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Internal Medicine

Despite the ongoing spread of Omicron, some European countries have decided to lift Covid-19 restrictions.

30 Jan, 2022 | 14:37h | UTC

England lifts COVID restrictions as omicron threat recedes – Associated Press

Denmark confirms plan to lift Covid-19 restrictions on February 1st – The Local dk

Netherlands lifts toughest Covid curbs with Denmark and France set to follow – The Guardian

Denmark will lift nearly ALL Covid restrictions within days and return to ‘life as we knew it before corona’ after vaccine programme proved a ‘super-weapon’ – despite soaring cases – Daily Mail

 

Commentary on Twitter

 

Myocarditis after BNT162b2 vaccination in Israeli adolescents.

30 Jan, 2022 | 14:34h | UTC

Myocarditis after BNT162b2 Vaccination in Israeli Adolescents – New England Journal of Medicine

Related:

Myocarditis cases reported after mRNA-Based COVID-19 vaccination in the US from December 2020 to August 2021.

A case-control study showed an increased risk of myocarditis after COVID-19 vaccination with a messenger RNA vaccine compared to an inactivated virus vaccine.

[Preprint] Risk of myocarditis following sequential COVID-19 vaccinations by age and sex.

Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination vs. SARS-CoV-2 infection.

Case series with 139 adolescents and young adults with suspected myocarditis following mRNA vaccination showed most cases had a mild clinical course and rapid resolution of symptoms.

Heart-inflammation risk from Pfizer COVID vaccine is very low.

Large cohort study with over 2.5 million individuals showed the incidence of myocarditis after the Pfizer vaccine was 2.13 cases per 100,000 persons.

Study with over 5.1 million vaccinated individuals showed the incidence of myocarditis after the receipt of the Pfizer vaccine was low and more common after the second dose in young male recipients.

Large Observational study shows Pfizer Covid vaccine is mostly safe but is associated with increased risk of myocarditis, adenopathy, appendicitis, and herpes zoster.

 

Commentary on Twitter

 

Systematic Review: Low‐carbohydrate vs. balanced‐carbohydrate diets for reducing weight and cardiovascular risk.

30 Jan, 2022 | 14:28h | UTC

Low‐carbohydrate versus balanced‐carbohydrate diets for reducing weight and cardiovascular risk – Cochrane Library

Summary: Low-carbohydrate diets or balanced-carbohydrate diets: which works better for weight loss and heart disease risks? – Cochrane Library

Commentary: Featured review: Low-carbohydrate versus balanced-carbohydrate diets for reducing weight and cardiovascular risk – Cochrane Library

 

Commentary on Twitter

https://twitter.com/CochraneUK/status/1487879806100414474

 

ESPEN practical guideline: Home enteral nutrition.

30 Jan, 2022 | 14:21h | UTC

ESPEN practical guideline: Home enteral nutrition – Clinical Nutrition

 

Guideline Summary: Management of the top 10 most common immune-related adverse events in patients treated with immune checkpoint inhibitor therapy.

30 Jan, 2022 | 14:11h | UTC

Management of the Top 10 Most Common Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy – JCO Oncology Practice

Original Article: ASCO Guideline Update: Management of immune-related adverse events in patients treated with immune checkpoint inhibitor therapy.

Related:

Clinical practice guideline on immune checkpoint inhibitor-related adverse events.

NCCN Guidelines Insights: Management of Immunotherapy-Related Toxicities (several resources on the subject)

 

Systematic Review: Combined intermittent pneumatic leg compression and pharmacological prophylaxis for prevention of venous thromboembolism.

30 Jan, 2022 | 14:04h | UTC

Combined intermittent pneumatic leg compression and pharmacological prophylaxis for prevention of venous thromboembolism – Cochrane Library

 

Review: Essential tremor.

30 Jan, 2022 | 14:08h | UTC

Essential tremor – Nature Reviews Disease Primers (if the link is paywalled, try this one)

Infographic: Essential tremor (if the link is paywalled, try this one)

 

Commentary on Twitter

 

M-A: Helicobacter pylori eradication may result in modest improvement in functional dyspepsia.

30 Jan, 2022 | 14:01h | UTC

Efficacy of Helicobacter pylori eradication therapy for functional dyspepsia: updated systematic review and meta-analysis – Gut (link to abstract – $ for full-text)

Commentary: H. pylori eradication therapy may lead to better outcomes for functional dyspepsia – ACP Gastroenterology

 

M-A: SGLT-2 inhibitors and cardiovascular outcomes in patients with and without a history of heart failure.

30 Jan, 2022 | 13:56h | UTC

SGLT-2 inhibitors and cardiovascular outcomes in patients with and without a history of heart failure: a systematic review and meta-analysis – European Heart Journal – Cardiovascular Pharmacotherapy

 

Commentary on Twitter

 

Differential levels of plasma biomarkers of neurodegeneration in Lewy body dementia, Alzheimer’s disease, frontotemporal dementia and progressive supranuclear palsy.

30 Jan, 2022 | 13:53h | UTC

Differential levels of plasma biomarkers of neurodegeneration in Lewy body dementia, Alzheimer’s disease, frontotemporal dementia and progressive supranuclear palsy – Journal of Neurology, Neurosurgery, and Psychiatry

Commentary: Blood Biomarkers May Distinguish Dementia Disorders – MedPage Today (free registration required)

 

10 mistakes in dietary management of irritable bowel syndrome and how to avoid them.

30 Jan, 2022 | 13:59h | UTC

Mistakes in dietary management of IBS and how to avoid them – United European Gastroenterology

Related:

Supplement: Irritable bowel syndrome and related conditions.

RCT: FODMAPs, but not gluten, elicit modest symptoms of irritable bowel syndrome.

RCT: Among patients with diarrhea-predominant irritable bowel syndrome, a low FODMAP diet achieved earlier symptomatic improvements in stool frequency and excessive wind.

British Society of Gastroenterology guidelines on the management of irritable bowel syndrome

Guidelines for the treatment of irritable bowel syndrome

ACG Clinical Guideline: Management of irritable bowel syndrome

M-A: Efficacy of a low-FODMAP diet in adult irritable bowel syndrome

 

Commentary on Twitter (thread – click for more)

 

Review: Geriatric syndromes in older adults undergoing cardiovascular interventions.

30 Jan, 2022 | 13:46h | UTC

Geriatric Syndromes in Older Adults Undergoing Cardiovascular Interventions – American College of Cardiology

 

Commentary on Twitter

 

Perspective | Where do we stand with Omicron? The data, the math, the patterns, and the exit.

28 Jan, 2022 | 08:39h | UTC

Where do we stand with Omicron? – by Dr. Eric Topol

 

Commentary on Twitter

 

RCT: Hyperimmune immunoglobulin did not improve outcomes in hospitalized patients with COVID-19.

28 Jan, 2022 | 08:42h | UTC

Hyperimmune immunoglobulin for hospitalised patients with COVID-19 (ITAC): a double-blind, placebo-controlled, phase 3, randomised trial – The Lancet

Commentaries:

High-dose immunoglobulins from convalescent donors for patients hospitalised with COVID-19 – The Lancet

Hyperimmune intravenous immunoglobulin does not improve outcomes for adults hospitalized with COVID-19 – NIH News Releases

 

After Omicron, some scientists foresee ‘a period of quiet’.

28 Jan, 2022 | 08:36h | UTC

After Omicron, some scientists foresee ‘a period of quiet’ – Science

 

Review: Juvenile idiopathic arthritis.

28 Jan, 2022 | 08:13h | UTC

Juvenile idiopathic arthritis – Nature Reviews Disease Primers (if the link is paywalled, try this one)

Infographic: Juvenile idiopathic arthritis (if the link is paywalled, try this one)

 

Commentary on Twitter

 

Cohort Study: Bullous Pemphigoid is associated with a 5-fold higher risk of cardiovascular mortality.

28 Jan, 2022 | 08:11h | UTC

Risk of All-Cause Mortality, Cardiovascular Disease Mortality, and Cancer Mortality in Patients With Bullous Pemphigoid – JAMA Dermatology (link to abstract – $ for full-text)

 

Lab study shows new antiviral pills maintain efficacy against Omicron, but antibody drugs are substantially less effective.

27 Jan, 2022 | 10:03h | UTC

Efficacy of Antibodies and Antiviral Drugs against Covid-19 Omicron Variant – New England Journal of Medicine

Commentary: Current anti-COVID pills work well against omicron, but antibody drugs are less effective, study finds – University of Wisconsin-Madison

 

Commentary on Twitter

 

Cases of lung transplantation for Covid-19–related respiratory failure in the US were associated with a three-month survival of 95.6%.

27 Jan, 2022 | 10:00h | UTC

Lung Transplantation for Covid-19–Related Respiratory Failure in the United States – New England Journal of Medicine

Commentaries:

New data on COVID-19 lung transplants – Cedars-Sinai Medical Center

~7 Percent of Lung Transplants Due to COVID-19 Respiratory Failure – HealthDay

 

Perspective: From vaginal laser treatment to spa breaks – it’s the great menopause gold rush.

27 Jan, 2022 | 09:36h | UTC

From vaginal laser treatment to spa breaks – it’s the great menopause gold rush – The Guardian

 

Review | Immune-checkpoint inhibitors: long-term implications of toxicity.

27 Jan, 2022 | 09:39h | UTC

Immune-checkpoint inhibitors: long-term implications of toxicity – Nature Reviews Clinical Oncology (if the link is paywalled, try this one)

 

Commentary on Twitter

 

ESC Position Statement: Cardiovascular effects of doping substances, commonly prescribed medications, and ergogenic aids in relation to sports.

27 Jan, 2022 | 09:43h | UTC

Cardiovascular effects of doping substances, commonly prescribed medications and ergogenic aids in relation to sports: a position statement of the sport cardiology and exercise nucleus of the European Association of Preventive Cardiology – European Journal of Preventive Cardiology

News Release: Athletes warned against potential dangers of natural supplements – European Society of Cardiology

 

Comprehensive review of chest tube management.

27 Jan, 2022 | 09:40h | UTC

Comprehensive Review of Chest Tube Management – JAMA Surgery (free for a limited period)

 

M-A: Not enough evidence that micronutrient supplementation in addition to standard nutritional support improves clinical outcomes in malnourished medical inpatients.

27 Jan, 2022 | 09:34h | UTC

Effect of micronutrient supplementation in addition to nutritional therapy on clinical outcomes of medical inpatients: results of an updated systematic review and meta-analysis – European Journal of Clinical Nutrition (link to abstract – $ for full-text)

 

Iron deficiency anemia: pathophysiology, assessment, practical management.

27 Jan, 2022 | 09:30h | UTC

Iron deficiency anaemia: pathophysiology, assessment, practical management – BMJ Open Gastroenterology

 

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