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Emergency Medicine

Treatments for mild COVID-19: Cochrane evidence.

17 Mar, 2022 | 09:17h | UTC

Treatments for mild COVID-19: Cochrane evidence – Cochrane Library

 

Malignant Hypertension: Current perspectives and challenges.

17 Mar, 2022 | 09:03h | UTC

Malignant Hypertension: Current Perspectives and Challenges – Journal of the American Heart Association

 

Open-Label, multicenter study of Flecainide Acetate oral inhalation solution for acute conversion of recent-onset, symptomatic atrial fibrillation to sinus rhythm.

17 Mar, 2022 | 09:01h | UTC

Open-Label, Multicenter Study of Flecainide Acetate Oral Inhalation Solution for Acute Conversion of Recent-Onset, Symptomatic Atrial Fibrillation to Sinus Rhythm – Circulation: Arrythmia & Electrophysiology

 

Commentary on Twitter

 

Happy TRALIdays: An overview of trauma resuscitation and transfusion complications.

17 Mar, 2022 | 08:08h | UTC

Happy TRALIdays: An Overview of Trauma Resuscitation and Transfusion Complications – emDocs

 

Review: Role of imaging in rare COVID-19 vaccine multiorgan complications.

16 Mar, 2022 | 10:00h | UTC

Role of imaging in rare COVID-19 vaccine multiorgan complications – Insights into Imaging

 

Management of respiratory failure: ventilator management 101 and noninvasive ventilation.

14 Mar, 2022 | 00:45h | UTC

Management of Respiratory Failure: Ventilator Management 101 and Noninvasive Ventilation – Clinical Journal of the American Society of Nephrology

 

Review: Drug-induced acute kidney injury.

14 Mar, 2022 | 00:48h | UTC

Drug-Induced Acute Kidney Injury – Clinical Journal of the American Society of Nephrology

 

Efficacy and safety of non-operative management of uncomplicated acute appendicitis compared to appendectomy: an umbrella review of systematic reviews and meta-analyses.

11 Mar, 2022 | 09:49h | UTC

Efficacy and Safety of Non-Operative Management of Uncomplicated Acute Appendicitis Compared to Appendectomy: An Umbrella Review of Systematic Reviews and Meta-Analyses – World Journal of Surgery

Related:

Cohort Study: Patient factors associated with appendectomy within 30 days of initiating antibiotic treatment for appendicitis – the presence of an appendicolith was associated with a nearly 2-fold increased risk of undergoing appendectomy within 30 days.

Review: Diagnosis of uncomplicated and complicated appendicitis in adults.

Another RCT evaluating the efficacy and quality of life of antibiotic-only treatment of acute uncomplicated appendicitis.

A Randomized trial comparing antibiotics with appendectomy for appendicitis

Antibiotics alone for uncomplicated appendicitis: Oral Moxifloxacin almost as good as intravenous Ertapenem + oral Levofloxacin

Observational study: 67.1% success rate with nonoperative management of children with uncomplicated appendicitis

Randomized Trial: Quality of Life and Patient Satisfaction at 7-Year Follow-up of Antibiotic Therapy vs. Appendectomy for Uncomplicated Acute Appendicitis

Meta-Analysis: Antibiotic Treatment vs. Appendectomy for Uncomplicated Acute Appendicitis in Adults and Children

Nonoperative treatment for nonperforated appendicitis in children: a systematic review and meta-analysis – Pediatric Surgery International

 

RCT: In patients with refractory out-of-hospital cardiac arrest, a strategy of intra-arrest transport, extracorporeal cardiopulmonary resuscitation, and immediate invasive assessment did not significantly improve survival with a favorable neurological outcome (OR 1.63; 95% CI 0.93 to 2.85; P = .09).

10 Mar, 2022 | 10:57h | UTC

Effect of Intra-arrest Transport, Extracorporeal Cardiopulmonary Resuscitation, and Immediate Invasive Assessment and Treatment on Functional Neurologic Outcome in Refractory Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentary: Early Invasive Therapy for Out-of-Hospital Cardiac Arrest – American College of Cardiology

 

Commentary on Twitter

https://twitter.com/JAMA_current/status/1496183512025677829

 

Perspective: Once viewed as a promising COVID-19 treatment, convalescent plasma falls out of favor.

10 Mar, 2022 | 10:47h | UTC

Once Viewed as a Promising COVID-19 Treatment, Convalescent Plasma Falls Out of Favor – JAMA

 

RCT: The SGLT2 inhibitor empagliflozin in patients hospitalized for acute heart failure.

9 Mar, 2022 | 10:04h | UTC

The SGLT2 inhibitor empagliflozin in patients hospitalized for acute heart failure: a multinational randomized trial – Nature Medicine

 

ACS Best Practice Guidelines: Spine injury.

9 Mar, 2022 | 10:00h | UTC

Spine Injury – American College of Surgeons

News Release: New guidelines will help trauma centers treat spinal injury patients

 

RCT: In patients with trauma-related hemorrhagic shock receiving prehospital care, there was no benefit from resuscitation with blood products compared to 0.9% sodium chloride.

9 Mar, 2022 | 09:55h | UTC

Resuscitation with blood products in patients with trauma-related haemorrhagic shock receiving prehospital care (RePHILL): a multicentre, open-label, randomised, controlled, phase 3 trial – The Lancet Haematology

Invited commentary: Prehospital blood transfusion: who benefits? – The Lancet Haematology

 

Commentary on Twitter

 

Study shows the number of covid-19 infections missed by lateral flow tests “substantial enough to be of clinical importance”.

8 Mar, 2022 | 08:57h | UTC

News Release: Number of covid-19 infections missed by lateral flow tests “substantial enough to be of clinical importance,” warn experts – BMJ

Original Study: SARS-CoV-2 antigen lateral flow tests for detecting infectious people: linked data analysis – The BMJ

Commentaries:

Lateral flow tests may be missing ‘substantial’ number of COVID-19 infections – Imperial College London

Self-testing for asymptomatic non-contacts using rapid antigen tests—is this leading to a cost effective reduction in infection transmission? – The BMJ

 

Fighting against sudden cardiac death: need for a paradigm shift—Adding near-term prevention and pre-emptive action to long-term prevention.

8 Mar, 2022 | 08:39h | UTC

Fighting against sudden cardiac death: need for a paradigm shift—Adding near-term prevention and pre-emptive action to long-term prevention – European Heart Journal

 

Commentary on Twitter

 

Case report: Nonthrombotic pulmonary embolism secondary to cyanoacrylate embolization of gastric varices.

8 Mar, 2022 | 08:35h | UTC

Nonthrombotic pulmonary embolism secondary to cyanoacrylate embolization of gastric varices – Canadian Medical Association Journal

 

RCT: In patients with stable chest pain with intermediate pretest probability of obstructive coronary artery disease, an initial diagnostic imaging strategy based on CT angiography resulted in similar risks of major adverse cardiovascular events compared to invasive coronary angiography.

7 Mar, 2022 | 00:55h | UTC

CT or Invasive Coronary Angiography in Stable Chest Pain – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: DISCHARGE Hailed as a Big Step Forward for CTA in Stable Chest Pain – TCTMD

 

Commentary on Twitter

 

RCT: Anterior–lateral electrode position is more effective compared to anterior–posterior electrode position for cardioverting atrial fibrillation.

7 Mar, 2022 | 00:45h | UTC

Anterior–Lateral Versus Anterior–Posterior Electrode Position for Cardioverting Atrial Fibrillation – Circulation

Commentary: Anterior-Lateral or Anterior-Posterior Pads for A-fib Cardioversion? – JournalFeed

 

Commentary on Twitter

 

Systematic Review: Anticoagulants for people hospitalized with COVID‐19.

7 Mar, 2022 | 00:48h | UTC

Anticoagulants for people hospitalised with COVID‐19 – Cochrane Library

Summary: Do blood thinners prevent people who are hospitalised with COVID-19 from developing blood clots? – Cochrane Library

Related: Anticoagulation in Patients With COVID-19: JACC Review Topic of the Week.

 

Systematic Review: Prediction of good neurological outcome in comatose survivors of cardiac arrest.

7 Mar, 2022 | 00:40h | UTC

Prediction of good neurological outcome in comatose survivors of cardiac arrest: a systematic review – Intensive Care Medicine

 

Commentary on Twitter

 

Ten myths about albumin.

7 Mar, 2022 | 00:44h | UTC

Ten myths about albumin – Intensive Care Medicine (free for a limited period)

 

Commentary on Twitter

 

WSES/GAIS/WSIS/SIS-E/AAST global clinical pathways for patients with skin and soft tissue infections.

7 Mar, 2022 | 00:09h | UTC

WSES/GAIS/WSIS/SIS-E/AAST global clinical pathways for patients with skin and soft tissue infections – World Journal of Emergency Surgery

 

WSES guidelines on blunt and penetrating bowel injury: diagnosis, investigations, and treatment.

7 Mar, 2022 | 00:11h | UTC

WSES guidelines on blunt and penetrating bowel injury: diagnosis, investigations, and treatment – World Journal of Emergency Surgery

 

Arterial blood gas analysis: as safe as we think? A multicentre historical cohort study.

7 Mar, 2022 | 00:00h | UTC

Arterial blood gas analysis: as safe as we think? A multicentre historical cohort study – ERJ Open

 

[Preprint] RECOVERY trial shows Baricitinib reduces deaths in patients hospitalized with COVID-19.

4 Mar, 2022 | 10:09h | UTC

News Release: RECOVERY trial shows Baricitinib reduces deaths in patients hospitalised with COVID-19 – University of Oxford

Original study: Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis – medRxiv

Commentaries:

Arthritis drug reduces mortality in severe COVID-19, huge clinical trial finds – Science

Covid-19: Anti-inflammatory treatment baricitinib reduces deaths in patients admitted to hospital, finds trial – The BMJ

Another life-saving Covid drug identified – BBC

Related:

WHO recommends two new drugs (Baricitinib and Sotrovimab) to treat COVID-19.

RCT: Baricitinib reduced mortality in hospitalized adults with COVID-19.

Randomized trial: Baricitinib plus remdesivir reduce recovery time in patients with COVID-19

 

Commentary from the author on Twitter (thread – click for more)

 

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