Emergency Medicine | Page 35 of 62 | Links Medicus Content Curation & Alerts in Medicine

M-A: In patients with transient ischemic attack (TIA), referral to a TIA clinic that can provide urgent investigation and initiation of preventive measures may be as effective for preventing stroke compared to impatient care.

18 Feb, 2022 | 08:29h | UTC

Risk of Subsequent Stroke Among Patients Receiving Outpatient vs Inpatient Care for Transient Ischemic Attack: A Systematic Review and Meta-analysis – JAMA Network Open

RCT: Oral Nirmatrelvir for high-risk adults with Covid-19 reduces the risk of hospitalization by 89%.

17 Feb, 2022 | 10:14h | UTC

Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with Covid-19 – New England Journal of Medicine

Audio Interview: A New Antiviral against Covid-19 – new England Journal of Medicine

[Press release – not published yet] Pfizer’s Covid pill remains 89% effective for reducing the risk of hospitalization or death in final analysis.

[Press release – not published yet] RCT: Pfizer’s novel Covid-19 oral antiviral treatment candidate reduced risk of hospitalization or death by 89% in interim analysis of phase 2/3 EPIC-HR study.

Statement on potential drug-drug interactions between Ritonavir-boosted Nirmatrelvir (Paxlovid) and concomitant medications; antiarrhythmics, oral anticoagulants, immunosuppressants, anticonvulsants, antineoplastics, and neuropsychiatric drugs are among the drugs of concern.

Commentary on Twitter

The Paxlovid pill (Nirmatrelvir) randomized, placebo-controlled trial published @NEJM:
89% efficacy vs Covid hospitalizations or deaths, and quick reduction of viral load.
The active pills had less serious adverse events or discontinuations than placebohttps://t.co/HBMRZt4wBo pic.twitter.com/LDQv41O56c

— Eric Topol (@EricTopol) February 16, 2022

Review: Diagnosis and treatment of acute coronary syndromes.

17 Feb, 2022 | 10:04h | UTC

Diagnosis and Treatment of Acute Coronary Syndromes: A Review – JAMA (free for a limited period)

Audio clinical review: Diagnosis and Treatment of Acute Coronary Syndromes – JAMA

SIMEU position paper on non-invasive respiratory support in COVID-19 pneumonia.

17 Feb, 2022 | 10:01h | UTC

SIMEU position paper on non-invasive respiratory support in COVID-19 pneumonia – Internal and Emergency Medicine

RCT: CPAP improved outcomes in patients with acute hypoxemic respiratory failure due to COVID-19, but high-flow nasal oxygen was not better than conventional oxygen therapy.

RCT: In patients with severe Covid-19, high-flow oxygen therapy reduced the likelihood of invasive mechanical ventilation and decreased the time to clinical recovery compared to conventional oxygen therapy.

Non-invasive respiratory support in the management of acute COVID-19 pneumonia: considerations for clinical practice and priorities for research – “The two randomized controlled trials indicate superiority of non-invasive ventilation over high-flow nasal oxygen in reducing the need for intubation”.

Management of the first stage of convulsive status epilepticus in adults: a systematic review of current randomized evidence.

17 Feb, 2022 | 08:37h | UTC

Management of the first stage of convulsive status epilepticus in adults: a systematic review of current randomised evidence – Journal of Neurology

Central vs. peripheral vision loss in emergency medicine.

17 Feb, 2022 | 08:32h | UTC

Central vs. Peripheral Vision Loss – emDocs

M-A: Impact of pharmacist-led antimicrobial stewardship on appropriate antibiotic prescribing in the emergency department.

17 Feb, 2022 | 08:23h | UTC

Impact of Pharmacist-Led Antimicrobial Stewardship on Appropriate Antibiotic Prescribing in the Emergency Department: A Systematic Review and Meta-Analysis – Annals of Emergency Medicine (link to abstract – $ for full-text)

Commentary on Twitter

Hot off the Press: Impact of Pharmacist-Led Antimicrobial
Stewardship on Appropriate Antibiotic Prescribing
in the Emergency Department: A Systematic
Review and Meta-Analysis https://t.co/NsZIubli8z pic.twitter.com/V2Sf6tLoKI

— AnnalsofEM (@AnnalsofEM) January 24, 2022

Diagnosis of deep vein thrombosis with D-dimer adjusted to clinical probability: prospective diagnostic management study.

16 Feb, 2022 | 08:39h | UTC

Diagnosis of deep vein thrombosis with D-dimer adjusted to clinical probability: prospective diagnostic management study – The BMJ

Systematic Review: Efficacy of antiviral therapies for COVID-19.

15 Feb, 2022 | 10:02h | UTC

Efficacy of antiviral therapies for COVID-19: a systematic review of randomized controlled trials – BMC Infectious Diseases

RCT: A supraclavicular ultrasound-guided right subclavian venous catheterization approach was non-inferior in terms of safety compared to an ultrasound-guided infraclavicular approach.

15 Feb, 2022 | 09:46h | UTC

Supraclavicular versus infraclavicular approach for ultrasound-guided right subclavian venous catheterisation: a randomised controlled non-inferiority trial – Anaesthesia (link to abstract – $ for full-text)

A practical guide to the evaluation of small bowel bleeding.

15 Feb, 2022 | 09:49h | UTC

A Practical Guide to the Evaluation of Small Bowel Bleeding – Mayo Clinic Proceedings

Review: Classic and exertional heatstroke.

15 Feb, 2022 | 08:43h | UTC

Classic and exertional heatstroke – Nature Reviews Disease Primers (if the link is paywalled, try this one)

Commentary on Twitter

Cooling of patients with #heatstroke includes evaporative strategies and conductive methods that aim to establishing the largest possible temperature gradient between the body core and the skin https://t.co/i53jyJBTl5 pic.twitter.com/tofUjiDJYG

— Nature Reviews Disease Primers (@DiseasePrimers) February 8, 2022

Conflicting reports raise questions about whether any monoclonals work against Omicron’s sister variant.

13 Feb, 2022 | 22:49h | UTC

Conflicting reports raise questions about whether any monoclonals work against Omicron’s sister variant – STAT

FDA halts use of antibody drugs that don’t work vs. Omicron.

Lab study shows new antiviral pills maintain efficacy against Omicron, but antibody drugs are substantially less effective.

RCT: Primary Norfloxacin prophylaxis prevents bacterial infections in patients with acute-on-chronic liver failure.

13 Feb, 2022 | 22:37h | UTC

Primary Norfloxacin Prophylaxis for APASL-Defined Acute-on-Chronic Liver Failure: A Placebo-Controlled Double-Blind Randomized Trial – The American Journal of Gastroenterology (link to abstract – $ for full-text)

AAST Consensus: Rhabdomyolysis.

13 Feb, 2022 | 22:21h | UTC

Rhabdomyolysis: an American Association for the Surgery of Trauma Critical Care Committee Clinical Consensus Document – Trauma Surgery & Acute Care Open

Opinion: Time to retire the concept of Transient Ischemic Attack.

13 Feb, 2022 | 22:01h | UTC

Time to Retire the Concept of Transient Ischemic Attack – JAMA (free for a limited period)

Commentary on Twitter

After spending my entire career studying TIAs, Don Easton and I are recommending we retire the term. It isn't clear that TIAs ever existed, at least as they were conceptualized. Rise up Acute Ischemic Cerebrovascular Event/Syndrome. https://t.co/FeG31pPHey

— Clay Johnston (@ClayJohnstonMD) February 11, 2022

Review: Management of venous thromboembolism in pregnancy.

13 Feb, 2022 | 21:57h | UTC

Management of venous thromboembolism in pregnancy – Thrombosis Research

Management of high-risk pulmonary embolism in pregnancy.

Study: Diagnosis of Pulmonary Embolism During Pregnancy

Imaging is the only way to diagnose blood clots in pregnancy

Prevention and Treatment of Pregnancy-Associated Venous Thromboembolism: Critical Appraisal of International Guidelines

ED management of the post-laryngectomy patient.

13 Feb, 2022 | 21:44h | UTC

ED Management of the Post-Laryngectomy Patient – emDocs

RCT: In patients with acute stroke with a large ischemic region, endovascular therapy resulted in better functional outcomes compared to medical care alone but was associated with increased risk of intracranial hemorrhage.

11 Feb, 2022 | 08:49h | UTC

Endovascular Therapy for Acute Stroke with a Large Ischemic Region – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Endovascular Stroke Therapy Works for Large Infarcts: RESCUE-Japan LIMIT – TCTMD

AHA Scientific Statement: Identifying best practices to improve evaluation and management of in-hospital stroke.

10 Feb, 2022 | 10:13h | UTC

Identifying Best Practices to Improve Evaluation and Management of In-Hospital Stroke: A Scientific Statement From the American Heart Association – Stroke

News Release: Five elements to optimize treatment of in-hospital stroke – American Heart Association

Commentary on Twitter

Identifying Best Practices to Improve Evaluation and Management of In-Hospital #Stroke: A Scientific Statement From the American Heart Association #AHAJournals #ISC22 https://t.co/e6zcLMeyBZ @American_Heart @AHAScience pic.twitter.com/eBgLc7OrBK

— Stroke AHA/ASA (@StrokeAHA_ASA) February 9, 2022

IDSA Updated Covid-19 Guideline now supports the use of convalescent plasma in ambulatory patients with mild to moderate COVID-19 at high risk for progression to severe disease.

9 Feb, 2022 | 10:15h | UTC

IDSA Guidelines on the Treatment and Management of Patients with COVID-19 – Infectious Diseases Society of America

Commentary on Twitter

Update Alert: Revised recommendation on the use of #convalescentplasma in ambulatory patients w/ COVID-19 at high risk of progression to severe disease w/ no other treatment options.

📄: https://t.co/YRCxtdilXT #COVID19Guidelines @JGPharmD @adarsh_bhimraj @RMKGandhi @ShohamTxID pic.twitter.com/KpXnywH362

— IDSA (@IDSAInfo) February 8, 2022