Emergency Medicine
RCT: In patients with severe Covid-19, high-flow oxygen therapy reduced the likelihood of invasive mechanical ventilation and decreased the time to clinical recovery compared to conventional oxygen therapy.
8 Dec, 2021 | 10:15h | UTCRelated:
Case series with 139 adolescents and young adults with suspected myocarditis following mRNA vaccination showed most cases had a mild clinical course and rapid resolution of symptoms.
7 Dec, 2021 | 10:19h | UTCNews Release: Young people recover quickly from rare myocarditis side effect of COVID-19 vaccine – American Heart Association
Care of older people and people requiring palliative care with COVID-19: guidance from the Australian National COVID-19 Clinical Evidence Taskforce.
7 Dec, 2021 | 10:12h | UTC
S2k guideline: diagnosis and treatment of carbon monoxide poisoning.
7 Dec, 2021 | 08:48h | UTCS2k guideline diagnosis and treatment of carbon monoxide poisoning – German Medical Science
Retrospective Cohort Study: Except for Rituximab, most immunosuppressive medicines were not associated with increased risk of mechanical ventilation or death in patients hospitalized with Covid-19.
2 Dec, 2021 | 10:07h | UTCCommentaries:
What does endemic COVID-19 mean for the future of rituximab? – The Lancet Rheumatology
Study: Immune-suppressed not at higher risk of poor COVID outcomes – CIDRAP
Commentary on Twitter
NEW RESEARCH—Long-term use of immunosuppressive medicines and in-hospital #COVID19 outcomes: data from N3C shows no increased risk of mechanical ventilation or in-hospital death with the exception of #rituximab https://t.co/vEyTzfvK5q #LancetRheumatology
@JohnsHopkins pic.twitter.com/NqlttjGrpj— The Lancet Rheumatology (@TheLancetRheum) November 16, 2021
Fluvoxamine for the early treatment of SARS-CoV-2 Infection: a review of current evidence.
2 Dec, 2021 | 10:04h | UTCFluvoxamine for the Early Treatment of SARS-CoV-2 Infection: A Review of Current Evidence – Drugs
Related:
FDA panel narrowly recommends authorization of first antiviral pill to treat COVID.
1 Dec, 2021 | 09:56h | UTCFDA panel narrowly recommends authorization of first antiviral pill to treat COVID – STAT
See also: An FDA panel supports Merck COVID drug in mixed vote – NPR
Related:
8 lingering questions about the new Covid pills from Merck and Pfizer.
The U.K. approves Merck’s COVID-19 antiviral pill, calling it a world first.
Merck to allow other nations to produce new COVID-19 antiviral.
Video: Merck’s Covid pill could transform treatment. Here’s how it works.
How antiviral pill Molnupiravir shot ahead in the COVID drug hunt.
What we know — and don’t know — about Merck’s new Covid-19 pill.
Merck’s Covid-19 pill is great news but may not be a game-changer.
Video | A Pill For COVID? A Doctor Explains Molnupiravir.
Using wearable data, a real-time alerting system can be used for the early detection of Covid-19 and other stress events.
1 Dec, 2021 | 09:59h | UTCReal-time alerting system for COVID-19 and other stress events using wearable data – Nature Medicine
Commentary: Scientists develop a smartwatch-based device for early detection of COVID-19 – News Medical
Commentary on Twitter
A study in @NatureMedicine shows that a smartwatch-based alerting system was able to detect pre-symptomatic and asymptomatic SARS-CoV-2 infection in a high percentage of cases. https://t.co/tquzpYa4pV pic.twitter.com/VIq3phKZ7J
— Nature Portfolio (@NaturePortfolio) November 30, 2021
Another randomized trial showed convalescent plasma does not benefit patients hospitalized with Covid-19.
1 Dec, 2021 | 09:49h | UTCRelated:
M-A: Convalescent plasma does not reduce mortality in COVID-19.
M-A: Convalescent plasma is safe but does not improve outcomes in the treatment of COVID-19.
RECOVERY Trial: No benefit from convalescent plasma in patients admitted to hospital with COVID-19.
Commentary on Twitter
The TSUNAMI RCT showed that high-titer convalescent plasma (CP) did not reduce the risk of severe respiratory failure or death in hospitalized patients with #COVID19 pneumonia. https://t.co/4q0S2AtfMj
— JAMA Network Open (@JAMANetworkOpen) November 29, 2021
RCT: Intravenous or intraosseous calcium does not improve the return of spontaneous circulation in adults with out-of-hospital cardiac arrest.
1 Dec, 2021 | 08:46h | UTC
Commentary on Twitter
RCT of IV/IO calcium in OHCA stopped early by safety committee due to concerns about increased mortality in those who received calcium.
Great prehospital research and good to see trial safety monitoring working.https://t.co/wFZEjOMyMO@JAMA_current @CritCareReviews pic.twitter.com/gdi7yfhxZo
— David Anderson (@expensivecare) November 30, 2021
M-A: Efficacy of non-invasive and invasive respiratory management strategies in adult patients with acute hypoxemic respiratory failure.
1 Dec, 2021 | 08:44h | UTC
RCT: Small caliber 14-Fr percutaneous catheters (pigtail) were as effective as 28- to 32-Fr chest tubes in their ability to drain traumatic hemothorax with no difference in complications.
30 Nov, 2021 | 10:11h | UTCThe small (14 Fr) percutaneous catheter (P-CAT) versus large (28–32 Fr) open chest tube for traumatic hemothorax: A multicenter randomized clinical trial – Trauma and Acute Care Surgery (link to abstract – $ for full-text)
Systematic Review: Anticoagulants for acute ischemic stroke.
30 Nov, 2021 | 10:01h | UTCSummary: Early treatment with blood-thinning drugs for people who have had a stroke – Cochrane Library
Original Study: Anticoagulants for acute ischaemic stroke – Cochrane Library
Transient Ischemic Attack: Emergency Department Evaluation and Disposition.
30 Nov, 2021 | 09:56h | UTCTIA: Emergency Department Evaluation and Disposition – emDocs
Related:
Canadian Stroke Best Practice Recommendations for Acute Stroke Management
Podcast: Metabolic Alkalosis and Hypokalemia.
30 Nov, 2021 | 09:57h | UTC#308 Metabolic Alkalosis and Hypokalemia: Kidney Boy Returns! – The Curbsiders
ESCMID COVID-19 Living guidelines: drug treatment and clinical management.
30 Nov, 2021 | 08:40h | UTC
[Press release – not published yet] Merck’s new Covid-19 pill Molnupiravir updated data shows reduced efficacy (30%) for preventing hospitalization and death compared to initial results (50%). Absolute risk reduction of hospitalization and death fell from 7% to 3%.
28 Nov, 2021 | 21:30h | UTCCommentary: New data, analyses take some of the shine off Merck’s Covid pill – STAT
Related:
8 lingering questions about the new Covid pills from Merck and Pfizer.
The U.K. approves Merck’s COVID-19 antiviral pill, calling it a world first.
Merck to allow other nations to produce new COVID-19 antiviral.
Video: Merck’s Covid pill could transform treatment. Here’s how it works.
How antiviral pill Molnupiravir shot ahead in the COVID drug hunt.
What we know — and don’t know — about Merck’s new Covid-19 pill.
Merck’s Covid-19 pill is great news but may not be a game-changer.
Video | A Pill For COVID? A Doctor Explains Molnupiravir.
Commentaries on Twitter
Disappointing!!
?Merck Provides Update on Results from MOVe-OUT Study of Molnupiravir, an Investigational Oral Antiviral Medicine, in At Risk Adults With Mild-to-Moderate COVID-19
N=1433
RRR fell from 50% to 30%
Absolute Risk reduction only 3% #IDTwitter https://t.co/aX2b3xrdnB pic.twitter.com/uXUSQRNWC7— Antibiotic Stewa®️x? Bassam Ghanem (@ABsteward) November 26, 2021
Disappointing from Merck. Updated data for efficacy of their Molnupiravir pill in full trial drops down to 30% from 50%, absolute reduction to 3 from 7 per 100 at interim analysis https://t.co/PyfIBnFNC7 pic.twitter.com/SBDL92aG5M
— Eric Topol (@EricTopol) November 26, 2021
Review: Prevention and management of thrombosis in hospitalized patients with COVID-19 pneumonia.
26 Nov, 2021 | 08:44h | UTC
Review: Noninvasive ventilation and oxygenation strategies.
25 Nov, 2021 | 10:08h | UTCNoninvasive Ventilation and Oxygenation Strategies – Surgical Clinics of North America
Review: COVID-19-associated Invasive Fungal Infection.
24 Nov, 2021 | 08:48h | UTCCOVID-19-associated Invasive Fungal Infection – Open Forum Infectious Diseases
Related:
Consensus Guideline: Defining and managing COVID-19-associated pulmonary aspergillosis
Bacterial and fungal superinfections in critically ill patients with COVID-19
Invasive Fungal Disease complicating COVID-19: when it rains it pours
A national strategy to diagnose COVID-19 associated invasive fungal disease in the ICU
Epidemiology of invasive pulmonary aspergillosis among COVID-19 intubated patients
Commentary on Twitter
A new article in OFID reviews COVID-19-associated fungal infections and addresses gaps in knowledge relating to the epidemiology, diagnosis and management of these infections: https://t.co/JIkkW70zHI#IDSAJournals #OpenForumInfectDis @PaulSaxMD @DrJLi @jobadd @DrPappasID pic.twitter.com/bPmFdKkjmb
— IDSA (@IDSAInfo) November 21, 2021
Chest Pain: Who needs additional testing beyond ECG and Troponin?
24 Nov, 2021 | 08:28h | UTCChest Pain: Who Needs Additional Testing Beyond ECG and Troponin? – JACC: Case Reports
A prospective cohort study showed a 3.1% risk for recurrent venous thromboembolism at 90 days in patients with subsegmental pulmonary embolism managed without anticoagulation.
24 Nov, 2021 | 08:31h | UTCRisk for Recurrent Venous Thromboembolism in Patients With Subsegmental Pulmonary Embolism Managed Without Anticoagulation: A Multicenter Prospective Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentary on Twitter
First prospective study including patients with isolated SSPE managed without anticoagulation published in @AnnalsofIM. Rate of recurrent VTE is 3.1% . Nice collaboration between @INNOVTE1 and @canvector funded by @HeartandStroke https://t.co/GdcbM1fRp1 @OttMethodsCentr
— Marc Carrier (@MarcCarrier1) November 23, 2021
M-A: Colchicine doesn’t lessen COVID-19 severity or stave off risk of death.
23 Nov, 2021 | 08:55h | UTCNews release: Gout drug colchicine doesn’t lessen COVID-19 severity or stave off risk of death – BMJ
Original Study: Efficacy and safety of colchicine in COVID-19: a meta-analysis of randomised controlled trials – RMD Open
Related:
Bowel Perforation: ED presentations, evaluation, and management.
23 Nov, 2021 | 08:19h | UTCBowel Perforation: ED presentations, evaluation, and management – emDocs
Non-invasive respiratory support in the management of acute COVID-19 pneumonia: considerations for clinical practice and priorities for research – “The two randomized controlled trials indicate superiority of non-invasive ventilation over high-flow nasal oxygen in reducing the need for intubation”.
21 Nov, 2021 | 23:15h | UTC
Commentary on Twitter
NEW Personal View—Non-invasive respiratory support in the management of acute #COVID19 #pneumonia: considerations for clinical practice and priorities for research
From Prof Hugh Montgomery & colleagues https://t.co/LLEFz2VLFu pic.twitter.com/owgAjLX5Z6
— The Lancet Respiratory Medicine (@LancetRespirMed) November 10, 2021