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Internal Medicine

Review: Atrial fibrillation in older adults with cancer.

6 Apr, 2022 | 09:53h | UTC

Atrial fibrillation in older adults with cancer – Journal of Geriatric Cardiology

 

Cohort Study: The five major autoimmune diseases are associated with increased risk of cancer.

6 Apr, 2022 | 09:52h | UTC

The five major autoimmune diseases increase the risk of cancer: epidemiological data from a large-scale cohort study in China – Cancer Communications

Commentary: Increased Cancer Risk with Autoimmune Disorders – RheumNow

 

Consensus Statement: Definition, diagnosis, and management of COVID-19-associated pulmonary mucormycosis.

5 Apr, 2022 | 09:54h | UTC

Definition, diagnosis, and management of COVID-19-associated pulmonary mucormycosis: Delphi consensus statement from the Fungal Infection Study Forum and Academy of Pulmonary Sciences, India – The Lancet Infectious Diseases

 

Perspective: The evidence on 4th doses of covid vaccines & the thorny question of age thresholds.

5 Apr, 2022 | 09:46h | UTC

The Evidence On 4th Doses of Covid Vaccines & the Thorny Question of Age Thresholds – Absolutely Maybe Blog, by Hilda Bastian

Related:

U.S. approves second Covid-19 booster for people 50 and older and immunocompromised individuals.

[Preprint] Retrospective cohort study: second booster vaccine and Covid-19 mortality in adults 60 to 100 years old.

Among health care workers, a fourth dose vaccine effectiveness against any SARS-CoV-2 Omicron variant infection was 30% for the Pfizer–BioNTech and 11% for the Moderna.

[Preprint] Fourth dose of COVID vaccine offers only slight boost against Omicron infection.

Covid-19: Fourth vaccine doses—who needs them and why?

[Not published yet] Study in Israel finds fourth COVID booster has limited efficacy.

 

Commentary on Twitter

https://twitter.com/hildabast/status/1509724907965665280

 

Seminar: Acute coronary syndromes.

5 Apr, 2022 | 09:48h | UTC

Acute coronary syndromes – The Lancet (free for a limited period)

 

Commentary on Twitter

https://twitter.com/TheLancet/status/1510213032143691776

 

Opinion | Medicinal cannabis for chronic pain: the Bermuda triangle of low-quality studies, countless meta-analyses and conflicting recommendations.

5 Apr, 2022 | 08:52h | UTC

Medicinal Cannabis for Chronic Pain: The Bermuda Triangle of Low Quality Studies, Countless Meta-analyses and Conflicting Recommendations – European Journal of Pain

Related:

RCT: Effect of medical marijuana card ownership on pain, insomnia, and affective disorder symptoms in adults.

Cohort Study: Long-term cannabis use is associated with cognitive deficits and smaller hippocampal volume in midlife.

AHA Scientific Statement | How does cannabis use affect brain health? Caution advised, more research needed.

M-A: Birth outcomes of neonates exposed to marijuana in utero.

Cannabis-related allergies: an international overview and consensus recommendations.

Review: Cannabis-based medicines and medical cannabis for chronic neuropathic pain.

Cannabinoid metabolites as inhibitors of major hepatic CYP450 enzymes, with implications for cannabis-drug interactions.

Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain.

The International Cannabis Toolkit (iCannToolkit): a multidisciplinary expert consensus on minimum standards for measuring cannabis use.

Cannabis products are being sold as sleep remedies – here’s the evidence about their effectiveness.

Guideline: Medical cannabis or cannabinoids for chronic pain.

Cannabis and Cannabinoid Analgesia position statement – “Due to the lack of high-quality clinical evidence, the IASP does not currently endorse general use of cannabis and cannabinoids for pain relief.”

NICE Guideline: Cannabis-Based Medicinal Products

Consensus recommendations for perioperative management of cannabis and cannabinoid-based medicine users

Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain – Agency for Healthcare Research and Quality

Short Review: Drug Interactions with Cannabinoids

Meta-Analysis: Cannabinoids Not Effective for Cancer-Related Pain

Review: Considerations for cannabinoids in perioperative care by anesthesiologists.

Review: Cannabis-based Medicines and the Perioperative Physician

Study: Cannabis Use Disorder May Increase the Risk of Cardiovascular Events in Major Elective Surgeries

Perspective: If You Smoke Pot, Your Anesthesiologist Needs To Know

Perioperative Care of Cannabis Users: A Comprehensive Review of Pharmacological and Anesthetic Considerations

 

Cohort study: Increased middle age serum sodium levels (may correlate with low water ingestion) are linked to increased risk of left ventricular hypertrophy and heart failure after 25 years of follow up.

5 Apr, 2022 | 09:44h | UTC

Middle age serum sodium levels in the upper part of normal range and risk of heart failure – European Heart journal (link to abstract – $ for full-text)

News Release: Good hydration may reduce long-term risks for heart failure – Serum sodium levels may help identify adults with a greater chance of experiencing heart disease. – National Institutes of Health

 

Cohort Study: Change in heart disease and stroke mortality before and during the Covid-19 pandemic.

5 Apr, 2022 | 08:47h | UTC

Age-Adjusted Mortality Rates and Age and Risk–Associated Contributions to Change in Heart Disease and Stroke Mortality, 2011-2019 and 2019-2020 – JAMA Network Open

Commentaries:

Several-Fold Increase in Stroke and Heart Disease Deaths During COVID-19 Pandemic – NeurologyToday

2019 to 2020 Saw Risk-Linked Deaths From Heart Disease, Stroke Up – HealthDay

 

Commentary from the author on Twitter (thread – click for more). Article and images under CC-BY License

 

EHRA practical guide: How to use digital devices to detect and manage arrhythmias.

5 Apr, 2022 | 08:41h | UTC

How to use digital devices to detect and manage arrhythmias: an EHRA practical guide – EP Europace

News Release: Advice on how to use digital devices to detect and manage arrhythmias published today – European Society of Cardiology

 

Review: Antiplatelet therapy after percutaneous coronary intervention.

5 Apr, 2022 | 08:38h | UTC

Antiplatelet therapy after percutaneous coronary intervention – EuroIntervention

 

Commentary on Twitter

 

M-A: Efficacy of interventions to reduce long term opioid treatment for chronic non-cancer pain.

5 Apr, 2022 | 08:29h | UTC

Efficacy of interventions to reduce long term opioid treatment for chronic non-cancer pain: systematic review and meta-analysis – The BMJ

 

RCT: Efficacy and safety of Daprodustat (oral drug) for treating anemia of chronic kidney disease in incident dialysis patients.

5 Apr, 2022 | 08:34h | UTC

Efficacy and Safety of Daprodustat for Treatment of Anemia of Chronic Kidney Disease in Incident Dialysis Patients: A Randomized Clinical Trial – JAMA Internal Medicine

Related:

RCT: In patients with chronic kidney diseases and anemia undergoing dialysis, Daprodustat (oral drug) was noninferior to darbepoetin alfa to increase hemoglobin levels and regarding cardiovascular outcomes.

RCT: In patients with chronic kidney diseases and anemia not undergoing dialysis, Daprodustat (oral drug) was noninferior to darbepoetin alfa in increasing hemoglobin levels and regarding cardiovascular outcomes.

 

Commentary on Twitter

 

Review: The intensivist’s perspective of shock, volume management, and hemodynamic monitoring.

5 Apr, 2022 | 08:20h | UTC

The Intensivist’s Perspective of Shock, Volume Management, and Hemodynamic Monitoring – Clinical Journal of the American Society of Nephrology

 

Commentary on Twitter

https://twitter.com/CJASN/status/1511025812283092992

 

Podcast: Acute pancreatitis pearls.

5 Apr, 2022 | 08:26h | UTC

#327 Acute Pancreatitis – The Curbsiders

 

Review: Patient-centered approaches for the management of unpleasant symptoms in kidney disease.

5 Apr, 2022 | 08:16h | UTC

Patient-centred approaches for the management of unpleasant symptoms in kidney disease – Nature Reviews Nephrology

 

Commentary on Twitter

 

Pericardial effusion and cardiac tamponade: pearls and pitfalls.

5 Apr, 2022 | 08:13h | UTC

Pericardial Effusion and Cardiac Tamponade: Pearls and Pitfalls – emDocs

 

Systematic Review: Endovascular vs. conventional open surgical repair for thoracoabdominal aortic aneurysms.

5 Apr, 2022 | 08:11h | UTC

Endovascular versus conventional open surgical repair for thoracoabdominal aortic aneurysms – Cochrane Library

Summary: Are patient outcomes superior after endovascular or open surgical repair of thoracoabdominal aortic aneurysms? – Cochrane Library

 

Commentary on Twitter

 

Review: Treatment strategies to improve outcomes in patients with chronic idiopathic constipation and irritable bowel syndrome with constipation.

5 Apr, 2022 | 08:00h | UTC

Real-World Treatment Strategies to Improve Outcomes in Patients With Chronic Idiopathic Constipation and Irritable Bowel Syndrome With Constipation – American Journal of Gastroenterology

 

Review: Tackling the emerging threat of antifungal resistance to human health.

5 Apr, 2022 | 08:02h | UTC

Tackling the emerging threat of antifungal resistance to human health – Nature Reviews Microbiology (if the link is paywalled, try this one)

 

#ACC22 – 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure.

4 Apr, 2022 | 01:42h | UTC

ACC Guideline Hub: Heart Failure

2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines – Journal of the American College of Cardiology

Executive Summary: 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure

News Release: ACC, AHA, HFSA Issue Heart Failure Guideline – American Heart Association

Key Perspectives: 2022 AHA/ACC/HFSA Heart Failure Guideline

Slide Set Download: 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure

Flipbook

 

Commentary on Twitter

 

#ACC22 – RCT: Treatment for mild chronic hypertension during pregnancy is associated with better pregnancy outcomes than a strategy of reserving treatment only for severe hypertension.

4 Apr, 2022 | 01:34h | UTC

Treatment for Mild Chronic Hypertension during Pregnancy – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries:

Treating chronic hypertension in early pregnancy benefits parents, babies – NIH News Releases

CHAP: Treating Mild Chronic HTN is Associated With Better Pregnancy Outcomes – American College of Cardiology

CHAP: Better Blood Pressure Control, Better Pregnancy Outcomes – TCTMD

 

Commentary on Twitter

 

#ACC22 – RCT: Among ambulatory patients with heart failure, a dietary intervention to reduce sodium intake did not reduce clinical events.

4 Apr, 2022 | 01:32h | UTC

Reduction of dietary sodium to less than 100 mmol in heart failure (SODIUM-HF): an international, open-label, randomised, controlled trial – The Lancet (free registration required)

Commentaries:

SODIUM-HF: No Impact of Dietary Salt Restriction on Death or Hospitalization – TCTMD

SODIUM-HF: Does Strictly Limiting Sodium Intake Reduce Cardiac Events, Improve QOL in HF Patients? – American College of Cardiology

Hold the salt: Study reveals how reducing sodium intake can help patients with heart failure – University of Alberta

 

Commentary on Twitter

 

Two new studies show vaccination provides additional protection after Covid-19 infection.

4 Apr, 2022 | 01:16h | UTC

Study 1: Risk of SARS-CoV-2 reinfection and COVID-19 hospitalisation in individuals with natural and hybrid immunity: a retrospective, total population cohort study in Sweden – The Lancet Infectious Diseases

Study 2: Effectiveness of CoronaVac, ChAdOx1 nCoV-19, BNT162b2, and Ad26.COV2.S among individuals with previous SARS-CoV-2 infection in Brazil: a test-negative, case-control study – The Lancet Infectious Diseases

Commentaries:

Interplay of infection and vaccination in long-term protection from COVID-19 – The Lancet Infectious Diseases

Effectiveness of SARS-CoV-2 vaccines in the post-natural infection world – The Lancet Infectious Diseases

Vaccines offer substantial extra protection after COVID-19 infection – CIDRAP

Had COVID? Getting Vaccine Boosts Resilience Even More, Studies Show – HealthDay

Related:

Retrospective cohort study: Pfizer vaccine reduces the risk of reinfection after recovery from Covid-19.

Cohort study: Protection against SARS-CoV-2 after Covid-19 vaccination lasts longer in patients with previous infection.

 

Commentary on Twitter (thread – click for more)

 

BSR guideline on management of pediatric, adolescent and adult patients with idiopathic inflammatory myopathy.

4 Apr, 2022 | 01:05h | UTC

British Society for Rheumatology guideline on management of paediatric, adolescent and adult patients with idiopathic inflammatory myopathy – Rheumatology

 

RCT: Effect of medical marijuana card ownership on pain, insomnia, and affective disorder symptoms in adults.

1 Apr, 2022 | 10:07h | UTC

Effect of Medical Marijuana Card Ownership on Pain, Insomnia, and Affective Disorder Symptoms in Adults: A Randomized Clinical Trial – JAMA Network Open

Commentaries:

Marijuana for medical use may result in rapid onset of cannabis use disorder – Massachusetts General Hospital

Study raises questions about risks of using medical marijuana for mood and anxiety disorders – CNN

Medical Marijuana Rx Ups Odds for Overuse, With No Benefit to Health: Study – HealthDay

 

Commentary on Twitter

 

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