Antibiotic Stewardship
The incidence of ocular complications in candidemic patients and implications for the practice of routine eye exams.
23 Mar, 2022 | 09:50h | UTC
Preventing and treating the common cold: what’s the evidence?
22 Mar, 2022 | 08:56h | UTCPreventing and treating the common cold: what’s the evidence? – Evidently Cochrane
Commentary on Twitter
https://twitter.com/CochraneUK/status/1505978560078659587
Rapid point-of-care genotyping to avoid aminoglycoside-induced ototoxicity in neonatal intensive care.
22 Mar, 2022 | 08:01h | UTCEditorial: Genetic Testing in Newborns Moves From Rare to Routine Application
Commentary on Twitter
The MT-RNR1 m.1555A>G variant predisposes to profound aminoglycoside-induced ototoxicity
The MT-RNR1 POCT was able to genotype the m.1555A>G variant in 26 minutes. #IDTwitter #medtwitter #TwitteRx #MedEd #PIDTwitter https://t.co/BbkpNMiNHN— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) March 21, 2022
RCT: Oral contezolid vs. linezolid in adults with complicated skin and soft tissue infections.
18 Mar, 2022 | 07:54h | UTCA Phase III multicentre, randomized, double-blind trial to evaluate the efficacy and safety of oral contezolid versus linezolid in adults with complicated skin and soft tissue infections – Journal of Antimicrobial Therapy (link to abstract – $ for full-text)
Commentary on Twitter
Phase III efficacy & safety of oral contezolid Vs linezolid in adults with c.SSTIs
📌Non inferior
📌Interestingly:Contezolid demonstrated significant lower incidence thrombocytopenia (0% Wow vs 2.3%) & leucopenia (0.3% vs 3.4%) than linezolid
📌QIDP https://t.co/wSvxUInnkZ— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) March 11, 2022
Antimicrobial therapies for preventing recurrent acute exacerbations of COPD: beyond the guidelines.
17 Mar, 2022 | 08:12h | UTC
Four priority actions to slow the silent pandemic of antimicrobial resistance.
16 Mar, 2022 | 09:42h | UTCFour Priority Actions to Slow the Silent Pandemic of Antimicrobial Resistance – Health Policy Watch
Related:
Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis.
How to: Clostridioides difficile infection in children.
16 Mar, 2022 | 08:39h | UTCHow to: Clostridioides difficile infection in children – Clinical Microbiology and Infection
Most antibiotic prophylaxis prescriptions prior to dental visits are inconsistent with guidelines.
16 Mar, 2022 | 08:33h | UTCAntibiotic prophylaxis prescriptions prior to dental visits in the Veterans’ Health Administration (VHA), 2015–2019 – Infection Control & Hospital Epidemiology (link to abstract – $ for full-text)
Commentary: Most antibiotics prescribed for dental visits inconsistent with guidelines, study finds – Healio (link to abstract – $ for full-text)
Commentary on Twitter
New in @ICHEJournal from @SUDAmonas et al:
➡️ Five out of six antibiotics prescribed for dental infection prophylaxis in VA were inconsistent with guidelines. Improving prophylaxis appropriateness may have large implications for stewardship.
📄: https://t.co/HTTO9eaYo5 pic.twitter.com/Ay9zgJIqml
— Infection Control & Hospital Epidemiology (@ICHEJournal) February 23, 2022
M-A: Intraoperative redosing of surgical antibiotic prophylaxis in addition to preoperative prophylaxis vs. single-dose prophylaxis for the prevention of surgical site infection.
16 Mar, 2022 | 08:34h | UTC
M-A: Similar outcomes with Beta-lactam monotherapy vs. combination therapy for bloodstream infections or pneumonia due to Pseudomonas aeruginosa.
15 Mar, 2022 | 08:29h | UTCBeta-lactam monotherapy or combination therapy for bloodstream infections or pneumonia due to Pseudomonas aeruginosa: a meta-analysis – International Journal of Antimicrobial Agents (link to abstract – $ for full-text)
Healthcare-associated infections in adult intensive care unit patients: Changes in epidemiology, diagnosis, prevention and contributions of new technologies.
14 Mar, 2022 | 01:04h | UTC
RCT: Effectiveness of Fosfomycin for treating multidrug-resistant Escherichia coli bacteremic urinary tract infections.
14 Mar, 2022 | 00:53h | UTCCommentaries:
The Role of Intravenous Fosfomycin: Finding Our Way Out of Dante’s Forest Dark – JAMA Network Open
Fosfomycin Not Noninferior to Comparators for Bacteremic UTI – HealthDay
‘Forgotten’ antibiotic recovered for resistant bacterial infections – University of Seville
Commentary on Twitter
In this RCT, fosfomycin did not demonstrate noninferiority in MDR-E coli bacteremic UTI, mostly due to adverse event-related withdrawals in mITT, but showed efficacy in per protocol analysis. #FORESTtrial @jesusrbano https://t.co/oiPtiQo2XA pic.twitter.com/Q44QQb18cN
— JAMA Network Open (@JAMANetworkOpen) January 13, 2022
RCT: Methenamine Hippurate (a non-antibiotic preventive treatment) is noninferior to prophylactic antibiotics for treating recurrent urinary tract infections in women.
11 Mar, 2022 | 10:21h | UTCNews Release: Antiseptic drug as good as antibiotics for preventing recurrent urinary tract infections – BMJ Newsroom
Editorial: Methenamine hippurate for recurrent urinary tract infections – The BMJ
Commentaries:
Trial supports antibiotic alternative for recurrent urinary infections – CIDRAP
Nonantibiotic Prophylaxis Noninferior for Recurrent UTI – HealthDay
Commentary on Twitter
https://twitter.com/bmj_latest/status/1501800030608494596
SHEA neonatal intensive care unit (NICU) white paper series: Practical approaches for preventing central line-associated bloodstream infections.
11 Mar, 2022 | 09:53h | UTC
Efficacy and safety of non-operative management of uncomplicated acute appendicitis compared to appendectomy: an umbrella review of systematic reviews and meta-analyses.
11 Mar, 2022 | 09:49h | UTCRelated:
Review: Diagnosis of uncomplicated and complicated appendicitis in adults.
A Randomized trial comparing antibiotics with appendectomy for appendicitis
Association between statin use and daptomycin-related musculoskeletal adverse events: A mixed approach combining a meta-analysis and a disproportionality analysis.
11 Mar, 2022 | 09:39h | UTC
Review: Acute cholecystitis.
11 Mar, 2022 | 09:40h | UTCAcute Cholecystitis: A Review – JAMA (free for a limited period)
Author Interview: Acute Cholecystitis
Safety and efficacy of antibiotic de-escalation and discontinuation in high-risk hematological patients with febrile neutropenia: a single-center experience.
10 Mar, 2022 | 10:09h | UTCRelated: Management of febrile neutropaenia: ESMO Clinical Practice Guidelines – Annals of Oncology
Commentary on Twitter
OFID: In high-risk hematological patients w/ febrile neutropenia, antibiotic de-escalation and discontinuation prior to neutrophil recovery did not lead to an increase in infectious complications. https://t.co/eUer1fmoc6 #IDSAJournals @PaulSaxMD @DrJLi @FungalDoc @jobadd pic.twitter.com/HuGRYA8YW3
— IDSA (@IDSAInfo) January 5, 2022
Extending the reach of antimicrobial stewardship to pediatric patients.
10 Mar, 2022 | 10:12h | UTC
IDSA Guidance on the treatment of antimicrobial-resistant Gram-Negative infections – A focus on extended-spectrum β-lactamase producing Enterobacterales, Carbapenem-resistant Enterobacterales, and Pseudomonas aeruginosa with difficult-to-treat resistance.
9 Mar, 2022 | 08:51h | UTCRelated:
IDSA Guidance on the Treatment of Antimicrobial-Resistant Gram-Negative Infections.
RCT: Azithromycin is not effective for the prevention of recurrent wheeze following severe respiratory syncytial virus bronchiolitis.
8 Mar, 2022 | 08:49h | UTCCommentaries:
Commentary on Twitter
This RCT tested oral azithromycin vs placebo to reduce recurrent wheeze (RW) in 1-18-month-olds hospitalized with acute severe RSV bronchiolitis. Azithromycin did not reduce occurrence of RW and may increase risk of RW in some groups. #AAAAI22 #Asthma #EBM https://t.co/jYcBuiQ8aY pic.twitter.com/u65NbQaIlX
— NEJM Evidence (@NEJMEvidence) February 28, 2022
WSES/GAIS/WSIS/SIS-E/AAST global clinical pathways for patients with skin and soft tissue infections.
7 Mar, 2022 | 00:09h | UTC
Carbapenem-resistant Acinetobacter Baumannii: colonization, infection and current treatment options.
4 Mar, 2022 | 08:31h | UTCRelated:
IDSA Guidance on the Treatment of Antimicrobial-Resistant Gram-Negative Infections.
Review: Therapeutic strategies for emerging multidrug-resistant Pseudomonas Aeruginosa.
4 Mar, 2022 | 08:32h | UTCRelated:
IDSA Guidance on the Treatment of Antimicrobial-Resistant Gram-Negative Infections.
RCT: Effect of therapeutic drug monitoring-based dose optimization of piperacillin/tazobactam on sepsis-related organ dysfunction in patients with sepsis.
3 Mar, 2022 | 08:40h | UTC
Commentary on Twitter
Therapeutic drug monitoring‑guided pip/tazo infusion vs fixed dose in #sepsis, TARGET RCT:
🧪no significant difference in mean SOFA
⬇️28-day mortality + ⬆️ clinical/microbiological cure if TDM (no statistical significance)
Results https://t.co/cLS1OQ173I
⬇️Below visual abstract pic.twitter.com/jRjzfNLj1T— Intensive Care Medicine (@yourICM) March 1, 2022