Internal Medicine
USPSTF Draft Statement: Postmenopausal women should not use hormone therapy to prevent chronic health problems.
20 Apr, 2022 | 10:15h | UTCDraft Recommendation Statement: Hormone Therapy for the Primary Prevention of Chronic Conditions in Postmenopausal Persons – U.S. Preventive Services Task Force
Commentary: USPSTF Advises Against Hormone Therapy to Prevent Chronic Conditions – HealthDay
Studies highlight meningitis vaccine’s potential against gonorrhea.
20 Apr, 2022 | 10:06h | UTCCommentary: Studies highlight meningitis vaccine’s potential against gonorrhea – CIDRAP
News Release: Threat of untreatable gonorrhoea could be tackled using an existing meningitis vaccine – The Lancet
Study 1: Effectiveness of a serogroup B outer membrane vesicle meningococcal vaccine against gonorrhoea: a retrospective observational study – The Lancet Infectious Diseases (link to abstract – $ for full-text)
Study 2: Effectiveness and impact of the 4CMenB vaccine against invasive serogroup B meningococcal disease and gonorrhoea in an infant, child, and adolescent programme: an observational cohort and case-control study – The Lancet Infectious Diseases (link to abstract – $ for full-text)
An observational study suggests coprescription of Phosphodiesterase Type 5 Inhibitors (i.e., sildenafil) and oral Nitrates is not associated with increased risk of adverse cardiovascular outcomes in male patients with ischemic heart disease.
20 Apr, 2022 | 10:11h | UTCCommentaries:
PDE5 Inhibitors Prescribed for Men on Oral Nitrates for IHD – HealthDay
Covid hasn’t given up all its secrets. Here are 6 mysteries experts hope to unravel.
20 Apr, 2022 | 09:57h | UTCCovid hasn’t given up all its secrets. Here are 6 mysteries experts hope to unravel – STAT
Expert Guidance: Strategies to prevent central line-associated bloodstream infections in acute-care hospitals.
20 Apr, 2022 | 10:13h | UTC
Commentary on Twitter
Prevention of central line-associated bloodstream infections in acute-care hospitals- 2022 updatehttps://t.co/o3AReYvJIu pic.twitter.com/QsgYYezhqj
— K Pavithran (@drkpavithran) April 19, 2022
Article under a http://creativecommons.org/licenses/by/4.0/ license
A nonrandomized controlled study found awake prone position (median of 4.2 hours per day) may not benefit hospitalized adults with Covid-19.
20 Apr, 2022 | 09:56h | UTCCommentaries:
Study suggests worse outcomes for awake COVID patients in prone position – CIDRAP
Putting Hospitalized COVID Patients on Their Belly May Not Be a Good Idea After All – HealthDay
Related:
RCT: Prone positioning of patients with moderate hypoxia due to COVID-19 – medRxiv
Commentary on Twitter (thread – click for more)
Important negative study: non randomized trial finds no clinical benefit to awake proning vs usual care in COVID
No difference in rates of intubation, length of stay, or 28 day mortality
Medicine is humbling. This emphasizes the importance of trials
📄https://t.co/ksh9Ic9XBL
1/ pic.twitter.com/sjHHv4WQs8— Nick Mark MD (@nickmmark) April 18, 2022
German guidelines for the diagnosis and treatment of varicose veins.
20 Apr, 2022 | 09:49h | UTCS2k guidelines: diagnosis and treatment of varicose veins – Leitlinien und Empfehlungen
Review | Blood pressure and its variability: classic and novel measurement techniques.
20 Apr, 2022 | 09:42h | UTCBlood pressure and its variability: classic and novel measurement techniques – Nature Reviews Cardiology (if the link is paywalled, try this one)
Cohort Study: Infertility in women linked to increased risk of heart failure with preserved ejection fraction.
20 Apr, 2022 | 09:44h | UTCInfertility and Risk of Heart Failure in the Women’s Health Initiative – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Podcast: Infertility and Risk of Heart Failure in the Women’s Health Initiative
Commentaries:
Infertility in Women Linked to Subsequent Risk of HFpEF – TCTMD
MGH study finds infertility associated with increased risk of heart failure – MedicalResearch
Systematic Review: Treatment of periodontitis for glycemic control in people with diabetes mellitus.
20 Apr, 2022 | 09:36h | UTCTreatment of periodontitis for glycaemic control in people with diabetes mellitus – Cochrane Library
Commentary on Twitter
Does treatment for gum disease help people with diabetes control their blood sugar levels? Evidence from @CochraneLibrary: https://t.co/lk6nGrAIpp pic.twitter.com/UZXKr5b4Rs
— Cochrane Oral Health (@CochraneOHG) April 19, 2022
Cohort Study: Association of subjective memory complaints with white matter hyperintensities and cognitive decline among older adults.
20 Apr, 2022 | 09:17h | UTCCommentary: Memory complaints associated with structural brain abnormalities and increased dementia risk – HealthImaging
Commentary on Twitter
In this cohort study, subjective memory complaints (SMCs) were associated with larger white matter hyperintensity volumes and faster cognitive decline, suggesting that SMCs are an important sign of cognitive impairment. https://t.co/mpCXDbylnf
— JAMA Network Open (@JAMANetworkOpen) April 15, 2022
Opinion | Low-grade prostate cancer (Gleason score 6): time to stop calling it cancer.
19 Apr, 2022 | 02:29h | UTCLow-Grade Prostate Cancer: Time to Stop Calling It Cancer – Journal of Clinical Oncology
Commentary: Doctors suggest new names for low-grade prostate cancer – Associated Press
Video: Here’s what we know about COVID-19’s impact on the brain.
19 Apr, 2022 | 02:22h | UTCHere’s what we know about COVID-19’s impact on the brain – Science
Related:
SARS-CoV-2 is associated with changes in brain structure in UK Biobank – Nature
Nervous system consequences of COVID-19 – Science
The COVID generation: how is the pandemic affecting kids’ brains? – Nature
Assessment of Cognitive Function in Patients After COVID-19 Infection – JAMA Network Open
M-A: Global prevalence of post COVID-19 condition or long COVID.
19 Apr, 2022 | 02:18h | UTCCommentary: Global data reveal half may have long COVID 4 months on – CIDRAP
Commentary on Twitter (thread – click for more)
🚨The so far largest meta-analysis of more than 1.5 million infected individuals puts the global prevalence of #LongCovid at 43%. Some additional key findings. 🧵https://t.co/XGu23MV3Ra
1/— Jonas R. Kunst (@kunstjonas.bsky.social) (@KunstJonas) April 17, 2022
Opinion | Learning the art and science of diagnosis.
19 Apr, 2022 | 02:12h | UTCLearning the Art and Science of Diagnosis – JAMA (free for a limited period)
Acute hepatitis in ED setting: etiologies, evaluation, and management.
19 Apr, 2022 | 01:54h | UTCAcute Hepatitis in ED Setting: Etiologies, Evaluation, and Management – emDocs
RCT: Allopurinol is noninferior to febuxostat for controlling gout flares.
19 Apr, 2022 | 02:05h | UTCComparative Effectiveness of Allopurinol and Febuxostat in Gout Management – NEJM Evidence (link to abstract – $ for full-text)
Review: Paradoxical reactions to biologicals in chronic inflammatory systemic diseases.
19 Apr, 2022 | 01:48h | UTC
Review: The safety of antirheumatic drugs.
19 Apr, 2022 | 01:42h | UTCThe Safety of Antirheumatic Drugs – Deutsches Ärzteblatt International
Palliative care for older people with dementia—we need a paradigm shift in our approach – “Advance care planning (ACP) is a central tenet of good dementia palliative care”.
19 Apr, 2022 | 01:30h | UTC
Cluster RCT: BABEL (Better tArgeting, Better outcomes for frail ELderly patients) advance care planning: a comprehensive approach to advance care planning in nursing homes.
19 Apr, 2022 | 01:26h | UTC
Endocrine therapies for breast and prostate cancers: Essentials for primary care.
19 Apr, 2022 | 01:14h | UTC
RCT: A 12-months oral itraconazole regimen is superior to 6-months of treatment to prevent relapses of chronic pulmonary aspergillosis.
18 Apr, 2022 | 10:36h | UTCEfficacy of 12-months oral itraconazole versus 6-months oral itraconazole to prevent relapses of chronic pulmonary aspergillosis: an open-label, randomised controlled trial in India – The Lancet Infectious Diseases (link to abstract – $ for full-text)
M-A: Myopericarditis following COVID-19 vaccination and non-COVID-19 vaccination.
18 Apr, 2022 | 10:32h | UTCCommentaries:
Myopericarditis following COVID-19 vaccination is rare, finds international study – The Lancet
Study explores myopericarditis incidence and COVID-19 vaccination – News Medical
Commentary on Twitter
NEW—Myopericarditis following #COVID19 vaccination is rare, finds international study published in @LancetRespirMed: https://t.co/d3ZRvTWrGB pic.twitter.com/6sHiRyEbTk
— The Lancet (@TheLancet) April 11, 2022
AHA Scientific Statement: Nonalcoholic fatty liver disease and cardiovascular risk.
18 Apr, 2022 | 10:37h | UTCNews Releases:
Fatty liver disease not caused by alcohol is common – and often missed – American Heart Association