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Internal Medicine

Evidence- and consensus-based guidelines for drug-drug interactions with anticancer drugs; A practical and universal tool for management.

12 Apr, 2022 | 10:02h | UTC

Evidence- and consensus-based guidelines for drug-drug interactions with anticancer drugs; A practical and universal tool for management – Seminars in Oncology

 

Opinion | Aligning incentives for improving diagnostic excellence.

12 Apr, 2022 | 09:54h | UTC

Aligning Incentives for Improving Diagnostic Excellence – JAMA (free for a limited period)

 

More data suggests the Omicron variant causes milder disease compared to the Delta variant.

12 Apr, 2022 | 09:49h | UTC

Symptom prevalence, duration, and risk of hospital admission in individuals infected with SARS-CoV-2 during periods of omicron and delta variant dominance: a prospective observational study from the ZOE COVID Study – The Lancet

Commentary: Covid-19: Symptomatic infection with omicron variant is milder and shorter than with delta, study reports – The BMJ

Related:

Another study suggests a lower risk of hospitalization and death from infection with SARS-CoV-2 Omicron variant vs. Delta.

Perspective: Challenges in inferring intrinsic severity of the SARS-CoV-2 Omicron variant.

Early assessment of the clinical severity of the SARS-CoV-2 omicron variant in South Africa.

Cohort Study: Incidence rates and clinical outcomes of SARS-CoV-2 infection with the Omicron and Delta variants in children younger than 5 years in the US.

[Preprint] SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters.

[Preprint] Study showed reduced clinical severity of Covid-19 patients admitted to hospitals in Gauteng, South Africa, during the Omicron-dominant fourth wave – “any combination of a less-virulent virus, comorbidities, high immunity from prior infection(s) or vaccination may be important contributors to this clinical presentation”.

Early data from South Africa hints Omicron variant may cause less severe Covid, but more research is needed.

Too early to tell, but preliminary information from doctors in South Africa suggests the new Covid variant Omicron may be associated with less severe disease.

 

M-A: The clinical effect and safety of new preoperative fasting time guidelines for elective surgery.

12 Apr, 2022 | 09:51h | UTC

The clinical effect and safety of new preoperative fasting time guidelines for elective surgery: a systematic review and meta-analysis – Gland Surgery

Related:

An international multidisciplinary consensus statement on fasting before procedural sedation in adults and children – Anaesthesia

Does my hospitalized patient need an NPO-after-midnight order preoperatively?

ESPEN practical guideline: Clinical nutrition in surgery – “Preoperative fasting from midnight is unnecessary in most patients. Patients undergoing surgery, who are considered to have no specific risk of aspiration, shall drink clear fluids until 2 h before anesthesia. Solids shall be allowed until 6 h before anesthesia.”

Pro-Con Debate: 1- vs 2-Hour Fast for Clear Liquids Before Anesthesia in Children.

Editorial: The rationale for the recommendations of the European Pediatric Fasting Guideline – “the authors of the 2021 ESAIC pediatric guideline have found reasons to recommend reductions to the minimum fasting times for infant formula to 4 h, for breast milk to 3 h and for clear fluids to 1 h”.

Practice Guidelines for Preoperative Fasting and the Use of Pharmacologic Agents to Reduce the Risk of Pulmonary Aspiration: Application to Healthy Patients Undergoing Elective Procedures: An Updated Report by the American Society of Anesthesiologists Task Force on Preoperative Fasting and the Use of Pharmacologic Agents to Reduce the Risk of Pulmonary Aspiration

Perioperative fasting in adults and children: guidelines from the European Society of Anaesthesiology

Clear fluids fasting for elective paediatric anaesthesia: The European Society of Anaesthesiology consensus statement – European Journal of Anaesthesiology

Canadian Pediatric Anesthesia Society statement on clear fluid fasting for elective pediatric anesthesia – Canadian Journal of Anesthesia (free)

 

Aspirin for primary cardiovascular prevention in patients with diabetes: uncertainties and opportunities.

12 Apr, 2022 | 08:45h | UTC

Aspirin for Primary Cardiovascular Prevention in Patients with Diabetes: Uncertainties and Opportunities – Thrombosis and Haemostasis

Related Guideline:

USPSTF draft statement revises previous guidance and now recommends against initiating low-dose aspirin use for the primary prevention of CVD in adults aged 60 years or older.

Related Randomized Trials:

Randomized Trial: Aspirin for Primary Prevention of Cardiovascular Disease

Randomized Trial: Effects of Aspirin for Primary Prevention in Persons with Diabetes

Randomized Trial: Effect of Aspirin on All-Cause Mortality in the Healthy Elderly

Related Meta-Analysis:

Meta-Analysis: Association of Aspirin Use for Primary Prevention with Cardiovascular Events and Bleeding Events

Meta-Analysis: Efficacy and Safety of Aspirin for Primary Prevention of Cardiovascular Events

Aspirin for primary prevention of cardiovascular disease: a meta-analysis with a particular focus on subgroups – BMC Medicine

Related Opinions:

Aspirin for Primary Prevention: Is This the End of the Road?

Evidence evolving on aspirin as prevention – ACP Internist

 

Empyema: ED presentation, evaluation, and management.

12 Apr, 2022 | 08:44h | UTC

Empyema: ED Presentation, Evaluation, and Management – emDocs

 

Cohort Study: Insomnia linked to increased risk of recurrent cardiovascular events in patients with coronary heart disease.

12 Apr, 2022 | 08:36h | UTC

Insomnia as a predictor of recurrent cardiovascular events in patients with coronary heart disease – Sleep Advances

Commentary: Insomnia is linked with recurrent heart events in coronary patients – European Society of Cardiology

 

Overview of diagnostic criteria and epidemiology of acute kidney injury and acute kidney disease in the critically ill patient.

12 Apr, 2022 | 08:30h | UTC

Overview of Diagnostic Criteria and Epidemiology of Acute Kidney Injury and Acute Kidney Disease in the Critically Ill Patient – Clinical Journal of the American Society of Nephrology

 

Review: Drug-induced interstitial lung disease.

12 Apr, 2022 | 08:29h | UTC

Drug-induced interstitial lung disease – European Respiratory Review

Related: Systematic Review: Drug-Induced Interstitial Lung Disease

 

Drug-induced interstitial lung disease during cancer therapies: expert opinion on diagnosis and treatment.

12 Apr, 2022 | 08:27h | UTC

Drug-induced interstitial lung disease during cancer therapies: expert opinion on diagnosis and treatment – ESMO Open

 

Prevention and management of postoperative ileus: a review of current practice.

12 Apr, 2022 | 08:20h | UTC

Prevention and Management of Postoperative Ileus: A Review of Current Practice – Cureus

 

Clinical update on COVID-19 for the emergency and critical care clinician: Medical management.

11 Apr, 2022 | 02:00h | UTC

Clinical update on COVID-19 for the emergency and critical care clinician: Medical management – American Journal of Emergency Medicine

 

Keep the size of your waist to less than half of your height, updated NICE draft guideline recommends.

11 Apr, 2022 | 02:01h | UTC

Keep the size of your waist to less than half of your height, updated NICE draft guideline recommends – National Institute for Health and Care Excellence

Commentaries:

Expert reaction to updated NICE draft guideline on weight management, including the suggestion for people to keep their waist measurement to less than half their height – Science Media Centre

Keep your waist to less than half your height, guidance says – BBC

Draft Guideline: Obesity: identification and classification of overweight and obesity – National Institute for Health and Care Excellence

 

RCT: For adults with HIV, a 4-days-on and 3-days-off treatment strategy is noninferior to standard treatment for maintaining viral suppression.

11 Apr, 2022 | 01:56h | UTC

A 4-days-on and 3-days-off maintenance treatment strategy for adults with HIV-1 (ANRS 170 QUATUOR): a randomised, open-label, multicentre, parallel, non-inferiority trial – The Lancet HIV (link to abstract – $ for full-text)

Commentary: Intermittent Treatment Strategy Is Effective for HIV – Consultant360

 

Commentaries on Twitter

 

Review: Atrial fibrillation.

11 Apr, 2022 | 01:57h | UTC

Atrial fibrillation – Nature Reviews Disease Primers (if the link is paywalled, try this one)

Infographic: Atrial fibrillation – Nature Reviews Disease Primers (if the link is paywalled, try this one)

 

Commentary on Twitter

 

Review: Gastrointestinal post-acute COVID-19 syndrome.

11 Apr, 2022 | 01:49h | UTC

Gastrointestinal post-acute COVID-19 syndrome – Nature Reviews Gastroenterology & Hepatology

 

Commentary on Twitter

 

RCT: Effect of Gram Stain–Guided initial antibiotic therapy on clinical response in patients with ventilator-associated pneumonia.

11 Apr, 2022 | 01:36h | UTC

Effect of Gram Stain–Guided Initial Antibiotic Therapy on Clinical Response in Patients With Ventilator-Associated Pneumonia: The GRACE-VAP Randomized Clinical Trial – JAMA Network Open

Commentary: Can Gram Stains Guide Antibiotics for Pneumonia in Critical Care? – Medscape (free registration required)

 

Commentary on Twitter

 

UK clinical guideline for the prevention and treatment of osteoporosis.

11 Apr, 2022 | 01:33h | UTC

UK clinical guideline for the prevention and treatment of osteoporosis – Archives of Osteoporosis

 

Guideline Synopsis: Management of chronic multisymptom illness.

11 Apr, 2022 | 01:29h | UTC

Management of Chronic Multisymptom Illness: Synopsis of the 2021 US Department of Veterans Affairs and US Department of Defense Clinical Practice Guideline – Mayo Clinic Proceedings

 

RCT: Efficacy and safety of gefapixant, a P2X3 receptor antagonist, in refractory chronic cough and unexplained chronic cough.

11 Apr, 2022 | 01:22h | UTC

Efficacy and safety of gefapixant, a P2X3 receptor antagonist, in refractory chronic cough and unexplained chronic cough (COUGH-1 and COUGH-2): results from two double-blind, randomised, parallel-group, placebo-controlled, phase 3 trials – The Lancet (link to abstract – $ for full-text)

 

Commentary on Twitter

 

Effects of aspirin on dementia and cognitive function in diabetic patients: the ASCEND trial.

11 Apr, 2022 | 00:50h | UTC

Effects of aspirin on dementia and cognitive function in diabetic patients: the ASCEND trial – European Heart Journal

Original Study: Randomized Trial: Effects of Aspirin for Primary Prevention in Persons with Diabetes

 

Commentary on Twitter (images under a https://creativecommons.org/licenses/by/4.0/ license)

 

Cohort Study: Use of Phosphodiesterase 5 Inhibitors linked to increased risk of ocular adverse events.

8 Apr, 2022 | 11:04h | UTC

Risk of Ocular Adverse Events Associated With Use of Phosphodiesterase 5 Inhibitors in Men in the US – JAMA Ophthalmology (free for a limited period)

News Release: U.S. insurance claims show strong link between ED medications and vision problems – University of British Columbia

Commentaries:

Phase 4 Studies on Phosphodiesterase 5 Inhibitors – JAMA Ophthalmology (free for a limited period)

Expert reaction to study looking at risk of vision impairment and loss, and use of phosphodiesterase type 5 inhibitors – Science Media Centre

Could Viagra, Cialis Raise Men’s Odds for Eye Trouble? – HealthDay

 

M-A: Thrombosis patterns and clinical outcome of COVID-19 vaccine-induced immune thrombotic thrombocytopenia.

8 Apr, 2022 | 10:50h | UTC

Thrombosis patterns and clinical outcome of COVID-19 vaccine-induced immune thrombotic thrombocytopenia: A Systematic Review and Meta-Analysis – International Journal of Infectious Diseases

Related:

Case series of Thrombosis with Thrombocytopenia Syndrome after Covid-19 vaccination in the US.

Review: Vaccine-induced immune thrombotic thrombocytopenia.

Vaccine induced immune thrombocytopenia and thrombosis: summary of NICE guidance.

Clinical features of vaccine-induced immune thrombocytopenia and thrombosis.

Review: Clinical characteristics and pharmacological management of COVID-19 vaccine–induced immune thrombotic thrombocytopenia with cerebral venous sinus thrombosis.

Vaccine-induced immune thrombotic thrombocytopenia: what we know and do not know.

Very rare cases of thrombosis with thrombocytopenia syndrome (TTS) after AstraZeneca vaccine: a global safety database analysis – the estimated rate of TTS after the first dose was 8.1 per million vaccinees; after the second dose, the estimated rate was 2.3 per million vaccinees. (several articles and resources on the subject)

 

M-A: Diagnostic performance of CO-RADS for Covid-19.

8 Apr, 2022 | 10:31h | UTC

Diagnostic performance of CO-RADS for COVID-19: a systematic review and meta-analysis – European Radiology

Related: CO-RADS – A categorical CT assessment scheme for patients with suspected COVID-19: definition and evaluation – Radiology

 

Review | Chronic pain and infection: mechanisms, causes, conditions, treatments, and controversies.

8 Apr, 2022 | 10:27h | UTC

Chronic pain and infection: mechanisms, causes, conditions, treatments, and controversies – BMJ Medicine

 

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