Emergency Medicine
Cohort Study: Patient factors associated with appendectomy within 30 days of initiating antibiotic treatment for appendicitis – the presence of an appendicolith was associated with a nearly 2-fold increased risk of undergoing appendectomy within 30 days.
13 Jan, 2022 | 08:39h | UTCPatient Factors Associated With Appendectomy Within 30 Days of Initiating Antibiotic Treatment for Appendicitis – JAMA Surgery (free for a limited period)
Invited commentary: Appendicoliths, Antibiotic Treatment Failure, and Appendectomy—Is the Glass Half Full or Half Empty? – JAMA Surgery
The COVID-19 Treatment Guidelines Panel’s Statement on Anticoagulation in Hospitalized Patients With COVID-19 – in the absence of contraindications, use therapeutic-dose anticoagulation with low molecular weight heparin for hospitalized patients not in the ICU who have a D-dimer above the upper limit of normal.
12 Jan, 2022 | 09:11h | UTC
Statement on potential drug-drug interactions between Ritonavir-boosted Nirmatrelvir (Paxlovid) and concomitant medications; antiarrhythmics, oral anticoagulants, immunosuppressants, anticonvulsants, antineoplastics, and neuropsychiatric drugs are among the drugs of concern.
12 Jan, 2022 | 09:09h | UTCCommentaries:
Pfizer antiviral pills may be risky with other medications – NBC News
See also: What’s New in the Guidelines – NIH COVID-19 Treatment Guidelines
German Guideline: Oxygen therapy in the acute care of adult patients.
12 Jan, 2022 | 08:57h | UTCGerman S3 Guideline: Oxygen Therapy in the Acute Care of Adult Patients – Respiration
RCT: Among patients younger than 21 years of age with provoked thromboembolism, anticoagulation for 6 weeks was non-inferior vs. 12 weeks on the risk of recurrence and bleeding events.
12 Jan, 2022 | 08:53h | UTCEffect of Anticoagulant Therapy for 6 Weeks vs 3 Months on Recurrence and Bleeding Events in Patients Younger Than 21 Years of Age With Provoked Venous Thromboembolism: The Kids-DOTT Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Duration of Anticoagulant Treatment for Acute Provoked Venous Thromboembolism in Pediatric Patients – JAMA (free for a limited period)
Review: Management of coagulopathy in bleeding patients.
12 Jan, 2022 | 08:34h | UTCManagement of Coagulopathy in Bleeding Patients – Journal of Clinical Medicine
Clinical Guideline: Acute-on-chronic liver failure.
11 Jan, 2022 | 02:43h | UTCAcute-on-Chronic Liver Failure Clinical Guidelines – American Journal of Gastroenterology
Related: Guidelines for the Management of Adult Acute and Acute-on-Chronic Liver Failure in the ICU
Commentary on Twitter
?NEW ACG Guidelines Acute-on-Chronic #Liver Failure by @JasmohanBajaj et al.
?https://t.co/T3CqvOAMrj#Cirrhosis #GItwitter #LiverTwitter #MostReadinRed pic.twitter.com/LHwIkUtGZt
— AJG – The American Journal of Gastroenterology (@AmJGastro) January 10, 2022
Position Statement: Prehospital surgical airway management.
11 Jan, 2022 | 02:39h | UTC
Special Issue: Peri‐operative and critical care management of the brain ‐ current evidence.
11 Jan, 2022 | 02:36h | UTCEditorials:
In search of the perfect outcome in neuroanaesthesia and neurocritical care
Anaesthesia and the older brain: what should we do?
Review Articles:
Implications of nocebo in anaesthesia care
Acute peri-operative neurocognitive disorders: a narrative review
Pragmatic sedation strategies to prevent secondary brain injury in low-resource settings
Delirium and COVID-19: a narrative review of emerging evidence
Anaesthesia for mechanical thrombectomy: a narrative review
Clinical applications of point-of-care ultrasound in brain injury: a narrative review
Management of status epilepticus: a narrative review
Evidence-based strategies to reduce the incidence of postoperative delirium: a narrative review
Management of traumatic brain injury: a narrative review of current evidence
Peri-operative management of patients with Parkinson’s disease
Review: Rapid diagnostic testing for SARS-CoV-2.
11 Jan, 2022 | 01:34h | UTCRapid Diagnostic Testing for SARS-CoV-2 – New England Journal of Medicine
Clinical Practice Guideline Summary: Recommended Drugs and Biologics in Adult Patients with COVID-19.
11 Jan, 2022 | 01:26h | UTC
Commentary on Twitter
Fantastic outpatient treatment approach from Ontario #COVID19 Clinical Practice Guidelines
Risk level:high mod low
Eg:high:Sotrovimab is recommended if NA Remdesivir if NA Fluvoxamine or Budesonide
Paxlovid/Molnupiravir not added coz not yet approved CA https://t.co/dDhj6vA0uv pic.twitter.com/4ucrKIcMn8— Antibiotic Stewa®️x? Bassam Ghanem (@ABsteward) January 8, 2022
New CDC Guidance shortens isolation and quarantine period for Covid-19; patients that tested positive should isolate for 5 days and, if asymptomatic after this period, can leave isolation if they can continue to mask for 5 days to minimize the risk of infecting others.
9 Jan, 2022 | 01:13h | UTCSee also: Quarantine and Isolation – Centers for Disease Control and Prevention
Commentaries:
Facing criticism, CDC updates Covid-19 isolation recommendations with guidance on testing – CNN
CDC posts rationale for shorter isolation, quarantine – Associated Press
Covid-19: CDC shortens isolation period as US cases hit record high – The BMJ
Shortened CDC COVID isolation guide draws sharply mixed reviews – CIDRAP
New CDC isolation guidelines raise concerns among health experts – NPR
CDC Reduces Recommended Isolation Time for People With COVID-19 – HealthDay
COVID isolation and quarantine period for general population shortened by CDC – News Medical
CDC shortens recommended Covid-19 isolation and quarantine time – CNN
CDC cuts the recommended isolation and quarantine periods for coronavirus infections – NPR
US officials recommend shorter COVID isolation, quarantine – Associated Press
See new recommendations from other countries:
Covid: Self-isolation cut from 10 days to seven with negative tests – BBC
[Preprint] RCT: In symptomatic adults above 18 years positive for SARS-CoV-2, early outpatient treatment with high-titer convalescent plasma significantly reduced hospitalizations.
8 Jan, 2022 | 23:28h | UTCNews release: Early Use of Convalescent Plasma May Help Outpatients with COVID-19 Avoid Hospitalization – Johns Hopkins Medicine
Commentary: Convalescent plasma shows renewed promise for COVID-19 in outpatient trial – Science
RCT: Molnupiravir reduced the risk of hospitalization or death in at-risk (i.e., obesity, over 60 years, etc.) unvaccinated adults with Covid-19.
17 Dec, 2021 | 09:52h | UTCRelated: Merck’s COVID pill loses its lustre: what that means for the pandemic – Nature (several articles on the subject)
NICE Guideline | Acute heart failure: diagnosis and management.
17 Dec, 2021 | 08:48h | UTCAcute heart failure: diagnosis and management – National Institute for Health and Care Excellence
Year In Review: Top Non-COVID Infectious Diseases Articles Of 2021.
17 Dec, 2021 | 08:36h | UTCYear In Review: Top Non-COVID Infectious Diseases Articles Of 2021 – IDStewardship
Commentary on Twitter
??NEW ??
My new post a great collaboration w the amazing @IDstewardship
Year In Review: Top✨ Non-COVID Infectious Diseases Articles Of 2021
18 high quality ? RCTs
6 RCTs @NEJM#Shorterisbetter #IDTwitter #MedEd #TwitteRx #ASPchat #SoMeDocs
Others?https://t.co/wJtdjYJ0Gf pic.twitter.com/ugILKX5RQO— Antibiotic Stewa®️x? Bassam Ghanem (@ABsteward) December 17, 2021
Autoimmune encephalitis after SARS-CoV-2 infection: case frequency, findings, and outcomes.
16 Dec, 2021 | 09:47h | UTC
Commentary on Twitter
Autoimmune Encephalitis After SARS-CoV-2 Infection: Case Frequency, Findings, and Outcomes https://t.co/KIKzlf3hev #COVID #Neurology pic.twitter.com/q2Qf7NeJHo
— Neurology Journal (@GreenJournal) December 11, 2021
Merck’s COVID pill loses its luster: what that means for the pandemic – “Molnupiravir was initially heralded by public-health officials as a game-changer for COVID-19, but full clinical-trial data showed lower-than-expected efficacy”.
16 Dec, 2021 | 09:52h | UTCMerck’s COVID pill loses its lustre: what that means for the pandemic – Nature
Related:
FDA panel narrowly recommends authorization of first antiviral pill to treat COVID.
8 lingering questions about the new Covid pills from Merck and Pfizer.
The U.K. approves Merck’s COVID-19 antiviral pill, calling it a world first.
Merck to allow other nations to produce new COVID-19 antiviral.
Video: Merck’s Covid pill could transform treatment. Here’s how it works.
How antiviral pill Molnupiravir shot ahead in the COVID drug hunt.
What we know — and don’t know — about Merck’s new Covid-19 pill.
Merck’s Covid-19 pill is great news but may not be a game-changer.
Video | A Pill For COVID? A Doctor Explains Molnupiravir.
[Press release – not published yet] Pfizer’s Covid pill remains 89% effective for reducing the risk of hospitalization or death in final analysis.
15 Dec, 2021 | 08:46h | UTCCommentaries:
Pfizer’s Covid pill remains 89% effective in final analysis, company says – STAT
Pfizer confirms COVID pill’s results, potency versus omicron – Associated Press
Related:
8 lingering questions about the new Covid pills from Merck and Pfizer.
Commentary on Twitter (thread – click for more)
@pfizer releases more nirmatrelvir (#Paxlovid) data on #COVID19 final outcomes. Data are consistent, slightly better thant interim analysis. #IDTwitter
▪️ 88% overall hospitalization <=5days
▪️ No deaths in High Risk Trial (EPIC-HR)
▪️ Stopping drug 2.1%https://t.co/1D2LKan7tM— David Boulware, MD MPH (@boulware_dr) December 14, 2021
Position Paper: Diagnosis, management, and prevention of button battery ingestion in childhood.
15 Dec, 2021 | 08:32h | UTCVisual summary: Diagnosis, Management, and Prevention of Button Battery Ingestion in Childhood
Commentary on Twitter (thread – click for more)
Button battery ingestion in children⚠️: Important? guidelines for diagnosis and management from @ESPGHANSociety #GITwitter https://t.co/TQ1rfjQOpShttps://t.co/fxzzCEl2F2
— ESGE (@ESGE_news) December 14, 2021
Review: Diagnosis and management of acute appendicitis in adults.
15 Dec, 2021 | 08:28h | UTCDiagnosis and Management of Acute Appendicitis in Adults: A Review – JAMA (free for a limited period)
Author Interview: Current Management of Acute Appendicitis: Antibiotics or Surgical Intervention
Commentary: Antibiotics can be first-line therapy for uncomplicated appendicitis cases – Duke University Medical Center
How to recognize and manage COVID-19-associated coagulopathy.
13 Dec, 2021 | 09:45h | UTCHow to recognize and manage COVID-19-associated coagulopathy – Hematology, ASH Education Program
COVID-19 and thrombosis: searching for evidence.
13 Dec, 2021 | 09:47h | UTCCOVID-19 and thrombosis: searching for evidence – Hematology, ASH Education Program
M-A: Performance of the European Society of Cardiology 0/1-hour, 0/2-hour, and 0/3-hour algorithms for rapid triage of acute myocardial infarction.
10 Dec, 2021 | 10:09h | UTCPerformance of the European Society of Cardiology 0/1-Hour, 0/2-Hour, and 0/3-Hour Algorithms for Rapid Triage of Acute Myocardial Infarction: An International Collaborative Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries:
Rapid ESC hs-cTn Algorithms Best 3-Hour Protocol for MI Rule-out: Meta-analysis – TCTMD
Performance of ESC 0/1-, 0/2-, 0/3-Hour Algorithms for AMI Compared – HealthDay
Commentary on Twitter
New meta-analysis published this week confirms new algorithms proposed by @escardio for ruling out #myocardialinfarction are more accurate than the previously preferred diagnostic tool: https://t.co/lAnozWXuOF pic.twitter.com/v2JGjyPRRW
— Annals of Int Med (@AnnalsofIM) November 25, 2021
M-A: Intravenous diltiazem vs. metoprolol for atrial fibrillation with rapid ventricular rate.
10 Dec, 2021 | 10:05h | UTCIntravenous diltiazem versus metoprolol for atrial fibrillation with rapid ventricular rate: A meta-analysis – The American Journal of Emergency Medicine (link to abstract – $ for full-text)