RCT: Effect of therapeutic drug monitoring-based dose optimization of piperacillin/tazobactam on sepsis-related organ dysfunction in patients with sepsis.

Effect of therapeutic drug monitoring-based dose optimization of piperacillin/tazobactam on sepsis-related organ dysfunction in patients with sepsis: a randomized controlled trial – Intensive Care Medicine

Commentary on Twitter

Therapeutic drug monitoring‑guided pip/tazo infusion vs fixed dose in #sepsis, TARGET RCT:
?no significant difference in mean SOFA
⬇️28-day mortality + ⬆️ clinical/microbiological cure if TDM (no statistical significance)
Results https://t.co/cLS1OQ173I
⬇️Below visual abstract pic.twitter.com/jRjzfNLj1T

— Intensive Care Medicine (@yourICM) March 1, 2022