Critical Care
[Preprint] RECOVERY trial shows Baricitinib reduces deaths in patients hospitalized with COVID-19.
4 Mar, 2022 | 10:09h | UTCNews Release: RECOVERY trial shows Baricitinib reduces deaths in patients hospitalised with COVID-19 – University of Oxford
Commentaries:
Arthritis drug reduces mortality in severe COVID-19, huge clinical trial finds – Science
Another life-saving Covid drug identified – BBC
Related:
WHO recommends two new drugs (Baricitinib and Sotrovimab) to treat COVID-19.
RCT: Baricitinib reduced mortality in hospitalized adults with COVID-19.
Randomized trial: Baricitinib plus remdesivir reduce recovery time in patients with COVID-19
Commentary from the author on Twitter (thread – click for more)
RECOVERY pre-print: Baricitinib
Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis https://t.co/g0cNjaBzEL
— Martin Landray (@MartinLandray) March 3, 2022
Carbapenem-resistant Acinetobacter Baumannii: colonization, infection and current treatment options.
4 Mar, 2022 | 08:31h | UTCRelated:
IDSA Guidance on the Treatment of Antimicrobial-Resistant Gram-Negative Infections.
Review: Therapeutic strategies for emerging multidrug-resistant Pseudomonas Aeruginosa.
4 Mar, 2022 | 08:32h | UTCRelated:
IDSA Guidance on the Treatment of Antimicrobial-Resistant Gram-Negative Infections.
RCT: Aspirin and unfractionated heparin increase the risk of symptomatic intracranial hemorrhage in patients undergoing endovascular treatment for ischemic stroke.
3 Mar, 2022 | 08:53h | UTCSafety and efficacy of aspirin, unfractionated heparin, both, or neither during endovascular stroke treatment (MR CLEAN-MED): an open-label, multicentre, randomised controlled trial – The Lancet (link to abstract – $ for full-text)
Cohort Study: High-sensitivity Troponin I after cardiac surgery and 30-day mortality.
3 Mar, 2022 | 08:54h | UTCHigh-Sensitivity Troponin I after Cardiac Surgery and 30-Day Mortality – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries:
NEJM study evaluates levels of HS Troponin after cardiac surgery and risk of death – MedicalResearch
Commentary on Twitter
The levels of high-sensitivity troponin I associated with an increased risk of death within 30 days after cardiac surgery are higher than levels currently used to define clinically important periprocedural myocardial injury. https://t.co/bnwPzQmh1h pic.twitter.com/pdmx23jPdz
— NEJM (@NEJM) March 2, 2022
M-A: Use of tocilizumab and sarilumab alone or in combination with corticosteroids for covid-19.
3 Mar, 2022 | 08:49h | UTCEditorial: Treatment of severe covid-19 with interleukin 6 receptor inhibition – BMJ Medicine
Related study (just published): Mortality Rates Among Hospitalized Patients With COVID-19 Infection Treated With Tocilizumab and Corticosteroids: A Bayesian Reanalysis of a Previous Meta-analysis – JAMA Network Open
RCT: Effect of therapeutic drug monitoring-based dose optimization of piperacillin/tazobactam on sepsis-related organ dysfunction in patients with sepsis.
3 Mar, 2022 | 08:40h | UTC
Commentary on Twitter
Therapeutic drug monitoring‑guided pip/tazo infusion vs fixed dose in #sepsis, TARGET RCT:
🧪no significant difference in mean SOFA
⬇️28-day mortality + ⬆️ clinical/microbiological cure if TDM (no statistical significance)
Results https://t.co/cLS1OQ173I
⬇️Below visual abstract pic.twitter.com/jRjzfNLj1T— Intensive Care Medicine (@yourICM) March 1, 2022
Observational study suggests norepinephrine is a better choice than epinephrine in cardiac arrest patients with post-resuscitation shock.
3 Mar, 2022 | 08:38h | UTCEpinephrine versus norepinephrine in cardiac arrest patients with post-resuscitation shock – Intensive Care Medicine (link to abstract – $ for full-text)
Noradrenaline better vs adrenaline in cardiac arrest pts with post #resus shock?
💉766 pts, 5 🏥
🏥 noradrenaline better survival/neuro-outcome: all-cause & cardiovascular mortality significantly ⬆️ with epinephrine
🖇️ Results #FOAMcc https://t.co/ihuEPg8sGq
⬇️ Visual Abstract pic.twitter.com/aakmkpPxXf— Intensive Care Medicine (@yourICM) February 24, 2022
M-A: Association of tranexamic acid administration with mortality and thromboembolic events in patients with traumatic injury.
3 Mar, 2022 | 07:57h | UTCRelated:
Meta-analysis: Efficacy and safety of tranexamic acid in acute traumatic brain injury
Editorial: Is Tranexamic Acid Going to CRASH the Management of Traumatic Brain Injury?
Cluster RCT: In adults with out-of-hospital cardiac arrest, placement of a supraglottic airway device resulted in similar rates of sustained return of spontaneous circulations compared to endotracheal intubation.
2 Mar, 2022 | 09:07h | UTCCommentary: Cardiac Arrest Patients Don’t Necessarily Do Better With Intubation— Debate on prehospital advanced airway management continues – MedPage Today (free registration required)
Commentary on Twitter
RCT of out-of-hospital cardiac arrest patients randomized to intubation or supraglottic airways, finds no difference in the rate of sustained return of spontaneous circulation, survival to hospital discharge or favorable neurologic outcomes. https://t.co/GX80iczmHC
— JAMA Network Open (@JAMANetworkOpen) February 18, 2022
Anticoagulation in Patients With COVID-19: JACC Review Topic of the Week.
2 Mar, 2022 | 09:03h | UTCCommentary: Review of Anticoagulation in Patients With COVID-19: Key Points – American College of Cardiology
The management of diabetic ketoacidosis in adults—An updated guideline from the Joint British Diabetes Society for Inpatient Care.
1 Mar, 2022 | 09:00h | UTC
RCT: Prophylactic melatonin does not reduce the incidence of delirium in intensive care patients.
1 Mar, 2022 | 08:45h | UTCProphylactic melatonin for delirium in intensive care (Pro-MEDIC): a randomized controlled trial – Intensive Care Medicine (link to abstract – $ for full-text)
Commentaries on Twitter
Enteral prophylactic melatonin initiated early (within 48h of admission) & continued throughout #ICU (MAX 14 consecutive days) do not ⬇️#delirium prevalence vs placebo, Pro-MEDIC multicentre RCT
➡️12🇦🇺ICUs
➡️841 pts
➡️delirium-free assessments 79.2% vs 80%https://t.co/Gt5o1VuRo7 pic.twitter.com/gPRWxxmhHS— Intensive Care Medicine (@yourICM) February 28, 2022
In 841 ICU patients with expected stay >72h, 4 mg melatonin within 48h after admission for 14 days vs placebo made no sign. differences in delirium-free assessments, LoS, 90d mortality, nor quality & quantity of sleep
Good bye Melatonin, we had a good timehttps://t.co/d0dayil99W— Peter Nydahl (@NydahlPeter) February 28, 2022
Guideline: Plasma exchange and glucocorticoid dosing for patients with ANCA-associated vasculitis.
27 Feb, 2022 | 22:40h | UTC
Commentary on Twitter
New rapid recommendation makes a weak recommendation against plasma exchange in patients with low risk of end stage kidney disease, and a weak recommendation in favour of plasma exchange in patients with moderate-high risk of ESKD https://t.co/PeEjSuRIxI #BMJInfographic pic.twitter.com/YR55t6XYhS
— The BMJ (@bmj_latest) February 25, 2022
Major burns: Part 1. Epidemiology, pathophysiology and initial management.
25 Feb, 2022 | 11:04h | UTCMajor burns: Part 1. Epidemiology, pathophysiology and initial management – BJA Education
Review: Aerosol-generating procedures and the anesthetist.
25 Feb, 2022 | 11:02h | UTCAerosol-generating procedures and the anaesthetist – BJA Education
Review: Safe tracheal extubation after general anesthesia.
25 Feb, 2022 | 11:03h | UTCSafe tracheal extubation after general anaesthesia – BJA Education
RCT: In comatose survivors of cardiac arrest, a strategy of suppressing rhythmic and periodic EEG activity with the use of antiseizure medication did not improve neurologic outcomes.
24 Feb, 2022 | 10:45h | UTCTreating Rhythmic and Periodic EEG Patterns in Comatose Survivors of Cardiac Arrest – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
In trial of comatose patients after cardiac arrest, intensive antiseizure treatment adapted from protocols for status epilepticus did not result in fewer poor outcomes at 3 mos than standard treatment. https://t.co/dpH5cgwhvW pic.twitter.com/zVBHBYMRK9
— NEJM (@NEJM) February 23, 2022
M-A: Diagnostic accuracy of point-of-care tests in acute community-acquired lower respiratory tract infections.
23 Feb, 2022 | 10:07h | UTC
Practice Guidance: The prevention of pressure injuries in the positioning and mobilization of patients in the ICU.
22 Feb, 2022 | 08:46h | UTC
M-A: Diagnostic features, management and prognosis of type 2 myocardial infarction compared to type 1 myocardial infarction.
22 Feb, 2022 | 08:34h | UTC
Review: Acute ischemic stroke and its challenges for the intensivist.
22 Feb, 2022 | 08:27h | UTC
Review: Cancer-associated venous thromboembolism.
21 Feb, 2022 | 08:42h | UTCCancer-associated venous thromboembolism – Nature Reviews Disease Primers (if the link is paywalled, try this one)
Infographic: Cancer-associated venous thromboembolism – Nature Reviews Disease Primers (if the link is paywalled, try this one)
Related:
NCCN Guideline: Cancer-Associated Venous Thromboembolic Disease.
ASH 2021 guidelines for prevention and treatment of venous thromboembolism in patients with cancer
Review: venous and arterial thromboembolism in patients with cancer.
RCT: Sub dissociative dose of ketamine with haloperidol vs. fentanyl on pain reduction in patients with acute pain in the emergency department.
21 Feb, 2022 | 08:37h | UTCSub dissociative dose of ketamine with haloperidol versus fentanyl on pain reduction in patients with acute pain in the emergency department; a randomized clinical trial – The American Journal of Emergency Medicine (link to abstract – $ for full-text)
Review | Acute traumatic brain injury in frail patients: the next pandemic.
21 Feb, 2022 | 08:31h | UTCAcute traumatic brain injury in frail patients: the next pandemic – Current Opinion in Critical Care