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Antibiotic Stewardship

RCT: Effect of Gram Stain–Guided initial antibiotic therapy on clinical response in patients with ventilator-associated pneumonia.

11 Apr, 2022 | 01:36h | UTC

Effect of Gram Stain–Guided Initial Antibiotic Therapy on Clinical Response in Patients With Ventilator-Associated Pneumonia: The GRACE-VAP Randomized Clinical Trial – JAMA Network Open

Commentary: Can Gram Stains Guide Antibiotics for Pneumonia in Critical Care? – Medscape (free registration required)

 

Commentary on Twitter

 

Interventions for treating catheter‐related bloodstream infections in people receiving maintenance hemodialysis.

8 Apr, 2022 | 10:18h | UTC

Interventions for treating catheter‐related bloodstream infections in people receiving maintenance haemodialysis – Cochrane Library

Summary: Interventions for treating catheter-related bloodstream infections in people receiving maintenance haemodialysis – Cochrane Library

 

RCT: Among patients with complicated urinary tract infection, oral Tebipenem Pivoxil Hydrobromide was noninferior to intravenous Ertapenem and showed a similar safety profile.

7 Apr, 2022 | 09:53h | UTC

Oral Tebipenem Pivoxil Hydrobromide in Complicated Urinary Tract Infection – New England Journal of Medicine (link to abstract – $ for full-text)

 

Commentary on Twitter

 

WHO Strategic framework for collaboration on antimicrobial resistance.

7 Apr, 2022 | 08:41h | UTC

Strategic framework for collaboration on antimicrobial resistance – World Health Organization

Related:

Four priority actions to slow the silent pandemic of antimicrobial resistance.

Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis.

Perspective | The hidden epidemic: Antibiotic resistance is approaching a crisis point, and the world needs to act.

 

Commentary on Twitter

 

Consensus Statement: Definition, diagnosis, and management of COVID-19-associated pulmonary mucormycosis.

5 Apr, 2022 | 09:54h | UTC

Definition, diagnosis, and management of COVID-19-associated pulmonary mucormycosis: Delphi consensus statement from the Fungal Infection Study Forum and Academy of Pulmonary Sciences, India – The Lancet Infectious Diseases

 

Systematic Review: Timing of antibiotic administration, wound debridement, and the stages of reconstructive surgery for open long bone fractures of the upper and lower limbs.

5 Apr, 2022 | 08:08h | UTC

Timing of antibiotic administration, wound debridement, and the stages of reconstructive surgery for open long bone fractures of the upper and lower limbs – Cochrane Library

Summary: The timing of treatment for broken bones in the legs and arms that also have open wounds – Cochrane Library

 

Review: Tackling the emerging threat of antifungal resistance to human health.

5 Apr, 2022 | 08:02h | UTC

Tackling the emerging threat of antifungal resistance to human health – Nature Reviews Microbiology (if the link is paywalled, try this one)

 

Before-and-after study: Antimicrobial stewardship in high-risk febrile neutropenia patients reduced carbapenem and glycopeptide use and was associated with improved clinical outcomes.

4 Apr, 2022 | 00:49h | UTC

Antimicrobial stewardship in high-risk febrile neutropenia patients – Antimicrobial Resistance & Infection Control

Related:

Safety and efficacy of antibiotic de-escalation and discontinuation in high-risk hematological patients with febrile neutropenia: a single-center experience.

Management of febrile neutropaenia: ESMO Clinical Practice Guidelines – Annals of Oncology

 

Commentary from the author on Twitter (thread – click for more)

 

Systematic review: there is insufficient evidence that therapeutic drug monitoring improves outcomes during treatment with penicillins.

4 Apr, 2022 | 00:47h | UTC

A systematic review of the effect of therapeutic drug monitoring on patient health outcomes during treatment with penicillins – Journal of Antimicrobial Chemotherapy

 

Systematic Review: There is insufficient evidence to support or refute the use of antibiotics for preventing infection following surgery to treat stress urinary incontinence in women.

4 Apr, 2022 | 00:26h | UTC

Prophylactic antibiotics for preventing infection after continence surgery in women with stress urinary incontinence – Cochrane Library

Summary: Antibiotics for preventing infection following surgery to treat stress urinary incontinence in women – Cochrane Library

 

Commentary on Twitter

 

A Narrative Review on the approach to antimicrobial use in ventilated patients with multidrug resistant organisms in respiratory samples—to treat or not to treat?

31 Mar, 2022 | 08:27h | UTC

A Narrative Review on the Approach to Antimicrobial Use in Ventilated Patients with Multidrug Resistant Organisms in Respiratory Samples—To Treat or Not to Treat? That Is the Question – Antibiotics

 

Commentary on Twitter

 

Complicated and uncomplicated S. aureus bacteremia: an international Delphi survey among infectious diseases experts on definitions and treatment.

30 Mar, 2022 | 10:34h | UTC

Complicated and uncomplicated S. aureus bacteremia: an international Delphi survey among infectious diseases experts on definitions and treatment – Clinical Microbiology and Infection

 

The harms of postoperative antibiotic prophylaxis: a teachable moment.

30 Mar, 2022 | 10:36h | UTC

The Harms of Postoperative Antibiotic Prophylaxis: A Teachable Moment – JAMA Internal Medicine (free for a limited period)

 

Cohort Study: Socio-economic variations determine the clinical presentation, etiology and outcome of infective endocarditis.

30 Mar, 2022 | 09:50h | UTC

Socio-Economic Variations Determine the Clinical Presentation, Aetiology and Outcome of Infective Endocarditis: a Prospective Cohort Study from the ESC-EORP EURO-ENDO (European Infective Endocarditis) Registry – European Heart Journal – Quality of Care and Clinical Outcomes

 

Commentary on Twitter

 

Before-and-after study: Effectiveness of implementing a preventive urinary catheter care bundle in hip fracture patients.

29 Mar, 2022 | 08:33h | UTC

Effectiveness of implementing a preventive urinary catheter care bundle in hip fracture patients – Journal of Infection Prevention

News Release: Catheter infections went down after more preventive efforts – University of Gothenburg

 

Review: Short and oral antimicrobial therapy for diabetic foot infection.

29 Mar, 2022 | 08:29h | UTC

Short and oral antimicrobial therapy for diabetic foot infection: a narrative review of current knowledge – Journal of Bone and Joint Infection

 

The prevalence of penicillin allergy labeling ranged from 0.9% to 10.2% across practices in a large pediatric cohort, raising questions regarding the validity of those labels and the unnecessary use of second-line antibiotics that may follow.

28 Mar, 2022 | 09:48h | UTC

Factors Associated With Penicillin Allergy Labels in Electronic Health Records of Children in 2 Large US Pediatric Primary Care Networks – JAMA Network Open

Related: A pharmacist-led penicillin allergy assessment program can delabel many “penicillin allergic” patients through allergy histories and penicillin skin testing. The program was associated with reduced use of high Clostridioides difficile infection–risk antibiotics.

M-A: Most patients with allergy to Penicillin can be given Cefazolin

Systematic review: Safety and efficacy of de-labelling penicillin allergy in adults using direct oral challenge

Penicillin allergy labels increase second-line broad-spectrum antibiotic prescribing for pediatric respiratory tract infections

Podcast: A Clinical Pharmacologist’s Perspective on Penicillin Allergy

Study: Development and Validation of a Penicillin Allergy Clinical Decision Rule

Consensus Recommendations: Management of a Surgical Patient with a Label of Penicillin Allergy

Practical Guide for Pharmacists to Successfully Implement Penicillin Allergy Skin Testing

NICE: Double Check Patients with ‘Penicillin Allergy’ to Avoid Increased MRSA Risk

Cohort Study: Risk of Meticillin Resistant Staphylococcus Aureus and Clostridium Difficile in Patients with a Documented Penicillin Allergy

 

Commentary on Twitter

 

M-A: Staphylococcus aureus bacteremia mortality.

25 Mar, 2022 | 08:36h | UTC

Staphylococcus aureus bacteremia mortality: A systematic review and meta-analysis – Clinical Microbiology and Infection

 

M-A: Tuberculosis screening among HIV-positive inpatients.

25 Mar, 2022 | 08:35h | UTC

Tuberculosis screening among HIV-positive inpatients: a systematic review and individual participant data meta-analysis – The Lancet HIV

 

Commentary on Twitter

 

RCT: Single-dose Liposomal Amphotericin B treatment for Cryptococcal Meningitis.

24 Mar, 2022 | 09:56h | UTC

Single-Dose Liposomal Amphotericin B Treatment for Cryptococcal Meningitis – New England Journal of Medicine (link to abstract – $ for full-text)

 

Commentary on Twitter

 

WHO releases clinical management guidelines for influenza.

23 Mar, 2022 | 10:41h | UTC

News Release: WHO releases clinical management guidelines for influenza – World Health Organization

Original Report: Guidelines for the clinical management of severe illness from influenza virus infections – World Health Organization

 

The incidence of ocular complications in candidemic patients and implications for the practice of routine eye exams.

23 Mar, 2022 | 09:50h | UTC

The Incidence of Ocular Complications in Candidemic Patients and Implications for the Practice of Routine Eye Exams – Open Forum Infectious Diseases

 

Preventing and treating the common cold: what’s the evidence?

22 Mar, 2022 | 08:56h | UTC

Preventing and treating the common cold: what’s the evidence? – Evidently Cochrane

 

Commentary on Twitter

 

Rapid point-of-care genotyping to avoid aminoglycoside-induced ototoxicity in neonatal intensive care.

22 Mar, 2022 | 08:01h | UTC

Rapid Point-of-Care Genotyping to Avoid Aminoglycoside-Induced Ototoxicity in Neonatal Intensive Care – JAMA Pediatrics

Editorial: Genetic Testing in Newborns Moves From Rare to Routine Application

 

Commentary on Twitter

 

RCT: Oral contezolid vs. linezolid in adults with complicated skin and soft tissue infections.

18 Mar, 2022 | 07:54h | UTC

A Phase III multicentre, randomized, double-blind trial to evaluate the efficacy and safety of oral contezolid versus linezolid in adults with complicated skin and soft tissue infections – Journal of Antimicrobial Therapy (link to abstract – $ for full-text)

 

Commentary on Twitter

 

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