Evidence-based Medicine
Perspective | Pragmatism in clinical trials: essential, not optional.
15 Aug, 2022 | 12:15h | UTCPragmatism in clinical trials: essential, not optional – European Journal of Cardiology (free for a limited period)
Commentary on Twitter
A call for pragmatism in the design and running of clinical trials:https://t.co/bXQ4Wp0x1i#EHJ@escardio pic.twitter.com/ES1X12zTGv
— EHJ Editor-in-Chief (@ehj_ed) August 11, 2022
Perspective | How to disseminate clinical research.
12 Aug, 2022 | 15:06h | UTCHow to disseminate clinical research – Anaesthesia
Commentary on Twitter
?How to disseminate clinical research.
"Traditionally, dissemination of scientific research ends at publication in a peer-reviewed journal. However, most clinicians and patients to whom the work is relevant will never read it."@GongGasGirl
?https://t.co/jQnfFSSt6m pic.twitter.com/IyeYWUCCiW
— ??????????? (@Anaes_Journal) July 8, 2022
Advancing digital health applications: priorities for innovation in real-world evidence generation.
10 Aug, 2022 | 12:15h | UTC
Is the contemporary care of older persons with acute coronary syndrome evidence-based?
8 Aug, 2022 | 11:48h | UTC
Commentary from the author on Twitter
♦️Heart disease leading cause of death in older adults
♦️Less likely to receive guideline recommended treatment
♦️Frailty, multi-morbidity linked to worse outcomes
♦️We explore this in our manuscript led by @GregBMills1
?Open access for free download?https://t.co/l452O1QJTJ pic.twitter.com/HCRuwle3KK— Professor Vijay Kunadian (@VijayKunadian) January 29, 2022
Statistical significance and its critics: practicing damaging science, or damaging scientific practice?
8 Aug, 2022 | 11:35h | UTCRelated:
Bayesian interpretation of p values in clinical trials – BMJ Evidence-Based Medicine
Scientists rise up against statistical significance – Nature
It’s time to talk about ditching statistical significance – Nature
PulmCrit- .050 shades of grey in p-value cutoffs
What a nerdy debate about p-values shows about science — and how to fix it – VOX
Big names in statistics want to shake up much-maligned P value – Nature News
‘One-size-fits-all’ threshold for P values under fire – Nature News
Statisticians issue warning over misuse of P values – Nature News
Understanding common misconceptions about p-values – The 20% Statistician
The clinician’s guide to p values, confidence intervals, and magnitude of effects – Eye (if the link is paywalled, try this one)
Viewpoint | Deimplementation of low-value care in surgery.
4 Aug, 2022 | 14:43h | UTCDeimplementation of Low-Value Care in Surgery – JAMA Surgery (free for a limited period)
Designing Infographics | Visual representations for enhancing education, communication, and scientific research.
3 Aug, 2022 | 14:24h | UTCRelated:
As scientists take to Twitter, study shows power of ‘visual abstract’ graphics – Scienmag
See also: an open-source primer on visual abstracts
When underlying biology threatens the randomization principle — initial gout flares of urate-lowering therapy.
1 Aug, 2022 | 12:12h | UTCWhen underlying biology threatens the randomization principle — initial gout flares of urate-lowering therapy – Nature Reviews Rheumatology (if the link is paywalled, try this one in PMC)
Commentary on Twitter
New content online! When underlying biology threatens the randomization principle — initial gout flares of urate-lowering therapy https://t.co/4vBcfXXNju pic.twitter.com/BuYwypWU15
— NatRevRheumatol (@NatRevRheumatol) July 25, 2022
Doctors tend to have unrealistic expectations of the success of multi-step medical procedures.
18 Jul, 2022 | 11:42h | UTCOriginal Study: Analysis of Physicians’ Probability Estimates of a Medical Outcome Based on a Sequence of Events – JAMA Network Open
Commentary on Twitter (thread – click for more)
This just out: Physicians do not logically/correctly estimate the probability of outcomes resulting from sequences of events – a thread. #conjunctionfallacy #probability #medicaldecisionmaking #clinicalreasoning #innumeracy #numeracy https://t.co/zGULPrdVBa @JAMANetworkOpen
— The Phlegmfighter (@phlegmfighter) June 27, 2022
How to bounce back from a PhD-project failure.
14 Jul, 2022 | 12:59h | UTCHow to bounce back from a PhD-project failure – Nature
Designing and conducting adaptive trials to evaluate interventions in health services and implementation research: practical considerations.
12 Jul, 2022 | 12:27h | UTC
Commentary on Twitter
Practical considerations in designing and conducting adaptive #trials to evaluate interventions in #healthservices and implementation research. ▶️ https://t.co/0kGY6nOSza
@jlauffen #MedTwitter #BMJMedicine pic.twitter.com/Dot9XT1KDu
— BMJMedicine (@BMJMedicine) July 11, 2022
The (R)evolution of social media in oncology: engage, enlighten, and encourage.
11 Jul, 2022 | 12:33h | UTCThe (R)evolution of Social Media in Oncology: Engage, Enlighten, and Encourage – Cancer Discovery
Related:
Twitter promotion is associated with higher citation rates of cardiovascular articles: the ESC Journals Randomized Study – European Society of Cardiology (link to abstract – $ for full-text)
Randomized Trial: Twitter Promotion Increases Citation Rates of Cardiovascular Articles
Does Tweeting Improve Citations? One-Year Results from the TSSMN Prospective Randomized Trial
A critical review on altmetrics: can we measure the social impact factor?
As scientists take to Twitter, study shows power of ‘visual abstract’ graphics
Perspective: How Twitter is Changing Medical Research
Keeping Up With Cardiology: Old-School Learning Versus the Twittersphere – TCTMD
Scientists on Twitter: Preaching to the choir or singing from the rooftops? – Facets
Rise of the Tweetorial – Precious Bodily Fluids
Social Medicine: Twitter in Healthcare – Journal of Clinical Medicine
University of Twitter? Scientists give impromptu lecture critiquing nutrition research – CBC
What’s your doctor reading? How social media is disrupting medical education – National Post
Perspective | How to find, read and organize papers.
8 Jul, 2022 | 11:57h | UTCHow to find, read and organize papers – Nature
How to write statistical analysis section in medical research.
29 Jun, 2022 | 12:03h | UTCHow to write statistical analysis section in medical research – Journal of Investigative Medicine
Commentary on Twitter
How to write statistical analysis section in medical research
Via @JIM_AFMR https://t.co/1lfbiPlcel pic.twitter.com/6LZaLT7AGl— Abraham E. Gracia R. (@Abraham_RMI) June 27, 2022
Under a http://creativecommons.org/licenses/by-nc/4.0/ license
Current recommendations/practices for anonymizing data from clinical trials in order to make it available for sharing: A scoping review.
29 Jun, 2022 | 11:17h | UTC
Commentary on Twitter
Aryelly Rodriguez et al systematically studied data anonymization recommendations, concluding that techniques by themselves are insufficient to protect privacy and need to be paired with controlled access. @SCTorg @AryellyR @SAGEClinMed @NIH @EdinburghUnihttps://t.co/SjqOxQBqzn
— Colin Begg (@ColinBBegg) June 24, 2022
Use of pragmatic and explanatory trial designs in acute care research: lessons from COVID-19.
27 Jun, 2022 | 11:49h | UTC
Commentary on Twitter
NEW Personal View—Use of pragmatic and explanatory trial designs in acute care research: lessons from #COVID19
From Jonathan Casey & colleagues https://t.co/3vJs5j6Q1Q pic.twitter.com/hEUFYxNKRf
— The Lancet Respiratory Medicine (@LancetRespirMed) June 14, 2022
New COVID drugs face delays as trials grow more difficult.
24 Jun, 2022 | 11:47h | UTCNew COVID drugs face delays as trials grow more difficult – Nature
Research must do no harm: new guidance addresses all studies relating to people.
24 Jun, 2022 | 11:46h | UTCResearch must do no harm: new guidance addresses all studies relating to people – Nature
See Guidance: Research Ethics – Nature Portfolio
Perspective | Four areas of health innovation boosted by the pandemic.
24 Jun, 2022 | 11:36h | UTCFour areas of health innovation boosted by the pandemic – Nature Medicine
Commentary on Twitter
Leading researchers speak with @NatureMedicine about how the COVID-19 pandemic has spurred research on wearables, genomic surveillance, behavioral interventions and drug discovery. https://t.co/k3Svb0xBVB
— Nature Portfolio (@NaturePortfolio) June 17, 2022
We don’t know whether most medical treatments work, and we know even less about whether they cause harm – new study.
23 Jun, 2022 | 10:32h | UTCOriginal Study: Most healthcare interventions tested in Cochrane Reviews are not effective according to high quality evidence: a systematic review and meta-analysis – Journal of Clinical Epidemiology (link to abstract – $ for full-text)
Commentary on Twitter
Of 1567 interventions tested in Cochrane reviews, only 5.6% had high quality evidence on first-listed primary outcomes and positive, statistically significant results. Harms were measured only for 36.8% of the interventions. https://t.co/Zl2GlZhiQZ
— Raffaele Rasoini (@RasoiniR) April 29, 2022
Many researchers say they’ll share data — but don’t.
23 Jun, 2022 | 10:13h | UTCMany researchers say they’ll share data — but don’t – Nature
Supplement: Digital strategy and social media in infectious diseases.
21 Jun, 2022 | 10:22h | UTCHomepage: Digital Strategy and Social Media in Infectious Diseases – Clinical Infectious Diseases
Digital Strategy and Social Media for Infectious Diseases
The Digital Classroom: How to Leverage Social Media for Infectious Diseases Education
Educational Impact of #IDJClub, a Twitter-Based Infectious Diseases Journal Club
Surgeons, Infectious Diseases, and Twitter Hit a Home Run for Antibiotic Stewardship
Go V.I.R.A.L.: Social Media Engagement Strategies in Infectious Diseases
Perspective | Cardiovascular meta-analyses: fool’s gold or gold for fools?
20 Jun, 2022 | 01:15h | UTCCardiovascular meta-analyses: fool’s gold or gold for fools? – European Heart Journal
Approach for reporting master protocol study designs on ClinicalTrials.gov: qualitative analysis.
14 Jun, 2022 | 10:32h | UTC
Subgroup analyses in randomized clinical trials: value and limitations.
13 Jun, 2022 | 07:57h | UTC