Cluster RCT: A shorter antimicrobial prophylaxis duration (less than 24 hours after surgery) is noninferior to a more extended regimen (24-48 hours) after clean orthopedic surgery.

Effect of Antimicrobial Prophylaxis Duration on Health Care–Associated Infections After Clean Orthopedic Surgery: A Cluster Randomized Trial – JAMA Network Open

Commentary on Twitter

Cluster RCT of patients who underwent clean orthopedic surgery found shorter antimicrobial prophylaxis duration (<24h postop) was noninferior to longer duration (<48h) in preventing health care associated infections and across a range of clinical outcomes. https://t.co/FFzxNiHxet

— JAMA Network Open (@JAMANetworkOpen) April 12, 2022