[Preprint] PRINCIPLE RCT: Colchicine does not improve time to recovery in outpatients with Covid-19 at higher risk of complications.

Colchicine for COVID-19 in adults in the community (PRINCIPLE): a randomised, controlled, adaptive platform trial – medRxiv

Related: COLCORONA RCT: Colchicine for community-treated patients with COVID-19 – findings suggest it may lower death and hospital admission rates, but further studies are required.

Commentary on Twitter

While COLCORONA trial found limited evidence that colchicine may reduce COVID-19 related hospitalisation/death
???@TrialPrinciple preprint
Colchicine did NOT improve time to recovery in people at higher risk of complications w COVID-19 in the communityhttps://t.co/2sUoeD7sGV pic.twitter.com/fi2THbxewW

— Antibiotic Stewa®️xd ??? Bassam Ghanem (@ABsteward) September 23, 2021