RCT: Effect of Gram Stain–Guided initial antibiotic therapy on clinical response in patients with ventilator-associated pneumonia.

Effect of Gram Stain–Guided Initial Antibiotic Therapy on Clinical Response in Patients With Ventilator-Associated Pneumonia: The GRACE-VAP Randomized Clinical Trial – JAMA Network Open

Commentary: Can Gram Stains Guide Antibiotics for Pneumonia in Critical Care? – Medscape (free registration required)

Commentary on Twitter

RCT found gram stain-guided antibiotic therapy for critically ill patients with VAP was noninferior to guideline-based antibiotics, with a reduction in antipseudomonal & antiMRSA use. https://t.co/1yoHO2pnER

— JAMA Network Open (@JAMANetworkOpen) April 8, 2022