Emergency Medicine
Updated WHO guidance conditionally recommends Molnupiravir for patients with non-severe covid-19 at highest risk of hospitalization.
4 Mar, 2022 | 09:57h | UTCBMJ News Release: WHO recommends antiviral drug for patients with non-severe covid-19 at highest risk of hospital admission – BMJ
WHO News Release: WHO updates its treatment guidelines to include molnupiravir
See updated guidance: A living WHO guideline on drugs for covid-19 – BMJ
Related:
Editorial (just published): Molnupiravir’s authorisation was premature – The BMJ
FDA panel narrowly recommends authorization of first antiviral pill to treat COVID.
8 lingering questions about the new Covid pills from Merck and Pfizer.
The U.K. approves Merck’s COVID-19 antiviral pill, calling it a world first.
Merck to allow other nations to produce new COVID-19 antiviral.
Video: Merck’s Covid pill could transform treatment. Here’s how it works.
How antiviral pill Molnupiravir shot ahead in the COVID drug hunt.
What we know — and don’t know — about Merck’s new Covid-19 pill.
Merck’s Covid-19 pill is great news but may not be a game-changer.
Video | A Pill For COVID? A Doctor Explains Molnupiravir.
Pre-post study: The introduction of a text-message alert system to alert volunteers close to a cardiac arrest patient at home was associated with increased survival to hospital discharge.
4 Mar, 2022 | 09:44h | UTC
Commentary on Twitter
For patients with a cardiac arrest at home, an alert system that includes nearby volunteers activated by the ambulance dispatch centre and many easily accessible AEDs saves lives https://t.co/0jfD9LsKip @escardio #EHJ #ESCYoung #cardiotwitter @ehj_ed @rladeiraslopes pic.twitter.com/pjPk3NJDla
— European Society of Cardiology Journals (@ESC_Journals) December 20, 2021
RCT: Aspirin and unfractionated heparin increase the risk of symptomatic intracranial hemorrhage in patients undergoing endovascular treatment for ischemic stroke.
3 Mar, 2022 | 08:53h | UTCSafety and efficacy of aspirin, unfractionated heparin, both, or neither during endovascular stroke treatment (MR CLEAN-MED): an open-label, multicentre, randomised controlled trial – The Lancet (link to abstract – $ for full-text)
M-A: Use of tocilizumab and sarilumab alone or in combination with corticosteroids for covid-19.
3 Mar, 2022 | 08:49h | UTCEditorial: Treatment of severe covid-19 with interleukin 6 receptor inhibition – BMJ Medicine
Related study (just published): Mortality Rates Among Hospitalized Patients With COVID-19 Infection Treated With Tocilizumab and Corticosteroids: A Bayesian Reanalysis of a Previous Meta-analysis – JAMA Network Open
Observational study suggests norepinephrine is a better choice than epinephrine in cardiac arrest patients with post-resuscitation shock.
3 Mar, 2022 | 08:38h | UTCEpinephrine versus norepinephrine in cardiac arrest patients with post-resuscitation shock – Intensive Care Medicine (link to abstract – $ for full-text)
Noradrenaline better vs adrenaline in cardiac arrest pts with post #resus shock?
💉766 pts, 5 🏥
🏥 noradrenaline better survival/neuro-outcome: all-cause & cardiovascular mortality significantly ⬆️ with epinephrine
🖇️ Results #FOAMcc https://t.co/ihuEPg8sGq
⬇️ Visual Abstract pic.twitter.com/aakmkpPxXf— Intensive Care Medicine (@yourICM) February 24, 2022
M-A: Association of tranexamic acid administration with mortality and thromboembolic events in patients with traumatic injury.
3 Mar, 2022 | 07:57h | UTCRelated:
Meta-analysis: Efficacy and safety of tranexamic acid in acute traumatic brain injury
Editorial: Is Tranexamic Acid Going to CRASH the Management of Traumatic Brain Injury?
Prescribing Nirmatrelvir–Ritonavir for Covid-19: How to recognize and manage drug–drug interactions.
2 Mar, 2022 | 09:01h | UTCRelated:
Pfizer antiviral pills may be risky with other medications – NBC News
Cluster RCT: In adults with out-of-hospital cardiac arrest, placement of a supraglottic airway device resulted in similar rates of sustained return of spontaneous circulations compared to endotracheal intubation.
2 Mar, 2022 | 09:07h | UTCCommentary: Cardiac Arrest Patients Don’t Necessarily Do Better With Intubation— Debate on prehospital advanced airway management continues – MedPage Today (free registration required)
Commentary on Twitter
RCT of out-of-hospital cardiac arrest patients randomized to intubation or supraglottic airways, finds no difference in the rate of sustained return of spontaneous circulation, survival to hospital discharge or favorable neurologic outcomes. https://t.co/GX80iczmHC
— JAMA Network Open (@JAMANetworkOpen) February 18, 2022
Anticoagulation in Patients With COVID-19: JACC Review Topic of the Week.
2 Mar, 2022 | 09:03h | UTCCommentary: Review of Anticoagulation in Patients With COVID-19: Key Points – American College of Cardiology
The management of diabetic ketoacidosis in adults—An updated guideline from the Joint British Diabetes Society for Inpatient Care.
1 Mar, 2022 | 09:00h | UTC
Guideline: Plasma exchange and glucocorticoid dosing for patients with ANCA-associated vasculitis.
27 Feb, 2022 | 22:40h | UTC
Commentary on Twitter
New rapid recommendation makes a weak recommendation against plasma exchange in patients with low risk of end stage kidney disease, and a weak recommendation in favour of plasma exchange in patients with moderate-high risk of ESKD https://t.co/PeEjSuRIxI #BMJInfographic pic.twitter.com/YR55t6XYhS
— The BMJ (@bmj_latest) February 25, 2022
Major burns: Part 1. Epidemiology, pathophysiology and initial management.
25 Feb, 2022 | 11:04h | UTCMajor burns: Part 1. Epidemiology, pathophysiology and initial management – BJA Education
RCT: In comatose survivors of cardiac arrest, a strategy of suppressing rhythmic and periodic EEG activity with the use of antiseizure medication did not improve neurologic outcomes.
24 Feb, 2022 | 10:45h | UTCTreating Rhythmic and Periodic EEG Patterns in Comatose Survivors of Cardiac Arrest – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
In trial of comatose patients after cardiac arrest, intensive antiseizure treatment adapted from protocols for status epilepticus did not result in fewer poor outcomes at 3 mos than standard treatment. https://t.co/dpH5cgwhvW pic.twitter.com/zVBHBYMRK9
— NEJM (@NEJM) February 23, 2022
M-A: Diagnostic accuracy of point-of-care tests in acute community-acquired lower respiratory tract infections.
23 Feb, 2022 | 10:07h | UTC
M-A: Diagnostic features, management and prognosis of type 2 myocardial infarction compared to type 1 myocardial infarction.
22 Feb, 2022 | 08:34h | UTC
Early and late-onset syncope: insight into mechanisms.
22 Feb, 2022 | 08:29h | UTCEarly and late-onset syncope: insight into mechanisms – European Heart Journal
Commentary on Twitter
Early and late-onset syncope: insight into mechanisms https://t.co/OlAT50jIt8 @escardio #EHJ #ESCYoung #cardiotwitter @ehj_ed @rladeiraslopes pic.twitter.com/F2gzBH9X2i
— European Society of Cardiology Journals (@ESC_Journals) February 17, 2022
RCT: In patients with mild to moderate Covid-19 and comorbidities, treatment with Ivermectin did not reduce the risk of disease progression.
21 Feb, 2022 | 09:34h | UTCCommentaries:
Ivermectin doesn’t prevent severe disease from Covid-19, new study finds – CNN
Ivermectin futile for mild to moderate COVID-19, study finds – CIDRAP
Related:
Case Series: Toxic effects from ivermectin use associated with prevention and treatment of Covid-19.
Long-term consequences of the misuse of ivermectin data.
Ivermectin: How false science created a Covid ‘miracle’ drug.
Fraudulent ivermectin studies open up new battleground between science and misinformation.
The lesson of ivermectin: meta-analyses based on summary data alone are inherently unreliable.
Ivermectin: Cochrane’s most talked about review so far, ever. Why?
Flawed ivermectin preprint highlights challenges of COVID drug studies.
Systematic review: no evidence to support the use of Ivermectin for treating or preventing COVID-19.
Why was a major study on ivermectin for covid-19 just retracted?
RCT: Ivermectin does not prevent hospitalizations in patients with COVID-19.
RCT: Ivermectin does not improve time to resolution of symptoms among adults with mild COVID-19
Review: Cancer-associated venous thromboembolism.
21 Feb, 2022 | 08:42h | UTCCancer-associated venous thromboembolism – Nature Reviews Disease Primers (if the link is paywalled, try this one)
Infographic: Cancer-associated venous thromboembolism – Nature Reviews Disease Primers (if the link is paywalled, try this one)
Related:
NCCN Guideline: Cancer-Associated Venous Thromboembolic Disease.
ASH 2021 guidelines for prevention and treatment of venous thromboembolism in patients with cancer
Review: venous and arterial thromboembolism in patients with cancer.
RCT: Sub dissociative dose of ketamine with haloperidol vs. fentanyl on pain reduction in patients with acute pain in the emergency department.
21 Feb, 2022 | 08:37h | UTCSub dissociative dose of ketamine with haloperidol versus fentanyl on pain reduction in patients with acute pain in the emergency department; a randomized clinical trial – The American Journal of Emergency Medicine (link to abstract – $ for full-text)
Review | Acute traumatic brain injury in frail patients: the next pandemic.
21 Feb, 2022 | 08:31h | UTCAcute traumatic brain injury in frail patients: the next pandemic – Current Opinion in Critical Care
Overview of Allergy and Anaphylaxis.
21 Feb, 2022 | 08:28h | UTCOverview of Allergy and Anaphylaxis – Emergency Clinics of North America
A Decision Tree Approach to Airway Management Pathways in the 2022 Difficult Airway Algorithm of the American Society of Anesthesiologists.
21 Feb, 2022 | 08:16h | UTCOriginal article: 2022 ASA Guidelines for Management of the Difficult Airway.
A clinical update on vasoactive medication in the management of cardiogenic shock.
21 Feb, 2022 | 08:14h | UTC
Arrhythmias in female patients: incidence, presentation and management.
18 Feb, 2022 | 08:31h | UTCArrhythmias in Female Patients: Incidence, Presentation and Management – Circulation Research (free for a limited period)
Bioterrorism: An analysis of biological agents used in terrorist events.
18 Feb, 2022 | 08:32h | UTC