Pediatrics – Infectious Diseases
Case-control study: In children 5 to 11 years of age, the Pfizer vaccine showed an effectiveness of 68% against hospitalization caused by the Omicron variant.
31 Mar, 2022 | 08:37h | UTCCommentary: COVID vaccination of children age 5-11 cut omicron hospitalizations by 68% – Children’s Hospital Boston
Commentary on Twitter
BNT162b2 vaccination reduced the risk of omicron-associated hospitalization by two thirds among children 5 to 11 years of age. https://t.co/mQcchQqbtH pic.twitter.com/Qzy8qKg1wC
— NEJM (@NEJM) March 30, 2022
Podcast: Deep dive into deep neck infections in children.
31 Mar, 2022 | 07:57h | UTC#47: Deep Dive into Deep Neck Infections with Dr. Travis Crook – The Cribsiders
Cohort Study: Short-term outcomes of corticosteroid monotherapy in multisystem inflammatory syndrome in children.
30 Mar, 2022 | 10:40h | UTC
Commentary on Twitter
In this study, corticosteroid monotherapy successfully treated a subset of patients with mild multisystem inflammatory syndrome in children. https://t.co/fuhHeBSaRp
— JAMA Pediatrics (@JAMAPediatrics) March 28, 2022
Moderna to ask FDA to authorize Covid-19 vaccine in children 6 months to 6 years.
28 Mar, 2022 | 10:01h | UTCModerna to ask FDA to authorize Covid-19 vaccine in children 6 months to 6 years – STAT
The prevalence of penicillin allergy labeling ranged from 0.9% to 10.2% across practices in a large pediatric cohort, raising questions regarding the validity of those labels and the unnecessary use of second-line antibiotics that may follow.
28 Mar, 2022 | 09:48h | UTCM-A: Most patients with allergy to Penicillin can be given Cefazolin
Podcast: A Clinical Pharmacologist’s Perspective on Penicillin Allergy
Study: Development and Validation of a Penicillin Allergy Clinical Decision Rule
Consensus Recommendations: Management of a Surgical Patient with a Label of Penicillin Allergy
Practical Guide for Pharmacists to Successfully Implement Penicillin Allergy Skin Testing
NICE: Double Check Patients with ‘Penicillin Allergy’ to Avoid Increased MRSA Risk
Commentary on Twitter
In this cohort study of more than 330,000 children, less than 5% were labeled with penicillin allergy with wide variation across practices, with 8% of those labeled despite not receiving any penicillin prescription. https://t.co/kvXcm1RKRd
— JAMA Network Open (@JAMANetworkOpen) March 15, 2022
Retrospective Cohort: A population-based study in Sweden and Norway did not find an increased risk of pregnancy complications after COVID-19 vaccination.
28 Mar, 2022 | 09:51h | UTCAssociation of SARS-CoV-2 Vaccination During Pregnancy With Pregnancy Outcomes – JAMA
See also: Association of COVID-19 Vaccination in Pregnancy With Adverse Peripartum Outcomes – JAMA
Editorial: COVID-19 mRNA Vaccines During Pregnancy: New Evidence to Help Address Vaccine Hesitancy – JAMA
News Release: No increase in pregnancy complications after COVID-19 vaccination – Karolinska Institutet
Test-negative, case-control study: effectiveness of the Pfizer vaccine against COVID-19 in adolescents.
24 Mar, 2022 | 09:44h | UTCEffectiveness of BNT162b2 against COVID-19 in adolescents – The Lancet Infectious Diseases
Commentary on Twitter
Our paper on #COVID19 vaccine effectiveness in teenagers (12-17y) is published @TheLancetInfDis. Rapid waning of protection against symptomatic disease, esp with omicron. Vaccines did reduce delta hospitalisations but too early to assess omicron effects
— Shamez Ladhani (@ShamezLadhani) March 23, 2022
RCT: High dose Rifampicin with or without Levofloxacin vs. standard of care for pediatric tuberculous meningitis.
24 Mar, 2022 | 08:12h | UTC
New WHO guidelines on the management of tuberculosis in children and adolescents.
22 Mar, 2022 | 09:52h | UTC
Rapid point-of-care genotyping to avoid aminoglycoside-induced ototoxicity in neonatal intensive care.
22 Mar, 2022 | 08:01h | UTCEditorial: Genetic Testing in Newborns Moves From Rare to Routine Application
Commentary on Twitter
The MT-RNR1 m.1555A>G variant predisposes to profound aminoglycoside-induced ototoxicity
The MT-RNR1 POCT was able to genotype the m.1555A>G variant in 26 minutes. #IDTwitter #medtwitter #TwitteRx #MedEd #PIDTwitter https://t.co/BbkpNMiNHN— Antibiotic Steward Bassam Ghanem (@ABsteward) March 21, 2022
M-A: Comparative efficacy and safety of pharmacological interventions to prevent Mother-to-Child transmission of hepatitis B virus.
18 Mar, 2022 | 07:37h | UTC
Trends in HPV–associated cancers, demographic characteristics, and vaccinations in the US, 2001-2017.
17 Mar, 2022 | 08:16h | UTCAuthor Interview: Trends in Human Papillomavirus–Associated Cancers, Demographic Characteristics, and Vaccinations
Related:
Three-year follow-up of 2-dose versus 3-dose HPV vaccine
CDC: 92% of Human Papillomavirus–Attributable Cancers can be Targeted by HPV Vaccination
Meta-Analysis: Population-level Impact of HPV Vaccination Programs
How to: Clostridioides difficile infection in children.
16 Mar, 2022 | 08:39h | UTCHow to: Clostridioides difficile infection in children – Clinical Microbiology and Infection
Retrospective Cohort: Asthma in children and adolescents is not associated with increased risk of SARS-CoV-2 infection.
15 Mar, 2022 | 08:55h | UTCAsthma and the Risk of SARS-CoV-2 Infection Among Children and Adolescents – Pediatrics
Commentary: Kids with asthma not at higher risk of COVID-19, study finds – CIDRAP
Related:
We expected people with asthma to fare worse during COVID. Turns out they’ve had a break.
Asthma in COVID-19 hospitalizations: An overestimated risk factor?
SHEA neonatal intensive care unit (NICU) white paper series: Practical approaches for preventing central line-associated bloodstream infections.
11 Mar, 2022 | 09:53h | UTC
RCT: In children with nonsevere, drug-susceptible tuberculosis, treatment for 4 months is noninferior to treatment for 6 months.
10 Mar, 2022 | 11:03h | UTCNews Release: Treatment length reduced for children with tuberculosis – University College London
Commentary on Twitter
Completing 6 months of treatment for tuberculosis in children is a challenge. In this open-label trial involving 1204 children in sub-Saharan Africa and India, 4 months of antituberculosis therapy was noninferior to 6 months of therapy. https://t.co/zkD4URWMru pic.twitter.com/LFR6ZzTKgs
— NEJM (@NEJM) March 9, 2022
Recommendations for diagnosis and prevention of Cytomegalovirus-associated necrotizing enterocolitis in breast-fed preterm infants.
10 Mar, 2022 | 10:37h | UTC
Extending the reach of antimicrobial stewardship to pediatric patients.
10 Mar, 2022 | 10:12h | UTC
Association of acute respiratory failure in early childhood with long-term neurocognitive outcomes.
9 Mar, 2022 | 08:41h | UTCAssociation of Acute Respiratory Failure in Early Childhood With Long-term Neurocognitive Outcomes – JAMA (link to abstract – $ for full-text)
Commentaries:
IQ Lower for Survivors of PICU Respiratory Failure Hospitalization – HealthDay
RCT: Azithromycin is not effective for the prevention of recurrent wheeze following severe respiratory syncytial virus bronchiolitis.
8 Mar, 2022 | 08:49h | UTCCommentaries:
Commentary on Twitter
This RCT tested oral azithromycin vs placebo to reduce recurrent wheeze (RW) in 1-18-month-olds hospitalized with acute severe RSV bronchiolitis. Azithromycin did not reduce occurrence of RW and may increase risk of RW in some groups. #AAAAI22 #Asthma #EBM https://t.co/jYcBuiQ8aY pic.twitter.com/u65NbQaIlX
— NEJM Evidence (@NEJMEvidence) February 28, 2022
RCT: Nirsevimab for prevention of RSV in healthy late-preterm and term infants.
3 Mar, 2022 | 09:42h | UTCCommentaries:
Nirsevimab Protects Late-Preterm, Term Infants from RSV-Related Lower RTI, Study Finds – AJMC
Nirsevimab Prophylaxis Wards Off RSV Infections in Healthy Infants— Monoclonal antibody showed 74.5% efficacy against RSV infections requiring medical care – MedPage Today (free registration required)
Related: Randomized trial: Single-dose nirsevimab for prevention of RSV in preterm infants
Myocarditis following COVID-19 BNT162b2 vaccination among adolescents in Hong Kong.
3 Mar, 2022 | 08:43h | UTCMyocarditis Following COVID-19 BNT162b2 Vaccination Among Adolescents in Hong Kong – JAMA Pediatrics
Commentary: Study: Dosing change could reduce COVID-19 vaccine heart side effect in teens – UPI
Related:
Myocarditis after BNT162b2 vaccination in Israeli adolescents.
[Preprint] Risk of myocarditis following sequential COVID-19 vaccinations by age and sex.
Heart-inflammation risk from Pfizer COVID vaccine is very low.
Guideline: Management of Clostridioides difficile infection in hematopoietic cell transplant recipients.
3 Mar, 2022 | 08:17h | UTCSee other articles in the series:
[Preprint] Study shows significantly reduced effectiveness of the Pfizer vaccine in children 5 to 11 after the emergency of the Omicron variant.
1 Mar, 2022 | 08:54h | UTCCommentaries:
Pfizer Covid vaccine is less effective in kids 5 to 11, study finds – STAT
More mask mandates fall as poor COVID vaccine protection noted in young kids – CIDRAP
Study suggests multisystem inflammatory syndrome in children (MIS-C) is rare among vaccinated teens.
25 Feb, 2022 | 11:29h | UTCCommentaries:
When vaccine adverse event reporting generates hope, not fear – The Lancet Child & Adolescent Health
MIS-C rare in COVID-vaccinated teens, study finds – CIDRAP
Vaccination Greatly Reduces Odds of MIS-C in Teens Who Get COVID – HealthDay
Commentary on Twitter
New study from @CDCgov finds that multi-system inflammatory syndrome in children (#MISC) is rare among 12 to 20-year-olds who have received #COVID19 vaccination (1.0 case per million individuals receiving one or more doses)https://t.co/BpsXSpMMcH
— The Lancet Child & Adolescent Health (@LancetChildAdol) February 23, 2022