RCT: Azithromycin is not effective for the prevention of recurrent wheeze following severe respiratory syncytial virus bronchiolitis.

Azithromycin to Prevent Recurrent Wheeze Following Severe Respiratory Syncytial Virus Bronchiolitis – NEJM Evidence

Commentaries:

Study finds azithromycin use during RSV not useful in preventing recurrent wheezing, may cause harm – Vanderbilt University Medical Center

Antibiotic doesn’t prevent future wheezing in babies hospitalized with RSV – Washington University in St. Louis

Commentary on Twitter

This RCT tested oral azithromycin vs placebo to reduce recurrent wheeze (RW) in 1-18-month-olds hospitalized with acute severe RSV bronchiolitis. Azithromycin did not reduce occurrence of RW and may increase risk of RW in some groups. #AAAAI22 #Asthma #EBM https://t.co/jYcBuiQ8aY pic.twitter.com/u65NbQaIlX

— NEJM Evidence (@NEJMEvidence) February 28, 2022