Pediatrics – Pulmonology
Test-negative, case-control study: effectiveness of the Pfizer vaccine against COVID-19 in adolescents.
24 Mar, 2022 | 09:44h | UTCEffectiveness of BNT162b2 against COVID-19 in adolescents – The Lancet Infectious Diseases
Commentary on Twitter
Our paper on #COVID19 vaccine effectiveness in teenagers (12-17y) is published @TheLancetInfDis. Rapid waning of protection against symptomatic disease, esp with omicron. Vaccines did reduce delta hospitalisations but too early to assess omicron effects
— Shamez Ladhani (@ShamezLadhani) March 23, 2022
Higher cigarette taxes could reduce child deaths, first global estimates suggest.
24 Mar, 2022 | 08:25h | UTCNews Release: Higher cigarette taxes reduce child deaths, first global estimates suggest – Imperial College London
Original Study: Cigarette taxation and neonatal and infant mortality: A longitudinal analysis of 159 countries – PLOS Global Public Health
New WHO guidelines on the management of tuberculosis in children and adolescents.
22 Mar, 2022 | 09:52h | UTC
Retrospective Cohort: Asthma in children and adolescents is not associated with increased risk of SARS-CoV-2 infection.
15 Mar, 2022 | 08:55h | UTCAsthma and the Risk of SARS-CoV-2 Infection Among Children and Adolescents – Pediatrics
Commentary: Kids with asthma not at higher risk of COVID-19, study finds – CIDRAP
Related:
We expected people with asthma to fare worse during COVID. Turns out they’ve had a break.
Asthma in COVID-19 hospitalizations: An overestimated risk factor?
Open Label RCT: Azithromycin for poorly controlled asthma in children.
15 Mar, 2022 | 08:39h | UTCAzithromycin for Poorly Controlled Asthma in Children: A randomized controlled trial – CHEST (link to abstract – $ for full-text)
Commentary: Adding azithromycin to standard care improves asthma control, exacerbations in children – Healio
RCT: In children with nonsevere, drug-susceptible tuberculosis, treatment for 4 months is noninferior to treatment for 6 months.
10 Mar, 2022 | 11:03h | UTCNews Release: Treatment length reduced for children with tuberculosis – University College London
Commentary on Twitter
Completing 6 months of treatment for tuberculosis in children is a challenge. In this open-label trial involving 1204 children in sub-Saharan Africa and India, 4 months of antituberculosis therapy was noninferior to 6 months of therapy. https://t.co/zkD4URWMru pic.twitter.com/LFR6ZzTKgs
— NEJM (@NEJM) March 9, 2022
Association of acute respiratory failure in early childhood with long-term neurocognitive outcomes.
9 Mar, 2022 | 08:41h | UTCAssociation of Acute Respiratory Failure in Early Childhood With Long-term Neurocognitive Outcomes – JAMA (link to abstract – $ for full-text)
Commentaries:
IQ Lower for Survivors of PICU Respiratory Failure Hospitalization – HealthDay
RCT: Azithromycin is not effective for the prevention of recurrent wheeze following severe respiratory syncytial virus bronchiolitis.
8 Mar, 2022 | 08:49h | UTCCommentaries:
Commentary on Twitter
This RCT tested oral azithromycin vs placebo to reduce recurrent wheeze (RW) in 1-18-month-olds hospitalized with acute severe RSV bronchiolitis. Azithromycin did not reduce occurrence of RW and may increase risk of RW in some groups. #AAAAI22 #Asthma #EBM https://t.co/jYcBuiQ8aY pic.twitter.com/u65NbQaIlX
— NEJM Evidence (@NEJMEvidence) February 28, 2022
Systematic Review: Effect of asthma education on health outcomes in children.
25 Feb, 2022 | 11:09h | UTC
Study identifies risk factors for severe CoviD-19 in children.
15 Feb, 2022 | 10:01h | UTCRisk Factors for Severe COVID-19 in Children – Pediatrics
Cohort Study: Physical and mental health 3 months after SARS-CoV-2 infection (long COVID) among adolescents in England.
9 Feb, 2022 | 10:12h | UTCCommentary: Long COVID and kids: more research is urgently needed – Nature
Related:
Editorial | Long covid in children and adolescents – “Risk appears low, but many questions remain”.
Review: Long COVID symptoms in children rarely persist beyond three months.
Commentary on Twitter (thread – click for more)
NEW RESEARCH: free! Two studies on adolescent #LongCovid. Both found high symptom burden in COVID positive and negative participants; very heterogenous symptom profile. Pandemic has had profound impact on all adolescents. https://t.co/YzU3ogXZrw pic.twitter.com/ina0DgPxBf
— The Lancet Child & Adolescent Health (@LancetChildAdol) February 8, 2022
ATS Guideline: Outpatient respiratory management of infants, children, and adolescents with post-prematurity respiratory disease.
21 Jan, 2022 | 09:55h | UTC
RCT: In children with community-acquired pneumonia, outpatient antibiotic therapy for 5 days resulted in similar clinical response rates compared to a standard 10-day strategy.
19 Jan, 2022 | 08:39h | UTCShort- vs Standard-Course Outpatient Antibiotic Therapy for Community-Acquired Pneumonia in Children: The SCOUT-CAP Randomized Clinical Trial – JAMA Pediatrics (free for a limited period)
Commentaries:
Trial finds 5 days of antibiotics superior to 10 for kids with pneumonia – CIDRAP
Related:
ACP Guidance: Appropriate Use of Short-Course Antibiotics in Common Infections
RCT: 7 days of antibiotic therapy as good as 14 days for afebrile men with urinary tract infection.
Meta-Analysis: Efficacy of Short-Course Antibiotic Treatments for Community-Acquired Pneumonia
RCT: Among children between the ages of 6 and 11 years with uncontrolled moderate-to-severe asthma, add-on Dupilumab reduced exacerbations and improved lung function.
9 Dec, 2021 | 10:21h | UTCDupilumab in Children with Uncontrolled Moderate-to-Severe Asthma – New England Journal of Medicine
Bronchiolitis: evidence and guidance for practice.
8 Dec, 2021 | 09:55h | UTCBronchiolitis: evidence and guidance for practice – Evidently Cochrane
AAP Clinical Report | Tuberculosis Infection in Children and Adolescents.
2 Dec, 2021 | 09:58h | UTCTuberculosis Infection in Children and Adolescents: Testing and Treatment – Pediatrics
AAP Clinical Report: Biologics for Asthma and Allergic Skin Diseases in Children.
19 Nov, 2021 | 10:34h | UTCBiologics for Asthma and Allergic Skin Diseases in Children – Pediatrics
Deaths in children and young people in England after SARS-CoV-2 infection during the first pandemic year – “In total, 99.995% of children and young people with a positive SARS-CoV-2 test survived”.
12 Nov, 2021 | 10:39h | UTCRelated:
Study: Children and young people remain at low risk of COVID-19 mortality
Commentaries on Twitter
Just published @NatureMedicine
An in-depth analysis of the 25 children who died from Covid in England during the 1st year of the pandemichttps://t.co/QK3gk1BXy5
Great that 99.995% of children w/ a positive test survived (not what is driving the need for ?in kids) pic.twitter.com/moXKl8ysmA— Eric Topol (@EricTopol) November 11, 2021
A clinical review of all pediatric deaths in England from March 2020 to February 2021 attributes 25 deaths to SARS-CoV-2 infection and identifies risk factors to guide interventions, according to a @NatureMedicine article. https://t.co/Bpjhf5sgow pic.twitter.com/v24Zf9CsXK
— Nature Portfolio (@NaturePortfolio) November 11, 2021
M-A: Risk factors for poor prognosis in children and adolescents with COVID-19.
22 Oct, 2021 | 10:24h | UTC
State of the Art Review: Diagnosis and management of bronchopulmonary dysplasia.
21 Oct, 2021 | 09:56h | UTCDiagnosis and management of bronchopulmonary dysplasia – The BMJ
Commentary on Twitter
This new clinical review evaluates the various clinical definitions, imaging modalities, and biomarker data that are helpful in making an early diagnosis of bronchopulmonary dysplasia (BPD), as well as the evidence on the prevention and treatment of BPD https://t.co/ITqe8WMkNl
— The BMJ (@bmj_latest) October 20, 2021
RCT confirms antibiotics are not needed for most children with uncomplicated lower respiratory tract infection if pneumonia is not suspected clinically.
24 Sep, 2021 | 09:00h | UTC
Commentary on Twitter
#Antibiotic resistance is a global public health threat.
New trial indicates, unless pneumonia is suspected, clinicians should provide safety-netting advice but not prescribe antibiotics for most children presenting with chest infections. https://t.co/mOwLG5rZd1 #AMR pic.twitter.com/b0c7Z5flQk
— The Lancet (@TheLancet) September 23, 2021
AHA Scientific Statement: Sleep‐disordered breathing and cardiovascular disease in children and adolescents.
23 Sep, 2021 | 10:02h | UTCNews release: Obstructive sleep apnea is common in kids and may impact blood pressure, heart health – American Heart Association
Covid: Single jab recommended for 12 to 15-year-olds by UK’s top doctors.
14 Sep, 2021 | 10:05h | UTCCovid: Single jab recommended for 12 to 15-year-olds by UK’s top doctors – BBC
See also: Covid-19: Children aged 12-15 should be offered vaccine, say UK’s chief medical officers – The BMJ
The Delta Covid variant and children: transmission in kids is low and only 2% hospitalized, report finds.
12 Sep, 2021 | 21:56h | UTCNews release: COVID-19 Delta variant in schools and early childhood education and care services in NSW, Australia: 16 June to 31 July 2021
Commentary on Twitter (thread – click for more)
Amazing education settings outbreak data from the Delta #COVID19 outbreak in NSW ??
Primary/Secondary schools mostly closed, so limited info to draw on (Attack rate v low, <2%)
BUT early years settings fully open with no masks!
What happened? ?https://t.co/mG05e5Mp3T
1/
— Alasdair Munro (@apsmunro) September 8, 2021
Kawasaki Disease and Multisystem Inflammatory Syndrome in Children: An Overview and Comparison.
13 Aug, 2021 | 10:01h | UTCRelated:
Cohort study: Six month follow-up of Multisystem Inflammatory Syndrome in Children.
Clinical Update: Acute covid-19 and multisystem inflammatory syndrome in children
Cutaneous findings in SARS-CoV-2-associated Multisystem Inflammatory Disease in Children (MIS-C)
SR: Multisystem inflammatory syndrome in children related to COVID-19