RCT: Prophylactic melatonin does not reduce the incidence of delirium in intensive care patients.

Prophylactic melatonin for delirium in intensive care (Pro-MEDIC): a randomized controlled trial – Intensive Care Medicine (link to abstract – $ for full-text)

Commentaries on Twitter

Enteral prophylactic melatonin initiated early (within 48h of admission) & continued throughout #ICU (MAX 14 consecutive days) do not ⬇️#delirium prevalence vs placebo, Pro-MEDIC multicentre RCT
➡️12??ICUs
➡️841 pts
➡️delirium-free assessments 79.2% vs 80%https://t.co/Gt5o1VuRo7 pic.twitter.com/gPRWxxmhHS

— Intensive Care Medicine (@yourICM) February 28, 2022

In 841 ICU patients with expected stay >72h, 4 mg melatonin within 48h after admission for 14 days vs placebo made no sign. differences in delirium-free assessments, LoS, 90d mortality, nor quality & quantity of sleep
Good bye Melatonin, we had a good timehttps://t.co/d0dayil99W

— Peter Nydahl (@NydahlPeter) February 28, 2022