RCT: CPAP improved outcomes in patients with acute hypoxemic respiratory failure due to COVID-19, but high-flow nasal oxygen was not better than conventional oxygen therapy.

RECOVERY Trial: In patients admitted to hospital with COVID-19, Colchicine did not reduce 28-day mortality, duration of hospital stay, or risk of progressing to invasive mechanical ventilation or death.

RECOVERY Trial: No benefit from convalescent plasma in patients admitted to hospital with COVID-19.

RECOVERY Trial: Aspirin as an add-on therapy did not reduce mortality in patients hospitalized with COVID-19.

RECOVERY trial: In hospitalized COVID-19 patients with hypoxia and systemic inflammation (C-reactive protein ≥75 mg/L), tocilizumab improved survival and other clinical outcomes

RECOVERY trial: Azithromycin not beneficial for patients admitted to hospital with COVID-19

[Preprint] RECOVERY trial finds Regeneron’s monoclonal antibody combination reduces deaths for hospitalized COVID-19 patients who have not mounted their own immune response.

RECOVERY trial: Effect of hydroxychloroquine in hospitalized patients with Covid-19

Randomized trial: Lopinavir–ritonavir not beneficial for patients admitted to hospital with COVID-19

 

Commentary on Twitter

https://twitter.com/MartinLandray/status/1508492188560371717

 


The harms of postoperative antibiotic prophylaxis: a teachable moment.

30 Mar, 2022 | 10:36h | UTC

The Harms of Postoperative Antibiotic Prophylaxis: A Teachable Moment – JAMA Internal Medicine (free for a limited period)

 


M-A: Parenchymal lung abnormalities following hospitalization for COVID-19 and viral pneumonitis.

30 Mar, 2022 | 10:26h | UTC

Parenchymal lung abnormalities following hospitalisation for COVID-19 and viral pneumonitis: a systematic review and meta-analysis – Thorax

 


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