Internal Medicine
Diarrhea during critical illness: a multicenter cohort study.
18 Apr, 2022 | 10:20h | UTCDiarrhea during critical illness: a multicenter cohort study – Intensive Care Medicine
Commentary on Twitter
Diarrhea in #ICU
➡️common but variable incidence (definition applied)
➡️rarely caused by Clostridioides difficile
➡️modifiable predictors include EN/duration of ABs exposure
➡️associated with longer time to discharge but not increased mortality#FOAMcc
📖 https://t.co/Wx0T7RWukV pic.twitter.com/CvhWgTEwJb— Intensive Care Medicine (@yourICM) April 14, 2022
Commentary: Loneliness and health.
18 Apr, 2022 | 10:16h | UTCLoneliness and health – Nature Reviews Disease Primers (if the link is paywalled, try this one)
Related:
The prevalence of loneliness across 113 countries: systematic review and meta-analysis – The BMJ
Social Isolation and Loneliness – World Health Organization
Psychological Distress and Loneliness Reported by US Adults in 2018 and April 2020 – JAMA
Commentary on Twitter
In this Comment, Louise Hawkley discusses associations of #Loneliness with increased mortality and disease risk, and that a multi-level approach including individuals, community organizations and society is needed to reduce loneliness.@NORCNewshttps://t.co/CzP5fR6G0n pic.twitter.com/X3use2Aybe
— Nature Reviews Disease Primers (@DiseasePrimers) April 14, 2022
Guidelines for therapeutic drug monitoring of vancomycin in the framework of model-informed precision dosing.
18 Apr, 2022 | 10:26h | UTCRelated Guideline:
Commentary on Twitter
https://twitter.com/IDPharmacometrx/status/1514219239732912131
An observational study in patients with chronic kidney disease suggests the optimum range of water intake is around 1–2 L/day.
18 Apr, 2022 | 10:12h | UTC
Prospective validation of a rapid host gene expression test to discriminate bacterial from viral respiratory infection.
18 Apr, 2022 | 09:58h | UTC
Commentary on Twitter
In this diagnostic study, a new host gene expression test identified patients unlikely to have bacterial infection in only 45 minutes, a potential new tool for antibiotic stewardship. https://t.co/3JiYl2N4b0
— JAMA Network Open (@JAMANetworkOpen) April 14, 2022
RCT: Among patients waiting for total knee arthroplasty with a BMI above 35, bariatric surgery before the procedure was associated with reduced risk of complications.
18 Apr, 2022 | 09:52h | UTCCommentary: Bariatric Surgery Before TKA Cuts Complications in Obese Patients – HealthDay
Commentary on Twitter
In this RCT, bariatric surgery before knee replacement (TKA) reduced the risk of complications in TKA in adults <65y with class II obesity scheduled to undergo TKA; 30% had sufficient symptom improvement to decline TKA altogether. https://t.co/qyhl0eIV2o
— JAMA Network Open (@JAMANetworkOpen) April 14, 2022
Risk for asymptomatic household transmission of Clostridioides difficile infection associated with recently hospitalized family members.
18 Apr, 2022 | 09:41h | UTCCommentary: Recently Discharged Patients Pose Risk for Spreading C. Difficile Infection – HealthDay
Incidental discovery of interstitial lung disease: diagnostic approach, surveillance and perspectives.
18 Apr, 2022 | 09:36h | UTC
Covid-19: What is the evidence for the antiviral molnupiravir?
14 Apr, 2022 | 08:47h | UTCCovid-19: What is the evidence for the antiviral molnupiravir? – The BMJ
The Lancet Series: Origins of chronic obstructive pulmonary disease.
14 Apr, 2022 | 08:38h | UTCHomepage: Origins of chronic obstructive pulmonary disease – The Lancet Respiratory Medicine (free registration required for all articles)
GETting to know the many causes and faces of COPD
COPD, smoking, and social justice
Commentary on Twitter (thread – click for more)
NEW Series—Origins of #COPD 1) Genetics of #COPD: understanding the pathobiology and heterogeneity of a complex disorder
From @mikecho95, @BrianDHobbs & Prof Edwin Silverman https://t.co/r2tGawHL8r pic.twitter.com/IfQhqJrDaR
— The Lancet Respiratory Medicine (@LancetRespirMed) April 13, 2022
M-A: Association between physical activity and risk of depression.
14 Apr, 2022 | 08:35h | UTCCommentary: Exercise Is Powerful Medicine for Depression – HealthDay
Commentary on Twitter
Meta-analysis found that adults meeting physical activity recommendations had 25% lower risk of #depression compared with adults reporting no #physicalactivity. https://t.co/LITlo954lB
— JAMA Psychiatry (@JAMAPsych) April 13, 2022
Cross-sectional study: The use of Selective Serotonin Reuptake Inhibitors is associated with a reduction in measured movements.
14 Apr, 2022 | 08:32h | UTC
Commentary on Twitter
This cross-sectional study found SSRI use was associated with a reduction in measured movements, highlighting the utility of passively collected data for exploring and characterizing adverse drug effects. https://t.co/54ZngDdt8u
— JAMA Network Open (@JAMANetworkOpen) April 7, 2022
Population based cohort study: Healthy lifestyle and life expectancy with and without Alzheimer’s dementia.
14 Apr, 2022 | 08:27h | UTCEditorial: Healthy lifestyles and more life years without dementia – The BMJ
Commentary on Twitter
A new US study suggests that a healthy lifestyle is associated with a longer life expectancy among both men and women, and they lived a larger proportion of their remaining years without Alzheimer’s diseasehttps://t.co/eXsQRd6mon
— The BMJ (@bmj_latest) April 14, 2022
M-A: Symptom burden and health-related quality of life in chronic kidney disease.
14 Apr, 2022 | 08:22h | UTC
Review: Diagnosis and treatment of pulmonary arterial hypertension.
13 Apr, 2022 | 10:58h | UTCDiagnosis and Treatment of Pulmonary Arterial Hypertension: A Review – JAMA (free for a limited period)
Audio Clinical Review: Diagnosis and Treatment of Pulmonary Arterial Hypertension – JAMA
Commentary on Twitter
This review summarizes current evidence regarding diagnosis and treatment of pulmonary arterial #hypertension. https://t.co/Ebo33PD8Qq
— JAMA (@JAMA_current) April 12, 2022
Cluster RCT: A shorter antimicrobial prophylaxis duration (less than 24 hours after surgery) is noninferior to a more extended regimen (24-48 hours) after clean orthopedic surgery.
13 Apr, 2022 | 10:56h | UTC
Commentary on Twitter
Cluster RCT of patients who underwent clean orthopedic surgery found shorter antimicrobial prophylaxis duration (<24h postop) was noninferior to longer duration (<48h) in preventing health care associated infections and across a range of clinical outcomes. https://t.co/FFzxNiHxet
— JAMA Network Open (@JAMANetworkOpen) April 12, 2022
M-A: Sodium-glucose Cotransporter 2 inhibitors are associated with reduced risk of hyperkalemia in people with type 2 diabetes.
13 Apr, 2022 | 10:52h | UTC
RCT: Dapagliflozin did not significantly improve glycemic control in children and young adults with type 2 diabetes.
13 Apr, 2022 | 10:46h | UTCEfficacy and safety of dapagliflozin in children and young adults with type 2 diabetes: a prospective, multicentre, randomised, parallel group, phase 3 study – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)
Review | Less is more: deprescribing medications in older adults with kidney disease.
13 Apr, 2022 | 10:44h | UTCLess is More: Deprescribing Medications in Older Adults with Kidney Disease: A Review – Kidney360
Related:
AGA clinical practice update on de-prescribing of proton pump inhibitors.
Development of a metric to detect and decrease low-value prescribing in older adults.
Deprescribing in palliative patients with cancer: a concise review of tools and guidelines.
A narrative review of evidence to guide deprescribing among older adults.
Polypharmacy Management in Older Patients – Mayo Clinic Proceedings
Eliminating Medication Overload: A National Action Plan
Position Statement: Reducing Inappropriate Medication Use & Polypharmacy (several articles and commentaries on the subject)
Cluster RCT: A multifaceted intervention did not reduce catheter related bloodstream infections in patients on hemodialysis.
13 Apr, 2022 | 10:29h | UTC
Cohort Study: Increased thoracic aortic diameter is associated with increased risk of cardiovascular events and mortality among women and men.
13 Apr, 2022 | 10:20h | UTCThoracic Aortic Diameter and Cardiovascular Events and Mortality among Women and Men – Radiology
News Release: Increased aortic diameter raises risk of heart attack, stroke – Radiological Society of North America
Brief review | Infective endocarditis: words of caution for management.
13 Apr, 2022 | 10:12h | UTCInfective Endocarditis: Words of Caution For Management – American College of Cardiology
Related:
Randomized Trial: Partial Oral vs. Intravenous Antibiotic Treatment of Endocarditis
Podcast: Infective Endocarditis Pearls.
Review: Infective endocarditis after surgical and transcatheter aortic valve replacement
Infective Endocarditis: A Contemporary Review
Summary: Current AATS Guidelines on Surgical Treatment of Infective Endocarditis
Review: Current Evidence on Oral Antibiotics for Infective Endocarditis
Research: Invasive Procedures Associated With the Development of Infective Endocarditis
Prosthetic Valve Endocarditis After Surgical Aortic Valve Replacement
Drug resistant TB – latest developments in epidemiology, diagnostics and management.
13 Apr, 2022 | 10:09h | UTCRelated:
Summary | WHO recommendations on the treatment of drug-resistant tuberculosis, 2020 update.
WHO Consolidated Guidelines on Drug-resistant Tuberculosis Treatment
Canadian Tuberculosis Standards – 8th Edition.
Guideline: Treatment of Drug-Resistant Tuberculosis
The Lancet Commission: Management of Multidrug-resistant and Incurable Tuberculosis
Regimens to Treat Multidrug-resistant Tuberculosis: Past, Present and Future Perspectives
RCT: Single-dose HPV vaccination found effective among young African women.
12 Apr, 2022 | 10:08h | UTCEfficacy of Single-Dose Human Papillomavirus Vaccination among Young African Women – NEJM Evidence
News Releases:
Study boosts support for single-dose HPV vaccine regimen – University of Washington
Related:
Three-year follow-up of 2-dose versus 3-dose HPV vaccine
Commentary on Twitter (thread – click for more)
🚨 GAME CHANGER 🚨
One-dose Human Papillomavirus (#HPV) vaccine offers solid protection against cervical cancer: WHO https://t.co/3uWlZlCCVK pic.twitter.com/ZKDvpf2qog— World Health Organization (WHO) (@WHO) April 11, 2022
M-A: SGLT2 inhibitors reduce hospitalizations in patients with heart failure regardless of the presence of diabetes.
12 Apr, 2022 | 10:05h | UTCSodium–Glucose Cotransporter-2 Inhibitors in Patients With Heart Failure: A Systematic Review and Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)
News Release: SGLT2 inhibitors reduces hospitalization for heart failure regardless of presence of diabetes – American College of Physicians