Antibiotic Stewardship
Cluster RCT: A shorter antimicrobial prophylaxis duration (less than 24 hours after surgery) is noninferior to a more extended regimen (24-48 hours) after clean orthopedic surgery.
13 Apr, 2022 | 10:56h | UTC
Commentary on Twitter
Cluster RCT of patients who underwent clean orthopedic surgery found shorter antimicrobial prophylaxis duration (<24h postop) was noninferior to longer duration (<48h) in preventing health care associated infections and across a range of clinical outcomes. https://t.co/FFzxNiHxet
— JAMA Network Open (@JAMANetworkOpen) April 12, 2022
Cluster RCT: A multifaceted intervention did not reduce catheter related bloodstream infections in patients on hemodialysis.
13 Apr, 2022 | 10:29h | UTC
Brief review | Infective endocarditis: words of caution for management.
13 Apr, 2022 | 10:12h | UTCInfective Endocarditis: Words of Caution For Management – American College of Cardiology
Related:
Randomized Trial: Partial Oral vs. Intravenous Antibiotic Treatment of Endocarditis
Podcast: Infective Endocarditis Pearls.
Review: Infective endocarditis after surgical and transcatheter aortic valve replacement
Infective Endocarditis: A Contemporary Review
Summary: Current AATS Guidelines on Surgical Treatment of Infective Endocarditis
Review: Current Evidence on Oral Antibiotics for Infective Endocarditis
Research: Invasive Procedures Associated With the Development of Infective Endocarditis
Prosthetic Valve Endocarditis After Surgical Aortic Valve Replacement
Empyema: ED presentation, evaluation, and management.
12 Apr, 2022 | 08:44h | UTCEmpyema: ED Presentation, Evaluation, and Management – emDocs
RCT: Effect of Gram Stain–Guided initial antibiotic therapy on clinical response in patients with ventilator-associated pneumonia.
11 Apr, 2022 | 01:36h | UTCCommentary: Can Gram Stains Guide Antibiotics for Pneumonia in Critical Care? – Medscape (free registration required)
Commentary on Twitter
RCT found gram stain-guided antibiotic therapy for critically ill patients with VAP was noninferior to guideline-based antibiotics, with a reduction in antipseudomonal & antiMRSA use. https://t.co/1yoHO2pnER
— JAMA Network Open (@JAMANetworkOpen) April 8, 2022
Interventions for treating catheter‐related bloodstream infections in people receiving maintenance hemodialysis.
8 Apr, 2022 | 10:18h | UTC
RCT: Among patients with complicated urinary tract infection, oral Tebipenem Pivoxil Hydrobromide was noninferior to intravenous Ertapenem and showed a similar safety profile.
7 Apr, 2022 | 09:53h | UTCOral Tebipenem Pivoxil Hydrobromide in Complicated Urinary Tract Infection – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
For complicated UTI or acute pyelonephritis, oral tebipenem pivoxil hydrobromide noninferior to IV ertapenem and has a similar safety profile. https://t.co/FRDMQOD0Pn pic.twitter.com/GFQz7SlciX
— NEJM (@NEJM) April 6, 2022
WHO Strategic framework for collaboration on antimicrobial resistance.
7 Apr, 2022 | 08:41h | UTCStrategic framework for collaboration on antimicrobial resistance – World Health Organization
Related:
Four priority actions to slow the silent pandemic of antimicrobial resistance.
Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis.
Commentary on Twitter
#DYK: Drug resistant organisms are found in people, animals, food, plants and the environment.
That's why WHO works in collaboration with @FAO, @OIEAnimalHealth & @UNEP to address #AntimicrobialResistance https://t.co/enhUb1jg2g pic.twitter.com/9elCBspx4y— World Health Organization (WHO) (@WHO) April 6, 2022
Consensus Statement: Definition, diagnosis, and management of COVID-19-associated pulmonary mucormycosis.
5 Apr, 2022 | 09:54h | UTC
Systematic Review: Timing of antibiotic administration, wound debridement, and the stages of reconstructive surgery for open long bone fractures of the upper and lower limbs.
5 Apr, 2022 | 08:08h | UTC
Review: Tackling the emerging threat of antifungal resistance to human health.
5 Apr, 2022 | 08:02h | UTCTackling the emerging threat of antifungal resistance to human health – Nature Reviews Microbiology (if the link is paywalled, try this one)
Before-and-after study: Antimicrobial stewardship in high-risk febrile neutropenia patients reduced carbapenem and glycopeptide use and was associated with improved clinical outcomes.
4 Apr, 2022 | 00:49h | UTCRelated:
Management of febrile neutropaenia: ESMO Clinical Practice Guidelines – Annals of Oncology
Commentary from the author on Twitter (thread – click for more)
https://twitter.com/AdrienContejean/status/1508792991917432838
Systematic review: there is insufficient evidence that therapeutic drug monitoring improves outcomes during treatment with penicillins.
4 Apr, 2022 | 00:47h | UTC
Systematic Review: There is insufficient evidence to support or refute the use of antibiotics for preventing infection following surgery to treat stress urinary incontinence in women.
4 Apr, 2022 | 00:26h | UTC
Commentary on Twitter
https://twitter.com/C_Incontinence/status/1509106659842564098
A Narrative Review on the approach to antimicrobial use in ventilated patients with multidrug resistant organisms in respiratory samples—to treat or not to treat?
31 Mar, 2022 | 08:27h | UTC
Commentary on Twitter
https://twitter.com/ABsteward/status/1508917245740818438
Complicated and uncomplicated S. aureus bacteremia: an international Delphi survey among infectious diseases experts on definitions and treatment.
30 Mar, 2022 | 10:34h | UTC
The harms of postoperative antibiotic prophylaxis: a teachable moment.
30 Mar, 2022 | 10:36h | UTCThe Harms of Postoperative Antibiotic Prophylaxis: A Teachable Moment – JAMA Internal Medicine (free for a limited period)
Cohort Study: Socio-economic variations determine the clinical presentation, etiology and outcome of infective endocarditis.
30 Mar, 2022 | 09:50h | UTC
Commentary on Twitter
Infective #endocarditis – do socio-economic factors impact presentation and prognosis? Unfortunately yes, according to data from EURO-ENDO Registry: https://t.co/JdKM5igihR #CVD #EHJQCCO @cpgale3 @diogoasantosfer pic.twitter.com/pkclJdRsdU
— European Society of Cardiology Journals (@ESC_Journals) March 28, 2022
Before-and-after study: Effectiveness of implementing a preventive urinary catheter care bundle in hip fracture patients.
29 Mar, 2022 | 08:33h | UTCNews Release: Catheter infections went down after more preventive efforts – University of Gothenburg
Review: Short and oral antimicrobial therapy for diabetic foot infection.
29 Mar, 2022 | 08:29h | UTC
The prevalence of penicillin allergy labeling ranged from 0.9% to 10.2% across practices in a large pediatric cohort, raising questions regarding the validity of those labels and the unnecessary use of second-line antibiotics that may follow.
28 Mar, 2022 | 09:48h | UTCM-A: Most patients with allergy to Penicillin can be given Cefazolin
Podcast: A Clinical Pharmacologist’s Perspective on Penicillin Allergy
Study: Development and Validation of a Penicillin Allergy Clinical Decision Rule
Consensus Recommendations: Management of a Surgical Patient with a Label of Penicillin Allergy
Practical Guide for Pharmacists to Successfully Implement Penicillin Allergy Skin Testing
NICE: Double Check Patients with ‘Penicillin Allergy’ to Avoid Increased MRSA Risk
Commentary on Twitter
In this cohort study of more than 330,000 children, less than 5% were labeled with penicillin allergy with wide variation across practices, with 8% of those labeled despite not receiving any penicillin prescription. https://t.co/kvXcm1RKRd
— JAMA Network Open (@JAMANetworkOpen) March 15, 2022
M-A: Staphylococcus aureus bacteremia mortality.
25 Mar, 2022 | 08:36h | UTC
M-A: Tuberculosis screening among HIV-positive inpatients.
25 Mar, 2022 | 08:35h | UTC
Commentary on Twitter
https://twitter.com/CarlosdelRio7/status/1506893108864335872
RCT: Single-dose Liposomal Amphotericin B treatment for Cryptococcal Meningitis.
24 Mar, 2022 | 09:56h | UTCSingle-Dose Liposomal Amphotericin B Treatment for Cryptococcal Meningitis – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
Cryptococcal meningitis is a major complication of HIV infection. Single-dose liposomal amphotericin B combined with flucytosine and fluconazole was noninferior to the WHO-recommended treatment and was associated with fewer adverse events. https://t.co/cg9DqSDhyN pic.twitter.com/SrKx4tDaph
— NEJM (@NEJM) March 23, 2022
WHO releases clinical management guidelines for influenza.
23 Mar, 2022 | 10:41h | UTCNews Release: WHO releases clinical management guidelines for influenza – World Health Organization
Original Report: Guidelines for the clinical management of severe illness from influenza virus infections – World Health Organization