Pediatrics – Infectious Diseases | Page 9 of 19 | Links Medicus Content Curation & Alerts in Medicine

This RCT tested oral azithromycin vs placebo to reduce recurrent wheeze (RW) in 1-18-month-olds hospitalized with acute severe RSV bronchiolitis. Azithromycin did not reduce occurrence of RW and may increase risk of RW in some groups. #AAAAI22 #Asthma #EBM https://t.co/jYcBuiQ8aY pic.twitter.com/u65NbQaIlX

— NEJM Evidence (@NEJMEvidence) February 28, 2022

RCT: Nirsevimab for prevention of RSV in healthy late-preterm and term infants.

3 Mar, 2022 | 09:42h | UTC

Nirsevimab for Prevention of RSV in Healthy Late-Preterm and Term Infants – New England Journal of Medicine

Commentaries:

Nirsevimab Protects Late-Preterm, Term Infants from RSV-Related Lower RTI, Study Finds – AJMC

Nirsevimab Prophylaxis Wards Off RSV Infections in Healthy Infants— Monoclonal antibody showed 74.5% efficacy against RSV infections requiring medical care – MedPage Today (free registration required)

Myocarditis following COVID-19 BNT162b2 vaccination among adolescents in Hong Kong.

3 Mar, 2022 | 08:43h | UTC

Myocarditis Following COVID-19 BNT162b2 Vaccination Among Adolescents in Hong Kong – JAMA Pediatrics

Commentary: Study: Dosing change could reduce COVID-19 vaccine heart side effect in teens – UPI

[Preprint] Post-marketing active surveillance of myocarditis and pericarditis following vaccination with COVID-19 mRNA vaccines in persons aged 12-39 years in Italy.

Myocarditis after BNT162b2 vaccination in Israeli adolescents.

Myocarditis cases reported after mRNA-Based COVID-19 vaccination in the US from December 2020 to August 2021.

A case-control study showed an increased risk of myocarditis after COVID-19 vaccination with a messenger RNA vaccine compared to an inactivated virus vaccine.

[Preprint] Risk of myocarditis following sequential COVID-19 vaccinations by age and sex.

Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination vs. SARS-CoV-2 infection.

Case series with 139 adolescents and young adults with suspected myocarditis following mRNA vaccination showed most cases had a mild clinical course and rapid resolution of symptoms.

Heart-inflammation risk from Pfizer COVID vaccine is very low.

Large cohort study with over 2.5 million individuals showed the incidence of myocarditis after the Pfizer vaccine was 2.13 cases per 100,000 persons.

Study with over 5.1 million vaccinated individuals showed the incidence of myocarditis after the receipt of the Pfizer vaccine was low and more common after the second dose in young male recipients.

Large Observational study shows Pfizer Covid vaccine is mostly safe but is associated with increased risk of myocarditis, adenopathy, appendicitis, and herpes zoster.

Guideline: Management of Clostridioides difficile infection in hematopoietic cell transplant recipients.

3 Mar, 2022 | 08:17h | UTC

American Society for Transplantation and Cellular Therapy Series: #5 – Management of Clostridioides difficile infection in hematopoietic cell transplant recipients – Transplantation and Cellular Therapy

See other articles in the series:

American Society of Transplantation and Cellular Therapy Series, 1: Enterobacterales Infection Prevention and Management after Hematopoietic Cell Transplantation

American Society of Transplantation and Cellular Therapy Series, 2: Management and Prevention of Aspergillosis in Hematopoietic Cell Transplantation Recipients

American Society for Transplantation and Cellular Therapy Series: #3—Prevention of Cytomegalovirus Infection and Disease After Hematopoietic Cell Transplantation

American Society for Transplantation and Cellular Therapy Series: #4 – Cytomegalovirus treatment and management of resistant or refractory infections after hematopoietic cell transplantation

[Preprint] Study shows significantly reduced effectiveness of the Pfizer vaccine in children 5 to 11 after the emergency of the Omicron variant.

1 Mar, 2022 | 08:54h | UTC

Effectiveness of the BNT162b2 vaccine among children 5-11 and 12-17 years in New York after the Emergence of the Omicron Variant – medRxiv

Commentaries:

Pfizer Covid vaccine is less effective in kids 5 to 11, study finds – STAT

Pfizer Covid-19 vaccine effectiveness fell quickly for kids during Omicron surge but still offered some protection against severe disease – CNN

More mask mandates fall as poor COVID vaccine protection noted in young kids – CIDRAP

Study suggests multisystem inflammatory syndrome in children (MIS-C) is rare among vaccinated teens.

25 Feb, 2022 | 11:29h | UTC

Reported cases of multisystem inflammatory syndrome in children aged 12–20 years in the USA who received a COVID-19 vaccine, December, 2020, through August, 2021: a surveillance investigation – The Lancet Child & Adolescent Health

Commentaries:

When vaccine adverse event reporting generates hope, not fear – The Lancet Child & Adolescent Health

MIS-C rare in COVID-vaccinated teens, study finds – CIDRAP

Vaccination Greatly Reduces Odds of MIS-C in Teens Who Get COVID – HealthDay

Commentary on Twitter

New study from @CDCgov finds that multi-system inflammatory syndrome in children (#MISC) is rare among 12 to 20-year-olds who have received #COVID19 vaccination (1.0 case per million individuals receiving one or more doses)https://t.co/BpsXSpMMcH

— The Lancet Child & Adolescent Health (@LancetChildAdol) February 23, 2022

Mortality from congenital Zika Syndrome — nationwide cohort study in Brazil.

24 Feb, 2022 | 10:18h | UTC

Mortality from Congenital Zika Syndrome — Nationwide Cohort Study in Brazil – New England Journal of Medicine

New U.S. childhood and adolescent immunization schedule released by ACIP.

18 Feb, 2022 | 10:05h | UTC

England to offer Covid jab to five to 11-year-olds.

17 Feb, 2022 | 10:09h | UTC

England to offer Covid jab to five to 11-year-olds – BBC

Risk factors for PICU admission and death among children and young people hospitalized with COVID-19 and PIMS-TS in England during the first pandemic year.

17 Feb, 2022 | 09:58h | UTC

Risk factors for PICU admission and death among children and young people hospitalized with COVID-19 and PIMS-TS in England during the first pandemic year – Nature Medicine

Commentary: Studies detail risk of severe COVID-19, GI problems in kids – CIDRAP

Commentary on Twitter

The risk of intensive care unit admission among children with COVID-19 is affected by age, ethnicity and comorbidities, according to a @NatureMedicine paper. Understanding these modifiers might help identify at-risk children and guide interventions. https://t.co/MIkLecyNI6 pic.twitter.com/JtN3Ab4Lu7

— Nature Portfolio (@NaturePortfolio) December 20, 2021

Guidance for systematic integration of undernutrition in attributing cause of death in children.

17 Feb, 2022 | 08:46h | UTC

Guidance for Systematic Integration of Undernutrition in Attributing Cause of Death in Children – Clinical Infectious Diseases

Seminar: Measles.

16 Feb, 2022 | 10:15h | UTC

Measles – The Lancet (free registration required)

ACR Guidance for Multisystem Inflammatory Syndrome in Children Associated With SARS–CoV-2 and Hyperinflammation in Pediatric COVID-19.

15 Feb, 2022 | 10:17h | UTC

American College of Rheumatology Clinical Guidance for Multisystem Inflammatory Syndrome in Children Associated With SARS–CoV-2 and Hyperinflammation in Pediatric COVID-19: Version 3 – Arthritis & Rheumatism

Commentary and summary: ACR Updates Clinical Guidance for Multisystem Inflammatory Syndrome in Children Associated With COVID – RheumNow

Study identifies risk factors for severe CoviD-19 in children.

15 Feb, 2022 | 10:01h | UTC

Risk Factors for Severe COVID-19 in Children – Pediatrics

Pfizer and FDA pull back from plan to expedite review of Covid-19 vaccine in children under 5.

13 Feb, 2022 | 22:51h | UTC

Pfizer and FDA pull back from plan to expedite review of Covid-19 vaccine in young children – STAT

Novavax says protein vaccine works for kids as young as 12.

13 Feb, 2022 | 22:54h | UTC

Novavax says protein vaccine works for kids as young as 12 – Associated Press

Press Release: Novavax Announces Positive Results of COVID-19 Vaccine in Pediatric Population of PREVENT-19 Phase 3 Clinical Trial

Randomized trial with nearly 30.000 individuals showed Novavax vaccine was safe and had an overall efficacy of 90.4% against symptomatic infections.

RCT: Novavax vaccine conferred 89.7% protection against symptomatic SARS-CoV-2 infection and 100% protection against hospitalizations or deaths.

Opinion | The mRNA vaccines are extraordinary, but Novavax is even better.

(Press release – not published yet) Novavax COVID-19 vaccine demonstrates 90% overall efficacy and 100% protection against moderate and severe disease.

RCT: Novavax vaccine is 49.4% effective against B.1.351 SARS-CoV-2 variant.

[Press release – not published yet] Novavax reports 96% efficacy against original strain of COVID-19, 86% efficacy against B.1.1.7 variant, and 55% efficacy against B1.351 variant

New COVID-19 vaccines: here’s how the promising Novavax and Johnson & Johnson jabs work

Covid-19: Novavax vaccine efficacy is 86% against UK variant and 60% against South African variant

First research definition for ‘Long COVID’ in kids and young people formally agreed.

13 Feb, 2022 | 22:45h | UTC

News Release: First research definition for ‘Long COVID’ in kids and young people formally agreed – BMJ

Original Article (preprint): Long COVID (Post-COVID-19 condition) in Children: a modified Delphi Process – Archives of Disease in Childhood

Commentaries:

Expert reaction to Delphi consensus study on a long-COVID definition in children – Science Media Centre

Long covid: “Holistic” approach is best, given range of symptoms, say researchers – The BMJ

Cohort Study: Physical and mental health 3 months after SARS-CoV-2 infection (long COVID) among adolescents in England.

A nationwide cohort study in Denmark showed Long Covid in children is rare and mainly of short duration.

E ditorial | Long covid in children and adolescents – “Risk appears low, but many questions remain”.

M-A: Persistent symptoms following SARS-CoV-2 infection among children and young people – “Higher study quality was associated with lower prevalence of all symptoms, except loss of smell and cognitive symptoms”.

Review: Long COVID symptoms in children rarely persist beyond three months.

Cohort study: long term follow-up showed most patients with post–COVID-19 Multisystem Inflammatory Syndrome in Children had good outcomes with no significant medium- or long-term sequelae.

Do kids get long COVID? And how often? A pediatrician looks at the data – Children also get Long Covid, but much less often than adults.

Illness duration and symptom profile in symptomatic school-aged children tested for SARS-CoV-2 – “Only 25 (1.8%) of 1379 children experienced symptoms for at least 56 days.”

Long-term Symptoms After SARS-CoV-2 Infection in Children and Adolescents – “This study found a low prevalence of symptoms compatible with long COVID in a randomly selected cohort of children assessed 6 months after serologic testing”.

Study shows low incidence of post-acute COVID-19 symptoms (“Long Covid”) in children after mild disease

Special Issue: Evidence-based strategies for better antibiotic prescribing in primary care.

13 Feb, 2022 | 22:40h | UTC

Editorial: Antibiotic stewardship – Australian Journal of General Practice

Antibiotic stewardship: A review of successful, evidence-based primary care strategies – Australian Journal of General Practice

Evidence-based strategies for better antibiotic prescribing – Australian Journal of General Practice

How can general practitioners reduce antibiotic prescribing in collaboration with their patients? – Australian Journal of General Practice

Study shows a lack of association of Group A Streptococcal infections and onset of tics.

13 Feb, 2022 | 22:04h | UTC

Lack of Association of Group A Streptococcal Infections and Onset of Tics: European Multicenter Tics in Children Study – Neurology (link to abstract – $ for full-text)

News Release: Does strep throat lead to the development of tics? – American Academy of Neurology

Commentaries:

Strep Does Not Lead to Tics, Study Finds – NeurologyToday

Group A Strep Infection Not Tied to Tics in Children With Family History – HealthDay

Commentary on Twitter

https://twitter.com/ChristosGanos/status/1491415406418231300

Clinical practice guideline on tympanostomy tubes in children.

10 Feb, 2022 | 10:10h | UTC

Executive Summary of Clinical Practice Guideline on Tympanostomy Tubes in Children (Update) – Otolaryngology–Head and Neck Surgery

Cohort Study: Physical and mental health 3 months after SARS-CoV-2 infection (long COVID) among adolescents in England.

9 Feb, 2022 | 10:12h | UTC

Physical and mental health 3 months after SARS-CoV-2 infection (long COVID) among adolescents in England (CLoCk): a national matched cohort study – The Lancet Child & Adolescent Health

Editorial: Assessing the impact of the pandemic in children and adolescents: SARS-CoV-2 infection and beyond – The Lancet Child & Adolescent Health

Commentary: Long COVID and kids: more research is urgently needed – Nature

A nationwide cohort study in Denmark showed Long Covid in children is rare and mainly of short duration.

E ditorial | Long covid in children and adolescents – “Risk appears low, but many questions remain”.

Review: Long COVID symptoms in children rarely persist beyond three months.

Cohort study: long term follow-up showed most patients with post–COVID-19 Multisystem Inflammatory Syndrome in Children had good outcomes with no significant medium- or long-term sequelae.

Do kids get long COVID? And how often? A pediatrician looks at the data – Children also get Long Covid, but much less often than adults.

Illness duration and symptom profile in symptomatic school-aged children tested for SARS-CoV-2 – “Only 25 (1.8%) of 1379 children experienced symptoms for at least 56 days.”

Study shows low incidence of post-acute COVID-19 symptoms (“Long Covid”) in children after mild disease

Commentary on Twitter (thread – click for more)

NEW RESEARCH: free! Two studies on adolescent #LongCovid. Both found high symptom burden in COVID positive and negative participants; very heterogenous symptom profile. Pandemic has had profound impact on all adolescents. https://t.co/YzU3ogXZrw pic.twitter.com/ina0DgPxBf

— The Lancet Child & Adolescent Health (@LancetChildAdol) February 8, 2022

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